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This study investigates the relationship between the Great Salt Lake (GSL) decline and air quality, focusing on PM2.5 concentrations and their impacts on public health. As the GSL continues to shrink, it has become a significant source of dust emissions, posing serious health and environmental risks to the surrounding areas. There search examines how diminishing water levels in the GSL, driven by climate change, agricultural water use, and urban development, affect local populations' mental health. Adopting an interdisciplinary approach, the study considers the long-term effects of air quality on mental health in relation to inorganic particulate matter, gaseous pollutants, and social vulnerability.