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At least 613 records · Page 34

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NASA NTRS1999

Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences

Relatively low levels of expression from naturally occurring promoters have limited the use of muscle as a gene therapy target. Myogenic restricted gene promoters display complex organization usually involving combinations of several myogenic regulatory elements. By random assembly of E-box, MEF-2, TEF-1, and SRE sites into synthetic promoter recombinant libraries, and screening of hundreds of individual clones for transcriptional activity in vitro and in vivo, several artificial promoters were isolated whose transcriptional potencies greatly exceed those of natural myogenic and viral gene promoters.

Non-NASA Center↗

NASA NTRS2004

A Bayesian approach to tracking patients having changing pharmacokinetic parameters

This paper considers the updating of Bayesian posterior densities for pharmacokinetic models associated with patients having changing parameter values. For estimation purposes it is proposed to use the Interacting Multiple Model (IMM) estimation algorithm, which is currently a popular algorithm in the aerospace community for tracking maneuvering targets. The IMM algorithm is described, and compared to the multiple model (MM) and Maximum A-Posteriori (MAP) Bayesian estimation methods, which are presently used for posterior updating when pharmacokinetic parameters do not change. Both the MM and MAP Bayesian estimation methods are used in their sequential forms, to facilitate tracking of changing parameters. Results indicate that the IMM algorithm is well suited for tracking time-varying pharmacokinetic parameters in acutely ill and unstable patients, incurring only about half of the integrated error compared to the sequential MM and MAP methods on the same example.

Bayes Theorem↗

NASA NTRS2002

Monitoring boreal ecosystem phenology with integrated active/passive microwave remote sensing

The important role of the high latitudes in the functioning of global processes is becoming well established. The size and remoteness of arctic and boreal ecosystems, however, pose a challenge to quantification of both terrestrial ecosystem processes and their feedbacks to regional and global climate conditions. Boreal and arctic regions form a complex land cover mosaic where vegetation structure, condition and distribution are strongly regulated by environmental factors such as moisture availability, permafrost, growing season length, disturbance and soil nutrients.

SeaWinds↗

NASA NTRS2008

Scintillation Breakdowns in Chip Tantalum Capacitors

Scintillations in solid tantalum capacitors are momentarily local breakdowns terminated by a self-healing or conversion to a high-resistive state of the manganese oxide cathode. This conversion effectively caps the defective area of the tantalum pentoxide dielectric and prevents short-circuit failures. Typically, this type of breakdown has no immediate catastrophic consequences and is often considered as nuisance rather than a failure. Scintillation breakdowns likely do not affect failures of parts under surge current conditions, and so-called "proofing" of tantalum chip capacitors, which is a controllable exposure of the part after soldering to voltages slightly higher than the operating voltage to verify that possible scintillations are self-healed, has been shown to improve the quality of the parts. However, no in-depth studies of the effect of scintillations on reliability of tantalum capacitors have been performed so far. KEMET is using scintillation breakdown testing as a tool for assessing process improvements and to compare quality of different manufacturing lots. Nevertheless, the relationship between failures and scintillation breakdowns is not clear, and this test is not considered as suitable for lot acceptance testing. In this work, scintillation breakdowns in different military-graded and commercial tantalum capacitors were characterized and related to the rated voltages and to life test failures. A model for assessment of times to failure, based on distributions of breakdown voltages, and accelerating factors of life testing are discussed.

Teverovsky, Alexander↗

NASA NTRS2007

Impact of Uncertainty in the Drop Size Distribution on Oceanic Rainfall Retrievals From Passive Microwave Observations

The variability of the drop size distribution (DSD) is one of the factors that must be considered in understanding the uncertainties in the retrieval of oceanic precipitation from passive microwave observations. Here, we have used observations from the Precipitation Radar on the Tropical Rainfall Measuring Mission spacecraft to infer the relationship between the DSD and the rain rate and the variability in this relationship. The impact on passive microwave rain rate retrievals varies with the frequency and rain rate. The total uncertainty for a given pixel can be slightly larger than 10% at the low end (ca. 10 GHz) of frequencies commonly used for this purpose and smaller at higher frequencies (up to 37 GHz). Since the error is not totally random, averaging many pixels, as in a monthly rainfall total, should roughly halve this uncertainty. The uncertainty may be lower at rain rates less than about 30 mm/h, but the lack of sensitivity of the surface reference technique to low rain rates makes it impossible to tell from the present data set.

Wilheit, Thomas T.↗

NASA NTRS2011

Probabilistic Analysis of a Composite Crew Module

An approach for conducting reliability-based analysis (RBA) of a Composite Crew Module (CCM) is presented. The goal is to identify and quantify the benefits of probabilistic design methods for the CCM and future space vehicles. The coarse finite element model from a previous NASA Engineering and Safety Center (NESC) project is used as the baseline deterministic analysis model to evaluate the performance of the CCM using a strength-based failure index. The first step in the probabilistic analysis process is the determination of the uncertainty distributions for key parameters in the model. Analytical data from water landing simulations are used to develop an uncertainty distribution, but such data were unavailable for other load cases. The uncertainty distributions for the other load scale factors and the strength allowables are generated based on assumed coefficients of variation. Probability of first-ply failure is estimated using three methods: the first order reliability method (FORM), Monte Carlo simulation, and conditional sampling. Results for the three methods were consistent. The reliability is shown to be driven by first ply failure in one region of the CCM at the high altitude abort load set. The final predicted probability of failure is on the order of 10-11 due to the conservative nature of the factors of safety on the deterministic loads.

FROM↗

NASA NTRS2005

Using Cloud-to-Ground Lightning Climatologies to Initialize Gridded Lightning Threat Forecasts for East Central Florida

Each morning, the forecasters at the National Weather Service in Melbourn, FL (NWS MLB) produce an experimental cloud-to-ground (CG) lightning threat index map for their county warning area (CWA) that is posted to their web site (http://www.srh.weather.gov/mlb/ghwo/lightning.shtml) . Given the hazardous nature of lightning in central Florida, especially during the warm season months of May-September, these maps help users factor the threat of lightning, relative to their location, into their daily plans. The maps are color-coded in five levels from Very Low to Extreme, with threat level definitions based on the probability of lightning occurrence and the expected amount of CG activity. On a day in which thunderstorms are expected, there are typically two or more threat levels depicted spatially across the CWA. The locations of relative lightning threat maxima and minima often depend on the position and orientation of the low-level ridge axis, forecast propagation and interaction of sea/lake/outflow boundaries, expected evolution of moisture and stability fields, and other factors that can influence the spatial distribution of thunderstorms over the CWA. The lightning threat index maps are issued for the 24-hour period beginning at 1200 UTC (0700 AM EST) each day with a grid resolution of 5 km x 5 km. Product preparation is performed on the AWIPS Graphical Forecast Editor (GFE), which is the standard NWS platform for graphical editing. Currently, the forecasters create each map manually, starting with a blank map. To improve efficiency of the forecast process, NWS MLB requested that the Applied Meteorology Unit (AMU) create gridded warm season lightning climatologies that could be used as first-guess inputs to initialize lightning threat index maps. The gridded values requested included CG strike densities and frequency of occurrence stratified by synoptic-scale flow regime. The intent is to increase consistency between forecasters while enabling them to focus on the mesoscale detail of the forecast, ultimately benefiting the end-users of the product. Several studies took place at the Florida State University (FSU) and NWS Tallahassee (TAE) for which they created daily flow regimes using Florida 1200 UTC synoptic soundings and CG strike densities from National Lightning Detection Network (NLDN) data. The densities were created on a 2.5 km x 2.5 km grid for every hour of every day during the warm seasons in the years 1989-2004. The grids encompass an area that includes the entire state of Florida and adjacent Atlantic and Gulf of Mexico waters. Personnel at the two organizations provided this data and supporting software for the work performed by the AMU. The densities were first stratified by flow regime, then by time in 1-, 3-, 6-, 12-, and 24-hour increments while maintaining the 2.5 km x 2.5 km grid resolution. A CG frequency of occurrence was calculated for each stratification and grid box by counting the number of days with lightning and dividing by the total number of days in the data set. New CG strike densities were calculated for each stratification and grid box by summing the strike number values over all warm seasons, then normalized by dividing the summed values by the number of lightning days. This makes the densities conditional on whether lightning occurred. The frequency climatology values will be used by forecasters as proxy inputs for lightning prObability, while the density climatology values will be used for CG amount. In addition to the benefits outlined above, these climatologies will provide improved temporal and spatial resolution, expansion of the lightning threat area to include adjacent coastal waters, and potential to extend the forecast to include the day-2 period. This presentation will describe the lightning threat index map, discuss the work done to create the maps initialized with climatological guidance, and show examples of the climatological CG lightning densities and frequencies of occurren based on flow regime.

Lambert, Winnie↗

NASA NTRS2006

Using Flow Regime Lightning and Sounding Climatologies to Initialize Gridded Lightning Threat Forecasts for East Central Florida

Each morning, the forecasters at the National Weather Service in Melbourne, FL (NWS MLB) produce an experimental cloud-to-ground (CG) lightning threat index map for their county warning area (CWA) that is posted to their web site (http://www.srh.weather.gov/mlb/ghwo/lightning.shtml) . Given the hazardous nature of lightning in East Central Florida, especially during the warm season months of May September, these maps help users factor the threat of lightning, relative to their location, into their daily plans. The maps are color-coded in five levels from Very Low to Extreme, with threat level definitions based on the probability of lightning occurrence and the expected amount of CG activity. On a day in which thunderstorms are expected, there are typically two or more threat levels depicted spatially across the CWA. The locations of relative lightning threat maxima and minima often depend on the position and orientation of the low-level ridge axis, forecast propagation and interaction of sea/lake/outflow boundaries, expected evolution of moisture and stability fields, and other factors that can influence the spatial distribution of thunderstorms over the CWA. The lightning threat index maps are issued for the 24-hour period beginning at 1200 UTC each day with a grid resolution of 5 km x 5 km. Product preparation is performed on the AWIPS Graphical Forecast Editor (GFE), which is the standard NWS platform for graphical editing. Currently, the forecasters create each map manually, starting with a blank map. To improve efficiency of the forecast process, NWS MLB requested that the Applied Meteorology Unit (AMU) create gridded warm season lightning climatologies that could be used as first-guess inputs to initialize lightning threat index maps. The gridded values requested included CG strike densities and frequency of occurrence stratified by synoptic-scale flow regime. The intent is to improve consistency between forecasters while allowing them to focus on the mesoscale detail of the forecast, ultimately benefiting the end-users of the product. Several studies took place at the Florida State University (FSU) and NWS Tallahassee (TAE) in which they created daily flow regimes using Florida 1200 UTC synoptic soundings and CG strike densities, or number of strikes per specified area. The soundings used to determine the flow regimes were taken at Miami (MIA), Tampa (TBW), and Jacksonville (JAX), FL, and the lightning data for the strike densities came from the National Lightning Detection Network (NLDN). The densities were created on a 2.5 km x 2.5 km grid for every hour of every day during the warm seasons in the years 1989-2004. The grids encompass an area that includes the entire state of Florida and adjacent Atlantic and Gulf of Mexico waters. Personnel at FSU and NWS TAE provided this data and supporting software for the work performed by the AMU.

Lambert, Winifred↗

NASA NTRS2007

Using Flow Regime Lightning and Sounding Climatologies to Initialize Gridded Lightning Threat Forecasts for East Central Florida

Each morning, the forecasters at the National Weather Service in Melbourne, FL (NWS MLB) produce an experimental cloud-to-ground (CG) lightning threat index map for their county warning area (CWA) that is posted to their web site (httl://www.srh.weather.gov/mlb/ghwo/lightning.shtml) . Given the hazardous nature of lightning in East Central Florida, especially during the warm season months of May September, these maps help users factor the threat of lightning, relative to their location, into their daily plans. The maps are color-coded in five levels from Very Low to Extreme, with threat level definitions based on the probability of lightning occurrence and the expected amount of CG activity. On a day in which thunderstorms are expected, there are typically two or more threat levels depicted spatially across the CWA. The locations of relative lightning threat maxima and minima often depend on the position and orientation of the low-level ridge axis, forecast propagation and interaction of sea/lake/outflow boundaries, expected evolution of moisture and stability fields, and other factors that can influence the spatial distribution of thunderstorms over the CWA. The lightning threat index maps are issued for the 24-hour period beginning at 1200 UTC each day with a grid resolution of 5 km x 5 km. Product preparation is performed on the AWIPS Graphical Forecast Editor (GFE), which is the standard NWS platform for graphical editing. Until recently, the forecasters created each map manually, starting with a blank map. To improve efficiency of the forecast process, NWS MLB requested that the Applied Meteorology Unit (AMU) create gridded warm season lightning climatologies that could be used as first-guess inputs to initialize lightning threat index maps. The gridded values requested included CG strike densities and frequency of occurrence stratified by synoptic-scale flow regime. The intent was to improve consistency between forecasters while allowing them to focus on the mesoscale detail of the forecast. Several studies took place at the Florida State University (FSU) and NWS Tallahassee (TAE) in which they created daily flow regimes using Florida 1200 UTC synoptic soundings and CG strike densities, or number of strikes per specified area. The soundings used to determine the flow regimes were taken at Miami (MIA), Tampa (TBW), and Jacksonville (JAX), FL, and the lightning data for the strike densities came from the National Lightning Detection Network (NLDN). The densities were created on a 2.5 km x 2.5 km grid for every hour of every day during the warm seasons in the years 1989-2004. The grids encompass an area that includes the entire state of Florida and adjacent Atlantic and Gulf of Mexico waters. Personnel at FSU and NWS TAE provided this data and supporting software for the work performed by the AMU.

Lambert, Winifred↗

NASA NTRS2013

The Hyperspectral Infrared Imager (HyspIRI) Public Health and Air Quality Applications

The neglected tropical diseases (NTDs), a group of chronic, debilitating, and poverty-promoting parasitic, bacterial, and some viral and fungal infections, are among the most common causes of illness of the poorest people living in developing countries. Abiotic environmental factors are important in determining the distribution of disease-causing vectors and their life-cycles. HyspIRI observations can be merged through a Land Data Assimilation System (LDAS) be used to drive spatially-explicit ecological models of NTD vectors distribution & life cycles. Assimilations will be driven by observational data LDAS and satellite-derived meteorological forcing data, parameter datasets, and assimilation observations. HyspIRI hyperspectral measurements would provide global measurements of surface mineralogy and biotic crusts important in accessing the impact of dust in human health. HyspIRI surface thermal measurements would also help identify the variability of dust sources due to surface moisture conditions and map mineralogy.

Luvall, Jeffrey C.↗

NASA NTRS2013

The Hyperspectral Infrared Imager (HyspIRI) Public Health and Air Quality Applications

Luvall, Jeffrey C.↗

NASA NTRS2013

The Hyperspectral Infrared Imager (HyspIRI) Public Health & Air Quality Applications

Luvall, Jeffrey C.↗

NASA NTRS2014

The Hyperspectral Infrared Imager (HyspIRI) Public Health and Air Quality Applications

The neglected tropical diseases (NTDs), a group of chronic, debilitating, and poverty-promoting parasitic, bacterial, and some viral and fungal infections, are among the most common causes of illness of the poorest people living in developing countries. Abiotic environmental factors are important in determining the distribution of disease-causing vectors and their life-cycles. HyspIRI observations can be merged through a Land Data Assimilation System (LDAS) be used to drive spatially-explicit ecological models of NTD vectors distribution and life cycles. Assimilations will be driven by observational data LDAS and satellite-derived meteorological forcing data, parameter datasets, and assimilation observations. HyspIRI hyperspectral measurements would provide global measurements of surface mineralogy and biotic crusts important in accessing the impact of dust in human health. HyspIRI surface thermal measurements would also help identify the variability of dust sources due to surface moisture conditions and map mineralogy.

Luvall, Jeffrey C.↗

NASA NTRSDate not supplied

INCORPORATION OF NITROGEN INTO ORGANICS PRODUCED BY FISCHER-TROPSCH TYPE CHEMISTRY

Laboratory simulations have demonstrated that hydrothermal systems have the potential to produce a range of organic compounds through Fischer-Tropsch type (FTT) chemistry. The distribution of products depends on several factors, including the abundance and composition of feedstock molecules, reaction temperature, and the physical and chemical characteristics of catalytic materials included in the reactions. The majority of studies per-formed to date have focused solely on inclusion of CO2 or CO and H2 as the carbon, oxygen and hydrogen sources, which limits the possible products to hydrocarbons, alcohols and carboxylic acids. A few studies have included nitrogen in the form of ammonia, which led to the production of amino acids and nitrogenous bases. Although these demonstrations provide compelling evidence that FTT reactions can produce compounds of interest for the origins of life, such reactions have been conducted under a very limited range of conditions and the synthetic reaction mechanisms have generally not been well-characterized. We have begun a series of laboratory experiments that will incorporate a range of precursor molecules in varying compositions to determine how these variables affect the relative amounts and speciation of life-essential elements in organic molecules produced under FTT conditions. In the present work, we focus on systems containing C, H, O and N. Reaction mixtures contained CO (~60-80 mM), 150 mM ammonium chloride, and water with a native iron catalyst, which also served as a source of H2 through the reduction of water. Three initial experiments were conducted at 110, 154 and 185 °C and heated for several days. Following the reaction, samples were analyzed by gas chromatography-mass spectrometry, direct analysis in real time mass spectrometry and liquid chromatography-mass spectrometry.

A. S. Burton↗

NASA NTRSDate not supplied

Uniform Dust Deposition System for Dust Tolerance Studies

Future missions to the Moon will require mechanisms and materials to effectively and reliably operate in the presences of lunar regolith. One of the challenges of developing such technologies is terrestrial testing with lunar dust simulants. Dust has a stochastic nature of depositing and it can be difficult to accurately apply it to surfaces of interest. Deposition density, particles size distribution, and percent coverage are all factors that affect the quality of dust mitigation testing. Therefore, to enable such testing the dust mitigation and seals teams at NASA Glenn Research Center (GRC) have developed a system that can uniformly and repeatably deposit lunar simulants on a range of surfaces. Testing of the Dust Deposition System (DDS) and an associatedsimulant preparation methodology have quantified the levels of uniformity and precision for this system. Furthermore, the deposition system has been paired with automated micrograph capturing and machine learning image analysis to correlate the images of dust on a surface to deposition density (in g/cm2). This correlation alleviates the need for tested samples to be accurately weighed with milligram precision and may be a useful tool for in-situ contamination evaluation on the Moon. This paper covers the design and validation testing for the DDS.

Stephen Gerdts↗

NASA NTRSDate not supplied

Characterizing the Seasonal and Diurnal Aerosol Cycles using CATS Space-Based Lidar

The broader effects aerosols have on the earth and climate system is determined by a host of factors including their composition and vertical distribution. Characterizing the vertical distribution of clouds and aerosols is especially important considering it remains one of the greatest uncertainties in climate predictions. Space-based lidar, such as Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) and Cloud-Aerosol Transport System (CATS), is especially well suited as a remote sensing tool in determining this vertical distribution. CALIOP has been used for over a decade to observe the global and vertical distribution of clouds and aerosols but is limited by Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations’ (CALIPSO’s) polar orbit to set equatorial crossing times of ~1:30AM/PM. This limited temporal sampling limits the use of CALIOP in determining the full diurnal variability of clouds and aerosols. On the International Space Station (ISS), with its inclined orbit and variable equatorial crossing times, the CATS lidar provided an opportunity to study the vertical profile of clouds and aerosols at a variety of local times. With this 33-month CATS record, we show that CATS captured the seasonal changes in global aerosol distributions and compares favorably with other instruments and models. Specifically targeting biomass burning regions, we also find CATS could observe the documented diurnal cycle in aerosol altitudes with some caveats. With the next generation of proposed space-based lidars including designs in similar orbits as the ISS and CATS, future studies of the aerosol diurnal and seasonal cycles would also be possible.

Kenneth Christian↗

NASA NTRSDate not supplied

Uniform Dust Deposition System for Dust Tolerance Studies

Future missions to the Moon will require mechanisms and materials to effectively and reliably operate in the presences of lunar regolith. One of the challenges of developing such technologies is terrestrial testing with lunar dust simulants. Dust has a stochastic nature of depositing and it can be difficult to accurately apply it to surfaces of interest. Deposition density, particles size distribution, and percent coverage are all factors that affect the quality of dust mitigation testing. Therefore, to enable such testing the dust mitigation and seals teams at NASA Glenn Research Center (GRC) have developed a system that can uniformly and repeatably deposit lunar simulants on a range of surfaces. Testing of the Dust Deposition System (DDS) and an associated simulant preparation methodology have quantified the levels of uniformity and precision for this system. Furthermore, the deposition system has been paired with automated micrograph capturing and machine learning image analysis to correlate the images of dust on a surface to deposition density (in g/cm2). This correlation alleviates the need for tested samples to be accurately weighed with milligram precision and may be a useful tool for in-situ contamination evaluation on the Moon. This paper covers the design and validation testing for the DDS.

Dust↗

NASA NTRS2021

Application of Radon Transform to Multi-Angle Measurements Made by the Research Scanning Polarimeter: A New Approach to Cloud Tomography. Part I: Theory and Tests on Simulated Data.

The Research Scanning Polarimeter (RSP) is an airborne along-track scanner measuring the polarized and total reflectances in 9 spectral channels. The RSP was a prototype for the Aerosol Polarimetry Sensor (APS) launched on-board the NASA Glory satellite. Currently the retrieval algorithms developed for the RSP are being adopted for the measurements of the space-borne polarimeters on the upcoming NASA’s Plankton, Aerosol, Cloud Ocean Ecosystem (PACE)satellite mission. The RSP’s uniquely high angular resolution coupled with the high frequency of measurements allows for characterization of liquid water cloud droplet sizes using the polarized rainbow structure. It also provides geometric constraints on the cumulus cloud’s 2D cross section yielding the cloud’s geometric shape estimates. In this study we further build on the latter technique to develop a new tomographic approach to retrieval of cloud internal structure from remote sensing measurements. While tomography in the strict definition is a technique based on active measurements yielding a tomogram (directional optical thickness as a function of angle and offset of the view ray), we developed a “semi-tomographic” approach in which tomogram of the cloud is estimated from passive observations instead of being measured directly. This tomogram is then converted into 2D spatial distribution of the extinction coefficient using inverse Radon transform (filtered back projection) which is the standard tomographic procedure used e.g., in medical CT scans. This algorithm is computationally inexpensive compared to techniques relying on highly-multi-dimensional least-square fitting; it does not require iterative 3D RT simulations. The resulting extinction distribution is defined up to an unknown constant factor, so we discuss the ways to calibrate it using additional independent measurements. In the next step we use the profile of the droplet size distribution parameters from the cloud’s side (derived by fitting the polarized rainbows) to convert the 2D extinction distribution into that of the droplet number concentration. We illustrate and validate the proposed technique using 3D-RT-simulatedRSP observations of a LES-generated Cu cloud. Quantitative comparisons between the retrieved and the original optical and microphysical parameters are presented.

clouds↗