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At least 613 records · Page 34

Chromosome Aberration in Human Blood Lymphocytes Exposed to Energetic Protons

During space flight, astronauts are exposed to a space radiation consisting of high-energy protons, high charge and energy (HZE) nuclei, as well as secondary particles that are generated when the primary particles penetrate the spacecraft shielding. Secondary particles have a higher LET value than primary protons and therefore expected to have a higher relative biological effectiveness (RBE). To investigate this theory, we exposed human peripheral blood lymphocytes to protons with energies of 250 MeV, 800MeV, 2 GeV, or 2.5 GeV. LET values for these protons ranged from 0.4 to 0.2 keV/micrometer. and doses ranged from 0.2 to 3 Gy. Over this energy the probability of nuclear reaction leading to secondary radiation, and the multiplicity of reaction produces such as neutrons and mesons increases substantially. The effect of aluminum and polyethylene shielding was also assessed using the 2 GeV and 2.5GeV proton beams. After exposure lymphocytes were stimulated to divide and chromosomes were collected from cells in the first G2 and metaphase cell cycle after exposure using a chemical induced premature chromosome condensation (PCC) technique. Dose response data for chromosome damage was analyzed using the fluorescence in situ hybridization (FISH) chromosome painting technique. Selected samples were also analyzed with multicolor FISH (mFISH) and multicolor banding FISH (mBAND) techniques. Data indicates that the dose response for simple-type exchanges is similar for proton and gamma exposure, whereas protons induce higher yields of complex exchanges that are LET dependent. RBE values will be presented for each proton energy, and the effects of shielding and possible cytogenetic signatures of proton exposure will be discussed.

Hada, M.↗

The Observed State of the Water Cycle in the Early Twenty-First Century

This study quantifies mean annual and monthly fluxes of Earth's water cycle over continents and ocean basins during the first decade of the millennium. To the extent possible, the flux estimates are based on satellite measurements first and data-integrating models second. A careful accounting of uncertainty in the estimates is included. It is applied within a routine that enforces multiple water and energy budget constraints simultaneously in a variational framework in order to produce objectively determined optimized flux estimates. In the majority of cases, the observed annual surface and atmospheric water budgets over the continents and oceans close with much less than 10% residual. Observed residuals and optimized uncertainty estimates are considerably larger for monthly surface and atmospheric water budget closure, often nearing or exceeding 20% in North America, Eurasia, Australia and neighboring islands, and the Arctic and South Atlantic Oceans. The residuals in South America and Africa tend to be smaller, possibly because cold land processes are negligible. Fluxes were poorly observed over the Arctic Ocean, certain seas, Antarctica, and the Australasian and Indonesian islands, leading to reliance on atmospheric analysis estimates. Many of the satellite systems that contributed data have been or will soon be lost or replaced. Models that integrate ground-based and remote observations will be critical for ameliorating gaps and discontinuities in the data records caused by these transitions. Continued development of such models is essential for maximizing the value of the observations. Next-generation observing systems are the best hope for significantly improving global water budget accounting.

Numerical analysis/modeling↗

Unusual Polar Conditions in Solar Cycle 24 and Their Implications for Cycle 25

We report on the prolonged solar-maximum conditions until late 2015 at the north-polar region of the Sun indicated by the occurrence of high-latitude prominence eruptions (PEs) and microwave brightness temperature close to the quiet-Sun level. These two aspects of solar activity indicate that the polarity reversal was completed by mid-2014 in the south and late 2015 in the north. The microwave brightness in the south-polar region has increased to a level exceeding the level of the Cycle 23/24 minimum, but just started to increase in the north. The northsouth asymmetry in the polarity reversal has switched from that in Cycle 23. These observations lead us to the hypothesis that the onset of Cycle 25 in the northern hemisphere is likely to be delayed with respect to that in the southern hemisphere. We find that the unusual condition in the north is a direct consequence of the arrival of poleward surges of opposite polarity from the active region belt. We also find that multiple rush-to-the-pole episodes were indicated by the PE locations that lined up at the boundary between opposite-polarity surges. The high-latitude PEs occurred in the boundary between the incumbent polar flux and the insurgent flux of opposite polarity.

Gopalswamy, Nat↗

Norton-Thevenin Receptance Coupling (NTRC) as a Payload Analysis Tool

The NASA Engineering and Safety Center (NESC) has funded a study of a new method formulated by NASA Engineers called Norton-Thevenin Receptance Coupling (NTRC) to perform coupled loads analysis (CLA). The problem that NTRC attempts to solve is the dependency of the payload organization to high CLA costs, long schedules, lack of standard capabilities to evaluate multiple configurations and unavailability of loads when needed. NTRC solves the problem by providing a tool that payload developers can use to obtain loads at a fraction of the cost of a CLA at any time that it is required. While NTRC is not intended to replace the formal load cycles performed by the launch vehicle (LV) provider, it will provide the ability to reduce the conservatism in defining preliminary design loads, assess the impact of design changes between formal load cycles, perform trade studies and perform parametric loads analysis where many different design configurations can be evaluated with a minimum amount of data required from the LV provider. NTRC condenses all the necessary information into the launch vehicle to payload/s connection points or boundary degrees of freedom (BD). The launch vehicle model is represented by its impedance at its BDs; its forcing functions are represented by the acceleration at those BDs when the payload is absent and the latter is represented by its impedance at the same BDs. Payload responses are represented by transfer functions of selected response to interface BDs. The methodology has contributed to the Loads and Dynamics discipline advancement and successfully passed Peer Reviews. NTRC is exact in the frequency domain. Time domain replication and accuracy is outstanding. A second phase is envisioned to benchmark the whole set of CLA events for the Agency's most utilized Launch Vehicles, and ready it for operational deployment at NASA.

Kaufman, Daniel↗

RadLab and the Environmental Data Application Dashboard: Graphical and Programming Interfaces for Interrogation of Space Telemetry Data

Sensors on the International Space Station (ISS) and multiple spacecraft elsewhere in Earth orbit and in deep space continuously monitor and collect environmental data, transmitting this information back to Earth. These data include ionizing radiation and, on the ISS, CO2, relative humidity levels, and temperature, and are of great importance to space biology research. Ionizing radiation in particular has been established in ground-based experiments as being correlated with increased risk of carcinogenesis and cardiovascular and neurological effects. Looking ahead to future long duration crewed missions beyond low Earth orbit, the ability to study how factors including CO2 levels, light cycle, temperature modulate the response to ionizing radiation and microgravity is essential. To date, access to these data has been fragmented across space agencies, spacecraft, and databases. To address this issue, NASA’s Open Science Data Repository (osdr.nasa.gov) has developed two Web applications: the Environmental Data Application (EDA) and a radiation-specific RadLab. Each consists of an API (application programming interface) and an associated GUI (graphical user interface) that provide single points of access to the data. To date, OSDR has focused on the sensors from payloads and radiation detectors located on the ISS. The Web applications process telemetry information and associated data, such as spacecraft location and orientation, from multiple international databases. The applications’ request syntax enables users to interrogate these data by craft, sensor type, time range, radiation type (galactic cosmic rays, solar particle events, the contribution of the South Atlantic Anomaly), facilitating arbitrary comparisons of original source data at varying time resolutions. The applications provide programmatic access for use in computational pipelines and GUIs for data visualization and exploration, making these data FAIR (Findable, Accessible, Interoperable, and Reusable), complementing the biological data contained in OSDR, and providing the space science community with a valuable resource for scientific analyses.

radiation↗

Procedures and tools for building large Ada systems

Some of the problems unique to building a very large Ada system are addressed. This is done through examples from experience. In the winter of 1985 and 1986, Intermetrics bootstrapped the Ada compiler, which was being built over the last few years. This system consists of about one million lines of full Ada. Over the last few years a number of procedures and tools were adopted for managing the life cycle of each of the many parts of an Ada system. Many of these procedures are well known to most system builders: release management, quality assurance testing; and source file revision control. Others are unique to working in an Ada language environment; i.e., recompilation management, Ada program library management, and managing multiple implementations. First a look is taken at how a large Ada system is broken down into pieces. The Ada definition leaves unspecified a number of issues that the system builder must address: versions, subsystems, multiple implementations, and synchronization of branched development paths. Having introduced how the Ada systems are decomposed, a look is taken, via a series of examples, at how the life cylces of those parts is managed. The procedures and tools used to manage the evolution of the system are examined. It is hoped that other Ada system builders can build upon the experience of the last few years.

Hyde, Ben↗

Magellan stereo images and Venusian geology

Areas of Venus imaged by Magellan radar with multiple viewing conditions provide unique data that will contribute to the solution of venusian geologic problems and provide a basis for quantitative comparison of venusian landforms with those on other planetary bodies. Three sets of images with different viewing conditions have been acquired: (1) left-looking with variable incidence angles (cycle 1 profile), (2) right-looking with nearly constant incidence angles (cycle 2 profile), and (3) left-looking with variable incidence angles that are almost always smaller than those in (1) (cycle 3 profiles). The unique data provided by paired images of the same scene with different incidence angles arises from image displacements caused by the relief of individual landforms at scales comparable to the ground-range and azimuth resolutions of the images. There are two aspects of the data: (1) Stereopsis achieved by simultaneous viewing of paired left-looking images of the same scene permits three-dimensional perception and interpretation of the morphologies of landforms at resolutions much finer than the altimetry footprints. (2) Measurements of differences of image displacements (parallax) on paired images with known imaging geometries provide quantitative estimates of the relief and shapes of landforms. The potential scientific contributions of the data can be grouped into two interrelated classes: (A) geologic mapping, analysis, and interpretation and (B) topical studies that involve topographic measurements. Stereopsis, without quantitative measurements, enhances geologic mapping, analysis, and interpretation of the rock units of Venus to a degree that cannot be overestimated. In geologic mapping, assemblages of landforms, assessments of backscatter and variations in backscatter, and fine-scale topography are used to define and characterize geologic map units that represent laterally continuous deposits or rock units. Stereopsis adds the important dimension of local relief for characterization of geologic units at a scale that is not possible with Magellan altimetry or products derived from the altimetry. Relative ages of the geologic units are determined using the well-known principles of superposition and intersection. Here, the perception of relief is invaluable because superposition relations among the geological units are more readily and clearly established. The recognition of folds, faults, and fault systems, regardless of their orientations, is facilitated with stereopsis so that sequences of deformation of the geologic units can be determined and structural analyses vastly improved. Shapes of landforms are readily perceived so that they can be properly interpreted. The end result of the mapping, analyses, and interpretations is a geologic history of Venus that includes the sequences of formation and deformation of various geologic units. Measurements of relief at the finest scale possible are necessary for numerous topical studies. Standard altimetry will provide the necessary information on the relief of most large landforms, but it tends to underestimate the relief of small landforms and distorts their shapes. Although special processing of the altimeter echoes improves the estimates of the relief and shapes of some landforms, there are uncertainties in the interpretations of the echoes. Examples of topical studies requiring measurements of relief are given.

Moore, H. J.↗

Getting through to circadian oscillators: why use constant routines?

Overt 24-h rhythmicity is composed of both exogenous and endogenous components, reflecting the product of multiple (periodic) feedback loops with a core pacemaker at their center. Researchers attempting to reveal the endogenous circadian (near 24-h) component of rhythms commonly conduct their experiments under constant environmental conditions. However, even under constant environmental conditions, rhythmic changes in behavior, such as food intake or the sleep-wake cycle, can contribute to observed rhythmicity in many physiological and endocrine variables. Assessment of characteristics of the core circadian pacemaker and its direct contribution to rhythmicity in different variables, including rhythmicity in gene expression, may be more reliable when such periodic behaviors are eliminated or kept constant across all circadian phases. This is relevant for the assessment of the status of the circadian pacemaker in situations in which the sleep-wake cycle or food intake regimes are altered because of external conditions, such as in shift work or jet lag. It is also relevant for situations in which differences in overt rhythmicity could be due to changes in either sleep oscillatory processes or circadian rhythmicity, such as advanced or delayed sleep phase syndromes, in aging, or in particular clinical conditions. Researchers studying human circadian rhythms have developed constant routine protocols to assess the status of the circadian pacemaker in constant behavioral and environmental conditions, whereas this technique is often thought to be unnecessary in the study of animal rhythms. In this short review, the authors summarize constant routine methodology and what has been learned from constant routines and argue that animal and human circadian rhythm researchers should (continue to) use constant routines as a step on the road to getting through to central and peripheral circadian oscillators in the intact organism.

Non-NASA Center↗

Design of a Long Endurance Titan VTOL Vehicle

Saturn s moon Titan promises insight into many key scientific questions, many of which can be investigated only by in situ exploration of the surface and atmosphere of the moon. This research presents a vertical takeoff and landing (VTOL) vehicle designed to conduct a scientific investigation of Titan s atmosphere, clouds, haze, surface, and any possible oceans. In this investigation, multiple options for vertical takeoff and horizontal mobility were considered. A helicopter was baselined because of its many advantages over other types of vehicles, namely access to hazardous terrain and the ability to perform low speed aerial surveys. Using a nuclear power source and the atmosphere of Titan, a turbo expander cycle produces the 1.9 kW required by the vehicle for flight and operations, allowing it to sustain a long range, long duration mission that could traverse the majority of Titan. Such a power source could increase the lifespan and quality of science for planetary aerial flight to an extent that the limiting factor for the mission life is not available power but the life of the mechanical parts. Therefore, the mission could potentially last for years. This design is the first to investigate the implications of this potentially revolutionary technology on a Titan aerial vehicle.

Prakash, Ravi↗

Nonlinear response of infinitely long circular cylindrical shells to subharmonic radial loads

The nonlinear response of infinitely long circular cylindrical shells (thin circular rings) in the presence of a two-to-one internal (autoparametric) resonance to a subharmonic excitation of order one-half of the higher mode is analyzed with the multiple-scale method. Four autonomous first-order ordinary differential equations are derived for the modulation of the amplitudes and phases of the interacting models. These modulation equations are used to determine the fixed points and their stability. The fixed points correspond to periodic oscillations of the shell, whereas the limit-cycle solutions of the modulation equations correspond to amplitude and phase-modulated oscillations of the shell. The force response curves exhibit saturation, jumps, and Hopf bifurcation. As excitation frequency changes, all limit cycles deform and lose stability through either pitchfork or cyclic-fold (saddle-node) bifurcations. Some of these saddle-node bifurcations cause a transition to chaos. The pitchfork bifurcations break the symmetry of the limit cycles.

Nayfeh, Ali H.↗

Reproduction and the renin-angiotensin system

A unique aspect of the circulating renin-angiotensin system and the many independent tissue renin-angiotensin systems is their interactions at multiple levels with reproduction. These interactions, which have received relatively little attention, include effects of estrogens and possibly androgens on hepatic and renal angiotensinogen mRNA; effects of androgens on the Ren-2 gene and salivary renin in mice; the prorenin surge that occurs with but outlasts the LH surge during the menstrual cycle; the inhibitory effects of estrogens on thirst and water intake; the tissue renin-angiotensin systems in the brain, the anterior pituitary, and the ovaries and testes, that is, in all the components of the hypothalamo-pituitary-gonadal axis; the presence of some components of the renin-angiotensin system in the uterus and the fetoplacental unit; and the possible relation of renin and angiotensin to ovulation and fetal well-being. These interactions are described and their significance considered in this short review.

NASA Program Space Biology↗

Circumlunar Free-Return Cycler Orbits for a Manned Earth-Moon Space Station

Multiple free-return circumlunar cycler orbits were designed to allow regular travel between the Earth and Moon by a manned space station. The presented cycler orbits contain circumlunar free-return "figure-8" segments and yield lunar encounters every month. Smaller space "taxi" vehicles can rendezvous with (and depart from) the cycling Earth-Moon space station to enter lunar orbit (and/or land on the lunar surface), return to Earth, or reach destinations including Earth-Moon L1 and L2 halo orbits, near-Earth objects (NEOs), Venus, and Mars. To assess the practicality of the selected orbits, relevant cycler characteristics (including (Delta)V maintenance requirements) are presented and compared.

Circumlunar Free-Return↗

NASA Proof-of-Concept 1-W Stirling Convertor Development for Small RPS

Low power Stirling convertors are being developed at NASA Glenn Research Center (GRC) to provide future small spacecraft with electrical power by converting heat from one or more Light Weight Radioisotope Heater Units (LWRHU). An initial design converts multiple watts of heat to one watt of electrical power output using a Stirling convertor. A variety of mission concepts have been studied by NASA and the U. S. Department of Energy (DOE) that would utilize low power Radioisotope Power Systems (RPS) for probes, landers, rovers, and repeaters. These missions would contain science instruments distributed across planetary surfaces or near objects of interest where solar flux is insufficient for using solar cells. Landers could be used to provide data such as, radiation, temperature, pressure, seismic activity, and other surface measurements for planetary science and to inform future mission planners. The studies propose using fractional versions of the General Purpose Heat Source (GPHS) or multiple LWRHUs to heat power conversion technologies for science instruments and communication. Dynamic power systems are capable of higher conversion efficiencies, which could enable equal power using less fuel or more power using equal fuel, when compared to less efficient static power conversion technologies. Providing spacecraft with more power would decrease duty cycling of basic functions and, therefore, increase the quality and abundance of science data. Efforts to develop the concept have focused on maturation of a 1-We convertor and controller design and performance evaluation of an evacuated metal foil insulation. A proof-of-concept 1-We convertor, controller, and evacuated metal foil insulation package have been fabricated and are undergoing characterization testing. The current status, findings, and path forward for the effort are explained in this paper.

Schifer, Nicholas A.↗

NASA Proof-of-Concept 1-W Stirling Convertor Development for Small RPS

Low power Stirling convertors are being developed at NASA Glenn Research Center (GRC) to provide future small spacecraft with electrical power by converting heat from one or more Light Weight Radioisotope Heater Units (LWRHU). An initial design converts multiple watts of heat to one watt of electrical power output using a Stirling convertor. A variety of mission concepts have been studied by NASA and the U.S. Department of Energy (DOE) that would utilize low power Radioisotope Power Systems (RPS) for probes, landers, rovers, and repeaters. These missions would contain science instruments distributed across planetary surfaces or near objects of interest where solar flux is insufficient for using solar cells. Landers could be used to provide data such as, radiation, temperature, pressure, seismic activity, and other surface measurements for planetary science and to inform future mission planners. The studies propose using fractional versions of the General Purpose Heat Source (GPHS) or multiple LWRHUs to heat power conversion technologies for science instruments and communication. Dynamic power systems are capable of higher conversion efficiencies, which could enable equal power using less fuel or more power using equal fuel, when compared to less efficient static power conversion technologies. Providing spacecraft with more power would decrease duty cycling of basic functions and, therefore, increase the quality and abundance of science data. Efforts to develop the concept have focused on maturation of a 1-We (1-watt electrical) convertor and controller design and performance evaluation of an evacuated metal foil insulation. A proof-of-concept 1-We convertor, controller, and evacuated metal foil insulation package have been fabricated and are undergoing characterization testing. The current status, findings, and path forward for the effort are explained in this paper.

Stirling↗

NASA Proof-of-Concept 1-W(sub e) Stirling Convertor Development for Small Radioisotope Power Systems

Low power Stirling convertors are being developed at NASA Glenn Research Center to provide future small spacecraft with electrical power by converting heat from one or more Light Weight Radioisotope Heater Units (LWRHU). An initial design converts multiple watts of heat to one watt of electrical power output using a Stirling convertor. A variety of mission concepts have been studied by NASA and the U. S. Department of Energy that would utilize low power Radioisotope Power Systems (RPS) for probes, landers, rovers, and repeaters. These missions would contain science instruments distributed across planetary surfaces or near objects of interest where solar flux is insufficient for using solar cells. Landers could be used to provide data such as, radiation, temperature, pressure, seismic activity, and other surface measurements for planetary science and to inform future mission planners. The studies propose using fractional versions of the General Purpose Heat Source or multiple LWRHUs to heat power conversion technologies for science instruments and communication. Dynamic power systems are capable of higher conversion efficiencies, which could enable equal power using less fuel or more power using equal fuel, when compared to less efficient static power conversion technologies. Providing spacecraft with more power would decrease duty cycling of basic functions and, therefore, increase the quality and abundance of science data. Efforts to develop the concept have focused on maturation of a 1-We convertor and controller design and performance evaluation of an evacuated metal foil insulation. A proof-of-concept 1-We convertor, controller, and evacuated metal foil insulation package have been fabricated and are undergoing characterization testing. The current status, findings, and path forward for the effort are explained in this paper.

Schifer, Nicholas A.↗

Flexible Microsensor Array for the Monitoring and Control of Plant Growth System

Testing for plant experiments in space has begun to explore active nutrient delivery concepts in which water and nutrients are replenished on a continuous basis for long-term growth. The goal of this study is to develop a novel microsensor array to provide information on the dissolved oxygen environment in the plant root zone for the optimum control of hydroponics and solid substrate plant cultivation systems in the space environment. Miniaturized polarographic dissolved oxygen sensors have been designed and fabricated on a flexible Kapton (trademark) (polyimide) substrate. Two capabilities of the new microsensor array were explored. First, measurements of dissolved oxygen in the plant root zone in hydroponics and solid substrate culture systems were made. The microsensor array was fabricated on a flexible substrate, and then cut out into a mesh type to make a suspended array that could be placed either in a hydroponics system or in a solid substrate cultivation system to measure the oxygen environments. Second, the in situ self-diagnostic and self-calibration capability (two-point for oxygen) was adopted by dynamically controlling the microenvironment in close proximity to the microsensors. With a built-in generating electrode that surrounds the microsensor, two kinds of microenvironments (oxygen-saturated and oxygen-depleted phases) could be established by water electrolysis depending on the polarity of the generating electrode. The unique features of the new microsensor array (small size, multiple sensors, flexibility and self-diagnosis) can have exceptional benefits for the study and optimization of plant cultivation systems in both terrestrial and microgravity environments. The in situ self-diagnostic and self-calibration features of the microsensor array will also enable continuous verification of the operability during entire plant growth cycles. This concept of automated control of a novel chemical monitoring system will minimize crew time required for maintenance, as well as reduce volume, mass, and power consumption by eliminating bulky diagnosis systems including calibrant (fluid and gas) reservoir and flow system hardware.

Kim, Chang-Soo↗

Advanced Sine Wave Modulation of Continuous Wave Laser System for Atmospheric CO2 Differential Absorption Measurements

NASA Langley Research Center in collaboration with ITT Exelis have been experimenting with Continuous Wave (CW) laser absorption spectrometer (LAS) as a means of performing atmospheric CO2 column measurements from space to support the Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) mission.Because range resolving Intensity Modulated (IM) CW lidar techniques presented here rely on matched filter correlations, autocorrelation properties without side lobes or other artifacts are highly desirable since the autocorrelation function is critical for the measurements of lidar return powers, laser path lengths, and CO2 column amounts. In this paper modulation techniques are investigated that improve autocorrelation properties. The modulation techniques investigated in this paper include sine waves modulated by maximum length (ML) sequences in various hardware configurations. A CW lidar system using sine waves modulated by ML pseudo random noise codes is described, which uses a time shifting approach to separate channels and make multiple, simultaneous online/offline differential absorption measurements. Unlike the pure ML sequence, this technique is useful in hardware that is band pass filtered as the IM sine wave carrier shifts the main power band. Both amplitude and Phase Shift Keying (PSK) modulated IM carriers are investigated that exibit perfect autocorrelation properties down to one cycle per code bit. In addition, a method is presented to bandwidth limit the ML sequence based on a Gaussian filter implemented in terms of Jacobi theta functions that does not seriously degrade the resolution or introduce side lobes as a means of reducing aliasing and IM carrier bandwidth.

Campbell, Joel F.↗

Comparison of Artemis 2 and Artemis 5 Model Outcomes Using the Impact Probabilistic Risk Assessment Tool

BACKGROUND The Artemis campaign is a Moon exploration program with a series of six planned missions, five of which will be crewed. These five crewed missions will contain a single mission segment (space flight), or multiple mission segments involving space flight (Orion), lunar landing (LTV) and/or space habitat (Gateway). Each crewed segment faces the risk of unique medical conditions, necessitating medical sets/kits tailored to those specificities. To support and enable a data-driven and evidence-based decision-making process through out a mission’s life cycle, a software tool called IMPACT was developed. Using probabilistic risk assessment (PRA) methodologies, IMPACT (Informing Mission Planning via Analysis of Complex Tradespaces) is a novel tool built for analyzing the possibility of encountering complex medical risks during space flight, and for identifying the medical resources and capabilities needed to treat those potential at-risk medical conditions. This presentation will seek to compare IMPACT’s computational results upon potential complex space medical conditions (e.g., sprain/strain back or sleep disturbance) using IMPACT’s risk metrics and the associated optimized medical sets/kits between two Artemis missions: single segment Artemis 2 and multi-segmented Artemis 5. OVERVIEW By identifying potential medical conditions in space using input criteria such as crew quantity and composition, certain crew physical characteristics, mission duration and mission activities, IMPACT can produce analyses on the type of medical resources and capabilities needed to produce an optimized medical set/kit to address those medical conditions. IMPACT achieves this by performing hundreds of thousands of Monte Carlo simulations of missions to build aggregate pictures of medical risk. IMPACT’s risk metrics include loss of crew life (LOCL) – a measure of crew mortality due to medical conditions in space, return to definitive care (RTDC) – the need to perform crew evacuation, and task time lost (TTL) – a measure of the inability to perform activities due to crew disability. These risk metrics are applied to every medical condition identified by IMPACT’s computation analyses for every segment of the mission. Medical sets/kits are optimized to address these medical conditions but must fit within the stated Artemis Design Reference Mission (DRM) request for mass and volume physical size constraints. ANTICIPATED ANALYSIS AND CONCLUSION Using two Artemis missions, Artemis 2 and Artemis 5, IMPACT will provide the analyses for comparison of medical set/kit contents based upon mass and/or volume requirements and identify the at-risk medical conditions within both missions. This paper serves as an initial exploration of probabilistic risk assessment (PRA) medical risk calculations between two crewed Artemis missions and is not intended to be deemed the official medical response for the Artemis campaign.

probabilistic risk assessment↗