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At least 649 records · Page 36

Dual Genes of Muscle Cell Senescence: Unraveling the Radiation-Induced Roles of HDAC4 and MORC2a

As the human race ventures further into space and plans missions to explore the Moon and the expanse that lies ahead, addressing health challenges that may hinder exploration becomes an imperative task. However, limited research exists on the molecular mechanisms within skeletal muscle cells in response to long-term radiation-induced oxidative stress. Upon analyzing GLDS-426 from the GeneLab Repository, upregulation of the DNA damage response gene HDAC4 in space radiation conditions with 1G was observed, where radiation-induced oxidative stress increased DNA damage. DNA damage response gene MORC2a was found to be downregulated in space radiation conditions in 1G with a culture treatment of nanoceria, an antioxidant that alleviates the effects of oxidative stress and causes less DNA damage. Literature review further indicated that MORC2a recruits HDAC4 at the promoter to prevent the transcription of p21. Upregulation of p21 has been linked to cell senescence and muscle atrophy on Earth, but no research has studied its changes in radiation conditions. To address the knowledge gap regarding the HDAC4/MORC2a pathway impact on p21 expression in radiation, our experiment aims to silence HDAC4 and MORC2a in the Mus musculus C2C12 cell culture line. These cultures will be exposed to radiation to assess the effects on cellular senescence (Aim 1). Additionally, we will silence p21 and subject the cell cultures to radiation to measure muscle cell proliferation (Aim 2). Muscle atrophy in future long-term space missions can contribute to the risk of degenerative diseases and hinder the completion of tasks in space. Furthermore, exploring the impact of these genes on muscle atrophy may provide therapeutic insights for individuals experiencing skeletal muscle degeneration and elderly individuals affected by sarcopenia.

GL4HS↗

NASA's Ground Test Unit (GTU) Lunar Terrain Vehicle (LTV) Conceptual Hand Controllers Studies

Over that past year, the National Aeronautics and Space Administration (NASA) has been preparing and developing a set of standardized testing protocols for the commercial LTV vendor selection. Two studies have been conducted on two possible hand controller concepts specifically designed for the operation of NASA’s Ground Test Unit (GTU) Lunar Terrain Vehicle (LTV) that can be applied to the heretofore unknown designs developed by future LTV vendors. The objective for the two studies were to determine which hand controller enable acceptable operation of the LTV in a simulated lunar traverse. In the first evaluation a total of nine subjects in shirtsleeves with ungloved hands performed two simulated lunar driving courses in an engineering simulator with each hand controller. Controller concept one was the T-handle fashioned after the Apollo Lunar Roving Vehicle’s (LRV) T-Handle controller. The rational for using this design is it’s a proven design while in a pressurized suit. However, the LTV does have a driving mode the LRV did not consider. The mode of crabbing or strafing the vehicle at different angles; thus, the idea of a dual T-Handle controllers to accommodate this function without using a switch or display was introduced. The second concept controller is a new innovative controller call the Tri-Rotor [NASA patent review MSC-27385-1]. Inspired by Formula One race steering, the Tri-Rotor was designed to take advantage of the restricted movement and dexterity of a pressurized space suit. During testing, all subjects were able to successfully navigate through two test courses of varying lengths and complexity. Results indicated the dual Thandle had minimal recommendations for improvement while the Tri-Rotor had more extensive ones. It must be noted, the Tri-Rotor is a first-generation prototype and has some known mechanical concerns; thus, recommendations from this study will be incorporated into the second generation.

Human Factors↗

Huntsville Urban Development II: Utilizing NASA Earth Observations to Map the Urban Heat Island and Evaluate Vulnerability in Huntsville, Alabama

Huntsville, Alabama has seen a boom in growth over recent years. One consequence of this urban expansion is the exacerbation of the Urban Heat Island (UHI) effect across the city. This project identified the areas within Huntsville the greatest potential for heat reduction and community health benefits from tree-planting efforts. The team created maps of land surface temperature (LST), the normalized difference vegetation index (NDVI), and the normalized difference built-up index (NDBI) over June through August from 2019 to 2022 using data from ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station, Landsat 8 Operational Land Imager (OLI) and Thermal Infrared Sensor (TIRS), Landsat 9 OLI-2 and TIRS-2. The team identified areas with high LST, low NDVI, and high NDBI as areas with the greatest potential for heat reduction via tree-planting. Social factors relating to age, race, income, and self-reported health were adapted from Tree Equity Score to map community need for tree cover. When combining social with environmental factors, the team determined areas with the greatest potential for UHI mitigation: west-central and north downtown Huntsville. The team’s partner organization, the City of Huntsville, can use this priority map to guide their future tree-planting, and weigh the factors assessed according to their preference.

James Karroum↗

Impacts of Non-Simultaneous Global Photospheric Magnetic Measurements on Coronal and Solar Wind Modeling

The intensity and arrival time of coronal mass ejections (CMEs) can be significantly influenced by the background solar wind encountered as they propagate outward from the Sun into the interplanetary medium. In addition, solar energetic particles (SEPs) race ahead of CME shock fronts and flare regions along magnetic field lines largely determined by the background solar wind. Predicting the solar wind accurately is therefore critical for improving forecasts of CMEs, SEPs, and high-speed streams. Modeling of the corona and solar wind is challenging in general, as it is highly dependent on global photospheric magnetic field maps, which serve as the boundary conditions to all coronal models that drive solar wind models. Unfortunately, less than half of the Sun’s photospheric magnetic field is reliably measured from any given vantage point and thus it is common for the maps to have highly dated and unreliable measurements in them. While Solar Obiter (SolO) now provides for the first time the opportunity to have simultaneous measurements of nearly the entire surface magnetic field of Sun (e.g., when SolO/PHI measurements are combined with those from SDO/HMI), the required alignment to accomplish this occurs only occasionally. Further, coronal models are extremely sensitive to the strengths of the polar magnetic fields of the Sun, which remain poorly observed. Recently, efforts to mitigate this problem include using flux transport models such as the Air Force Data Assimilative Photospheric Flux Transport (ADAPT) model, which evolves the field forward in time using well known transport processes occurring on the Sun. However, it cannot account for the emergence of new magnetic flux without direct observations. The ESA VIGIL mission will eventually provide continuous observations from the L5, and the proposed SunCHASER mission will likewise do this at the L4 vantage point should it be funded. Ultimately, what is needed is a constellation of spacecraft distributed around the Sun with magnetographs that continuously measure the global surface magnetic field. In this talk, we discuss how the lack of simultaneous global measurements of the photospheric magnetic field adversely impacts the predictive performance of coronal and solar wind models.

C. Nick Arge↗

Baltimore Energy & Infrastructure: Assessing Urban Heat Vulnerability in Baltimore Neighborhoods to Inform Transportation Resiliency Planning Efforts

Across the world, climate change is altering cities and their local climate systems. Following global trends of rising mean temperatures, Baltimore, Maryland is projected to experience more frequent extreme heat events. Exacerbated by Urban Heat Island (UHI) effects, residents of the city face high temperatures from limited tree canopy, highly paved and impervious surfaces, limited air flow, and high concentrations of localized emissions. Urban heat is dispersed asymmetrically, with historically marginalized populations experiencing disproportionately severe heat. Recognizing the impacts of extreme urban heat, the Maryland Transit Administration (MTA) collaborated with us, the Spring 2024 Goddard Energy and Infrastructure NASA DEVELOP team to assess urban impacts of MTA users and assets and explore opportunities to enhance resiliency planning. We evaluated the feasibility of NASA Earth observations (EOs) in visualizing heat vulnerability in Baltimore City and County. We mapped UHI and extreme heat using remote sensing observations, tailored a Heat Priority Score (HPS) to analyze heat data in tandem with socioeconomic data from American Community Survey (ACS), and utilized SOlar and LongWave Environmental Irradiance Geometry (SOLWEIG) model to estimate MTA riders’ thermal comfort. NASA EOs served to quantify the distribution and severity of extreme heat at the block group level, which was found to correlate with a lack of vegetation and presence of densely built-up surroundings. The HPS revealed that extreme heat events most negatively impact communities that exhibit social vulnerability through indicators such as age, race, and income. These findings will inform neighborhood resiliency plans for the MTA that can be incorporated into their Adaptation Resiliency Toolbox (ART).

Baltimore,↗

Development of the Volatile Organic Compound (VOC) Removal System Final Report

The United States, along with other countries around the world, is preparing to return humankind to the Lunar surface. This endeavor will require the development of new technologies if a human presence beyond the Earth’s sphere of influence is to be maintained. Indeed, during the space race of the 20th century, a mere twelve astronauts traveled to the Moon and returned to Earth. Now, in the 21st century as we prepare to travel back to the Moon and on to Mars a more substantial effort will be needed to develop how astronauts can sustain themselves for long duration. Among the technologies that need further development are CO 2 and removal along with the removal of volatile organic compounds (VOCs). Long-term human exploration necessitates CO 2 and VOC removal systems which require little to no maintenance, i.e., no sorbent materials. Currently, NASA AMES is developing a CO 2 Deposition System (CDep) which does not rely on sorbent materials. Rather, by chilling the incoming air the system is able to “freeze-out” the CO 2 while allowing oxygen and nitrogen to pass through the system. However, this system in its current configuration is unable to filter out all VOCs. Therefore, it is necessary to further develop this system with the addition of a VOC removal element to provide a complete solution to the long-term problem of air revitalization in a safe and reliable manner.

Nilton De Oliveira Renno↗

Revisiting the Soyuz-1 Parachute Failure in the Context of Safety in the Modern Era

The Soyuz‑1 accident remains one of the most consequential parachute related failures in human spaceflight history and provides enduring lessons for modern Entry, Descent, and Landing (EDL) system design. Occurring during the height of the Cold War and the Space Race, the mission unfolded under extraordinary political and schedule pressure as the Soviet Union sought to maintain its early leadership in space achievements following the death of chief designer Sergei Korolev. Despite unresolved propulsion, electrical, and parachute system deficiencies, Soyuz‑1 proceeded to launch and immediately encountered critical inflight anomalies, including a failed solar panel deployment, attitude control issues, and communication dropouts. Upon reentry, a malfunction in the parachute system, driven by a primary main canopy that failed to deploy, and subsequent entanglement of the reserve main canopy with the primary drogue parachute, resulted in insufficient deceleration and the fatal crash of cosmonaut Vladimir Komarov. Subsequent investigations revealed deep rooted cultural and organizational issues within the Soviet space program, including inadequate testing, suppression of dissent, undocumented last minute design changes, and the absence of integrated parachute system verification. More than 200 design flaws were identified after the accident, and firsthand accounts, including those from Yuri Gagarin, highlighted widespread concern prior to launch. Over time, the Soviet program implemented substantial reforms: systematic design corrections, rigorous process documentation, and an extensive series of drop tests that ultimately transformed the Soyuz system into one of the world’s most reliable human-rated return vehicles. This paper examines the technical architecture of the Soyuz‑1 parachute system, reconstructs the likely deployment sequence and failure mechanism, and analyzes the cultural contributors that shaped the accident. The study draws parallels to modern spacecraft parachute development, emphasizing the critical importance of integrated system testing, transparent engineering culture, and continuous hardware surveillance. These lessons remain directly relevant to today’s NASA and Commercial Crew Programs (CCP), where the Government continues to refine its understanding of aggregate risk and strengthen overall astronaut safety in the face of increasingly complex parachute systems.

Aaron L Morris↗

Keeping Classified Information Secret in the World of Quantum Computing

Quantum computing is a technology that promises to revolutionize computing by speeding up key computing tasks in are as such as machine learning and solving otherwise intractable problems.Some influential American policymakers, scholars, and analysts are extremely concerned about the effects quantum computing will have on national security. Similar to the way space technology was viewed in the context of the US-Soviet rivalry during the Cold War, scientific advancement in quantum computing is seen as a race with significant national security consequences, particularly in the emerging US-China rivalry.

97 MATHEMATICS AND COMPUTING↗

Continued Discussion of Failure Mode Modeling and Overall Component Reliability: Is the Data Missing or Censored?

This paper is a continuation of a paper presented at the 13th Probabilistic Safety Assessment and Management Conference, in which a discussion of modeling failure modes of complex components was presented; see Paulos and Smith (2016). The paper demonstrated how the typical method of treating failure modes as being exponential in nature may yield optimistic predictions when estimating how improvements to components will perform in the real world. Instead of relying on textbook methods, it is more accurate to model the failure modes as a race in time; unfortunately, this does not give a closed-form solution. This work uses a simulation to solve for the model of the world, and is compared to the standard methodology of treating the failure modes as exponential random failures. The standard method is shown to have optimistic predictions, which will lead to prediction errors when failure modes were removed or “fixed.” The failure mode methodology presented in the first paper treated the data as being censored when the test stopped. In this paper, we will compare the results from treating the data as both censored and missing, and comparisons will be shown showing which method is more accurate and under what conditions.

97 MATHEMATICS AND COMPUTING↗

EVALUATING NUCLEAR SECURITY IMPLICATIONS OF THE SPLINTERNET

The internet, which for years has been viewed as a global online commons with standardized protocols but few regulations is, according to some experts, starting to mirror the contentious political and commercial contours of the physical world. Contributing to this is the rise in data breaches, cyber-enabled attacks on critical infrastructure, government surveillance operations, theft of intellectual property, manipulation of electoral processes, and perceived erosion of privacy, all of which are resulting in a growing skepticism that an open internet will naturally serve the best interests of users, communities, countries, and the global economy. In addition, the rapidly emerging and increasingly lucrative power of data has global superpowers scrambling to protect their informational sovereignty as an urgent matter of national security. Underscoring this urgency is the fact that, despite its global reach and cosmopolitan contributor base, internet infrastructure and governance of the World Wide Web remain largely under U.S. corporate auspices, which reinforces the perception of U.S. control. Whether fragmentation is politically, economically, or socially motivated, there appears to be a growing appetite for an internet that is partitioned and controlled at the national level. From “the Great Firewall of China” to the “Halal” internet of Iran, the trend towards a “Splinternet” has courts and governments embarking on what some call a "legal arms race" to impose a maze of national or regional rules, often conflicting, in the digital realm. The paper explores the emerging Splinternet phenomenon, analyses the implications of this trend on nuclear security, and identifies questions that present opportunities for future research.

Internet, Data Security, Cyber Security, Nuclear S↗

A Memory Efficient Lock-Free Circular Queue

Hardware queues are import in many applications, such as data transfer, synchronization of concurrent modules with the need of mutual exclusion constructs. State of the art bounded (of a fixed size) lock free circular queues are implemented either by read/write atomic operations, or barrier conditions, or by separating dequeue and enqueue operations. However, these queues always require an unused element at all the times to safe-guard the front and rear pointers of the queue, so as to avoid data race conditions, which leads to the waste of memory. The waste of memory is especially disadvantageous in applications such as I/O data transfer, and image transfer between processing filters, when large element size is needed, We propose a lock-free solution of the bounded circular queue through read/write atomic operations, but without the need of an extra element in the queue. The proposed solution is implemented and verified in both Verilog and ’C’ languages. We also demonstrate its effectiveness by comparing its area and delay metrics with the implementations of other existing designs of queue.

Miniskar, Narasinga Rao↗

Power Dynamics in Physics

The purpose of this white paper is to describe how unfair power dynamics related to various aspects of identity -- race, gender identity, gender expression, sexual orientation, and ability status -- operate in physics settings and offer concrete steps that one can take to make our discipline more equitable and just.

Hodari, Apriel K.↗

Engaging a Diverse Workforce in the Building Sciences Through the JUMP Into STEM Program: Impact Study; Preprint

Ensuring inclusivity in building science professions requires engaging people from underrepresented demographics; unfortunately, many races, ethnicities, and genders continue to be underrepresented. The JUMP into STEM program works to rectify this, encouraging creative ideation and highlighting the unique perspectives of a diverse array of students. The top students are awarded internships that provide opportunities to work in building science research with close supervision from mentors in the field. In the research presented here, we investigate the impact of participation in JUMP into STEM on students' careers, including the impact on students from diverse backgrounds. Furthermore, we research students' awareness of career opportunities in building science, students' perception of their ability to meaningfully contribute to this field, and the career building opportunities that JUMP into STEM provides for students. Through participant interviews and data analysis, we measure program diversity, inclusion, and effectiveness at achieving goals. We find that among the hundreds of students who have participated in this program, more than 25 different majors and/or educational degree programs are represented and more than 45% of students attend minority serving institutions or historically black colleges and universities. The JUMP into STEM experience had a significant effect on career choices or career development for more than 80% of participants. Our results also indicate that the JUMP into STEM program is effective at promoting diversity in the building sciences and is successfully contributing to the larger effort within the building science industry to promote and ensure equity in technological progress and innovation.

building energy science↗

A Comparison of Generator Technologies for Offshore Wind Turbines

Leading wind turbine manufacturers are racing to build larger and more powerful offshore machines. Drivetrain configurations often use a permanent-magnet synchronous generator (PMSG), in either a direct-drive configuration or coupled to a gearbox. With increasing demand for critical rare-earth magnets, new generator technologies are emerging to ensure a stable and secure supply chain. We evaluate three different topologies of radial flux synchronous generators employing high field magnets with reduced or no rare-earth content: a direct-drive interior PMSG (DD-IPMSG), a geared drivetrain combining a medium speed gearbox with a PMSG (MS-PMSG), and a direct-drive low-temperature superconducting generator (DD-LTSG). We develop a conceptual design module for each of these technologies within a larger framework for full turbine design. This provides the fairest comparison between technologies at nominal power ratings from 15-25MW, which represent the next generation of offshore wind turbines. The analyses show that if operational expenditures (OpEx) are constant across the technologies, MS-PMSG results in the lowest LCOE with reductions of up to 7% relative to DD-IPMSG. DD-LTSG also yields lower LCOE values by 2-3% for fixed-bottom turbines and 3-5% with a floating platform. However, results are sensitive to OpEx assumptions, with a mere 10% increase causing the conclusions to shift.

direct drive↗

Envisioning Tomorrow's Sustainable Mobility Systems

In the race to achieve efficient, accessible, affordable, and decarbonized transportation, which mobility solutions and strategies will get us to the finish line? Thought leaders from government, industry, and academia convened in mid-2023 at the National Renewable Energy Laboratory (NREL) to propose answers to this question. They worked to determine the research, development, and deployment challenges and opportunities that should be prioritized to create tomorrow's sustainable mobility systems. This fact sheet outlines cross-cutting themes and key findings from the workshop.

ADVANCED PROPULSION SYSTEMS,ENERGY PLANNING, POLIC↗

Optics Studies for Multipass Energy Recovery at CEBAF: ER@CEBAF

Energy recovery linacs (ERLs), focus on recycling the kinetic energy of electron beam for the purpose of accelerating a newly injected beam within the same accelerating structure. The rising developments in the super conducting radio frequency technology, ERL technology has achieved several noteworthy milestones over the past few decades. In year 2003, Jefferson Lab has successfully demonstrated a single pass energy recovery at the CEBAF accelerator. Furthermore, they conducted successful experiments with IR-FEL demo and upgrades, as well as the UV FEL driver. This multi-pass, multi-GeV range energy recovery demonstration proposed to be carried out at CEBAF accelerator at Jefferson Lab focuses on demonstrating highest energy recovery in super conducting linac in the low-current range. Continuous electron beam accelerate up to 7.5 GeV within 5-passes and decelerate in the next 5-passes recovering RF energy and dumps at a low energy dump. The beamline optics design for recirculating linacs require special attention to avoid beam instabilities due to RF wakefields. Usually, multi-pass linac beam lines require stronger focusing at lower energies as that is necessary to avoid beam breakup (BBU) instabilities, even with this small beam current. The CEBAF linac optics optimization is focused on balancing over-focusing at higher energies and beta excursions at lower energies. The race-track-shaped geometry of CEBAF accelerator allows its linacs to accommodate multiple energy beams simultaneously, while individual recirculating arcs transporting one beam energy, are shared between accelerating/decelerating beams. For the linac optics optimization process, an extended strategy is used that is originally used in 6-pass Recirculating Linac design of the LHeC, to represent the ten passes through a single linac. Using proper mathematical expressions, linac optics optimization can be achieved with evolutionary genetic algorithms, with Multi-Objective optimization. This thesis introduces a CEBAF optics redesign tailored to accommodates the ER@CEBAF multi-pass ER scheme. The isochronous arcs were retuned to match into optics solutions for optimized 10-pass linacs. Within this work, a single bunch particle tracking analysis presented here focuses on the further improvements of the beamline and beam transportation.

Neththikumara, Isurumali↗

Decarbonizing the Building Sector: A Human-Centered Study Focused on Small/Light Commercial Building Energy Equity

Decarbonization of the building sector is no small feat; buildings account for 40% of primary energy consumption, and fossil-fuel combustion in buildings leads to roughly 30% of total greenhouse gas emissions. Energy efficiency, electrification and smart technologies are fundamental strategies to reduce consumption and shift away from fossil-fuel use in buildings. This energy transition carries significant societal risks unless the shift is carried out with equity and justice as a top priority. Low-income, vulnerable and communities of color have higher energy burdens compared to affluent populations. Furthermore, systemic racism and historic exclusionary policies have resulted in increased risks (environmental, climatic, economic, and social) to low-income and communities of color, and underserved communities often do not have financial resources for, or access to, advanced building technologies. The U.S. Department of Energy is funding research to characterize and develop solutions to the challenges of equity and justice that complicate the ability of communities to contribute to goals for decarbonization. Our project has a specific focus on small commercial buildings and the businesses that occupy them. Significantly less is known about the burdens and risks these businesses experience or the challenges they face in pursuing decarbonization, or how those are affected by income and race, in comparison to research on energy equity and justice for diverse households. The project team includes the Pacific Northwest National Laboratory, Arizona State University and Clark Atlanta University. Researchers are conducting semi-structured interviews with small business owners in underserved communities in Phoenix and Atlanta, followed by a survey distributed to the larger community to learn more about the equity and justice issues that communities with different racial, economic, and cultural backgrounds face. Results will help inform an actionable and replicable framework for engaging small commercial building owners/operators to catalyze the reduction of energy burdens and increase equity.

Antonopoulos, Chrissi A.↗