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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sourcesNASA NTRSDOE OSTI
NASA NTRSDate not supplied

Designing Experiments for SpinSat, A Novel Variable-Gravity-and-Radiation Platform for Deep-Space Science

Conducting experiments to measure the effects of deep-space radiation and reduced gravity on biological and physical systems remains challenging. The result is a substantial knowledge gap that poses risks to our ability to sustain life and conduct critical operations in deep space. The SpinSat spacecraft platform is designed to bridge such gaps by providing low-cost, reliable, and frequent access to deep space. A disk-shaped rotating satellite that can provide artificial gravity and exposure to space radiation simultaneously, SpinSat is designed to accommodate payloads in a CubeSat form factor (with at least 48 “U” volume), providing power, communications, and a benign thermal environment. It is orbit-agnostic, enabling access to a variety of radiation environments (Van Allen belts, deep space, cis-lunar); and can be equipped with shielding to mimic planetary radiation environments, for both short- and long-term experiments. Because of its versatility and prioritization of late loading for biological payloads, it is well suited to host a wide range of ranging from human tissues and organoids to microorganisms, plants, chemistry, and regolith. Here, we present examples of potential experiment concepts for SpinSat, and discuss the details of how experimental designs could interact with the platform. Potential SpinSat studies have diverse applications, including fundamental radiation biology and DNA repair; cancer biology and countermeasure development; space agriculture; bioproduction of nutrients and pharmaceuticals; understanding regolith dynamics in low gravity; prebiotic chemistry and panspermia. We will further highlight ideas for SpinSat-compatible experimental hardware, existing and in development, and experiment-relevant details on SpinSat capabilities including artificial gravity, potential radiation environments, data, and power. This presentation will aim to provide investigators with the high-level technical information necessary to inspire experiments for SpinSat. We also seek to stimulate conversation and to gain community input on accommodations needs to help guide the evolving design of this platform.

experiment design↗
NASA NTRS2024

Comparison of Geant4-DNA and RITRACKS/RITCARD: Microdosimetry, Nanodosimetry and DNA Damage Predictions for Low to High LET Ions

Low linear energy transfer (LET) ionizing radiations induce homogeneously distributed DNA damage at the cellular scale, while high LET ionizing radiations are well known to create complex biological damage including clustered double strand breaks (DSB). Clustered DSB are critical events that are difficult to repair, leading to increased biological outcomes compared to low LET radiation exposure. Recent studies have shown that DNA compaction, which can be actively modified by the cell to allow DNA repair, influences the yield of DSB [1]. The goal of this work is to determine the impact of DNA compaction on chromosome aberration formation, a biomarker of radiation-induced cancer risk. The RITRACKS track structure code [2], together with the RITCARD code [3], allow one to simulate the transport of high LET ions, calculate DNA damage and repair, and chromosome aberration formation, but does not include detailed geometrical models of DNA. The Geant4-DNA toolkit provides such detailed models with different levels of DNA compaction [1,4], but does not model chromosome aberration formation. In this work, these highly detailed DNA geometries are used to compute DNA breaks with Geant4-DNA and combine the results with the RITCARD tool to compute chromosome aberrations. As a first step, we compared the transport models used in RITRACKS and Geant4-DNA and newly released heavy ion model transport (G4DNARuddIonisationExtendedModel Geant4 v11.2) to ensure consistency between the physical stage of the two radiation transport codes. We compared energy deposition at the micrometric and nanometric scales for different ions (H 250 MeV, H 150 Me, He 250 MeV/n, C 290 MeV/n, O 350 MeV/n, O 55 MeV/n, Si 170MeV/n, Ti 300 MeV/n, Ti 300 MeV/n, Fe 600 MeV/n, Fe 450 MeV/n and Fe 300 MeV/n) with LET ranging from ~0.4 keV/μm up to 235 keV/μm. Excellent agreement is found for both microdosimetric and nanodosimetric spectra for all ion types and energies. The calculation of DNA breaks and their complexity with the Geant4-DNA is an ongoing work, and comparison with RITCARD will be presented based on result availability at the time of the conference. [1] Tang et al. (2019). Med. Phys., 46(3), 1501-1511. [2] Plante et al. (2008). NJP, 10(12), 125020. [3] Plante et al. (2019). Rad. Res., 192(3), 282-298. [4] Incerti et al. (2018). Med. Phys., 45(8), e722-e739.

Floriane Poignant↗
NASA NTRSDate not supplied

Deflection of Solar Energetic Protons by an Ion Thruster

While Galactic Cosmic Rays (GCR) represent a long-term cancer risk to deep space human missions, Solar Energetic Particles (SEP) represent a significant acute radiation hazard to human spaceflight. This work investigates wave-particle interactions caused by the incidence of a beam of energetic protons, representing a notional SEP event, onto a cloud of ions representing a notional ion thruster plume. The resulting electromagnetic ion/ion instability is developed to investigate the degree to which energetic protons can be scattered out of the initial beam. This work includes investigations of deflection rate dependences on incident SEP energy and flux, ion thruster power and orientation relative to SEP incidence, plume ion species, and background plasma. Also investigated are the spectrum and angular distribution of electromagnetic radiation resulting from the wave-particle interactions. The primary objective of this investigation is to develop a technique for active mitigation of SEP radiation threats to spacecraft and crew, by exploring the wave-particle interaction of a SEP event with the plasma plume expelled from an ion thruster. Since the cost in expended fuel restricts this technique to intermittent use during interplanetary flights, effective prediction of when a SEP event might impact the mission is still important, and the observation of conditions that might lead to SEP events, human-in-the-loop space weather analyses, and development of SEP prediction models remain essential to crew safety, spacecraft function, and mission success.

Interplanetary Space Flight↗
NASA NTRSDate not supplied

Benchmarking Computational Tools for Calling SNPs and Indels in Complex Microbial Populations

The NASA BioNutrients missions seek to understand the suitability of microorganisms for bioproduction during space flight. One topic of interest is the stability of microbial genomes during long-term ambient storage and subsequent rehydration and growth. To address these questions, samples from 8 species were flown to ISS for 5 years of desiccated storage at ambient temperature (Stasis Packs) and 2 species were packaged along with powdered media inside a bioreactor system to allow hydration and growth in microgravity (Production Packs). For both systems, Whole Genome Sequencing (WGS) of the DNA extracted from the returned samples and paired ground controls will be conducted to identify changes in genome stability due to time, storage conditions and growth in space. Across the technical replicates, ground controls, 10 timepoints, and multiple experimental conditions, ~300 samples have been selected for initial analysis with WGS sequencing to 100x coverage. A flexible and resource efficient mutation calling pipeline is needed to process this large dataset and allow for comparisons between species. Many bioinformatics tools for calling Indels and Single Nucleotide Variants (SNVs) are designed for use with pure isolates, where true variations from the reference genome are expected to dominate the reads aligning to the location of mutation. In contrast, DNA from the Stasis Pack (SP) samples was collected directly after recovery from desiccated storage and the Production Pack (PP) samples were collected after fermentation. In this context, reads with mutations are expected to be less frequent than reads that align with the reference genome, as each sample will include multiple lines of cells. Thus, BioNutrients samples are expected to be similar to samples from cancer cell or “pooled” sequencing approaches. In preparation for the analysis of the BioNutrients samples, we have tested three mutation calling tools (GATK for Microbes, BreSeq and DiscoSNP) designed for complex samples. A challenge of validating mutation identification pipelines is a lack of “Ground Truth” datasets, especially for complex samples. To compare these three tools, we sought to identify mutations in pre-existing WGS data collected from populations of Chlamydomonas reinhardtii that were exposed to UV mutagenesis and growth in LEO as part of the Space Algae-1 mission. Here we present a summary of these tools against the analysis originally conducted using the CRISP tool. Critical metrics are compared such as runtime, the number of SNPs, the number and size of Indels, and patterns of transversion and transitions identified by each tool are reported. By sharing these benchmarking results collected in support of the BioNutrients mission, we aim to guide others seeking to identify SNVs in similarly complex microbial samples.

Biology↗
NASA NTRSDate not supplied

Yeast Strain Development and Hardware Testing in Preparation of a Lunar BioSensor

With Artemis missions underway, it is clear we are going back to the Moon to stay. Before sending Astronauts for long-duration missions, it is crucial to understand the technological and biomedical countermeasures needed to protect them before they get there. We can use knowledge gained from biological CubeSats to guide the next generation of experiments to support human habitation on the Moon. Lunar Explorer Instrument for space biology Applications (LEIA) is NASA’s latest BioSensor, adapted BioSentinel, the only CubeSat to travel Beyond Low Earth Orbit. BioSentinel launched on Artemis I and is currently >50 million kilometers from Earth (as of July 2024). LEIA aims to identify biological responses to the Lunar environment, which unprotected against would pose a threat to astronauts (cancer, cardiovascular disease, neurological impairment). The suite of instruments within LEIA detects Lunar radiation using two on-board radiation sensors (ARES charged particle detector, Mini-Fast Neutron Detector), then monitors real-time biological responses to the Lunar environment via an autonomous microfluidic system, fit with 3-LED emitter and detector boards and the alamarBlue metabolic indicator dye. LEIA will use a genetic approach in addition to synthetic biology to test counter-measure production in space, with the goal to inform and protect astronauts for future Moon missions. We have conducted preliminary tests in preparation for launch to the anticipated South Pole of the Moon, optimizing the biology (strain down-selection, desiccation tolerance, radiation sensitivity) and improving the hardware (including a blue LED to detect the beta-carotene countermeasure product). Our team will discuss these findings in several parts – an overview of the LEIA mission (Mark Settles), adapting flexible CubeSat platforms for deep-space applications (Sergio Santa Maria, Kira Rienecker), developing new technologies to support LEIA ground studies (Chinmayee Govinda Raj), and yeast strain development and hardware testing in preparation for LEIA (presented here).

synthetic biology↗
NASA NTRSDate not supplied

Extraordinary Accomplishments of the In Space Production Applications Portfolio in 2024

The purpose of the NASA In-Space Production Applications (InSPA) program is to provide funding and expertise to help brilliant United States innovators and businesses traverse the technology “Valley of Death” by proving out their concepts for in-space manufactured materials and products that will ultimately be sold to customers on the Earth. Scientific and technological advances on the International Space Station (ISS) and on Earth coupled with evolving societal needs are collectively enabling InSPA-funded teams to produce data streams and advanced biological, chemical, and physical materials solutions with economic value. We report on an extraordinary year of accomplishments on the ISS and highlight top InSPA and ISS National Lab results that span historic firsts in cancer research, stem cells, crystal production, optical fiber production, drug discovery, in-space treatments with RNA therapeutics, and production of artificial retinas from space. We assert that the results have enormous potential, are transforming the space exploration ecosystem and are the “seeds” of a microgravity industrial revolution that are shaping national microgravity strategy.

in spa↗
NASA NTRSDate not supplied

Somatic Mutation Analysis in Spaceflight: NASA Twins Genome Study

The NASA Twins Genome Study investigates the effects of spaceflight on somatic mutation accumulation by comparing genome-wide sequence data from a spaceflight astronaut and his Earth-bound twin. Utilizing advanced computational software on high performance computers, this study identifies and maps somatic mutations, with implications for understanding spaceflight-associated health risks, including cancer, neurodegeneration, and cardiovascular disease. The findings aim to bridge rodent and human space research, offering insights into tissue-specific pathophysiology, risk models, and potential therapeutic interventions.

somatic mutation↗
NASA NTRS2001

Analysis of biomaterial using Neural Computing Methodology

This paper describes a novel learning methodology used to analyze bio-materials. The premise of this research is to help pathologists quickly identify anomalous cells in a cost efficient method.

biomaterial neural computing methodology neural ne↗
NASA NTRS2013

Silicon Micromachining for Terahertz Component Development

Waveguide component technology at terahertz frequencies has come of age in recent years. Essential components such as ortho-mode transducers (OMT), quadrature hybrids, filters, and others for high performance system development were either impossible to build or too difficult to fabricate with traditional machining techniques. With micromachining of silicon wafers coated with sputtered gold it is now possible to fabricate and test these waveguide components. Using a highly optimized Deep Reactive Ion Etching (DRIE) process, we are now able to fabricate silicon micromachined waveguide structures working beyond 1 THz. In this paper, we describe in detail our approach of design, fabrication, and measurement of silicon micromachined waveguide components and report the results of a 1 THz canonical E-plane filter.

Filter↗
NASA NTRSDate not supplied

NASA Radiation Operations Sources, Models, and Standards

Space radiation is one of the major challenges of spaceflight. Astronauts spending time in low Earth orbit, the lunar surface, deep space, and elsewhere will all be exposed to multiple space radiation sources. These sources include trapped radiation in Earth’s upper atmosphere, solar energetic particles, and the omnipresent galactic cosmic radiation, as well as non-ionizing radiation from inside and outside a vehicle or habitat. The Space Radiation Analysis Group (SRAG) at Johnson Space Center is responsible for ensuring astronauts are protected from short- and long-term risks of radiation exposure. This talk details the radiation operational standards employed by NASA.

space radiation↗