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At least 649 records · Page 36

Pre Symptomatic COVID Screening

Temperature checks for fever are extensively used for preliminary COVID screenings but are ineffective during the incubation stage of infection when a person is asymptotic. Researchers at the European Centre for Disease Prevention and Control concluded that approximately 75% of passengers infected with COVID-19 and traveling from affected Chinese cities would not be detected by early screening. Core body temperature is normally kept within a narrow range and has the smallest relative standard deviation of all vital signs. Heat in the body is prioritized around internal organs at the expense of the periphery by controlling blood flow. In fact, blood flow to the skin may vary by a factor of 100 depending on thermal conditions. This adaptation causes rapid temperature fluctuations in different skin regions from changes in cardiac output, metabolism, and likely cytokine diffusion during inflammation that would not be seen in average core body temperature. Current IR and thermal scanners used for temperature checks are not necessarily reflective of core body temperatures and require cautious interpretation as they frequently result in false positive and false negative diagnosis. Hand held thermometers measure average skin temperatures and can get readings that differ from core body temperature by as much as 7°. Rather than focusing on a core body temperature threshold assessment we believe that variability of temperature patterns using a novel wearable transdermal microneedle sensor will be more sensitive to infections in the incubation stage and propose to develop a wearable transdermal temperature sensor using established Sandia microneedle technology for pre symptomatic COVID screening that can additionally be used to monitor disease progression at later stages.

59 BASIC BIOLOGICAL SCIENCES↗

Development of a six-man, self-contained carbon dioxide collection subsystem for spacecraft application

Life Systems, working with NASA, has developed an electrochemical, six-man, self-contained carbon dioxide concentrator subsystem (CX-6) designed to normally remove 13.2 lb/day of CO2 while maintaining the CO2 partial pressure (pCO2) of the cabin atmosphere at 3 mm Hg or less. The CX-6 was subjected to extensive parametric and endurance testing. The effects of operating conditions on CO2 removal and electrical efficiencies were determined, including effects of hydrogen (H2) flow rate, process airflow rate, pCO2, operating temperature and current density. A total of 209 days of operation was accumulated. The subsystem was designed with self-contained electronic control and monitoring instrumentation. The CX-6 was redesigned and repackaged into the CO2 collection subsystem for the air revitalization group of the space station prototype.

Schubert, F. H.↗

The effect of contraction on a homogeneous turbulent shear flow

In the present study, a homogeneous flow was generated and allowed to reach its asymptotic state. A two-dimensional contraction was inserted a short distance downstream. Both mean velocity and turbulence-stress profiles (normal and shear) were measured at several points along the flow direction. The pressure-strain terms were evaluated from the energy balance made along the wind-tunnel axis. On the basis of the obtained results, it is concluded that a uniformly sheared turbulent flow with approximate transverse homogeneity remains in its condition at all stages of its development through a two-dimensional contraction. Small deviations from homogeneity observed upstream of contraction become much less visible towards the end of contraction. The mean-flow development can be predicted adequately by the Bernoulli equation.

Sreenivasan, K. R.↗

A computer controlled signal preprocessor for laser fringe anemometer applications

The operation of most commercially available laser fringe anemometer (LFA) counter-processors assumes that adjustments are made to the signal processing independent of the computer used for reducing the data acquired. Not only does the researcher desire a record of these parameters attached to the data acquired, but changes in flow conditions generally require that these settings be changed to improve data quality. Because of this limitation, on-line modification of the data acquisition parameters can be difficult and time consuming. A computer-controlled signal preprocessor has been developed which makes possible this optimization of the photomultiplier signal as a normal part of the data acquisition process. It allows computer control of the filter selection, signal gain, and photo-multiplier voltage. The raw signal from the photomultiplier tube is input to the preprocessor which, under the control of a digital computer, filters the signal and amplifies it to an acceptable level. The counter-processor used at Lewis Research Center generates the particle interarrival times, as well as the time-of-flight of the particle through the probe volume. The signal preprocessor allows computer control of the acquisition of these data.Through the preprocessor, the computer also can control the hand shaking signals for the interface between itself and the counter-processor. Finally, the signal preprocessor splits the pedestal from the signal before filtering, and monitors the photo-multiplier dc current, sends a signal proportional to this current to the computer through an analog to digital converter, and provides an alarm if the current exceeds a predefined maximum. Complete drawings and explanations are provided in the text as well as a sample interface program for use with the data acquisition software.

Oberle, Lawrence G.↗

Testing and Selection of Fire-Resistant Materials for Spacecraft Use

Spacecraft fire-safety strategy emphasizes prevention, mostly through the selection of onboard items classified accord- ing to their fire resistance. The principal NASA acceptance tests described in this paper assess the flammability of materials and components under "worst-case" normal-gravity conditions of upward flame spread in controlled-oxygen atmospheres. Tests conducted on the ground, however, cannot duplicate the unique fire characteristics in the nonbuoyant low-gravity environment of orbiting spacecraft. Research shows that flammability an fire-spread rates in low gravity are sensitive to forced convection (ventilation flows) and atmospheric-oxygen concentration. These research results are helping to define new material-screening test methods that will better evaluate material performance in spacecraft.

Friedman, Robert↗

Benchmark Data for Evaluation of NASA Impedance Eduction Methods

Results achieved with three acoustic liner configurations are used to evaluate the effects of recent modifications to the NASA Normal Incidence Tube and Grazing Flow Impedance Tube. These include a calibration liner, a wire mesh liner, and a perforate liner. The effects of source type, source level, and mean flow Mach number on the impedances educed with these liners are explored. Existing models are used to predict the impedance for each test condition and are compared with educed impedance spectra to determine their validity. The results suggest that educed impedances are similar for either a stepped sine or swept sine source. The predicted models are acceptable for the perforate liner and are quite good for the calibration and wire mesh liners.

acoustic↗

Benchmark Data for Evaluation of NASA Impedance Eduction Methods

Results achieved with three acoustic liner configurations are used to evaluate the effects of recent modifications to the NASA Normal Incidence Tube and Grazing Flow Impedance Tube. These include a calibration liner, a wire mesh liner, and a perforate liner. The effects of source type, source level, and mean flow Mach number on the impedances educed with these liners are explored. Existing models are used to predict the impedance for each test condition, and are compared with educed impedance spectra to determine their validity. The results suggest that educed impedances are similar for either a stepped sine or swept sine source. The predicted models are acceptable for the perforate liner, and are quite good for the calibration and wire mesh liners.

acoustic↗

Stability of hypersonic boundary-layer flows with chemistry

The effects of nonequilibrium chemistry and three dimensionality on the stability characteristics of hypersonic flows are discussed. In two-dimensional (2-D) and axisymmetric flows, the inclusion of chemistry causes a shift of the second mode of Mack to lower frequencies. This is found to be due to the increase in size of the region of relative supersonic flow because of the lower speeds of sound in the relatively cooler boundary layers. Although this shift in frequency is present in both the equilibrium and nonequilibrium air results, the equilibrium approximation predicts modes which are not observed in the nonequilibrium calculations (for the flight conditions considered). These modes are superpositions of incoming and outgoing unstable disturbances which travel supersonically relative to the boundary-layer edge velocity. Such solutions are possible because of the finite shock stand-off distance. Their corresponding wall-normal profiles exhibit an oscillatory behavior in the inviscid region between the boundary-layer edge and the bow shock. For the examination of three-dimensional (3-D) effects, a rotating cone is used as a model of a swept wing. An increase of stagnation temperature is found to be only slightly stabilizing. The correlation of transition location (N = 9) with parameters describing the crossflow profile is discussed. Transition location does not correlate with the traditional crossflow Reynolds number. A new parameter that appears to correlate for boundary-layer flow was found. A verification with experiments on a yawed cone is provided.

Reed, Helen L.↗

Effect of viscosity and shear flow on the nonlinear two fluid interfacial structures

A nonlinear formulation is presented to deal with the combined action of Rayleigh-Taylor and Kelvin-Helmholtz instabilities as well as combined Ricthmyer-Meshkov and Kelvin-Helmholtz instabilities at the two fluid interface under the influence of viscosity and consequent shear flow. Using Layzer's model, the development of the interfacial structures like bubbles is investigated analytically and numerically. It is found that the growth and normal velocity of the structures are dependent on the relative velocity shear and the kinematic coefficient of viscosity of both the fluids. Both the bubble growth and growth rate are reduced significantly for fluids of higher viscosity coefficient with small velocity shear difference. It is also observed that, for viscous fluids, the transverse velocity of the perturbed interface becomes slower under certain conditions.

42 ENGINEERING↗

Absence of arterial baroreflex modulation of skin sympathetic activity and sweat rate during whole-body heating in humans

1. Prior findings suggest that baroreflexes are capable of modulating skin blood flow, but the effects of baroreceptor loading/unloading on sweating are less clear. Therefore, this project tested the hypothesis that pharmacologically induced alterations in arterial blood pressure in heated humans would lead to baroreflex-mediated changes in both skin sympathetic nerve activity (SSNA) and sweat rate. 2. In seven subjects mean arterial blood pressure was lowered (approximately 8 mmHg) and then raised (approximately 13 mmHg) by bolus injections of sodium nitroprusside and phenylephrine, respectively. Moreover, in a separate protocol, arterial blood pressure was reduced via steady-state administration of sodium nitroprusside. In both normothermia and heat-stress conditions the following responses were monitored: sublingual and mean skin temperatures, heart rate, beat-by-beat blood pressure, skin blood flow (laser-Doppler flowmetry), local sweat rate and SSNA (microneurography from peroneal nerve). 3. Whole-body heating increased skin and sublingual temperatures, heart rate, cutaneous blood flow, sweat rate and SSNA, but did not change arterial blood pressure. Heart rate was significantly elevated (from 74 +/- 3 to 92 +/- 4 beats x min(-1); P < 0.001) during bolus sodium nitroprusside-induced reductions in blood pressure, and significantly reduced (from 92 +/- 4 to 68 +/- 4 beats x min(-1); P < 0.001) during bolus phenylephrine-induced elevations in blood pressure, thereby demonstrating normal baroreflex function in these subjects. 4. Neither SSNA nor sweat rate was altered by rapid (bolus infusion) or sustained (steady-state infusion) changes in blood pressure regardless of the thermal condition. 5. These data suggest that SSNA and sweat rate are not modulated by arterial baroreflexes in normothermic or moderately heated individuals.

Clinical Trial↗

FY23 Report on Water NSTF Testing at Two-Phase Conditions: Off-normal Scenarios

Under support from the Department of Energy (DOE) and the Office of Advanced Reactor Technologies (ART), a large-scale test facility has been constructed at Argonne National Laboratory to generate NQA-1 qualified validation data for passive decay heat removal systems in advanced reactors. The Natural convection Shutdown heat removal Test Facility (NSTF) reflects key features of a ½ scale, water-based, Reactor Cavity Cooling System (RCCS) and is intended to study the behavior, bound performance, and ultimately guide design decisions for passive decay heat removal systems for advanced reactors. In addition to the experimental activities detailed in this report, a supportive computational modeling effort is on-going which has been demonstrated to significantly strengthen the experimental program while also improving accuracy of the computer models. Together these create a mutually beneficial relationship integral to meeting the overall program objective of examining the heat removal performance of the RCCS concept. This report details the experimental activities and upgrades performed during the program’s fifth year of water-based operation. The theme of this year of testing was examining off-normal scenarios. In practice, that meant examining scenarios with blockages or other design basis conditions. From a maintenance and capability standpoint that meant assessing valving options for implementing blockages, assessing drain and refill capabilities, and ensuring in all cases that operators could safely, efficiently, and repeatably bring the facility to an off-normal condition and return it to the normal operating state. In one notable case, no solution existed, nor was a solution commercially available, that met the facility needs for implementing blockages within the two-phase region of the chimney. A valve and feedthrough were custom-designed for NSTF to operate submerged in saturated water while being safely actuated from outside the tank. The fifth year of testing included eight matrix tests consisting of 162 hours of active heating, 9,735 kWh of electrical heating, with seven tests classified as Accepted per NQA-1 and one as Trending. All matrix tests were performed at two-phase flow conditions. The power parametric series from previous years was extended to include another scenario with a decay load equivalent to 1.75 MWt, full scale, further resolving the system flow oscillation response as a function of input power. A depletion test was performed to extend previous work and examine the system’s approach to stagnation and geysering that were not previously observed. This test began at an initial inventory level of 50%, prototypic power of 2.1 MWt, and employed an accelerated drain of 0.75 gpm plus boiloff until stagnation conditions were achieved and multiple geysering events were recorded. Further exploring the geysering phenomenon was a separate effects test examining static boiling in the risers and chimney. This static boiling test was performed at 48 kWe, a higher power than testing in the previous year, and included enhancements to the drain system to remove inventory in a better-controlled and more reliable manner. Two tests were performed, at prototypic conditions of 1.4 MWt and 2.4 MWt, respectively, examining the system response to throttled conditions in the singlephase region of the piping. A ball valve immediately before he riser inlet header was increasingly throttled, progressing the system through a repeatable pattern of two-phase oscillations and stable regimes before ultimately inducing stagnation and geysering. Concluding the year, two tests were performed at baseline conditions of 70% initial inventory level and 2.1 MWt of prototypic decay heat to examine both repeatability and the response to throttling within the two-phase region, at the inventory tank inlet using the custom valve mentioned above. The first such test repeated transient operating conditions and revealed significant sensitivity t

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Ionospheric convection during the magnetic storm of 20-21 March 1991

We report on the response of high-latitude ionospheric convection during the magnetic storm of March 20-21 1990. IMP-8 measurements of solar wind plasma and interplanetary magnetic field (IMF), ionospheric convection flow measurements from the Wick and Goose Bay coherent radars, EISCAT, Millstone Hill and Sondrestorm incoherent radars and three digisondes at Millstone Hill, Goose Bay and Qaanaaq are presented. Two intervals of particular interest have been indentified. The first starts with a storm sudden commencement at 2243 UT on March 20 and includes the ionospheric activity in the following 7 h. The response time of the ionospheric convection to the southward tuning of the IMF in the dusk to midnight local times is found to be approximately half that measured in a similar study at comparable local times during more normal solar wind conditions. A subsequent reconfiguration of the nightside convection pattern was also observed, although it was not possible to distinguish between effects due to possible changes in B(sub y) and effects due to substorm activity. The second interval, 1200-2100 UT 21 March 1990, included a southward turning of the IMF which resulted in the B(sub z) component becoming -10 nT. The response time on the dayside to this change in the IMF at the magnetopause was approximately 15 min to 30 min which is a factor of approximately 2 greater than those previously measured at higher latitudes. A movement of the nightside flow reversal, possibly driven by current systems associated with the substorm expansion phases, was observed, implying that the nightside convection pattern can be dominated by substorm activity.

Taylor, J. R.↗

A new method for solving problems of sound radiation from a duct for the case of low Mach number

A method for rapidly solving duct end-plane impedance problems is presented which is based on deriving a form of the Helmholtz integral formula expressing the normal derivative of the acoustic pressure at a boundary point. A set of integral expressions is obtained by satisfying the existing boundary conditions and then solved using a general collocation method. The results obtained for the Levine-Schwinger (1948) problem agree well with the exact values. In the case of a duct flow having a temperature mismatch with the surroundings, the results show an increase in the magnitude of the reflection coefficient for the case of a cold core, and a decrease in its value for the case of a hot core, as compared with the case of exhaust into a uniform medium. A phase change of between pi/2 and pi is nearly always achieved, which indicates the tendency towards maintaining a constant pressure at the exit plane. The method can easily be extended to arbitrary duct shapes as long as they are axisymmetric.

Wahbah, M. M.↗

Structure and stabilization of hydrogen-rich transverse jets in a vitiated turbulent flow

This paper reports the results of a joint experimental and numerical study of the ow characteristics and flame stabilization of a hydrogen rich jet injected normal to a turbulent, vitiated cross ow of lean methane combustion products. Simultaneous high-speed stereoscopic PIV and OH PLIF measurements were obtained and analyzed alongside three-dimensional direct numerical simulations of inert and reacting JICF with detailed H 2 /CO chemistry. Both the experiment and the simulation reveal that, contrary to most previous studies of reacting JICF stabilized in low-to-moderate temperature air cross ow, the present conditions lead to an autoigniting, burner-attached flame that initiates uniformly around the burner edge. Significant asymmetry is observed, however, between the reaction zones located on the windward and leeward sides of the jet, due to the substantially different scalar dissipation rates. The windward reaction zone is much thinner in the near field, while also exhibiting significantly higher local and global heat release than the much broader reaction zone found on the leeward side of the jet. The unsteady dynamics of the windward shear layer, which largely control the important jet/cross flow mixing processes in that region, are explored in order to elucidate the important flow stability implications arising in the reacting JICF. Vorticity spectra extracted from the windward shear layer reveal that the reacting jet is globally unstable and features two high frequency peaks, including a fundamental mode whose Strouhal number of ~0.7 agrees well with previous non-reacting JICF stability studies. The paper concludes with an analysis of the ignition, ame stabilization, and global structure of the burner-attached flame. Chemical explosive mode analysis (CEMA) shows that the entire windward shear layer, and a large region on the leeward side of the jet, are highly explosive prior to ignition and are dominated by non-premixed flame structures after ignition. The predominantly mixing limited nature of the flow after ignition is confirmed by computing the Takeno flame index, which shows that ~70% of the heat release occurs in non-premixed regions.

33 ADVANCED PROPULSION SYSTEMS↗

USING TWISTED FILAMENTS TO MODEL THE INNER JET IN M 87

Radio and optical images of the M 87 jet show bright filaments, twisted into an apparent double helix, extending from HST-1 to knot A. Proper motions within the jet suggest a decelerating jet flow passing through a slower, accelerating wave pattern. We use these observations to develop a mass and energy flux-conserving model describing the jet flow and conditions along the jet. Our model requires the jet to be an internally hot, but subrelativistic plasma, from HST-1 to knot A. Subsequently, we assume that the jet is in pressure balance with an external cocoon and we determine the cocoon conditions required if the twisted filaments are the result of the Kelvin-Helmholtz (KH) unstable elliptical mode. We find that the cocoon must be cooler than the jet at HST-1 but must be about as hot as the jet at knot A. Under these conditions, we find that the observed filament wavelength is near the elliptical mode maximum growth rate and growth is rapid enough for the filaments to develop and saturate well before HST-1. We generate a pseudo-synchrotron image of a model jet carrying a combination of normal modes of the KH instability. The pseudo-synchrotron image of the jet reveals that (1) a slow decline in the model jet's surface brightness is still about five times faster than the real jet, (2) KH-produced dual helically twisted filaments can appear qualitatively similar to those on the real jet if any helical perturbation to the jet is very small or nonexistent inside knot A, and (3) the knots in the real jet cannot be associated with the twisted filamentary features and are unlikely to be the result of a KH instability. The existence of the knots in the real jet, the limb brightening of the real jet in the radio, and the slower decline of the surface brightness of the real jet indicate that additional processes-such as unsteady jet flow and internal particle acceleration-are occurring within the jet. Disruption of the real jet beyond knot A by KH instability is consistent with the jet and cocoon conditions we find at knot A.

79 ASTRONOMY AND ASTROPHYSICS↗

Resonant alteration of propagation in guiding structures with complex Robin parameter and its magnetic-field-induced restoration

Highlights: > Solutions of the wave equation are analyzed for the confined circular geometry with complex Robin boundary conditions. > Sharp extremum is found in the energy dependence on the imaginary part of the extrapolation length. > Nonzero real part of the Robin length or/and magnetic field wipe out the resonance. - Abstract: Solutions of the scalar Helmholtz wave equation are derived for the analysis of the transport and thermodynamic properties of the two-dimensional disk and three-dimensional infinitely long straight wire in the external uniform longitudinal magnetic field B under the assumption that the Robin boundary condition contains extrapolation length {Lambda} with nonzero imaginary part {Lambda}{sub i}. As a result of this complexity, the self-adjointness of the Hamiltonian is lost, its eigenvalues E become complex too and the discrete bound states of the disk characteristic for the real {Lambda} turn into the corresponding quasibound states with their lifetime defined by the eigenenergies imaginary parts E{sub i}. Accordingly, the longitudinal flux undergoes an alteration as it flows along the wire with its attenuation/amplification being E{sub i}-dependent too. It is shown that, for zero magnetic field, the component E{sub i} as a function of the Robin imaginary part exhibits a pronounced sharp extremum with its magnitude being the largest for the zero real part {Lambda}{sub r} of the extrapolation length. Increasing magnitude of {Lambda}{sub r} quenches the E{sub i} - {Lambda}{sub i} resonance and at very large {Lambda}{sub r} the eigenenergies E approach the asymptotic real values independent of {Lambda}{sub i}. The extremum is also wiped out by the magnetic field when, for the large B, the energies tend to the Landau levels. Mathematical and physical interpretations of the obtained results are provided; in particular, it is shown that the finite lifetime of the disk quasibound states stems from the {Lambda}{sub i}-induced currents flowing through the sample boundary. Possible experimental tests of the calculated effect are discussed; namely, it is argued that it can be observed in superconductors by applying to them the external electric field E normal to the surface.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

A Study of Blood Flow and of Aggregation of Blood Cells Under Conditions of Zero Gravity: Its Relevance to the Occlusive Diseases and Cancer

The objectives of this program are: (1) to determine whether the size of red cell aggregates, kinetics and morphology of these aggregates are influenced by near-zero gravity; (2) whether viscosity, especially at low shear rate, is afflicted by near-zero gravity (the latter preventing sedimentation of red cells); (3) whether the actual shape of red cells changes; and (4) whether blood samples obtained from different donors (normal and patients suffering from different disorders) react in the same manner to near-zero gravity.

Dintenfass, L.↗