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At least 631 records · Page 35

An improved approach to the analysis of drug-protein binding by distance geometry

The calculation of side chain centers of coordinates and the subsequent generation of side chain-side chain and side chain-backbone distance matrices is suggested as an improved method for viewing interactions inside proteins and for the comparison of protein structures. The use of side chain distance matrices is demonstrated with free PTI, and the use of difference distance matrices for side chains is shown for free and trypsin-bound PTI as well as for the X-ray structures of trypsin complexes with PTI and with benzamidine. It is found that conformational variations are reflected in the side chain distance matrices much more than in the standard C-C distance representations.

NASA Discipline Exobiology↗

A Formal Methods Approach to the Analysis of Mode Confusion

The goal of the new NASA Aviation Safety Program (AvSP) is to reduce the civil aviation fatal accident rate by 80% in ten years and 90% in twenty years. This program is being driven by the accident data with a focus on the most recent history. Pilot error is the most commonly cited cause for fatal accidents (up to 70%) and obviously must be given major consideration in this program. While the greatest source of pilot error is the loss of situation awareness , mode confusion is increasingly becoming a major contributor as well. The January 30, 1995 issue of Aviation Week lists 184 incidents and accidents involving mode awareness including the Bangalore A320 crash 2/14/90, the Strasbourg A320 crash 1/20/92, the Mulhouse-Habsheim A320 crash 6/26/88, and the Toulouse A330 crash 6/30/94. These incidents and accidents reveal that pilots sometimes become confused about what the cockpit automation is doing. Consequently, human factors research is an obvious investment area. However, even a cursory look at the accident data reveals that the mode confusion problem is much deeper than just training deficiencies and a lack of human-oriented design. This is readily acknowledged by human factors experts. It seems that further progress in human factors must come through a deeper scrutiny of the internals of the automation. It is in this arena that formal methods can contribute. Formal methods refers to the use of techniques from logic and discrete mathematics in the specification, design, and verification of computer systems, both hardware and software. The fundamental goal of formal methods is to capture requirements, designs and implementations in a mathematically based model that can be analyzed in a rigorous manner. Research in formal methods is aimed at automating this analysis as much as possible. By capturing the internal behavior of a flight deck in a rigorous and detailed formal model, the dark corners of a design can be analyzed. This paper will explore how formal models and analyses can be used to help eliminate mode confusion from flight deck designs and at the same time increase our confidence in the safety of the implementation. The paper is based upon interim results from a new project involving NASA Langley and Rockwell Collins in applying formal methods to a realistic business jet Flight Guidance System (FGS).

Butler, Ricky W.↗

A Verification-Driven Approach to Control Analysis and Tuning

This paper proposes a methodology for the analysis and tuning of controllers using control verification metrics. These metrics, which are introduced in a companion paper, measure the size of the largest uncertainty set of a given class for which the closed-loop specifications are satisfied. This framework integrates deterministic and probabilistic uncertainty models into a setting that enables the deformation of sets in the parameter space, the control design space, and in the union of these two spaces. In regard to control analysis, we propose strategies that enable bounding regions of the design space where the specifications are satisfied by all the closed-loop systems associated with a prescribed uncertainty set. When this is unfeasible, we bound regions where the probability of satisfying the requirements exceeds a prescribed value. In regard to control tuning, we propose strategies for the improvement of the robust characteristics of a baseline controller. Some of these strategies use multi-point approximations to the control verification metrics in order to alleviate the numerical burden of solving a min-max problem. Since this methodology targets non-linear systems having an arbitrary, possibly implicit, functional dependency on the uncertain parameters and for which high-fidelity simulations are available, they are applicable to realistic engineering problems..

Crespo, Luis G.↗

Modeling, Analysis and Simulation Approaches Used in Development of the National Aeronautics and Space Administration Max Launch Abort System

The National Aeronautics and Space Administration (NASA) Engineering and Safety Center was chartered to develop an alternate launch abort system (LAS) as risk mitigation for the Orion Project. Its successful flight test provided data for the design of future LAS vehicles. Design of the flight test vehicle (FTV) and pad abort trajectory relied heavily on modeling and simulation including computational fluid dynamics for vehicle aero modeling, 6-degree-of-freedom kinematics models for flight trajectory modeling, and 3-degree-of-freedom kinematics models for parachute force modeling. This paper highlights the simulation techniques and the interaction between the aerodynamics, flight mechanics, and aerodynamic decelerator disciplines during development of the Max Launch Abort System FTV.

Yuchnovicz, Daniel E.↗

Review and Analysis of Algorithmic Approaches Developed for Prognostics on CMAPSS Dataset

Benchmarking of prognostic algorithms has been challenging due to limited availability of common datasets suitable for prognostics. In an attempt to alleviate this problem several benchmarking datasets have been collected by NASA's prognostic center of excellence and made available to the Prognostics and Health Management (PHM) community to allow evaluation and comparison of prognostics algorithms. Among those datasets are five C-MAPSS datasets that have been extremely popular due to their unique characteristics making them suitable for prognostics. The C-MAPSS datasets pose several challenges that have been tackled by different methods in the PHM literature. In particular, management of high variability due to sensor noise, effects of operating conditions, and presence of multiple simultaneous fault modes are some factors that have great impact on the generalization capabilities of prognostics algorithms. More than 70 publications have used the C-MAPSS datasets for developing data-driven prognostic algorithms. The C-MAPSS datasets are also shown to be well-suited for development of new machine learning and pattern recognition tools for several key preprocessing steps such as feature extraction and selection, failure mode assessment, operating conditions assessment, health status estimation, uncertainty management, and prognostics performance evaluation. This paper summarizes a comprehensive literature review of publications using C-MAPSS datasets and provides guidelines and references to further usage of these datasets in a manner that allows clear and consistent comparison between different approaches.

Uncertainty↗

Exploration Capabilities Data Analysis: An Integrated Approach

In preparation for humanity’s return to the Moon, it is necessary to advance technologies and capabilities that will allow for human sustainability on the lunar surface, as well as on eventual missions to send humans to Mars. Guided by Space Policy Directive-1 and through the National Aeronautical and Space Administration (NASA) Artemis program, the advancement and development of technologies on the lunar surface will be leveraged towards technologies and knowledge needed for humans to successfully and safely go to Mars and return. In order to understand the capability needs for lunar and Mars missions, the Capabilities Integration Team identifies integration approaches and overlaps between missions to develop strategies for advancing key capabilities that support those needs. Since 2013, the Capabilities Integration Team has reached out to subject matter experts, principal technologists, and system capability leadership teams throughout NASA to gather information about the critical technologies and capabilities needed in order to support the lunar and Mars exploration missions. To properly gather this data, the Capabilities Integration Team used a capability-driven approach to identify gaps between the current state of the art and the needs of proposed exploration missions, as well as activities that may close those gaps. These inputs are used to shape technology investment strategies and are incorporated in missions to the lunar and Mars surfaces. Data collected included: gap definitions and identifying information; gap closure information and metrics for success; mapping of gaps to elements of NASA's Artemis program and future exploration architecture. . The data collected, specifically from the technology gap list, has been used to support the NASA Human Exploration and Operations Mission Directorate Planning, Programming, Budgeting, and Execution processes, as well as the NASA Space Technology Mission Directorate Strategic Technology Plans. This paper discusses the integration approach used by the Capabilities Integration Team to identify current capability gaps for the Moon to Mars architecture and what capabilities exist or must be developed to support those architecture needs. In addition, this paper also details the performance, gap characterization, current capability gap closure opportunities, and risk impacts towards Artemis, and the overall Moon to Mars architecture.

Gregory Benjamin↗

A hierarchical finite element approach for integrated thermal-structural analysis

A hierarchical finite element approach for thermal-structural analysis is presented. The approach employs a common nodal discritization and seeks improvements in the accuracy of the analyses by using hierarchical interpolation functions with nodeless variables. The effectiveness of the integrated approach is assessed for three applications with two-dimensional elements by comparison with conventional finite element thermal-structural solutions. Improvements in the accuracy of temperatures and thermal-stresses are demonstrated. The applications demonstrate the practical importance of having flexibility in refining each analysis independently while maintaining a common discretization, and show that the hierarchical approach offers potential for the development of a general method for integrated thermal-structural analysis.

Thornton, E. A.↗

A new approach in cascade flow analysis using the finite element method

A new approach in analyzing the potential flow past cascades and single airfoils using the finite element method is developed. In this analysis the circulation around the airfoil is not externally imposed but is directly computed in the numerical solution. Different finite element discretization patterns, orders of piecewise approximation, and grid sizes are used in the solution. The results obtained are compared with existing experimental measurements and exact solutions in cascades and single airfoils.

Baskharone, E.↗

Asymptotic modal analysis and statistical energy analysis

Statistical Energy Analysis (SEA) is defined by considering the asymptotic limit of Classical Modal Analysis, an approach called Asymptotic Modal Analysis (AMA). The general approach is described for both structural and acoustical systems. The theoretical foundation is presented for structural systems, and experimental verification is presented for a structural plate responding to a random force. Work accomplished subsequent to the grant initiation focusses on the acoustic response of an interior cavity (i.e., an aircraft or spacecraft fuselage) with a portion of the wall vibrating in a large number of structural modes. First results were presented at the ASME Winter Annual Meeting in December, 1987, and accepted for publication in the Journal of Vibration, Acoustics, Stress and Reliability in Design. It is shown that asymptotically as the number of acoustic modes excited becomes large, the pressure level in the cavity becomes uniform except at the cavity boundaries. However, the mean square pressure at the cavity corner, edge and wall is, respectively, 8, 4, and 2 times the value in the cavity interior. Also it is shown that when the portion of the wall which is vibrating is near a cavity corner or edge, the response is significantly higher.

Dowell, Earl H.↗

Evaluating Novel Approaches for In Situ Analysis in the Search for Extraterrestrial Life

Universal approaches to detect extraterrestrial life are required to determine whether life exists outside of earth. A significant limitation of current detection strategies is the absence of a reliable, universal approach. They do not provide mechanisms to detect life that has evolved distinctly from life on Earth. We hypothesize that the most basic, essential features of life that can be detected are that they decrease their internal entropy at the expense of free energy obtained from their surroundings and that they produce heat associated with metabolic reactions. We propose that by using a thermodynamic analysis of the energy associated with these fundamental components of life, one can readily quantify the degree of free energy difference between life forms or their remnants and their abiotic surroundings. Analysis of the free energy entropy term (and thus structural complexity) and enthalpy term (as a manifestation of the energy release caused by metabolic reactions) may provide definitive detection of the presence of life. As a part of our analysis we review data available in the literature about the thermodynamics of microbial growth to assess the extent microbial metabolism and growth may contribute to negative entropy of maintenance (metabolism) and structural complexity. Additionally, we evaluate the different mechanisms by which structural complexity can be measured using calorimetry. An experimental framework is considered using concepts from previous work that could be used to further validate the calorimetric methods for life detection by potentially differentiating between life forms or their remnants from an abiotic surrounding. Results obtained demonstrate the applications of this approach and indicate that modification of a microcalorimetric technique has potential for incorporation into a space exploration platform as a life-detection payload.

Life Detection, Calorimetry↗

Liquid rocket spray combustion stability analysis

A computational approach to the analysis of spray combustion stability in liquid rocket combustors is proposed which is based on the unsteady quasi-two-dimensional Euler equations with interphase source terms derived from a Lagrangian treatment of the combusting spray. Based on a preliminary evaluation, the computational methodology presented here is a promising research tool and a potential design/development aid for investigating the stability characteristics of liquid rocket engines. The method is characterized by low numerical noise; the Lagrangian treatment of the spray offers improved flexibility for the direct modeling of spray combustion.

Litchford, Ron J.↗