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All sourcesNASA NTRSDOE OSTI
NASA NTRSDate not supplied

Uncrewed Lunar Surface Operations and Support Activities

Sustained human presence on the surface of the Moon and future missions to Mars require increased independence from surface crews and Earth-based mission control to operate efficiently, safely, and reliably. The time for surface crews to perform tasks will be limited. Extravehicular activities by surface personnel are burdensome and time-consuming, even when a continuous human presence on the surface occurs. Identifying and balancing human/automation roles and tasks and infusing automation and autonomy practices early in a system’s lifecycle will be essential to achieve mission objectives. Among these objectives are attaining a sustained human presence, improving performance and mission effectiveness, reducing operations and maintenance (O&M) costs, and ensuring operations that are robust to communication delays. To achieve these objectives, an operational shift toward increased automation and autonomy with less reliance on humans is needed. Uncrewed lunar surface operations and support activities occur when surface crews are not present or are independent of surface crew timeline activities requiring no surface crew oversight or intervention. These uncrewed surface opportunities can also be planned to minimize crew workload that avoids routine maintenance and support tasks, thus maximizing crew exploration time. Uncrewed preparations such as staging and prepositioning equipment and materials before the crew arrives could improve crew task efficiency. Additional opportunities exist to conduct uncrewed science, exploration, and utilization. Uncrewed surface architecture functions can include science and exploration; habitation; launch and landing support; surface communication and navigation; surface power generation and distribution; human surface mobility; lifting, handling, manipulating; excavation, construction, and site preparation; logistics management; maintenance and repair; surface resource utilization; integrated site operations and shared support services (e.g., site scheduling/prioritization, dust mitigation/contamination control, and surface safety). Early robotic lunar surface campaigns will provide information on the availability of resources, such as oxygen and water, and demonstrate surface-based technologies. After the Artemis III human lunar return mission, a series of landers will deliver surface systems, cargo, supplies, science packages, spare parts, and commodities. A balance of crewed and uncrewed surface operations will enable a sustained lunar surface presence at the South Pole of the Moon at a site that will be known as the Artemis Base Camp (ABC). It is envisioned that base camp operations on and around the Moon will then help prepare for the mission durations and activities needed to support the first human mission to Mars. Before long-duration crew missions to the base camp can occur, the necessary surface infrastructure will be pre-deployed and verified operational. Surface assets will be teleoperated and remotely managed from Earth. Additionally, robotic and short-duration crewed missions to the ABC will ensure the site’s merit to achieve long-term science objectives, availability of usable resources, and that terrain, seasonal variations, and illumination conditions are acceptable. ABC will consist of different areas where specific functions and services are rendered, including: • Launch and Landing Area • Habitation Area • Power Production Area • Resource Areas Launch and Landing Area—The launch and landing area will support associated functions for the arrival and departure of vehicles, such as crewed landing and ascent and uncrewed cargo deliveries and offloading. It will evolve from an unimproved site at the beginning of the exploration campaign to a more sustainable landing and launch area that can support repeated arrivals and departures. Initial uncrewed Lunar Terrain Vehicle (LTV) surface operations may include emplacement of navigation beacons and communication equipment, real-time video and photography of landing/liftoff events, and element repositioning, such as portable utility power (PUP) (applicable for other landed assets at other areas). Site preparations, such as surface leveling, soil compaction, and berm/path construction, may be needed for a more sustainable launch and landing area capable of accommodating vehicles that are increasingly more reusable and reduce the effects of plume surface interactions and ejecta impacts on nearby surface assets. During the ABC missions, cargo and logistics will be delivered to the lunar surface via robotic cargo landers before the crew arrives. These shipments, which can arrive in pressurized logistics carriers, will deliver the logistics necessary to support a crewed mission and include items such as food, water, equipment spares, etc. Providing the capability to retrieve, offload, and transport the logistics closer to the ABC site before the arrival of the crew will increase the overall efficiency of crew operations once they arrive. In the sustained phase of exploration, other supporting services may be needed, such as lander propellant servicing, surface power services, commodity refreshes, and additional inspection, maintenance, and repair capabilities, to sustain a cadence of extended personnel stays and cargo arrivals and departures. Habitation Area—Uncrewed support to surface habitation could involve supporting activation and pre-entry operations of the habitat while the crew is in orbit at the Gateway outpost preparing for a surface landing. Surface Habitat (SH) uncrewed operations may include bringing the cabin environment to a habitable temperature and air mix and activating other critical crew support systems. Potential crop production uncrewed tasks in the SH could also include autonomous watering and tending. Additionally, when the crew departs, the SH enters dormancy for the long period of uncrewed operation. A logistical staging area could also be collocated near the SH. If so, staging operations for crew supplies, waste re-location, and recycling operations may be opportunities for uncrewed operations. Power Production Area—The Fission Surface Power (FSP) element and its supporting distribution equipment provide power to surface elements as needed across the ABC to supplement day-to-day operations and survive lunar nights. Uncrewed support of this power system includes any initial LTV-assisted deployments of cables and other distributed equipment, associated electrical connections, and system testing and activation operations. Robotically performing some inspections, maintenance, or repair tasks on the power distribution equipment could reduce the surface crew workload. Resource Area— Uncrewed resource prospecting, mapping, and characterizing possible resource sites is likely to be time-consuming and represents an opportunity for uncrewed operations between crewed missions. Uncrewed mobile equipment operations will be needed in the extreme environments of permanently shadowed locations where resource extractions occur. As In-Situ Resource Utilization (ISRU) pilot plant operations begin, uncrewed surface support activities with available mobile and portable assets (LTV, PUP, etc.) will better support these operations. Any produced commodities can be stored at a centralized storage location for future use. Also associated with these operations is the use of mobile robotic excavators for resource acquisition and robotic/autonomous regolith processing. The waste tailings generated during excavation and regolith processing would also need to be transported and deposited at a dedicated location. Surface assets will continue operating between crew visits to maintain surface capabilities, conduct lunar surface science, technology demonstrations, and public outreach opportunities. Additionally, certain sustaining tasks that would consume valuable crew time could be performed before crew arrival, or after their departure. This capability may offer more affordable options to construct, activate, test, and maintain a broad set of surface assets. Telerobotically operated human surface mobility systems, such as the LTV and Pressurized Rover (PR), can be utilized for various tasks. Surface environmental conditions pose a distinct challenge for all these activities. Surface illumination and localized shadows are one such factor. Night-survival operations could consist of thermal management, battery pre-charging, and load shedding. Some surface systems may hibernate through the night and then awake and continue nominal operations. Uncrewed mobile assets may use a more adaptive approach to optimize their power and operations; one method is to follow the sunlight. Night-survival operations may be initiated remotely by teleoperation, automated, or accomplished by supervised autonomous operation. The ability to pre-deploy and control remote assets in orbit or on Mars before the arrival of the mission crew is a key capability that can be simulated on the moon. The base camp provides a venue where these advanced operational concepts, technologies, and autonomous methods and techniques, including the incorporation of time delays to simulate Earth-Mars latency can be replicated to help buy down future Mars mission risks. This paper will examine the evolution of uncrewed lunar surface operations and support activities. It will also discuss the lunar surface environmental conditions (thermal, lighting, terrain, topography, communications) along with the challenges they pose on uncrewed surface operations, and the performance of these activities with limited to minimal human interaction and/or teleoperation. Since lunar missions include Mars mission analogs, such investigation provides the framework for future uncrewed Mars mission support.

Mark E Lewis↗
NASA NTRS2002

Influence of vestibular activation on respiration in humans

The purpose of this study was to determine the effects of the semicircular canals and otolith organs on respiration in humans. On the basis of animal studies, we hypothesized that vestibular activation would elicit a vestibulorespiratory reflex. To test this hypothesis, respiratory measures, arterial blood pressure, and heart rate were measured during engagement of semicircular canals and/or otolith organs. Dynamic upright pitch and roll (15 cycles/min), which activate the otolith organs and semicircular canals, increased respiratory rate (Delta2 +/- 1 and Delta3 +/- 1 breaths/min, respectively; P < 0.05). Dynamic yaw and lateral pitch (15 cycles/min), which activate the semicircular canals, increased respiration similarly (Delta3 +/- 1 and Delta2 +/- 1, respectively; P < 0.05). Dynamic chair rotation (15 cycles/min), which mimics dynamic yaw but eliminates neck muscle afferent, increased respiration (Delta3 +/- 1; P < 0.05) comparable to dynamic yaw (15 cycles/min). Increases in respiratory rate were graded as greater responses occurred during upright (Delta5 +/- 2 breaths/min) and lateral pitch (Delta4 +/- 1) and roll (Delta5 +/- 1) performed at 30 cycles/min. Increases in breathing frequency resulted in increases in minute ventilation during most interventions. Static head-down rotation, which activates otolith organs, did not alter respiratory rate (Delta1 +/- 1 breaths/min). Collectively, these data indicate that semicircular canals, but not otolith organs or neck muscle afferents, mediate increased ventilation in humans and support the concept that vestibular activation alters respiration in humans.

NASA Discipline Neuroscience↗
NASA NTRS2023

Actively Controlled Louver for Human Spacecraft Radiator Ultraviolet (UV), Dust, and Freeze Protection

The paper examines the use of actively controlled louvers for human spacecraft radiators. State of the Art (SOA) radiators were design for Low Earth Orbit (LEO) operations where Ultraviolet (UV) radiation and dust have miniscule performance impacts. However, Artemis missions to the lunar orbit or surface will expose the radiators to high dose UV radiation and dust, which can degrade the radiator coating emissivity by up to 50% and consequently reduce performance early in missions. In addition, environmental nighttime temperatures at the lunar south pole are significantly colder and linger longer than LEO, and may require up to 4 kW of heater power to prevent coolant tubes from freezing, thawing, and rupturing. Analysis showed equipping the radiators with actively controlled louvers attenuated the UV radiation and dust effects, and limited degradation to less than 10% through End of Life (EOL) of missions. Furthermore, analysis demonstrated the ability to eliminate the heater power needed for freeze protection. Louver technology is a promising solution to maintain radiator performance and integrity for Artemis missions, but heritage louvers are passively controlled and only been used on small satellites. The technology requires maturing to active control, or motor actuated, to achieve faster thermal response times. Design considerations are discussed in this paper.

Louver↗
NASA NTRS2014

NASA's UAS Integration into the NAS: A Report on the Human Systems Integration Phase 1 Simulation Activities

In 2011 the National Aeronautics and Space Administration (NASA) began a five-year Project to address the technical barriers related to routine access of Unmanned Aerial Systems (UAS) in the National Airspace System (NAS). Planned in two phases, the goal of the first phase was to lay the foundations for the Project by identifying those barriers and key issues to be addressed to achieve integration. Phase 1 activities were completed two years into the five-year Project. The purpose of this paper is to review activities within the Human Systems Integration (HSI) subproject in Phase 1 toward its two objectives: 1) develop GCS guidelines for routine UAS access to the NAS, and 2) develop a prototype display suite within an existing Ground Control Station (GCS). The first objective directly addresses a critical barrier for UAS integration into the NAS - a lack of GCS design standards or requirements. First, the paper describes the initial development of a prototype GCS display suite and supporting simulation software capabilities. Then, three simulation experiments utilizing this simulation architecture are summarized. The first experiment sought to determine a baseline performance of UAS pilots operating in civil airspace under current instrument flight rules for manned aircraft. The second experiment examined the effect of currently employed UAS contingency procedures on Air Traffic Control (ATC) participants. The third experiment compared three GCS command and control interfaces on UAS pilot response times in compliance with ATC clearances. The authors discuss how the results of these and future simulation and flight-testing activities contribute to the development of GCS guidelines to support the safe integration of UAS into the NAS. Finally, the planned activities for Phase 2, including an integrated human-in-the-loop simulation and two flight tests are briefly described.

National Airspace System↗
NASA NTRSDate not supplied

Actively Controlled Louver for Human Spacecraft Radiator Ultraviolet (UV), Dust, and Freeze Protection

This paper examines the use of actively controlled louvers to attenuate UV and dust, as well as mitigate freezing concerns for human spacecraft radiators during Artemis missions. Artemis missions to the lunar orbit or surface will expose the radiators to high energy UV radiation and dust, which will degrade the radiator’s coating emissivity and consequently reduce heat rejection performance. In addition, subfreezing environmental temperatures during transit to lunar orbit and nighttime on lunar south pole can rupture coolant tubes, reduce heat rejection performance, and worst-case scenario result in a Loss of Mission (LOM). Louver technology would be a promising solution to maintaining radiator performance and integrity for Artemis missions, but heritage louvers are passively controlled. This technology needs maturing to active control, or motor actuation, to achieve faster thermal response times. Actively controlled louver design considerations are discussed in this paper. The analysis that follows shows actively controlled louvers can attenuate high energy UV radiation and dust, as well as protect the coolant from freezing.

Louver↗
NASA NTRS2023

Actively Controlled Louver for Human Spacecraft Radiator Ultraviolet (UV), Dust, and Freeze Protection

This paper examines the use of actively controlled louvers to attenuate UV and dust, as well as mitigate freezing concerns for human spacecraft radiators during Artemis missions. Artemis missions to the lunar orbit or surface will expose the radiators to high energy UV radiation and dust, which will degrade the radiator’s coating emissivity and consequently reduce heat rejection performance. In addition, subfreezing environmental temperatures during transit to lunar orbit and nighttime on lunar south pole can rupture coolant tubes, reduce heat rejection performance, and worst-case scenario result in a Loss of Mission (LOM). Louver technology would be a promising solution to maintaining radiator performance and integrity for Artemis missions, but heritage louvers are passively controlled. This technology needs maturing to active control, or motor actuation, to achieve faster thermal response times. Actively controlled louver design considerations are discussed in this paper. The analysis that follows shows actively controlled louvers can attenuate high energy UV radiation and dust, as well as protect the coolant from freezing.

Louver↗
DOE OSTI2026

AIF for Vis (Active Inference for simulating human interpretation of data visualization) [SWR-26-084]

AIF for Vis contains the Active Inference models and analysis scripts used to study a simple visualization-interpretation task: estimating the average value of two bars in a bar chart. The work is a proof of concept for translating hypothesized cognitive strategies into executable, inspectable process models. We implement two idealized strategies inspired by dual-process accounts of visualization-aided decision making: *Fast model: a compressed, heuristic strategy that estimates the visual midpoint of the two bars and maintains a single belief over their average. *Slow model: a sequential, analytic strategy that estimates the two bar heights separately and maintains them in working memory before computing an average. Both models use a common Active-Inference-inspired framework for sequential perception, belief updating, action selection, and reporting. Their different internal representations produce distinct predicted vulnerabilities: *the Fast model is more susceptible to tick-salience bias; *the Slow model is more susceptible to working-memory decay. The repository includes the model implementations, scripts used for the experiments reported in the paper, precomputed trial-level results, and plotting scripts.

Goldwyn, Harrison [National Laboratory of the Rock↗
NASA NTRS2013

Postures and Motions Library Development for Verification of Ground Crew Human Factors Requirements

Spacecraft and launch vehicle ground processing activities require a variety of unique human activities. These activities are being documented in a primitive motion capture library. The library will be used by human factors engineering analysts to infuse real to life human activities into the CAD models to verify ground systems human factors requirements. As the primitive models are being developed for the library, the project has selected several current human factors issues to be addressed for the Space Launch System (SLS) and Orion launch systems. This paper explains how the motion capture of unique ground systems activities is being used to verify the human factors engineering requirements for ground systems used to process the SLS and Orion vehicles, and how the primitive models will be applied to future spacecraft and launch vehicle processing.

Stambolian, Damon↗
NASA NTRS2024

Southern Indiana Ecological Conservation: Assessing Canopy Cover Dynamics and Forest Type Groupings in Southern Indiana to Inform Restoration Activities

As human influence continues to negatively impact natural habitats, timely assessment of ecosystem changes and restoration is critical to protect forest health and biodiversity. In our study, we focused on oak-hickory forests in southern Indiana. Oak-hickory forests were the dominant ecosystem dynamic in present-day Indiana for centuries until European colonization, which brought about fire suppression and, eventually, fire exclusion. Anthropogenic fire exclusion in this fire-adapted habitat led to the encroachment of mesic species, such as beech and maple trees. This process, commonly referred to as mesophication, was the focus of our study. Our team performed a feasibility study in using NASA Earth observations to support our end-user partners, Let the Sun Shine In and the US Forest Service, Hoosier National Forest, in their selection of oak-hickory restoration sites. To aid in our analysis of the forest dynamics of southern Indiana, our team used Landsat 5, 8, and 9 imageries, along with other ancillary datasets to create maps to illustrate areas that would most benefit from partners’ forest restoration and management practices. By constructing a Green Vegetation Fraction change map across our 39-year study period (1984-2023) to visualize the change in forest cover and creating a restoration suitability assessment map to reveal sites that met requirements for oak-hickory growth, we provided our partners with suitable site selection for restorative management and found that 3.3% of our entire study area and 4.4% of the Hoosier National Forest were deemed suitable. Our feasibility study benefits southern Indiana restoration by aiding our partners in efficiently selecting sites for prescribed burning, forest thinning, and other restoration management practices.

restoration↗
NASA NTRS2012

Postures and Motions Library Development for Verification of Ground Crew Human Systems Integration Requirements

Spacecraft and launch vehicle ground processing activities require a variety of unique human activities. These activities are being documented in a Primitive motion capture library. The Library will be used by the human factors engineering in the future to infuse real to life human activities into the CAD models to verify ground systems human factors requirements. As the Primitive models are being developed for the library the project has selected several current human factors issues to be addressed for the SLS and Orion launch systems. This paper explains how the Motion Capture of unique ground systems activities are being used to verify the human factors analysis requirements for ground system used to process the STS and Orion vehicles, and how the primitive models will be applied to future spacecraft and launch vehicle processing.

Jackson, Mariea Dunn↗
NASA NTRSDate not supplied

Analysis of the Value Added When Deploying a Model-Based Approach for the Validation and Verification of the Medical Database Software

The Medical Database (MD) is a virtual repository consisting of two software components: Medical Item Database (MedID) and the Evidence Library (EL). MedID consists of engineering data and associated information for specific medical resource items (e.g., pharmaceutical, medical devices, and supporting components), while the EL is a tool which provides all of the medical evidence necessary. The MD will 1) serve as the single “source of truth” for the Informing Mission Planning via Analysis of Complex Tradespaces (IMPACT) tool suite for both medical evidence and medical resource engineering data and 2) will be used in conjunction with the IMPACT tool suite to inform research prioritizations and perform systematic trade study evaluations to aid stakeholders in making informed decisions regarding simulated human spaceflight missions. The MD project used a Model-Based Systems Engineering (MBSE) approach to support all life cycles of the software development, while in parallel the human factors engineering team used modeling to support Human Centered Design (HCD) strategies in an effort to improve software usability. HCD is a frequently used approach in design frameworks that develops resolutions to complexities and challenges by involving the human perspective in all steps of the problem-solving process. By integrating the model-based approaches used for systems engineering and human factors activities, the project is able to leverage the model-based artifacts originally created for HCD activities for system level and human factors validation. In this presentation, our team highlights the value added when leveraging these model-based artifacts to support the on-going verification and validation activities.

C. Laing↗
NASA NTRS2007

Designing for Our Future in Space

Over the past several years, the disciplines of architecture and human factors have been increasingly recognized as specialties that have focused upon "human-centered design" in the development of spacecraft and surface habitats. These specialties have been instrumental in the conceptual design of overall spacecraft configurations and layouts, as well as habitability outfitting hardware, such as the galley, hygiene facility, sleep quarters, or the layout of displays and controls. From the human-centered perspective, this approach to design assists in the mitigation of risk when designing for an extreme environment such as space. It takes into account the human s physical and cognitive capabilities and limitations, the human s performance in the context of human space flight, the human s interaction with machines that are both physically and cognitively complex, the activities required of the human to accomplish the goals of missions, and the use of design practices that promote products to enable human activity. It is this latter aspect - the use of design practices that promote products to enable human activity - that is the focus of the approach used by the Rhode Island School of Design (RISD) in collaboration with the Habitability and Human Factors Branch (HHFB) at the NASA Johnson Space Center (JSC). During the past few years, there has been a growing recognition of the value added by utilizing industrial designers to further the conceptual development of space hardware, that when used in conjunction with architecture and human factors, provides a robust solution to the design challenge. The "Design for Extreme Environments" Studio at RISD has taken suggested design topics from the NASA JSC HHFB and asked the students to investigate solutions to these challenges. The topics have demanded that the student pay particular attention to a variety of aspects of the space environment and understand how the human responds to each. The student must then adapt the design to these responses. The studio environment has been one way to introduce these challenges, but providing for an "in-residence" opportunity at JSC has given the students a broader vision and set of experiences. The accompanying presentation highlights the studio as well as in-residence work that has been accomplished.

Connolly, Janis↗
NASA NTRSDate not supplied

Enterprise Mission Integration for Artemis Lunar Missions

Mission integration is an iterative process by which a specific mission is formulated, refined, planned, and executed within the established vehicle(s), architecture, and ground systems design. Mission integration includes the people, vehicle(s) and ground hardware/software, products, processes, analyses, schedules, facilities, Certification of Flight Readiness, etc. The Artemis Mission Integration Task Team (MITT) developed a series of products and processes to support the complex mission integration across various Programs within the Artemis Mission Campaign (Orion, Space Launch Systems, Exploration Ground Systems, Gateway, Human Landing System, and Extravehicular Activity and Human Surface Mobility). The Moon to Mars (M2M) Program is referred to as ‘the enterprise’ as it includes both the M2M organization and the Programs supporting the Artemis Mission Campaign. Artemis Mission Integration has five phases: mission capability, mission definition, mission preparation, mission execution, and post-mission assessment. This paper focuses on one of the enterprise-level mission checkpoints as a kick-off to the Mission Preparation phase, the Mission Integration Review (MIR), which occurs 18-24 months prior to launch. The MIR helps to confirm the defined mission technical baseline is within the existing analyzed design envelope. Details are provided on the identification of dependencies, issues, or gaps for mission-specific objectives and requirements, as well as the definition of the analysis, training, mission execution products, facilities, and detailed supporting operations requirements. The MIR was held for both Artemis I and II and this paper aims to share with the aerospace community its value as we prepare for upcoming Artemis Missions.

Mary Anne Plaza↗
NASA NTRS2024

Loads and Structural Dynamics Requirements for Spaceflight Hardware

The NASA Exploration Systems Development Mission Directorate requires Crewed Space Systems (CSS) to meet the intent of a set of Engineering Technical Authority (TA) documents called out in HEOMD-003, Crewed Deep Space Systems Human Rating Certification Requirements and Standards for NASA Missions. For the Loads and Dynamics technical discipline, the document invoked by the HEOMD-003 is JSC 65829, Loads and Structural Dynamics Requirements for Spaceflight Hardware. JSC 65829 was originally developed for the NASA Commercial Crew Program as an implementation of NASA STD-5002, Load Analyses of Spacecraft and Payloads, for that Program. Since that time, tailored alternatives to JSC 65829 have been produced for the Gateway, Human Landing System, and Extravehicular Activity and Human Surface Mobility Programs. Experience with those Programs has shown that the reduced set of less-prescriptive requirements in those tailored documents offers an advantage over the set of requirements in JSC 65829 Rev A and is a better fit for the paradigm of NASA procurement of commercially developed systems for crewed spaceflight. Revision B of JSC 65829 has been constructed to align with those tailored documents. The reduction in the number and specificity of requirements is balanced by a new requirement for hardware developers to create and provide a Loads Control Plan which describes how the approaches used to generate design-to loads and dynamic environments and substantiate dynamic model validity satisfy the requirements herein. The Plan will establish an agreement between the hardware developer and the TA for the loads and dynamics discipline and offer an opportunity for reengagement if the Plan changes during development.

Kenneth Schultz↗
DOE OSTI2021

An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation

Human uracil DNA-glycosylase (UDG) is the prototypic and first identified DNA glycosylase with a vital role in removing deaminated cytosine and incorporated uracil and 5-fluorouracil (5-FU) from DNA. UDG depletion sensitizes cells to high APOBEC3B deaminase and to pemetrexed (PEM) and floxuridine (5-FdU), which are toxic to tumor cells through incorporation of uracil and 5-FU into DNA. To identify small-molecule UDG inhibitors for pre-clinical evaluation, we optimized biochemical screening of a selected diversity collection of >3,000 small-molecules. We found aurintricarboxylic acid (ATA) as an inhibitor of purified UDG at an initial calculated IC 50 < 100 nM. Subsequent enzymatic assays confirmed effective ATA inhibition but with an IC50 of 700 nM and showed direct binding to the human UDG with a K D of <700 nM. ATA displays preferential, dose-dependent binding to purified human UDG compared to human 8-oxoguanine DNA glycosylase. ATA did not bind uracil-containing DNA at these concentrations. Yet, combined crystal structure and in silico docking results unveil ATA interactions with the DNA binding channel and uracil-binding pocket in an open, destabilized UDG conformation. Biologically relevant ATA inhibition of UDG was measured in cell lysates from human DLD1 colon cancer cells and in MCF-7 breast cancer cells using a host cell reactivation assay. Collective findings provide proof-of-principle for development of an ATA-based chemotype and “door stopper” strategy targeting inhibitor binding to a destabilized, open pre-catalytic glycosylase conformation that prevents active site closing for functional DNA binding and nucleotide flipping needed to excise altered bases in DNA.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1985

The human role in space: Technology, economics and optimization

Man-machine interactions in space are explored in detail. The role and the degree of direct involvement of humans that will be required in future space missions are investigated. An attempt is made to establish valid criteria for allocating functional activities between humans and machines and to provide insight into the technological requirements, economics, and benefits of the human presence in space. Six basic categories of man-machine interactions are considered: manual, supported, augmented, teleoperated, supervised, and independent. Appendices are included which provide human capability data, project analyses, activity timeline profiles and data sheets for 37 generic activities, support equipment and human capabilities required in these activities, and cumulative costs as a function of activity for seven man-machine modes.

Hall, S. B.↗
NASA NTRS2007

A Review of Antenna Technologies for Future NASA Exploration Missions

NASA's plans for the manned exploration of the Moon and Mars will rely heavily on the development of a reliable communications infrastructure from planetary surface-to-surface, surface-to-orbit and back to Earth. Future missions will thus focus not only on gathering scientific data, but also on the formation of the communications network. In either case, unique requirements become imposed on the antenna technologies necessary to accomplish these tasks. For example, proximity (i.e., short distance) surface activity applications such as robotic rovers, human extravehicular activities (EVA), and probes will require small size, lightweight, low power, multi-functionality, and robustness for the antenna elements being considered. In contrast, trunk-line communications to a centralized habitat on the surface and back to Earth (e.g., relays, satellites, and landers) will necessitate high gain, low mass antennas such as novel inflatable/deployable antennas. Likewise, the plethora of low to high data rate services desired to guarantee the safety and quality of mission data for robotic and human exploration will place additional demands on the technology. Over the last few years, NASA Glenn Research Center has been heavily involved in the development and evaluation of candidate antenna technologies with the potential for meeting the aforementioned requirements. These technologies range from electrically small antennas to phased arrays and large inflatable antenna structures. A summary of these efforts will be discussed in this paper. NASA planned activities under the Exploration Vision as they pertain to the communications architecture for the Lunar and Martian scenarios will be discussed, with emphasis on the desirable qualities of potential antenna element designs for envisioned communications assets. Identified frequency allocations for the Lunar and Martian surfaces, as well as asset-specific data services will be described to develop a foundation for viable antenna technologies which might address these requirements and help guide future technology development decisions.

Miranda, Felix A.↗