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NASA NTRSDate not supplied

Hydrodynamics of Two-Phase Flows through Porous Media in Microgravity: Packed Bed Reactor Experiment onboard of the International Space Station

The objective of the Packed Bed Reactor Experiment was to develop a fundamental understanding of the hydrodynamics of two-phase flow with no phase transition through porous media in microgravity. This work describes two experimental campaigns flown on the International Space Station (ISS) that were designed to achieve the objective. This work presents the results on flow patterns observed, two-phase flow pressure drop in porous media, and the impact of capillary effects on pressure drop at various gas and liquid flow rates. This work is the first to present predictive correlations of the two-phase friction factor for the different regimes identified based on the superficial liquid and gas velocity in microgravity, the first to hypothesize the different regimes based on the change in slope of the pressure gradient versus flow rate plots, the first to address the effects of the capillarity on the pressure gradient and the first to measure column holdup and assess the effective porosity based on the packing and the trapped gas bubbles. Experimental data on pressure drop in gas (N2) – liquid (water) flow show the presence of four different flow regimes in microgravity. Dispersed bubble flow (DB) and pulse (P) flow regimes are detected at high liquid flow rates, whereas at low liquid flow rates “large bubble” or elongated bubble (LB) and “gas channeling” (GC) regimes are observed. For these different flow regimes, different two-phase flow friction factor and pressure gradient correlations are presented for the first time as a function of the gas and liquid modified Reynolds numbers and Suratman number. Within the viscous-capillary (V-C) regime, it is found that the capillary contribution is the dominant force that contributes to the pressure drop for the wetting case (glass). However, for the non-wetting packing (Teflon), the viscous contribution dominates. It was found that the gas hold-up and pressure drop are functions of bed history at low liquid and gas flow rates with the magnitude of the hysteresis decreasing with increasing flow rates. PBRE-2 results show that the capillary force is a strong function of the superficial liquid velocity but is a much weaker function of the superficial gas velocity and varies inversely with the particle diameter. Within the Viscous-Capillary (V-C) regime, over 90% of the pressure gradient is attributed to the capillary contribution in the gas continuous regime. However, in the large bubble regime, the viscous and capillary contributions were comparable. After the completion of PBRE-2 with glass spherical beads, another bed packed with alumina was installed. Pressure gradient data for the alumina packed bed (PBRE-Water Recovery) were transferred to the PI and were not analyzed by the authors of this work. The Packed Bed Reactor Experiment concluded its on-orbit operation after two successful campaigns of testing in 2017 and in 2021. The flight hardware was brought back from orbit and is being reconditioned for a series of future experiments referred to as PBRE-WRS in support of water recovery (WRS). The WRS series consists of testing different two-phase fluid system components and packed beds to assess their pressure gradient characteristics, which will be used for designing packed bed reactors for various applications relevant to life support. Although there is so much relevance of the experimental results obtained from the two PBRE campaign in microgravity to life support, these findings also apply to other applications that involve two phase flow in porous medium such as fuel cells, transport of nutrient to plants in space and other chemical and materials processing that involve two phase flows. These systems operate differently in microgravity because, due to the lack of buoyancy, the density difference between the phases becomes irrelevant and no longer leads to phase separation.

Packed Bed↗

NASA NTRS1991

Scaling analysis applied to the NORVEX code development and thermal energy flight experiment

A scaling analysis is used to study the dominant flow processes that occur in molten phase change material (PCM) under 1 g and microgravity conditions. Results of the scaling analysis are applied to the development of the NORVEX (NASA Oak Ridge Void Experiment) computer program and the preparation of the Thermal Energy Storage (TES) flight experiment. The NORVEX computer program which is being developed to predict melting and freezing with void formation in a 1 g or microgravity environment of the PCM is described. NORVEX predictions are compared with the scaling and similarity results. The approach to be used to validate NORVEX with TES flight data is also discussed. Similarity and scaling show that the inertial terms must be included as part of the momentum equation in either the 1 g or microgravity environment (a creeping flow assumption is invalid). A 10(exp -4) environment was found to be a suitable microgravity environment for the proposed PCM.

Skarda, J. Raymond Lee↗

NASA NTRS1991

Scaling analysis applied to the NORVEX code development and thermal energy flight experiment

Skarda, J. R. L.↗

NASA NTRS1999

Characteristics of Non-Premixed Turbulent Flames in Microgravity

The momentum of the fuel (and/or air) jet is important in classifying gas-jet diffusion flame behavior. Normal-gravity data on gas-jet flames show that the flame height (non-dimensionalized with respect to an effective diameter) can be correlated to a density weighted Froude number in the buoyancy-dominated limit. In the momentum-dominated limit this non-dimensional flame height asymptotes to a constant value. The momentum-dominated limit under normal gravity conditions is usually obtained for very high injection velocities which in turn results in high values of the injection Reynolds number. This results in a complicated flame structure because of the large number of turbulence scales involved. In order to gain better insight into the structure of these flames it would be useful to reduce the injection Reynolds number while still maintaining turbulent conditions. This can be done in microgravity where momentum-dominated turbulent flames are obtained at much smaller velocities than in normal gravity. In this paper, experimental results on the effects of nozzle diameter and fuel dilution on flame height are discussed. The experimental values are compared with predictions from a numerical procedure utilizing the standard k-epsilon turbulence model. Flame height scaling with nozzle size and dilution is established. Differences between model predictions and measurements are presented. In order to explain these differences, evolutions of turbulent spectra and Taylor microscale along the flame axis are considered.

Hegde, U.↗

NASA NTRSDate not supplied

An Oculometric Standard to Assess the Performance of the Ocular System for Long Duration Spaceflight

Changes in the human brain, due to spaceflight, have been a challenge to the space program since its inception; a challenge that is becoming more acute as extended International Space Station (ISS) missions become routine, a return to crewed lunar exploration is about to begin, and a multi-year crewed trip to Mars is being planned. Determining the extent to which neurophysiological adaptations may adversely impact performance in operational tasks, assessing the full-time course of these changes, and identifying/mitigating any potential long-term health consequences are crucial steps required to enable safe crew-autonomous, long-duration, deep-space missions. Vision is the predominant perceptual sense used to guide cognition and motor control in humans. Thus, it is critical for the success of any future, long-duration mission to understand how long-term exposure to microgravity and to other stressors of spaceflight and their interactions, impact visual function. This is an especially challenging task given the small and disparate samples from which we have been and will be able to collect human performance data. NASA has recently been carefully tracking spaceflight-induced ophthalmic changes, driven in large part by the fluid shifts related to microgravity. In particular, a recent study of Optical Coherence Tomography (OCT) postflight measures revealed that more than two-thirds of US crew members experience significant increases in retinal thickness after 6month or longer ISS missions. Space Associated Neuro-ocular Syndrome (SANS) also includes visual acuity decrements and other ocular structural changes that could adversely impact in-flight performance as missions become longer. However, the impact of spaceflight on the visual system is not limited to the retina. Recent comparisons of pre-and post-flight brain images have revealed structural changes throughout the brain that implicate visual, visuomotor, and visual-cognitive pathways, consistent with observed functional impacts (e.g., decreased speed/accuracy/timing of fine goal-oriented movements). Current limitations on inflight testing make it very difficult to determine when and under what conditions SANS and other disruptions of human neurological subsystems arise. Currently, one cannot anticipate the time course and extent of impairment and recovery. This study addresses this knowledge gap by creating an integrated framework of the relevant existing literature on visual and oculomotor function during spaceflight with an eye towards complementing current structural measures of visuomotor impairment with new oculometric standard measures. Using eye-movement based visual function assessment and diagnostics would provide a valuable enhancement of crew health and performance monitoring in support of deepspace exploration.

Vision↗

NASA NTRS1996

Experimental Modification of Rat Pituitary Prolactin Cell Function During and After Spaceflight

Experimental modification of rat pituitary prolactin cell function during and after spaceflight. This study was done to evaluate the effects of microgravity on prolactin (PRL) cells of the male rat pituitary gland. We used the identical passive closed-vial cell culture system that was described for the culture of growth hormone cells (W C. Hymer, R. E. Grindeland, T. Salada, P. Nye, E. Grossman, and R Lane). After an 8-day spaceflight, all flight media (containing released PRL), as well as extracts (containing intracellular PRL), contained significantly lower amounts of immunoreactive PRL than their corresponding ground control samples. On the other hand, these same samples, when assessed for their biological activities by two different in vitro lymphocyte assays, yielded disparate results that may reflect posttranslational modifications to the hormone molecule. Other data showed that: (1) the apparent molecular weights of released PRL molecules were not altered by microgravity; but (2) the region from which the PRL cells came (dorsal or ventral) made a significant difference in the amount and activity of PRL released from the flight cells. Because there is much current interest in the role that PRL may play in the regulation of the immune system and because changes in both cellular and humoral immunity accompany spaceflight, this study could help define future microgravity research in this area.

Hymer, W. C.↗

NASA NTRS1996

Turbulent Premixed Flames in Microgravity

The experimental cold-flow facility is now full operational and is currently being used to obtain baseline turbulence data in a Couette flow. The baseline turbulence data is necessary to confirm the capability of the chosen device to generate and maintain the required turbulence intensity. Subsequent reacting flow studies will assume that a similar turbulent flow field exists ahead of the premixed flame. Some modifications and refinements had to be made to enable accurate measurements. It consists of two rollers, one (driven by a motor) which drives a continuous belt and four smaller rollers used to set the belt spacing and tension to minimize belt flutter. The entire assemble is enclosed in a structure that has the dimensions to enable future drop tower experiments of the hot facility. All critical dimensions are the same as the original plans except for the pulley ratio which has been changed to enable a wider operating regime in terms of the Reynolds number. With the current setup, Reynolds numbers as low as 100 and as high as 14,000 can be achieved. This is because the in-between belt spacing can be varied from 1 cm to 7.6 cm, and the belt speed can be accurately varied from .15 m/sec to 3.1 m/sec.

Menon, Suresh↗

NASA NTRS1999

Telescience Operations on International Space Station

This paper describes the concept of telescience operations for the International Space Station (ISS). The extended duration microgravity environment of the ISS will enable microgravity science research to enter into a new era of increased scientific and technological data return. The National Aeronautics and Space Administration (NASA) has a vision of distributed ground operations which enables the Principal Investigator direct interaction with his/her on-board experiment from his/her home location. This is the concept of telescience and is essential for maximizing the use of the long duration science environment that ISS provides. The goal of telescience is to provide the capability to fully tele-operate an experiment from any ground location in such a way as to increase the amount and quality of scientific and technological data return and decrease the operations cost of an individual experiment relative to the era of Space Shuttle experiments. This paper also describes the NASA Lewis Research Center (LeRC) implementation approach for the LeRC Telescience Support Center (TSC) and Principal Investigator Science Operations Sites (SOS) which will fully meet the concept of telescience as prescribed by the Agency.

Schubert, Kathleen E.↗

NASA NTRS1999

Soot Aerosol Properties in Laminar Soot-Emitting Microgravity Nonpremixed Flames

The 0-g flame soot measurements reported in previous studies are extended by adding new 0-g data for different fuel flow rates and burner diameters. The new flame conditions allow more conclusive comparisons regarding the effect of characteristic flow residence times on soot field structure, the influence of fuel preheat on fuel pyrolysis rates near the flame centerline, and the premature cessation of soot growth along the soot annulus in 0-g when the fuel is preheated. The paper also reports on the implementation of thermophoretic soot sampling in a specific 0-g flame featuring burner exit velocities typical of buoyant flames and presents quantitative data on the radial variation of soot microstructure at a fixed height above the burner mouth.

FLAME STRUCTURE↗

NASA NTRS1999

Influence of Gravity on Blood Volume and Flow Distribution

In our previous experiments during NASA Shuttle flights SLS 1 and 2 (9-15 days) and EUROMIR flights (30-90 days) we observed that pulmonary blood flow (cardiac output) was elevated initially, and surprisingly remained elevated for the duration of the flights. Stroke volume increased initially and then decreased, but was still above 1 Gz values. As venous return was constant, the changes in SV were secondary to modulation of heart rate. Mean blood pressure was at or slightly below 1 Gz levels in space, indicating a decrease in total peripheral resistance. It has been suggested that plasma volume is reduced in space, however cardiac output/venous return do not return to 1 Gz levels over the duration of flight. In spite of the increased cardiac output, central venous pressure was not elevated in space. These data suggest that there is a change in the basic relationship between cardiac output and central venous pressure, a persistent "hyperperfusion" and a re-distribution of blood flow and volume during space flight. Increased pulmonary blood flow has been reported to increase diffusing capacity in space, presumably due to the improved homogeneity of ventilation and perfusion. Other studies have suggested that ventilation may be independent of gravity, and perfusion may not be gravity- dependent. No data for the distribution of pulmonary blood volume were available for flight or simulated microgravity. Recent studies have suggested that the pulmonary vascular tree is influenced by sympathetic tone in a manner similar to that of the systemic system. This implies that the pulmonary circulation is dilated during microgravity and that the distribution of blood flow and volume may be influenced more by vascular control than by gravity. The cerebral circulation is influenced by sympathetic tone similarly to that of the systemic and pulmonary circulations; however its effects are modulated by cerebral autoregulation. Thus it is difficult to predict if cerebral perfusion is increased and if there is edema in space. Anecdotal evidence suggests there may be cerebral edema early in flight. Cerebral artery velocity has been shown to be elevated in simulated microgravity. The elevated cerebral artery velocity during simulated microgravity may reflect vasoconstriction of the arteries and not increased cerebral blood flow. The purpose of our investigations was to evaluate the effects of alterations in simulated gravity (+/-), resulting in changes in cardiac output (+/-), and on the blood flow and volume distribution in the lung and brain of human subjects. The first hypothesis of these studies was that blood flow and volume would be affected by gravity, but their distribution in the lung would be independent of gravity and due to vasoactivity changing vascular resistance in lung vessels. The vasodilitation of the lung vasculature (lower resistance) along with increased "compliance" of the heart could account for the absence of increased central venous pressure in microgravity. Secondly, we postulate that cerebral blood velocity is increased in microgravity due to large artery vasoconstriction, but that cerebral blood flow would be reduced due to autoregulation.

Pendergast, D.↗

NASA NTRS1994

Physiological Adaptations and Countermeasures Associated with Long-Duration Space Flights

On earth, the presence of gravity imposes weight-bearing gradients on tissues which influence the functions of multiple integrative systems. On the other hand, conditions of actual or simulated microgravity can modify and/or nullify these gradients and subsequently alter structure and function. The purpose of this symposium is to discuss the results from short-term Shuttle flights, long term Skylab or Mir missions, or long-term ground based experiments which indicate or suggest that performance has been or could be compromised in space missions of long durations (>one year) or with space tasks (e.g. building space stations) with the goal of identifying countermeasures that could minimize or eliminate the expected anatomical and physiological consequences. After an overview by C. Tipton from the U. Arizona, the countermeasures necessary for the fluid shifts and select functions of the cardiovascular system will be discussed by A. Hargens from NASA Ames Research Center. He will be followed by K. Baldwin of the U. California at Irvine who will discuss the countermeasures needed to prevent the changes that alter the structure, function and control of skeletal muscles. Since changes in bone mass with microgravity are a major concern of NASA, V. Schneider from NASA Headquarters will present data and the countermeasures for bone. Although the results are limited, the changes in the endocrine and immune system deserve mentioning and C. Tipton will assume this responsibility. V. Convertino from the Air Force School of Aerospace Medicine has the challenge of discussing the role, importance, and the specificity of exercise as an effective countermeasure while I. Kozlovskaya from Moscow will elaborate on the Russian experiences with past countermeasures and provide a viewpoint on future ones. After the brief (25 min.) presentations, the speakers will assemble as a panel to discuss the issues raised and the concerns of the audience.

Tipton, C. M.↗

NASA NTRS2003

Flight Hardware Development and Research at MSFC for Optimizing Success on the International Space Station

To optimize biological crystallization success in microgravity in-house personnel at the MSFC are working on the development of innovative flight hardware such as Delta-L and the Iterative Biological Crystallization (IBC) apparatus as well as troubleshooting the performance of existing hardware. Delta-L will provide a diagnostic hardware to examine the relationship between crystal growth characteristics and crystal quality improvement in microgravity. IBC is a new hardware being designed to allow iteration of crystal growth experiments in microgravity using innovative lab on a chip technology. While being built to obtain scientific data of benefit to the scientific community, the design methods involved in the development of these hardware have directly benefited other groups within NASA and keep NASA at the forefront of innovation.

Source record↗

NASA NTRS1994

Effect of hexylene glycol-altered microtubule distributions on cytokinesis and polar lobe formation in fertilized eggs of Ilyanassa obsoleta

Some effects of gravity on early morphogenesis are correlated with microtubule locations within cells. During first cleavage in Ilyanassa obsoleta embryos, a transitory polar lobe constriction forms and then relaxes, allowing the polar lobe to merge with one daughter cell. If the polar lobe is equally divided or removed, morphogenesis is severely disrupted. To examine microtuble locations during early Ilyanassa development, eggs were fixed and stained for polymerized alpha-tubulin during first cleavage. The mitotic apparatus assembles at the animal pole. The cleavage furrow forms between the asters, constricting to a stabilized intercellular bridge encircling midbody-bound microtubules, whereas the polar lobe constriction forms below and parallel to the spindle, constricting to a transitory intercellular bridge encircling no detectable microtubules. At metaphase an alpha-tubulin epitope is distributed throughout the spindle, whereas a beta-tubulin epitope is present predominantly in the asters. Incubation in hexylene glycol, a drug that increases microtubule polymerization, during mitosis causes the polar lobe constriction to tighten around polymerized alpha-tubulin and remain stably constricted. If hexylene glycol is removed, alpha-tubulin staining disappears from the polar lobe constriction, which relaxes, whereas microtubules remain in the cleavage furrow, which remains constricted. These observations suggest that asymmetric distribution of microtubules affects early Ilyanassa cleavage patterns, and that continued presence of microtubules extending through an intercellular bridge is important for stabilization of the bridge constriction prior to completion of cytokinesis. These data provide the basis for further analysis of the role of microtubules in possible microgravity disruptions of Ilyanassa development.

NASA Discipline Cell Biology↗

NASA NTRS2004

Analysis of the Spread Across Liquid-5 (SAL-5) Experiment Failure to Fill Properly During Flight

When a pool of flammable liquid is ignited, the flame spread rate can vary widely depending on the initial fuel temperature, pool geometry, ambient atmospheric conditions, and gravitational level. There is substantial decades-old debate in the scientific literature about the role of gravity in these phenomena. The objective of the research was to measure ignition and flame spread across liquid pools in both normal and microgravity with and without forced airflow, and to obtain detailed thermal and velocity field data for comparison to a predictive numerical model that is concurrently being developed. To that end, an experiment known as Spread Across Liquids 5 (SAL 5) was designed to be conducted in a low-gravity environment on a sounding rocket. Unfortunately, during the sounding rocket flight the fuel tray for the experiment failed to fill properly prior to ignition. The primary cause of the failure to fill properly is the geometry of the fuel tray; that is, the presence of the gaps on the side walls and the sharp edge around the thermocouple through-holes. The contamination resulting from the cleaning process is a strong secondary factor which would have prevented proper, timely filling had the primary cause not been present.

Allen, Jeffrey Stuart↗

NASA NTRS1995

Spread Across Liquids: The World's First Microgravity Combustion Experiment on a Sounding Rocket

The Spread Across Liquids (SAL) experiment characterizes how flames spread over liquid pools in a low-gravity environment in comparison to test data at Earth's gravity and with numerical models. The modeling and experimental data provide a more complete understanding of flame spread, an area of textbook interest, and add to our knowledge about on-orbit and Earthbound fire behavior and fire hazards. The experiment was performed on a sounding rocket to obtain the necessary microgravity period. Such crewless sounding rockets provide a comparatively inexpensive means to fly very complex, and potentially hazardous, experiments and perform reflights at a very low additional cost. SAL was the first sounding-rocket-based, microgravity combustion experiment in the world. It was expected that gravity would affect ignition susceptibility and flame spread through buoyant convection in both the liquid pool and the gas above the pool. Prior to these sounding rocket tests, however, it was not clear whether the fuel would ignite readily and whether a flame would be sustained in microgravity. It also was not clear whether the flame spread rate would be faster or slower than in Earth's gravity.

Source record↗

NASA NTRS2005

Responses across the gravity continuum: hypergravity to microgravity

In response to hypergravity, it appears that the larger the animal, the greater the response, if present. Therefore, the response of a rat exceeds that of a mouse in the same hypergravity environment. When investigated in the microgravity environment of space flight, this appears to hold true. The lack of definitive data obtained in space for either species makes the extrapolation of the continuum to levels below Earth-gravity problematic. However, in systems where responses are detected for both space flight and acceleration by centrifugation, a gravitational continuum is present supporting the "principle of continuity". For those and similar systems, it appears that the use of hypergravity could be used to predict responses to space flight.

Review, Tutorial↗

NASA NTRS2009

Human Research Program Human Health Countermeasures Element Sensorimotor Risk Standing Review Panel (SRP) Final Report

The Sensorimotor Risk Standing Review Panel (SRP) met at the NASA Johnson Space Center on October 4-6, 2009 to discuss the areas of future research targeted by the Human Health Countermeasures (HHC) Element of the Human Research Program (HRP). Using evidence-based knowledge as a background for risks, NASA had identified gaps in knowledge to address those risks. Ongoing and proposed tasks were presented to address the gaps. The charge to the Sensorimotor Risk SRP was to review the gaps, evaluate whether the tasks addressed these gaps and to make recommendations to NASA s HRP Science Management Office regarding the SRP's review. The SRP was requested to evaluate the practicality of the proposed efforts in light of the realistic demands placed on the HRP. In short, all tasks presented in the Integrated Research Plan (IRP) should address specific risks related to the challenges faced by the astronauts as a result of prolonged exposure to microgravity. All tasks proposed to fill the gaps in knowledge should provide applied, translational data necessary to address the specific risks. Several presentations were made to the SRP during the site visit and the SRP spent sufficient time to address the panel charge, either as a group or in separate sessions. The SRP made a final debriefing to the HRP Program Scientist. Taking the evidence and the risk as givens, the SRP reached the following conclusions: 1) the panel is very supportive of and endorses the present activities of the Sensorimotor Risk; and the panel is likewise supportive of the gaps and associated tasks in the IRP; 2) overall, the tasks addressed the gaps in the IRP; 3) there were some gaps and tasks that merit further enhancement and some new gaps/tasks that the SRP recommends.

Peterson, Barry↗

NASA NTRS2009

Human Research Program Human Health Countermeasures Element Bone and Muscle Risk Standing Review Panel (SRP)

The Bone and Muscle Risk Standing Review Panel (SRP) met at the NASA Johnson Space Center (JSC) on October 4-6, 2009 to discuss the areas of current and future research targeted by the Human Health Countermeasures (HHC) Element of the Human Research Program (HRP). Using evidence-based knowledge as a background for identified risks to astronaut health and performance, NASA had identified gaps in knowledge to address those risks. Ongoing and proposed tasks were presented to address the gaps. The charge to the Bone and Muscle Risk SRP was to review the gaps, evaluate whether the tasks addressed these gaps and to make recommendations to NASA s HRP Science Management Office regarding the Panel's review. The Bone and Muscle Risk SRP consisted of scientists who are experts in muscle, bone, or both and could evaluate the existing evidence with sufficient knowledge of the potential effects of long duration exposure to microgravity. More important, although expertise in basic science is important, the SRP was requested to evaluate the practicality of the proposed efforts in light of the realistic demands placed on the HRP. In short, all tasks presented in the Integrated Research Plan (IRP) should address specific questions related to the challenges faced by the astronauts as a result of prolonged exposure to microgravity. All tasks proposed to fill the gaps in knowledge should provide applied, translational data necessary to answer the specific questions. Several presentations were made to the SRP during the site visit and the SRP spent sufficient time to address the panel charge, either as a group or in separate sessions for the Bone and Muscle Risk subgroups. The SRP made a final debriefing to the HRP Program Scientist, Dr. John B. Charles, on October 6, 2009. Taking the evidence and identified risks as givens, the SRP concluded that 1) integration of information should lead to a more comprehensive approach to identifying the gaps, 2) not all tasks addressed the gaps as stated in the IRP, 3) better access should be given to the SRP to existing data to include in its review, and 4) there were some missing gaps and tasks. As a result the SRP recommended 1) combining certain gaps, which in some cases were addressed with identical tasks, 2) additional gaps and tasks to address some of the gaps, 3) deleting some gaps and tasks to better focus the efforts of NASA s HRP in prioritizing their efforts, and 4) prioritizing gaps to address significant issues needing resolution in the short term while maintaining an awareness of long-term goals. The SRP commended the efforts by the HHC Element to integrate knowledge gaps and design tasks to address the higher order questions. This integration did not apply to the Bone and Muscle Risk alone, but the musculoskeletal system as its functions integrate with issues in

Glowacki, Julie↗