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At least 631 records · Page 35

WE-G-18C-05: Characterization of Cross-Vendor, Cross-Field Strength MR Image Intensity Variations

Purpose: Variations in MR image intensity and image intensity nonuniformity (IINU) can challenge the accuracy of intensity-based image segmentation and registration algorithms commonly applied in radiotherapy. The goal of this work was to characterize MR image intensity variations across scanner vendors and field strengths commonly used in radiotherapy. Methods: ACR-MRI phantom images were acquired at 1.5T and 3.0T on GE (450w and 750, 23.1), Siemens (Espree and Verio, VB17B), and Philips (Ingenia, 4.1.3) scanners using commercial spin-echo sequences with matched parameters (TE/TR: 20/500 ms, rBW: 62.5 kHz, TH/skip: 5/5mm). Two radiofrequency (RF) coil combinations were used for each scanner: body coil alone, and combined body and phased-array head coils. Vendorspecific B1- corrections (PURE/Pre-Scan Normalize/CLEAR) were applied in all head coil cases. Images were transferred offline, corrected for IINU using the MNI N3 algorithm, and normalized. Coefficients of variation (CV=σ/μ) and peak image uniformity (PIU = 1−(Smax−Smin)/(Smax+Smin)) estimates were calculated for one homogeneous phantom slice. Kruskal-Wallis and Wilcoxon matched-pairs tests compared mean MR signal intensities and differences between original and N3 image CV and PIU. Results: Wide variations in both MR image intensity and IINU were observed across scanner vendors, field strengths, and RF coil configurations. Applying the MNI N3 correction for IINU resulted in significant improvements in both CV and PIU (p=0.0115, p=0.0235). However, wide variations in overall image intensity persisted, requiring image normalization to improve consistency across vendors, field strengths, and RF coils. These results indicate that B1- correction routines alone may be insufficient in compensating for IINU and image scaling, warranting additional corrections prior to use of MR images in radiotherapy. Conclusions: MR image intensities and IINU vary as a function of scanner vendor, field strength, and RF coil configuration. A two-step strategy consisting of MNI N3 correction followed by normalization was required to improve MR image consistency. Funding provided by Advancing a Healthier Wisconsin.

60 APPLIED LIFE SCIENCES↗

Analysis of the shearout failure mode in composite bolted joints

A semi-empirical shearout strength model has been formulated for the analysis of composite bolted joints with allowance for the effects of joint geometry. The model employs a polynomial stress function in conjunction with a point stress failure criterion to predict strength as a function of fastener size, edge distance, and half spacing. The stress function is obtained by two-dimensional plane-stress finite element analysis using quadrilateral elements with orthotropic material properties. Comparison of experimentally determined shearout strength data with model predicted failures has substantiated the accuracy of the model.

Wilson, D. W.↗

Statistical fatigue of unnotched composite laminates

A general analytical, phenomenological model is developed for characterizing fatigue damage accumulation in unnotched composite laminates, and experimental results are used to evaluate the model. The fatigue model, which is developed for various types of cyclic loadings, is based on the assumption that the residual strength reduction is a monotonically decreasing function of the fatigue life. Parameters are determined from baseline test data consisting of one set of residual strength data, one set of static strength data, and one set of constant amplitude fatigue life data. Once the parameters are determined, the model is able to predict: (1) the statistical distribution of the fatigue life, and the residual strength under constant and variable amplitude loads, and (2) the effect of periodic proof tests, without any additional experimental data. Experimental test results show that predictions made from the present model agree quite well with the experimental results. The model is also applicable to fatigue of bonded or bolted composite joints.

Yang, J. N.↗

In-situ magnetic alignment model for additive manufacturing of anisotropic bonded magnets

In this work, we report a mathematical framework which predicts the degree of alignment (DoA) in an in-situ aligned additively manufactured 3D printed bonded magnets. A multiphysics model is developed which couples the harmonious interactions of magnetic particles in a viscous flowing polymer under the presence of an external magnetic field. The hydrodynamic fluid-particle interaction is paired with the magnetophoretic force to predict the particle trajectory and distribution during extrusion through a 3D printer nozzle. Succeeding the force balance, a magnetohydrodynamic torque equilibrium analysis is performed to predict the net-orientation of the magnetic particles as a function of the applied field strength, viscous forces, and particle-to-particle interactions (P2P). Experimental validation of the DoA predictions is performed using 65 vol% Nd-Fe-B+Sm-Fe-N in Nylon12 (DoA exp = 0.620 and DoA theory = 0.686) and 15 vol% Sm-Co in PLA (DoA exp = 0.830 and DoA theory = 0.863). A parametric analysis is performed to analyze the effect of operating and design parameters like alignment field strength, magnetic loading fraction, extrusion load, and particle size. The model predicts a competing behavior between particle-fluid and particle-particle interactions under the presence of an applied field. Lastly, the model provides a framework to efficiently predict the DoA in tandem with a functionalized-magnetic 3D printer and allows the user to adjust the operating parameters according to the desired DoA.

36 MATERIALS SCIENCE↗

Latitudinal dependence of solar wind speed

The data of King (1979, 1983) and of Hoeksema et al. (1982, 1983) are used to investigate the solar-cycle evolution of solar wind bulk speed as a function of source magnetic field strength. The effects of solar transient events are removed. The data suggest that the latitudinal gradient in background solar wind speed is steepest at solar minimum and broadest at solar maximum. The lowest and highest background speeds are found to remain fairly constant throughout the solar cycle. A function developed for the background solar wind speed is inserted into the improved kinematic code of Hakamada and Akasofu (1982), and solar wind speed and IMF are simulated for two periods in the solar cycle. The observed parameters for specific coronal hole passage are well reproduced by the analysis.

Fry, C. D.↗

The effect of new interstellar medium parameters on the heliosphere and energetic neutral atoms from the interstellar boundary

We present new results from three-dimensional simulations of the solar wind interaction with the local interstellar medium (LISM) using recent observations by NASA's Interstellar Boundary EXplorer (IBEX) mission estimates of the velocity and temperature of the LISM. We investigate four strengths of the LISM magnetic field, from 1 to 4 μG, and adjust the LISM proton and hydrogen densities so that the distance to the termination shock (TS) in the directions of the Voyager spacecraft is just below 90 AU, and the density of hydrogen at the TS is close to 0.09 cm{sup –3} in the nose direction. The orientation of the magnetic field is chosen to point toward the center of the ribbon of enhanced energetic neutral atom (ENA) flux seen in the IBEX data. Our simulations show that the plasma and neutral properties in the outer heliosheath vary considerably as a function of the LISM magnetic field strength. We also show that the heliotail points downwind in all cases, though its structure is strongly affected by the external magnetic field. Comparison and consistency between the simulated ENA flux and the circularity of the ribbon as measured by IBEX are most consistent with a LISM magnetic field strength aligned with the center of the ribbon and a magnitude in the range 2.5-3 μG.

79 ASTRONOMY AND ASTROPHYSICS↗

CRISPRi functional genomics in bacteria and its application to medical and industrial research

SUMMARY Functional genomics is the use of systematic gene perturbation approaches to determine the contributions of genes under conditions of interest. Although functional genomic strategies have been used in bacteria for decades, recent studies have taken advantage of CRISPR (clustered regularly interspaced short palindromic repeats) technologies, such as CRISPRi (CRISPR interference), that are capable of precisely modulating expression of all genes in the genome. Here, we discuss and review the use of CRISPRi and related technologies for bacterial functional genomics. We discuss the strengths and weaknesses of CRISPRi as well as design considerations for CRISPRi genetic screens. We also review examples of how CRISPRi screens have defined relevant genetic targets for medical and industrial applications. Finally, we outline a few of the many possible directions that could be pursued using CRISPR-based functional genomics in bacteria. Our view is that the most exciting screens and discoveries are yet to come.

Microbiology↗

Characterization of tissue magnetic susceptibility-induced distortions for MRIgRT

Purpose: MR image geometric integrity is one of the building blocks of MRI-guided radiotherapy. In particular, tissue magnetic susceptibility-induced effects are patient-dependent and their behavior is difficult to assess and predict. In this study, the authors investigated in detail the characteristics of susceptibility ({chi}) distortions in the context of MRIgRT, including the case of two common MR-linac system configurations. Methods: The magnetic field distortions were numerically simulated for several imaging parameters and anatomical sites, i.e., brain, lung, pelvis (with air pockets), and prostate. The simulation process consisted of (a) segmentation of patient CT data into susceptibility relevant anatomical volumes (i.e., soft-tissue, bone and air/lung), (b) conversion of CT data into susceptibility masks by assigning bulk {chi} values to the structures defined at (a), (c) numerical computations of the local magnetic fields by using a finite difference algorithm, and (d) generation of the geometric distortion maps from the magnetic field distributions. For each patient anatomy, the distortions were quantified at the interfaces of anatomical structures with significantly different {chi} values. The analysis was performed for two specific orientations of the external main magnetic field (B{sub 0}) characteristic to the MR-linac systems, specifically along the z-axis for a bore MR scanner and in the (x,y)-plane for a biplanner magnet. The magnetic field local perturbations were reported in ppm. The metrics used to quantify the geometric distortions were the maximum, mean, and range of distortions. The numerical simulation algorithm was validated using phantom data measurements. Results: Susceptibility-induced distortions were determined for both quadratic and patient specific geometries. The numerical simulations showed a good agreement with the experimental data. The measurements were acquired at 1.5 and 3 T and with an encoding gradient varying between 3 and 20 mT/m by using an annular phantom mimicking the water-air and water-oil {chi} interfaces. For quadratic geometries, the magnitude of field distortion increased rapidly with the size of the inhomogeneity up to about 10 mm and then tended to plateau. This trend became more evident for materials with a larger {Delta}{chi} relative to water. The simulations showed only a slight increase in the maximum distortion values when the B{sub 0} orientation was varied with regard to the shape of the {chi} inhomogeneity. In the case of patient anatomy, the largest distortion values arose at the air-soft-tissue interface. Considering the two MR-linac system configurations and comparing the field distortion values corresponding to all organ structures, the distortions tended to be larger for the biplanar magnet. The authors provide a reference table with ppm values which can be used to easily evaluate the geometric distortions for patient data as a function of B{sub 0} and the strength of the encoding gradient. Conclusions: The susceptibility distortions were quantified as a function of multiple parameters such as the {chi} inhomogeneity size and shape, the magnitude of B{sub 0} and the readout gradient, and the orientation of B{sub 0} with respect to the sample geometry. The analysis was performed for several anatomical sites and corresponding to two B{sub 0} orientations as featured by MR-linac systems.

60 APPLIED LIFE SCIENCES↗

Float-Zone Growth of Gel-xSix (x ? 10 at .%) Single Crystals: Influence of Thermocapillary and Solutocapillary Convection

Gel-xSix (x ? 10 at.%) single crystals have been grown with the float-zone technique applied within a monoellipsoid mirror furnace. The feed crystal consisted of synthesized GeO.95siO.05 polycrystalline material. Two Boron-doped (much much more than 1-2 (raised dot) 1017 at/cm3) crystals were grown under identical conditions using <100> Ge seeds. One Ge:Ga-doped (much much more than 1018 at/cm3) reference crystal was also grown in the same furnace. Compositional profiles were measured with an energy dispersive analysis by X-ray (EDAX). The maximum silicon concentration attained was 10 at.%. Micrographs of the etched crystals show sharp changes in interface curvature at the crystal edges. These are considered to be caused by solutal Marangoni convection, whose strength is assumed to be a direct function of silicon concentration, Theoretical considerations show that the flow direction, velocity, and strength varies significantly from a solutal Marangoni convection regime directly in front of the solid-liquid interface to a thermal Marangoni convection regime within the bulk melt.

Campbell, Tom A.↗

Compression, bend, and tension studies on forged Al67Ti25Cr8 and Al66Ti25Mn(g) L1(2) compounds

Cast, homogenized, and isothermally forged aluminum-rich L1(2) compounds Al67Ti25Cr8 and Al66Ti25Mn(g) were tested in compression as a function of temperature and as a function of strain rate at elevated temperatures (1000 K and 1100 K). Three-point bend specimens were tested as a function of temperature in the range 300 K to 873 K. Strain gages glued on the tensile side of the ambient and 473 K specimens enabled direct strain measurements. A number of 'buttonhead' tensile specimens were electro-discharge machined, fine polished, and tested between ambient and 1073 K for yield strength and ductility as a function of temperature. Scanning electron microscope (SEM) examination of fracture surfaces from both the bend and tensile specimens revealed a gradual transition from transgranular cleavage to intergranular failure with increasing temperature.

Kumar, K. S.↗

A machine learning aided interpretable model for rupture strength prediction in Fe-based martensitic and austenitic alloys

Abstract The class of 9–12% Cr ferritic-martensitic alloys (FMA) and austenitic stainless steels have received considerable attention due to their numerous applications in high temperature power generation industries. To design high strength steels with prolonged service life requires a thorough understanding of the long-term properties, e.g., creep rupture strength, rupture life, etc., as a function of the chemical composition and processing parameters that govern the microstructural characteristics. In this article, the creep rupture strength of both 9–12% Cr FMA and austenitic stainless steel has been parameterized using curated experimental datasets with a gradient boosting machine. The trained model has been cross validated against unseen test data and achieved high predictive performance in terms of correlation coefficient ( $$R^{2} > 0.98 $$ R 2 > 0.98 for 9–12% Cr FMA and $$R^{2} > 0.95 $$ R 2 > 0.95 for austenitic stainless steel) thus bypassing the need for additional comprehensive tensile test campaigns or physical theoretical calculations. Furthermore, the feature importance has been computed using the Shapley value analysis to understand the complex interplay of different features.

36 MATERIALS SCIENCE↗

IUPAC-NIST Solubility Data Series. 100. Rare Earth Metal Fluorides in Water and Aqueous Systems. Part 3. Heavy Lanthanides (Gd–Lu)

This is the third part of the volume devoted to solubility data for the rare earth metal (REM) fluorides in water and in aqueous ternary and multicomponent systems. It covers experimental results of trivalent fluorides of Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu (so-called heavy lanthanides), since no quantitative data on solubilities of TbF{sub 4} and YbF{sub 2} (the most stable compounds at these valencies) are available. The related literature has been covered through the end of 2014. Compilations of all available papers with the solubility data are introduced for each REM fluoride with a corresponding critical evaluation. Every such assessment contains a collection of all solubility results in aqueous solution, a selection of suggested solubility data, a solubility equation, and a brief discussion of the multicomponent systems. Only simple fluorides (no complexes or double salts) are treated as the input substances in this report. General features of the systems, such as nature of the equilibrium solid phases, solubility as a function of temperature, influence of ionic strength, solution pH, mixed solvent medium on the solubility, quality of the solubility results, and the solubility as a function of REM atomic number, have already been presented in Part 1 of the volume.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Trade-offs among restored ecosystem functions are context-dependent in Mediterranean-type regions

Global biodiversity hotspots, including Mediterranean-type ecosystems worldwide, are highly threatened by global change that alters biodiversity, ecosystem functions, and services. Some restoration activities enhance ecosystem functions by reintroducing plant species based on known relationships between plant traits and ecosystem processes. Achieving multiple functions across different site conditions, however, requires understanding how abiotic factors like climate and soil, along with plant assemblages, influence ecosystem functions, including their trade-offs and synergies. We used the ModEST ecosystem simulation model, which integrates carbon, water, and nutrient processes with plant traits, to assess the relationships between restored plant assemblages and ecosystem functions in Mediterranean-type climates and soils. We investigated whether maximised carbon increment, water use efficiency, and nitrogen use efficiency, along with their trade-offs and synergies, varied across different abiotic contexts. Further, we asked whether assemblages that maximised functions varied across environments and among these functions. We found that maximised ecosystem carbon increment and nitrogen use efficiency occurred under moist, warm conditions, while water use efficiency peaked under drier conditions. Generally, the assemblage that maximised one function differed from those for other maximised functions. Synergies were rare, except between water and nitrogen use efficiencies in loam soils across most climates. Trade-offs among maximised functions were common, varying in strength with abiotic context and plant assemblages, and were more pronounced in sandy loam soils compared to clay-rich soils. Our findings suggest that due to variation in abiotic conditions within and across Mediterranean-type regions at the global scale, site-specific plant assemblages are required to maximise ecosystem functions. Thus, lessons from a single site cannot be transferred to another site, even where the same plant functional types are available for restoration. Our simulation results offer valuable insights into potential ecosystem performance under specific abiotic conditions following restoration with particular plant functional types, thereby informing local restoration efforts.

54 ENVIRONMENTAL SCIENCES↗

Ignition dynamics of a laminar diffusion flame in the field of a vortex embedded in a shear flow

The role of streamwise-spanwise vorticity interactions that occur in turbulent shear flows on flame/vortex interactions is examined by means of asymptotic analysis and numerical simulation in the limit of small Mach number. An idealized model is employed to describe the interaction process. The model consists of a one-step, irreversible Arrhenius reaction between initially unmixed species occupying adjacent half-planes which are then allowed to mix and react in the presence of a streamwise vortex embedded in a shear flow. It is found that the interaction of the streamwise vortex with shear gives rise to small-scale velocity oscillations which increase in magnitude with shear strength. These oscillations give rise to regions of strong temperature gradients via viscous heating, which can lead to multiple ignition points and substantially decrease ignition times. The evolution in time of the temperature and mass-fraction fields is followed, and emphasis is placed on the ignition time and structure as a function of vortex and shear strength.

Macaraeg, Michele G.↗

A machine-learning framework for the simulation of nuclear deflection of Planet-Killer-Asteroids

Here, as detection capabilities in astronomy have dramatically improved over the last two decades, concerns over Planet-Killer-Asteroids (PKAs) have become widespread, with nuclear weapons being proposed to destroy or deflect asteroids that are on a short-term projected collision course with Earth. Two main mitigation strategies have been proposed: • Case 1: Break up an incoming asteroid into smaller pieces that will disperse widely, resulting in smaller-scale, less detrimental, Earth-impacts or • Case 2: Deflect an incoming asteroid trajectory to avoid collision altogether. While the two strategies are not mutually exclusive, deflection is a safer strategy, ideally by harnessing all of the released energy from a nuclear device to move the asteroid as a rigid body. However, this case may not be always possible, since the strength of the energy release may break up the asteroid. In this work, the dynamical response of a PKA to a series of ultra-high energy impulses, such as those generated by nuclear devices, is formulated. A rapid iterative Discrete Element Method (DEM) method is developed to describe the deflection and potential breakup of the PKA as a function of a material bonding strength parameter within the asteroid and the magnitude of the applied impulse. The use of DEM allows for fragmentation of the PKA and the ability to compute the trajectories and distribution of the resulting debris field. Finally, a machine-learning algorithm is then developed and combined with the DEM approach to optimize the pulsation strategy for maximum possible safety and success.

42 ENGINEERING↗

Galactic X-ray emission from pulsars

The contribution of pulsars to the gamma-ray flux from the galactic plane is examined using data from the most recent pulsar surveys. It is assumed that pulsar gamma-rays are produced by curvature radiation from relativistic particles above the polar cap and attenuated by pair production in the strong magnetic and electric fields. Assuming that all pulsars produce gamma-rays in this way, their luminosities can be predicted as a function of period and magnetic field strength. Using the distribution of pulsars in the galaxy as determined from data on 328 pulsars detected in three surveys, the local gamma-ray production spectrum, the longitude profile, and the latitude profile of pulsar gamma-ray flux are calculated. The largest sources of uncertainty in the size of the pulsar contribution are the value of the mean interstellar electron density, the turnover in the pulsar radio luminosity function, and the average pulsar magnetic field strength. A present estimate is that pulsars contribute from 15 to 20 % of the total flux of gamma-rays from the galactic plane.

Harding, A. K.↗

Wear Trends of the HERMeS Thruster as a Function of Throttle Point

A series of short-duration (200 hour) wear tests were conducted with two Hall Effect Rocket with Magnetic Shielding (HERMeS) technology demonstration units (TDU). Front pole covers, cathode keeper, and discharge channel wear were characterized as a function of discharge voltage, magnetic field strength, and chamber pressure. No discharge channel erosion was observed. Inner pole cover erosion was shown to be a weak function of discharge voltage with most erosion occurring at the lowest value, 300 volts. The TDU-3 keeper electrode eroded with each operating condition, with high magnetic field yielding the greatest erosion rate. The TDU-1 keeper electrode exhibited net deposition suggesting its configuration is more consistent with meeting overall HERMeS service life requirements. Ratios of molybdenum to graphite erosion rates suggests, with high uncertainty, that the sputtering ions are originating downstream of the thruster exit plane, striking the surface with small angles of incidence.

life (durability)↗

Wear Trends of the HERMeS Thruster as a Function of Throttle Point

A series of short-duration (200 h) wear tests were conducted with two Hall Effect Rocket with Magnetic Shielding (HERMeS) technology demonstration units. Front pole covers, cathode keeper, and discharge channel wear were characterized as a function of discharge voltage, magnetic field strength, and chamber pressure. No discharge channel erosion was observed. Inner pole cover erosion was shown to be a weak function of discharge voltage with most erosion occurring at the lowest value, 300 V. The Technology Demonstration Unit (TDU) 3 keeper electrode eroded with each operating condition, with high magnetic field yielding the greatest erosion rate. The TDU-1 keeper electrode exhibited net deposition suggesting its configuration is more consistent with meeting overall HERMeS service life requirements. Ratios of molybdenum to graphite erosion rates suggests, with high uncertainty, that the sputtering ions are originating downstream of the thruster exit plane, striking the surface with small angles of incidence.

Williams, George J., Jr.↗