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NASA NTRS1994

Non-dipolar magnetic field models and patterns of radio emission: Uranus and Neptune compared

The magnetic field geometries of Uranus and Neptune are superficially similar, and are similarly unlike those of other planets: the field strengths are similar, and they contain extraordinarily large non-dipolar components. As a corollary, the best dipolar field models of each of the two planets comprises a dipole that is considerably offset from the planetary center and tilted away from the rotational axis. However, in other respects the best field models of the two planets are quite different. Uranus has a quadrupole model in which all the terms are well determined and in which none of the higher order terms is determined. To represent the magnetometer data acquired during Voyager's Neptune encounter requires a model of order 8 (instead of Uranus' order 2), yet many of the coefficients are poorly determined. A second model, an octupole model comprising the terms up to order three of the order 8 model, has been suggested by the magnetometer team as being useful; its use, however, is limited only to the region outside of about 2R(exp N), whereas planetary radio emissions have their sources well inside this surface. Computer code has been written that permits an analysis of the detailed motion of low energy charged particles moving in general planetary magnetic fields. At Uranus, this code reveals the existence of an isolated region of the inner magnetosphere above the day side in which particles may be trapped, separate from the more general magnetospheric trapping. An examination of the so-call ordinary mode uranian radio emissions leads us to believe that these emissions are in fact extraordinary mode emissions coming from particles trapped in this isolated region. A similar attempt to discover trapping regions at Neptune has proved, unfortunately, to be impossible. This arises from three factors: (1) the computation needed to track particles in an eighth order field is more than an order of magnitude greater than that needed to perform a similar calculation in a quadrupole field, and is beyond the capacity of workstation-class computers; (2) the octupole field model is known to be in error by too large an ammount for it, or any similarly truncated version of the eighth order model, to produce trustworthy results; (3) the eighth order model can, in effect, be infinitely varied without affecting the field strength along the spacecraft trajectory.

Evans, D. R.↗

NASA NTRS2015

Low Cost Upper Stage-Class Propulsion (LCUSP)

NASA is making space exploration more affordable and viable by developing and utilizing innovative manufacturing technologies. Technology development efforts at NASA in propulsion are committed to continuous innovation of design and manufacturing technologies for rocket engines in order to reduce the cost of NASA's journey to Mars. The Low Cost Upper Stage-Class Propulsion (LCUSP) effort will develop and utilize emerging Additive Manufacturing (AM) to significantly reduce the development time and cost for complex rocket propulsion hardware. Benefit of Additive Manufacturing (3-D Printing) Current rocket propulsion manufacturing techniques are costly and have lengthy development times. In order to fabricate rocket engines, numerous complex parts made of different materials are assembled in a way that allow the propellant to collect heat at the right places to drive the turbopump and simultaneously keep the thrust chamber from melting. The heat conditioned fuel and oxidizer come together and burn inside the combustion chamber to provide thrust. The efforts to make multiple parts precisely fit together and not leak after experiencing cryogenic temperatures on one-side and combustion temperatures on the other is quite challenging. Additive manufacturing has the potential to significantly reduce the time and cost of making rocket parts like the copper liner and Nickel-alloy jackets found in rocket combustion chambers where super-cold cryogenic propellants are heated and mixed to the extreme temperatures needed to propel rockets in space. The Selective Laser Melting (SLM) machine fuses 8,255 layers of copper powder to make a section of the chamber in 10 days. Machining an equivalent part and assembling it with welding and brazing techniques could take months to accomplish with potential failures or leaks that could require fixes. The design process is also enhanced since it does not require the 3D model to be converted to 2-D drawings. The design and fabrication process can be sped up and improved with fewer errors to be accomplished in weeks instead of months.

Vickers, John↗

DOE OSTI2021

Constraints on dark matter to dark radiation conversion in the late universe with DES-Y1 and external data

We study a phenomenological class of models where dark matter converts to dark radiation in the low redshift epoch. This class of models, dubbed DMDR, characterizes the evolution of comoving dark-matter density with two extra parameters, and may be able to help alleviate the observed discrepancies between early and late-time probes of the Universe. We investigate how the conversion affects key cosmological observables such as the cosmic microwave background (CMB) temperature and matter power spectra. Combining 3x2pt data from Year 1 of the Dark Energy Survey, Planck-2018 CMB temperature and polarization data, supernovae (SN) Type Ia data from Pantheon, and baryon acoustic oscillation (BAO) data from BOSS DR12, MGS and 6dFGS, we place new constraints on the amount of dark matter that has converted to dark radiation and the rate of this conversion. The fraction of the dark matter that has converted since the beginning of the Universe in units of the current amount of dark matter, ζ, is constrained at 68% confidence level to be <0.32 for DES-Y1 3x2pt data, <0.030 for CMB+SN+BAO data, and <0.037 for the combined dataset. The probability that the DES and CMB+SN+BAO datasets are concordant increases from 4% for the ΛCDM model to 8% (less tension) for DMDR. The tension in S8=σ8Ωm/0.3 between DES-Y1 3x2pt and CMB+SN+BAO is slightly reduced from 2.3σ to 1.9σ. We find no reduction in the Hubble tension when the combined data is compared to distance-ladder measurements in the DMDR model. The maximum-posterior goodness-of-fit statistics of DMDR and ΛCDM model are comparable, indicating no preference for the DMDR cosmology over ΛCDM.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

NASA NTRS2001

Configuration Studies of Personal Air Vehicles. Personal Air Vehicle and Flying Jeep Concepts: A Commentary on Promising Approaches or What Goes Around Comes Around (About Every Twenty Years)

The NASA/Langley Personal Air Vehicle (PAV) Exploration (PAVE) and the DARPA (Defense Advanced Research Projects Agency) Dual Air/Road Transportation System (DARTS) projects were established to investigate the feasibility of creating vehicles which could replace, or at the very least augment, personal ground and air transportation schemes. This overall goal implies integrating several technology areas with practical everyday transportation requirements to design a class of vehicles which will achieve the following goals: (1) Vertical, Extremely Short, or Short Takeoff and Landing (VTOL, ESTOL, STOL) capability; (2) Operation at block speeds markedly faster than current combinations of land and air transportation, particularly in critical market areas; (3) Unit cost comparable to current luxury cars and small general aviation aircraft; (4) Excellent reliability; (5) Excellent safety; (6) Ability to integrate with existing land and air transportation systems. The conclusions of these configuration studies are summarized as follows: (1) Creation of the five assigned configurations prompted added explorations, some of which were dead-ends; (2) Some components could be common to all configurations such as avionics and dual-mode suspension schemes; (3) Single-Mode PAVs can be created by removing dual-mode-specific items; (4) Aviation history provided some intriguing starting points, as in what goes around comes around; (5) CTOL (Conventional Take-off and Landing) and STOL dual-mode PAVs look feasible with single-mode PAVs being simplifications of the dual-mode approach; (6) VTOL PAVs will require development; (7) More exotic collapsing mechanisms mechanisms need development; (8) As a teaching tool, PAVs are not yet a well-enough bounded design problem.

Hall, David W.↗

NASA NTRS2017

SAEVe: A Long Duration Small Sat Class Venus Lander - Seismic and Atmospheric Exploration of Venus

NASA's science mission directorate has put increasing emphasis on innovative, smaller, and lower cost missions to achieve their science objectives. One example of this was the recent call by the Planetary Science Division for cube and small satellite concepts expected to cost $100M or less, not including launch and weighing less than 180kg. Over 100 proposals were submitted suggesting that indeed this is a size of mission worthy of being considered in future planning. Nineteen missions were selected for study, one being a long-lived Venus mission called SAEVe, for Seismic and Atmospheric Exploration of Venus. The science objectives and relevance of SAEVe include: Is Venus seismically active? What can we learn about its crust (thickness and composition) and its interior (lithosphere, mantle, and core)? What can be learned about its evolutionary history or about the planet / atmosphere interactions? SAEVe begins to address these science questions with simple, but capable, instrumented probes that can survive on the surface of Venus and take temporal measurements over months something never attempted before. The data returned will further our understanding of the solar system and Earth, and aid in meeting the NASA Science Plan goal to ascertain the content, origin, and evolution of the solar system and the chemical and physical processes in our solar system. SAEVe is delivered to Venus as a ride-along on another mission to Venus. Its two small probes are placed into the Venus atmosphere via a single Stardust-like entry capsule, are ejected at different times, free fall, and decelerate in the thickening atmosphere to touchdown under 8 m/s2 or less. The probes will begin taking measurements and transmitting important parameters at or near the surface and will focus on measurements like seismic activity, heat flux, wind speed and direction, basic chemical abundances, temperature, and pressure. At preset intervals, the probes acquire the science measurements and beam the data to the orbiting host spacecraft. SAEVe will serve as a highly capable precursor and pave the way for larger and more complex lander missions to explore Venus.

lander↗

DOE OSTI2022

A multiwavelength study of the flat-spectrum radio quasar NVSS J141922−083830 covering four flaring episodes

We present multiwavelength observations and a model for flat-spectrum radio quasar (FSRQ) NVSS J141922−083830, originally classified as a blazar candidate of unknown type (BCU II object) in the Third Fermi-LAT AGN Catalog. Relatively bright flares (>3 magnitudes) were observed on 2015 February 21 (MJD 57074) and 2018 September 8 (MJD 58369) in the optical band with the MASTER Global Robotic Net telescopes. Optical spectra obtained with the Southern African Large Telescope on 2015 March 1 (MJD 57082), during outburst, and on 2017 May 30 (MJD 57903), during quiescence, showed emission lines at 5325 Å and at ≈3630 Å that we identified as the Mg II III] 1909 Å lines, respectively, and hence derived a redshift z = 0.903. Analysis of Fermi-Large Area Telescope (LAT) data was performed in the quiescent regime (5 yr of data) and during four prominent flaring states in 2014 February–April, 2014 October–November, 2015 February–March, and 2018 September. We present spectral and timing analysis with Fermi-LAT . We report a hardening of the gamma-ray spectrum during the last three flaring periods, with a power-law spectral index Γ = 2.0–2.1. The maximum gamma-ray flux level was observed on 2014 October 24 (MJD 56954) at (7.57 ± 1.83) × 10 −7 ph cm −2 s −1 . The multiwavelength spectral energy distribution (SED) during the 2015 February–March flare supports the earlier evidence of this blazar to belong to the FSRQ class. The SED can be well represented with a single-zone leptonic model with parameters typical of FSRQs, but also a hadronic origin of the high-energy emission cannot be ruled out.

79 ASTRONOMY AND ASTROPHYSICS↗

NASA NTRS2000

The AstroBiology Explorer (ABE) MIDEX Mission

The Astrobiology Explorer (ABE) is a Medium-Class Explorer (MIDEX) mission concept currently under study at NASA's Ames Research Center. ABE will conduct infrared (IR) spectroscopic observations with much better sensitivity than Infrared Space Observatory (ISO) or the Stratospheric Observatory for Infrared Astronomy program (SOFIA) in order to address outstanding astrobiologically important problems in astrochemistry as well as important astrophysical investigations. The core observational astrobiology program would make fundamental scientific progress in understanding the cosmic history of molecular carbon, the distribution of organic matter in the diffuse interstellar medium, tracing the chemical history of complex organic molecules in the interstellar medium, and the evolution of organic ices in young planetary systems. The ABE instrument concept includes a 0.5 m aperture Cassegrain telescope and a suite of three moderate resolution (R = 1000 - 4000) spectrographs which cover the entire lambda = 2.5-20 micron spectral region. Use of large format (1024 x 1024 pixel or larger) IR detector arrays will allow each spectrograph to cover an entire octave of spectral range per exposure without any moving parts. The telescope is passively cooled by a sun shade to below 65 K, and the detectors are cooled with solid H2 cryogen to approximately 8 K. ABE will be placed in an Earth-trailing one AU solar orbit by a Delta II launch vehicle. This energetically favorable orbit provides a low thermal background, affords good access to the entire sky over the one year mission lifetime, and allows adequate communications bandwidth. The spacecraft will be stabilized in three axes and will be pointed to an accuracy of approximately one arcsecond at ABE's several thousand individual scientific targets.

Greene, Thomas↗

NASA NTRS1988

Efficient use of bit planes in the generation of motion stimuli

The production of animated motion sequences on computer-controlled display systems presents a technical problem because large images cannot be transferred from disk storage to image memory at conventional frame rates. A technique is described in which a single base image can be used to generate a broad class of motion stimuli without the need for such memory transfers. This technique was applied to the generation of drifting sine-wave gratings (and by extension, sine wave plaids). For each drifting grating, sine and cosine spatial phase components are first reduced to 1 bit/pixel using a digital halftoning technique. The resulting pairs of 1-bit images are then loaded into pairs of bit planes of the display memory. To animate the patterns, the display hardware's color lookup table is modified on a frame-by-frame basis; for each frame the lookup table is set to display a weighted sum of the spatial sine and cosine phase components. Because the contrasts and temporal frequencies of the various components are mutually independent in each frame, the sine and cosine components can be counterphase modulated in temporal quadrature, yielding a single drifting grating. Using additional bit planes, multiple drifting gratings can be combined to form sine-wave plaid patterns. A large number of resultant plaid motions can be produced from a single image file because the temporal frequencies of all the components can be varied independently. For a graphics device having 8 bits/pixel, up to four drifting gratings may be combined, each having independently variable contrast and speed.

Mulligan, Jeffrey B.↗

NASA NTRS1985

Proceedings of the Airborne Imaging Spectrometer Data Analysis Workshop

The Airborne Imaging Spectrometer (AIS) Data Analysis Workshop was held at the Jet Propulsion Laboratory on April 8 to 10, 1985. It was attended by 92 people who heard reports on 30 investigations currently under way using AIS data that have been collected over the past two years. Written summaries of 27 of the presentations are in these Proceedings. Many of the results presented at the Workshop are preliminary because most investigators have been working with this fundamentally new type of data for only a relatively short time. Nevertheless, several conclusions can be drawn from the Workshop presentations concerning the value of imaging spectrometry to Earth remote sensing. First, work with AIS has shown that direct identification of minerals through high spectral resolution imaging is a reality for a wide range of materials and geological settings. Second, there are strong indications that high spectral resolution remote sensing will enhance the ability to map vegetation species. There are also good indications that imaging spectrometry will be useful for biochemical studies of vegetation. Finally, there are a number of new data analysis techniques under development which should lead to more efficient and complete information extraction from imaging spectrometer data. The results of the Workshop indicate that as experience is gained with this new class of data, and as new analysis methodologies are developed and applied, the value of imaging spectrometry should increase.

Vane, G.↗

DOE OSTI2026

Goal-oriented real-time Bayesian inference for linear autonomous dynamical systems with application to digital twins for tsunami early warning

We present a goal-oriented framework for constructing digital twins with the following properties: (1) they employ discretizations of high-fidelity partial differential equation (PDE) models governed by autonomous dynamical systems, leading to large-scale forward problems; (2) they solve a linear inverse problem to assimilate observational data to infer uncertain model components followed by a forward prediction of the evolving dynamics; and (3) the entire end-to-end, data-to-inference-to-prediction computation is carried out without approximation and in real time through a Bayesian framework that rigorously accounts for uncertainties. Several challenges must be overcome to realize this framework, including the large scale of the forward problem, the high dimensionality of the parameter space, and for a class of problems including those we target, the slow decay of the singular values of the parameter-to-observable map. Here we introduce a methodology to overcome these challenges by exploiting the autonomous structure of the forward model to decompose the solution of the inverse problem into a one-time-only offline phase in which the PDE model is solved a limited number of times (equal to the number of sensors), and an online phase that maps well onto GPUs and computes the parameter inference and prediction of quantities of interest in real time, given observational data. Our ultimate goal is to apply this framework to construct digital twins for subduction zones, including Cascadia, to provide early warning for tsunamis generated by megathrust earthquakes. To this end, we demonstrate how our methodology can be used to employ seafloor pressure observations, along with the coupled acoustic–gravity wave equations, to infer the earthquake-induced spatiotemporal seafloor motion (discretized with $\mathscr{O}$ (10 9 ) parameters) and forward predict the tsunami propagation. We present results of an end-to-end inference, prediction, and uncertainty quantification for a representative test problem with $\mathscr{O}$ (10 8 ) inversion parameters for which goal-oriented Bayesian inference is accomplished exactly and in real time, that is, in a matter of seconds.

97 MATHEMATICS AND COMPUTING↗

NASA NTRS2010

Assessing the Health and Performance Risks of Carbon Dioxide Exposures

Carbon dioxide (CO2) is an anthropogenic gas that accumulates in spacecraft to much higher levels than earth-normal levels. Controlling concentrations of this gas to acceptable levels to ensure crew health and optimal performance demands major commitment of resources. NASA has many decades of experience monitoring and controlling CO2, yet we are uncertain of the levels at which subtle performance decrements develop. There is limited evidence from ground-based studies that visual disturbances can occur during brief exposures and visual changes have been noted in spaceflight crews. These changes may be due to CO2 alone or in combination with other known spaceflight factors such as increased intracranial pressure due to fluid shifts. Discerning the comparative contribution of each to performance decrements is an urgent issue if we hope to optimize astronaut performance aboard the ISS. Long-term, we must know the appropriate control levels for exploration-class missions to ensure that crewmembers can remain cooperative and productive in a highly stressful environment. Furthermore, we must know the magnitude of interindividual variability in susceptibility to the adverse effects of CO2 so that the most tolerant crewmembers can be identified. Ground-based studies have been conducted for many years to set exposure limits for submariners; however, these studies are typically limited and incompletely reported. Nonetheless, NASA, in cooperation with the National Research Council, has set exposure limits for astronauts using this limited database. These studies do not consider the interactions of spaceflight-induced fluid shifts and CO2 exposures. In an attempt to discern whether CO2 levels affect the incidence of headache and visual disturbances in astronauts we performed a retrospective study comparing average CO2 levels and the prevalence of headache and visual disturbances. Our goal is to narrow gaps in the risk profile for in-flight CO2 exposures. Such studies can provide no more than partial answers to the questions of environmental interactions, interindividual variability, and optimal control levels. Future prospective studies should involve assessment of astronaut well being using sophisticated measures during exposures to levels of CO2 in the range from 2 to 8 mmHg.

James, John T.↗

DOE OSTI2026

Strangeness enhancement at its extremes: multiple (multi-)strange hadron production in pp collisions at $\sqrt{s}=5.02$ TeV

The probability to observe a specific number of strange and multi-strange hadrons (nS), denoted as P(nS), is measured by ALICE at midrapidity (|y| < 0.5) in $$\sqrt{s}=5.02$$ TeV proton-proton (pp) collisions, dividing events into several multiplicity-density classes. Exploiting, for the first time, a technique based on counting the number of strange-particle candidates event-by-event, this measurement allows one to extend the study of strangeness production beyond the mean of the distribution. This constitutes a new test bench for production mechanisms, probing events with a large imbalance between strange and non-strange content. The analysis of a large-statistics data sample makes it possible to extract P(nS) up to a maximum nS of 7 for $${\text{K}}_{\text{S}}^{0}$$, 5 for Λ and $$\overline{\Lambda }$$, 4 for Ξ− and $${\overline{\Xi } }^{+}$$, and 2 for Ω− and $${\overline{\Omega } }^{+}$$. From this, the probability of producing strange hadron multiplets per event is calculated, thereby enabling the extension of the study of strangeness enhancement to extreme situations where several strange quarks hadronize in a single event at midrapidity. Moreover, comparing hadron combinations with different u and d quark compositions and equal overall s quark content, the contribution to the enhancement pattern coming from non-strangeness related mechanisms is isolated. The results are compared with state-of-the-art phenomenological models implemented in commonly used Monte Carlo event generators, including PYTHIA 8 Monash 2013, PYTHIA 8 with QCD-based Color Reconnection and Rope Hadronization (QCD-CR + Ropes), and EPOS LHC, which incorporates both partonic interactions and hydrodynamic evolution. These comparisons show that the new approach dramatically enhances the sensitivity to the different underlying physics mechanisms modeled by each generator.

Abualrob, I J↗

DOE OSTI2025

Effect of Viscosity of a Deep Eutectic Solvent on CO 2 Capture Performance in an Energy-Efficient Membrane Contactor-Based Process

Greenhouse gas contributions to climate change have driven intense interest in the separation of CO 2 from wet flue gas streams. Deep eutectic solvents (DESs) are an emerging class of highly selective CO 2 absorbents. A prototypical DES, reline, is a mixture of choline chloride and urea. Reline is a thermally stable, nontoxic, and biodegradable solvent with negligible volatility and is inexpensive. We demonstrate a scalable and energy-efficient hollow fiber membrane contactor (HFMC)-based process using a green solvent for CO 2 capture. This process uses reline in HFMC to provide close interfacial interactions and contact between DES and CO 2 . This approach overcomes the disadvantages associated with direct absorption in DES and could potentially be applied to a variety of solvent-based CO 2 capture methods. Commercial, low-cost polymer hollow fiber membranes were evaluated for the capture of CO 2 with reline. From a mixed gas containing N 2 and CO 2 , the DES-based HFMC separated CO 2 with a purity of 97 mol %. The effect of the viscosity of reline on the CO 2 capture performance was investigated by adding water to the reline. The addition of water to reline significantly reduced its viscosity, which led to a permeate flux of 170 mmol/(m 2 ·h) at 35 °C, 4 bar, and 60 wt % water in solvent, which was approximately 8 times higher than that of the pure reline in the membrane contactor system. In situ Fourier transform infrared spectroscopy and nuclear magnetic resonance (NMR) revealed that reline absorbs CO 2 by physical absorption without forming new chemical compounds and that CO 2 separation by reline occurs via the pressure swing mechanism. This research provides fundamental insights about green physical solvent-based separation processes and a pathway toward industrial deployment.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

NASA NTRSDate not supplied

Effects of Replacing Treadmill Running with Alternative Exercise Countermeasures During Long-Duration Spaceflight

Introduction: Current exercise countermeasures on the International Space Station (ISS), including treadmill running, cycle ergometry, and resistive exercise, are used to protect crewmember health and performance during long-duration spaceflight. However, exploration vehicles for Artemis and beyond will have volume and power restrictions, requiring exercise hardware to have a smaller footprint and use fewer resources. Thus, recent efforts have focused on developing exercise devices (such as the European Enhanced Exploration Exercise Device [E4D]) that provide both aerobic and resistive training on one platform without including a treadmill. It is critical to validate the efficacy of exploration-focused exercise modalities to preserve muscle strength, aerobic fitness, bone density, and sensorimotor performance. Thus, the aim of this study is to determine the physiological effects of spaceflight that occur with nominal ISS exercise prescriptions compared to exploration-forward exercise modalities to determine if a treadmill is required to maintain current levels of protection during long-duration missions. Methods: Crewmembers will be assigned to one of three groups: 1) Control Group (n ≥ 40), who will partake in nominal exercise on the ISS, including running on the Treadmill with Vibration Isolation and Stabilization 2 (T2), ergometry on the Cycle Ergometer with Vibration Isolation and Stabilization (CEVIS) device, and strength training on the Advanced Resistive Exercise Device (ARED); 2) Active Group 1, who will partake in CEVIS and ARED exercise only (n = 8); and 3) Active Group 2, who will partake in aerobic and resistive exercise on the E4D only (n = 8). For Active Group 1, nominal aerobic exercise on T2 will be replaced with corresponding exercise on CEVIS. For Active Group 2, a dedicated exercise prescription will be designed to maximize the capabilities of the E4D to include resistive exercise, cycle ergometry, rowing, and rope pulling. Crewmembers in both active groups will not be permitted to perform treadmill exercise. Health and performance markers including bone mineral density (dual-energy x-ray absorptiometry [DXA]), body composition (DXA), cardiovascular fitness (cycle VO2peak), muscle strength and endurance (isometric/isokinetic testing, power endurance testing), sensorimotor performance (sit-to-stand, obstacle course), postural control (computerized dynamic posturography), Results: Eight subjects (2 Active [CEVIS + ARED], 6 Control) have been recruited for this study. Data collection is currently in progress. Conclusions: This study will assess the efficacy of exploration exercise modalities, including the effects of removing the treadmill exercise capability or of exclusively using the E4D, compared to nominal ISS exercise across an entire mission on bone, muscle, aerobic, and sensorimotor health and performance. Findings from this study will help provide a recommendation on whether these exploration exercise modalities can sufficiently protect against physiological deconditioning during spaceflight or whether a treadmill may be required to maintain current levels of protection during future exploration class spaceflight missions.

A.N. Varanoske↗

NASA NTRS2010

Effects of Modeled Microgravity on Expression Profiles of Micro RNA in Human Lymphoblastoid Cells

Among space radiation and other environmental factors, microgravity or an altered gravity is undoubtedly the most significant stress experienced by living organisms during flight. In comparison to the static 1g, microgravity has been shown to alter global gene expression patterns and protein levels in cultured cells or animals. Micro RNA (miRNA) has recently emerged as an important regulator of gene expression, possibly regulating as many as one-third of all human genes. miRNA represents a class of single-stranded noncoding regulatory RNA molecules (~ 22 nt) that control gene expressions by inhibiting the translation of mRNA to proteins. However, very little is known on the effect of altered gravity on miRNA expression. We hypothesized that the miRNA expression profile will be altered in zero gravity resulting in regulation of the gene expression and functional changes of the cells. To test this hypothesis, we cultured TK6 human lymphoblastoid cells in Synthecon s Rotary cell culture system (bioreactors) for 72 h either in the rotating (10 rpm) to model the microgravity in space or in the static condition. The cell viability was determined before and after culturing the cells in the bioreactor using both trypan blue and guava via count. Expressions of a panel of 352 human miRNA were analyzed using the miRNA PCRarray. Out of 352 miRNAs, expressions of 75 were significantly altered by a change of greater than 1.5 folds and seven miRNAs were altered by a fold change greater than 2 under the rotating culture condition. Among these seven, miR-545 and miR-517a were down regulated by 2 folds, whereas miR-150, miR-302a, miR-139-3p, miR-515-3p and miR-564 were up regulated by 2 to 8 folds. To confirm whether this altered miRNA expression correlates with gene expression and functional changes of the cells, we performed DNA Illumina Microarray Analysis and validated the related genes using q-RT PCR.

Mangala, Lingegowda S.↗

NASA NTRS2015

Forest Disturbance Across the Conterminous United States from 1985-2012: The Emerging Dominance of Forest Decline

Evidence of shifting dominance among major forest disturbance agent classes regionally to globally has been emerging in the literature. For example, climate-related stress and secondary stressors on forests (e.g., insect and disease, fire) have dramatically increased since the turn of the century globally, while harvest rates in the western US and elsewhere have declined. For shifts to be quantified, accurate historical forest disturbance estimates are required as a baseline for examining current trends. We report annual disturbance rates (with uncertainties) in the aggregate and by major change causal agent class for the conterminous US and five geographic subregions between 1985 and 2012. Results are based on human interpretations of Landsat time series from a probability sample of 7200 plots (30 m) distributed throughout the study area. Forest disturbance information was recorded with a Landsat time series visualization and data collection tool that incorporates ancillary high-resolution data. National rates of disturbance varied between 1.5% and 4.5% of forest area per year, with trends being strongly affected by shifting dominance among specific disturbance agent influences at the regional scale. Throughout the time series, national harvest disturbance rates varied between one and two percent, and were largely a function of harvest in the more heavily forested regions of the US (Mountain West, Northeast, and Southeast). During the first part of the time series, national disturbance rates largely reflected trends in harvest disturbance. Beginning in the mid-90s, forest decline-related disturbances associated with diminishing forest health (e.g., physiological stress leading to tree canopy cover loss, increases in tree mortality above background levels), especially in the Mountain West and Lowland West regions of the US, increased dramatically. Consequently, national disturbance rates greatly increased by 2000, and remained high for much of the decade. Decline-related disturbance rates reached as high as 8% per year in the western regions during the early-2000s. Although low compared to harvest and decline, fire disturbance rates also increased in the early- to mid-2000s. We segmented annual decline-related disturbance rates to distinguish between newly impacted areas and areas undergoing gradual but consistent decline over multiple years. We also translated Landsat reflectance change into tree canopy cover change information for greater relevance to ecosystem modelers and forest managers, who can derive better understanding of forest-climate interactions and better adapt management strategies to changing climate regimes. Similar studies could be carried out for other countries where there are sufficient Landsat data and historic temporal snapshots of high-resolution imagery.

Cohen, Warren B.↗

NASA NTRSDate not supplied

Effects of Replacing Treadmill Running with Alternative Exercise Countermeasures During Long-Duration Spaceflight

Introduction: Current exercise countermeasures on the International Space Station (ISS), including treadmill running, cycle ergometry, and resistive exercise, are used to protect crewmember health and performance during long-duration spaceflight. However, exploration vehicles for Artemis and beyond will have volume and power restrictions, requiring exercise hardware to have a smaller footprint and use fewer resources. Thus, recent efforts have focused on developing exercise devices that provide both aerobic and resistive training on one platform without including a treadmill, such as the European Enhanced Exploration Exercise Device (E4D). It is critical to validate the efficacy of exploration-focused exercise modalities to preserve muscle strength, aerobic fitness, bone density, and sensorimotor performance. Thus, the aim of this study is to determine the physiological effects of spaceflight that occur with nominal ISS exercise prescriptions compared to exploration-forward exercise modalities to determine if a treadmill is required to maintain current levels of protection during long-duration missions. Methods: Crewmembers will be assigned to one of three groups: 1) Control Group (n ≥ 40) who will partake in nominal exercise on the ISS, including running on the treadmill with vibration isolation system 2 (T2), ergometry on the cycle ergometer with vibration isolation and stabilization device (CEVIS), and strength training on the advanced resistive exercise device (ARED); 2) Active Group 1, who will partake in CEVIS and ARED exercise only (n = 8); and 3) Active Group 2, who will partake in aerobic and resistive exercise on the E4D only (n = 8). For Active Group 1, nominal aerobic exercise on T2 will be replaced with corresponding exercise on CEVIS. For Active Group 2, a dedicated exercise prescription will be designed to maximize the capabilities of the E4D to include resistive exercise, cycle ergometry, rowing, and rope pulling. Crewmembers in both active groups will not be permitted to perform treadmill exercise. Health and performance markers including bone mineral density (dual-energy x-ray absorptiometry [DXA]), body composition (DXA), cardiovascular fitness (cycle VO2peak), muscle strength and endurance (isometric/isokinetic testing, power endurance testing), sensorimotor performance (sit-to-stand, obstacle course), postural control (computerized dynamic posturography), and blood and urine biochemical markers of bone metabolism will be assessed before, during, and following spaceflight. Results: Data collection for this study is currently in progress. Conclusions: This study will assess the efficacy of exploration exercise modalities, including the effects of removing the treadmill exercise capability or of exclusively using the E4D, compared to nominal ISS exercise across an entire mission on bone, muscle, aerobic, and sensorimotor health and performance. Findings from this study will help provide a recommendation on whether these exploration exercise modalities can sufficiently protect against physiological deconditioning during spaceflight or whether a treadmill may be required to maintain current levels of protection during future exploration class spaceflight missions.

A.N. Varanoske↗

NASA NTRS2017

Ground-Based Observing Campaign of Briz-M Debris

In 2015, NASA's Orbital Debris Program Office (ODPO) completed the installation of the Meter Class Autonomous Telescope (MCAT) on Ascension Island. MCAT is a 1.3m optical telescope designed with a fast tracking capability for observing orbital debris at all orbital regimes (Low-Erath orbits to Geosyncronous (GEO) orbits) from a low latitude site. This new asset is dedicated year-round for debris observations, and its location fills a geographical gap in the Ground-based Electro Optical Space Surveillance (GEODSS) network. A commercial off the shelf (COTS) research grade 0.4m telescope (named the Benbrook telescope) will also be installed on Ascension at the end of 2016. This smaller version is controlled by the same master software, designed by Euclid Research, and can be tasked to work independently or in concert with MCAT. Like MCAT, it has a the same suite of filters, a similar field of view, and a fast-tracking Astelco mount, and is also capable of tracking debris at all orbital regimes. These assets are well suited for targeted campagins or surveys of debris. Since 2013, NASA's ODPO has also had extensive access to the 3.8m infrared UKIRT telescope, located on Mauna Kea. At nearly 14,000-ft, this site affords excellent conditions for collecting both photometery and spectroscopy at near-IR (0.9 - 2.5 micrometers SWIR) and thermal-IR (8 - 25 micrometers; LWIR) regimes, ideal for investigating material properties as well as thermal characteristics and sizes of debris. For the purposes of understanding orbital debris, taking data in both survey mode as well as targeting individual objects for more in-depth characterizations are desired. With the recent break-ups of Briz-M rocket bodies, we have collected a suite of data in the optical, near-infrared, and mid-infrared of in-tact objects as well as those classified as debris. A break-up at GEO of a Briz-M rocket occurred in January, 2016, well timed for the first remote observing survey-campaign with MCAT. Access to the 3.8m UKIRT telescope has also allowed for investigating this break-up in the near-infrared at wavelengths where debris is often much more reflective, allowing for the potential detection of a smaller population of these debris. In addition, a suite of near-IR reflectance spectroscopy (0.8-2.5 micrometers) and thermal-IR (8-15 micrometers) of individual in-tact and debris Briz-M objects has been collected. Analysis of the survey data will be discussed.

Lederer, S. M.↗