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Exposure to g-forces causes changes in the vascular systems of animals. The vessels are distorted and their contents may escape. Various parts of a given organ may react differently according to their structure, and arteries will undergo changes that depend on their position relative to the direction of the g-force vector.
Arteries in the brain are constricted by g-forces applied in the head-pelvis direction. Transversely applied g-forces have less effect. Appropriate conditioning can reduce the severity of all g-force applications.
A transcutanous method to measure instantaneous mean blood flow in peripheral arteries of the human body was defined. Transcutanous and implanted cuff ultrasound velocity measurements were evaluated, and the accuracies of velocity, flow, and diameter measurements were assessed for steady flow. Performance criteria were established for the pulsed Doppler velocity meter (PUDVM), and performance tests were conducted. Several improvements are suggested.
The technology transfer application this report describes is the result of a pilot study of image-processing methods applied to the image enhancement, coding, and analysis of arteriograms. Angiography is a subspecialty of radiology that employs the introduction of media with high X-ray absorption into arteries in order to study vessel pathology as well as to infer disease of the organs supplied by the vessel in question.
Extensive studies of blood circulation functions during manned space flight demonstrated a pronounced tendency toward an increase in minute volume of the blood and a decrease in pulse wave propagation rate. Individual blood circulation indices had large amplitude fluctuations. Physical work loads caused slow recovery of heart rate, arterial pressure and minute blood volume.
The performance quality of movements away and approaches to an airlock by astronauts was tested during parabolic flights for weightlessness simulation. Coordination of movement, orientation and performance capacity of the astronauts were not singificantly disrupted. Observed physiological shifts are characterized by an increase in pulse and respiration rate and an increase in arterial pressure under g-forces, a gradual decrease in these indices during repeated stays in weightlessness or during the prolonged effect of it, by a reduction of the length of postrotational nystagmus and counterrotation illusions under weightless conditions.
A 1.2- by 1.8-m variable conductance heat pipe radiator was designed, built, and tested. The radiator has deployment capability and can passively control Freon-21 fluid loop temperatures under varying loads and environments. It consists of six grooved variable conductance heat pipes attached to a 0.032-in. aluminum panel. Heat is supplied to the radiator via a fluid header or a single-fluid flexible heat pipe header. The heat pipe header is an artery design that has a flexible section capable of bending up to 90 degrees. Radiator loads as high as 850 watts were successfully tested. Over a load variation of 200 watts, the outlet temperature of the Freon-21 fluid varied by 7 F. An alternate control system was also investigated which used a variable conductance heat pipe header attached to the heat pipe radiator panel.
The intravenous administration of DEHP solubilized by means of a number of different detergents leads to respiratory distress and death in rats. At autopsy the lungs are grossly enlarged, edamatous, and hemorrhagic. Light and electron microscopic evaluation of the lungs indicate engorgement of the interalveolar septa with edema fluid and polymorphonuclear leucocytes, degranulation of the leukocytes, and progessive destruction of the endothelial and epithelial cells. Consistent with the conclusion that solubilized DEHP results in a syndrome of "shock lung" is the associated massive fall in arterial blood pressure and the prevention of the lung pathology by pretreatment with pharmacologic doses of an antiinflammatory steroid, methylprednisolone. Evidence is also presented that suggests that the DEHP inadvertently administered to humans during transfusions is also in a solubilized state in the plasma.
Principles and descriptive fragments which may contribute to a model of the regulating chains in the cardiovascular system are presented. Attention is given to the strain sensitivity of blood vessels, the law of the autonomy of the heart beat oscillator, the law of the encapsulation of body fluids, the law of the conservation of protein, the law of minimum 'arterial' pressure, the design of the 'mammalian' kidney, questions of homeokinetic organization, and the development of self-regulatory chains. Details concerning the development program for the heart muscle are considered along with the speed of response of the breathing rate and the significance of the pulmonary vascular pressure-flow characteristics.
A novel variable-conductance heat-pipe approach has been developed that delivers high-capacity loads, while eliminating the problem of artery gas blockage present in conventional designs. The unit, known as a transverse header, uses ammonia as the working fluid and nitrogen as the control gas. Its overall cylindrical shape is 5.1 cm in diameter by 0.61 m long. Under test with a fluid heat source, the maximum load achieved as a VCHP was 3,600W. As with conventional gas-loaded pipes, good temperature control was also obtained. An application of this device as a VCHP header for a heat-pipe radiator is described.-
Potential medical applications are presented of lower body negative pressure to the evaluation and treatment of cardiac patients. The essential features of an LBNP unit and the basic cardiovascular physiology of lower body negative pressure (LBNP) testing are described. Some of the results of previous spaceflight experiences and bedrest studies are summarized. The deconditioning effects of weightlessness experienced by orbiting astronauts are compared with the effects of bedrest restrictions prescribed for convalescing cardiac patients. The potential of LBNP for evaluating both pharmacological and physical activity regimens was examined, particularly in relation to post-myocardial infarction and coronary artery bypass patients. Applications of LBNP to the cardiac catheterization laboratory and the out-patient follow-up of cardiac patients are proposed.
The development of a cardiovascular monitoring system to noninvasively monitor the blood pressure and heart rate using pulse wave velocity was described. The following topics were covered: (1) pulse wave velocity as a measure of arterial blood pressure, (2) diastolic blood pressure and pulse wave velocity in humans, (3) transducer development for blood pressure measuring device, and (4) cardiovascular monitoring system. It was found, in experiments on dogs, that the pulse wave velocity is linearly related to diastolic blood pressure over a wide range of blood pressure and in the presence of many physiological perturbations. A similar relationship was observed in normal, young human males over a moderate range of pressures. Past methods for monitoring blood pressure and a new method based on pulse wave velocity determination were described. Two systems were tested: a Doppler ultrasonic transducer and a photoelectric plethysmograph. A cardiovascular monitoring system was described, including operating instructions.
This bibliography lists 149 references with abstracts and 47 patents dealing with applications of heat pipe technology. Topics covered include: heat exchangers for heat recovery; electrical and electronic equipment cooling; temperature control of spacecraft; cryosurgery; cryogenic, cooling; nuclear reactor heat transfer; solar collectors; laser mirror cooling; laser vapor cavitites; cooling of permafrost; snow melting; thermal diodes variable conductance; artery gas venting; and venting; and gravity assisted pipes.
The measurement of the volume flow-rate of blood in an artery or vein requires both an estimate of the flow velocity and its spatial distribution and the corresponding cross-sectional area. Transcutaneous measurements of these parameters can be performed using ultrasonic techniques that are analogous to the measurement of moving objects by use of a radar. Modern digital data recording and preprocessing methods were applied to the measurement of blood-flow velocity by means of the CW Doppler ultrasonic technique. Only the average flow velocity was measured and no distribution or size information was obtained. Evaluations of current flowmeter design and performance, ultrasonic transducer fabrication methods, and other related items are given. The main thrust was the development of effective data-handling and processing methods by application of modern digital techniques. The evaluation resulted in useful improvements in both the flowmeter instrumentation and the ultrasonic transducers. Effective digital processing algorithms that provided enhanced blood-flow measurement accuracy and sensitivity were developed. Block diagrams illustrative of the equipment setup are included.
Certain hemodynamic phenomena that arise in connection with the use of artificial blood pumping devices are reviewed. Among these are: (1) Flows produced by collapsing bulbs; (2) the impedance presented by the aorta; (3) limiting velocities and instability of flow in elastic vessels; (4) effectiveness of valveless arterio-arterial pumps, and (5) wave reflection phenomena and instabilities associated with the intra-aortic balloon pump.
A force transducer for measuring dynamic force activity within the heart of a subject essentially consists of a U-shaped beam of low elastic compliance material. Two lines extend from the beams's legs and a long coil spring is attached to the beam. A strain gauge is coupled to one of the beam's legs to sense deflections thereof. The beam with the tines and most of the spring are surrounded by a flexible tube, defining a catheter, which is insertable into a subject's heart through an appropriate artery. The tines are extractable from the catheter for implantation into the myocardium by pushing on the end of the spring which extends beyond the external end of the catheter.
Effects of indomethacin and meclofenamate, inhibitors of prostaglandin synthesis, were evaluated in the regulation of renal blood flow in conscious and anesthetized dogs and in tranquilized baboons, instrumented with arterial pressure catheters and renal blood flow probes. Indomethacin, 10 mg/kg, did not alter renal blood flow or resistance significantly in the conscious dog. In the anesthetized dog, however, indomethacin caused a reduction in renal blood flow and an elevation of renal vascular resistance. Meclofenamate, 4 mg/kg, reduced renal flow and increased renal vascular resistance in conscious dogs. In conscious dogs and tranquilized primates, indomethacin and meclofenamate reduced the reactive hyperemia in the renal bed. Methoxamine and angiotensin II infused in graded doses induced significantly greater renal vasoconstriction in conscious dogs in the presence of indomethacin. Thus, in the conscious animal, prostaglandins appear to play only a minor part in the control of renal circulation at rest, but they are of greater importance in mediating the renal responses to reactive hyperemia and to vasoconstriction.
The extent to which norepinephrine (NE) and angiotensin II (AN) constrict the mesenteric, renal, and iliac beds in conscious dogs is evaluated with a view to elicit opposing reflex actions tempering the vasoconstriction in the limb of the animals tested. The afferent and efferent mechanisms mediating this reflex are analyzed. It is shown that intravenous NE and AN cause striking reflex iliac dilatation in the limb of the conscious dog. The afferent arc of this reflex involves both arterial baroreceptor and vagal path-ways, whereas the efferent mechanism involves an interaction of alpha-adrenergic and histaminergic receptors.