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At least 613 records · Page 34

Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV

The 3-dimensional crystal structure of glutathione S-transferase (GST) of Schistosoma japonicum (Sj) fused with a conserved neutralizing epitope on gp41 (glycoprotein, 41 kDa) of human immunodeficiency virus type 1 (HIV-1) (Muster T et al., 1993, J Virol 67:6642-6647) was determined at 2.5 A resolution. The structure of the 3-3 isozyme rat GST of the mu gene class (Ji X, Zhang P, Armstrong RN, Gilliland GL, 1992, Biochemistry 31:10169-10184) was used as a molecular replacement model. The structure consists of a 4-stranded beta-sheet and 3 alpha-helices in domain 1 and 5 alpha-helices in domain 2. The space group of the Sj GST crystal is P4(3)2(1)2, with unit cell dimensions of a = b = 94.7 A, and c = 58.1 A. The crystal has 1 GST monomer per asymmetric unit, and 2 monomers that form an active dimer are related by crystallographic 2-fold symmetry. In the binding site, the ordered structure of reduced glutathione is observed. The gp41 peptide (Glu-Leu-Asp-Lys-Trp-Ala) fused to the C-terminus of Sj GST forms a loop stabilized by symmetry-related GSTs. The Sj GST structure is compared with previously determined GST structures of mammalian gene classes mu, alpha, and pi. Conserved amino acid residues among the 4 GSTs that are important for hydrophobic and hydrophilic interactions for dimer association and glutathione binding are discussed.

Schistosoma japonicum/enzymology/genetics/immunolo↗

Test Report on Three-and Six-Component Measurements on a Series of Tapered Wings of Small Aspect Ratio (Partial Report: Elliptic Wing)

The report UM No. 1023/1 which presented the results of measurements for a series of trapezoidal wings was the beginning of a series on wings with aspect ratio 1 to 3 and various contours. In report No. 1023/1 the aspect ratio (Lambda = 4/3) remained the same; the tapering was modified. The present report gives the results of the series of elliptic wings. Here the aspect ratio varies from 1 to 2 with the sweepback. The contour is formed by elliptic arcs. The influence of sweepback and contour upon the neutral point is shown.

Lange↗

The First Six Months of Iapetus Observations by the Cassini ISS Camera

Since Saturn arrival in June 2004, Iapetus has been studied intensively by the Cassini ISS camera [1] at various ranges. The first of two relatively close flybys in the primary mission occurred on Dec 31, 2004 at an altitude of approx.123,400 km over the northern leading hemisphere, resulting in images with a minimum pixel scale of 740 m. Detailed results of this flyby are given in [2], while this abstract covers the observations obtained earlier. Among the most important discoveries are: (a) Four giant impact basins with diameters between 390 and 550 km were detected, three of them are located in the dark terrain [3]. (b) Data revealed a >1300 km long ridge that marks exactly Iapetus' equator within the dark terrain. Individual mountains within the western part of the ridge reach heights of approx.20 km over surrounding terrain [3]. (c) Impact craters were confirmed to be the main geological feature within the dark terrain and at high southern latitudes. (d) There are numerous craters with dark walls roughly facing towards the central parts of the dark hemisphere [3]. (e) Almost all parts of Iapetus have been imaged at least at low resolution (< 60 km/pxl).

Denk, T.↗

Six Years of Science with the Chandra X-Ray Observatory

The Chandra X-ray Observatory had its origins in a 1963 proposal led by Riccardo Giacconi that called for a 1-meter diameter, 1-arcsecond class X-Ray telescope for studying the Universe in X-rays. We will briefly discuss the history of the mission, the development of the hardware, its testing, and the launch on 1999, July 23. The remainder of the talk will be an admittedly eclectic review of some of the most exciting scientific highlights. These include the detection and identification of the first source seen with Chandra - an unusual Seyfert 1 we nicknamed Leon X-1, the detailed study of the Crab Nebula and its pulsar, and spectacular images of other supernova remnants including a 1-Million second exposure on Cas A. We also will summarize some of the major Chandra findings for normal and active galaxies and we will illustrate the breadth of science enabled by Chandra observations of clusters of galaxies and their implications for cosmology.

Weisskopf, Martin↗

MER : from landing to six wheels on Mars ... twice

Application of the Pathfinder landing system design to enclose the much larger Mars Exploration Rover required a variety of Rover deployments to achieve the surface driving configuration. The project schedule demanded that software design, engineering model test, and flight hardware build to be accomplished in parallel. This challenge was met through (a) bounding unknown environments against which to design and test, (b) early mechanical prototype testing, (c) constraining the scope of on-board autonomy to survival-critical deployments, (d) executing a balance of nominal and off-nominal test cases, (e) developing off-nominal event mitigation techniques before landing, (f) flexible replanning in response to surprises during operations. Here is discussed several specific events encountered during initial MER surface operations.

Mars Exploration Rover (MER)↗

Six Decades of Flight Research: An Annotated Bibliography of Technical Publications of NASA Dryden Flight Research Center, 1946-2006

Titles, authors, report numbers, and abstracts are given for nearly 2900 unclassified and unrestricted technical reports and papers published from September 1946 to December 2006 by the NASA Dryden Flight Research Center and its predecessor organizations. These technical reports and papers describe and give the results of 60 years of flight research performed by the NACA and NASA, from the X-1 and other early X-airplanes, to the X-15, Space Shuttle, X-29 Forward Swept Wing, X-31, and X-43 aircraft. Some of the other research airplanes tested were the D-558, phase 1 and 2; M-2, HL-10 and X-24 lifting bodies; Digital Fly-By-Wire and Supercritical Wing F-8; XB-70; YF-12; AFTI F-111 TACT and MAW; F-15 HiDEC; F-18 High Alpha Research Vehicle, F-18 Systems Research Aircraft and the NASA Landing Systems Research aircraft. The citations of reports and papers are listed in chronological order, with author and aircraft indices. In addition, in the appendices, citations of 270 contractor reports, more than 200 UCLA Flight System Research Center reports, nearly 200 Tech Briefs, 30 Dryden Historical Publications, and over 30 videotapes are included.

Fisher, David F.↗

Fermi (Formerly GLAST) at Six Months

The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy range 20 MeV to more than 300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. In addition to breakthrough capabilities in energy coverage and localization, the very large field of view enables observations of 20% of the sky at any instant, and the entire sky on a timescale of a few hours. With its recent launch on 11 June 2008, Fermi now opens a new and important window on a wide variety of phenomena, including pulsars, black holes and active galactic nuclei, gamma-ray bursts, the origin of cosmic rays and supernova remnants, and searches for hypothetical new phenomena such as supersymmetric dark matter annihilations. In addition to early results and the science opportunities, this talk includes a description of the instruments and the mission status and plans.

Ritz, Steven M.↗

Fermi (nee GLAST) at Six Months

The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy range 20 MeV to >300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. In addition to breakthrough capabilities in energy coverage and localization, the very large field of view enables observations of 20% of the sky at any instant, and the entire sky on a timescale of a few hours. With its recent launch on 11 June 2008, Fermi now opens a new and important window on a wide variety of phenomena, including pulsars, black holes and active galactic nuclei, gamma-ray bursts, the origin of cosmic rays and supernova remnants, and searches for hypothetical new phenomena such as supersymmetric dark matter annihilations. In addition to early results and the science opportunities, this talk includes a description of the instruments and the mission status and plans.

Ritz, Steve↗

Carbon XANES Data from Six Aerogel Picokeystones Cut from the Top and Bottom Sides of the Stardust Comet Sample Tray

Great care and a large effort was made to minimize the amount of organic matter contained within the flight aerogel used to collect Comet 81P/Wild 2 samples. Even so, by the very nature of the production process and silica aerogel s affinity for volatile organics keeping silica aerogel free from organics is a monumental task. Silica aerogel from three production batches was flown on the Stardust sample return mission. All 3 types had layered densities varying from 5mg/ml to 50 mg/ml where the densest aerogel was farthest away from the collection area. A 2 step gelation process was used to make the flight aerogel and organics used in this process were tetraethylorthosilicate, ethanol and acetonitrile. Both ammonium hydroxide and nitric acid were also used in the aerogel production process. The flight aerogel was baked at JPL at 300 C for 72 hours, most of the baking was done at atmosphere but twice a day the oven was pumped to 10 torr for hour [1]. After the aerogel was baked it was stored in a nitrogen purged cabinet until flight time. One aerogel cell was located in the SRC away from any sample collection area as a witness to possible contamination from out gassing of the space craft, re-entry gases and any other organic encounter. This aerogel was aerogel used in the interstellar collection sample tray and is the least dense of the 3 batches of aerogel flown. Organics found in the witness tile include organics containing Si-CH3 bonds, amines and PAHS. Besides organic contamination, hot spots of calcium were reported in the flight aerogel. Carbonates have been detected in comet 81P/Wild2 samples . During preflight analyses, no technique was used to analyze for carbonates in aerogel. To determine if the carbonates found in 81P/Wild2 samples were from the comet, it is necessary to analyze the flight aerogel for carbonate as well as for organics.

Wirick, S.↗

Fermi at Six Months

An overview of the Fermi Gamma-ray Space Telescope's first 6 months in operation is provided. The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy rage 20 MeV to more than 300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. It contains a Large Area Telescope capable of viewing the entire sky every 3 hours and a Gamma-ray Burst Monitor for viewing the entire unocculted sky. Since its launch on June 11, 2008 Fermi has provided information on pulsars, gamma ray bursts, relativistic jets, the active galactic nucleus, and a globular star cluster. This presentation describes Fermi's development, mission, instruments and recent findings.

Hays, Elizabeth↗

The CIRS Investigation on Cassini after Six Years at Saturn

The CIRS investigation designed to provide: 1) infrared spectroscopy of thermal emission from atmospheres, rings, and surfaces in 10 +/- 1450 cm(exp -1) (1000 +/- 7 micron) region; 2) global mapping in atmospheres of three dimensional and temporal variation of gas composition, temperatures, dynamics, and aerosols and clouds; and 3) mapping of rings and icy satellite surfaces for composition and thermal properties. Topics include: optical and mechanical layouts, instrument description, preparation for launch, Saturn's rings in the light spectrum, Saturn brightness temperature spectrum, and views of Saturn's surface, rings, and Saturn's moons and their atmospheres.

Jennings, Donald↗

Six-Tube Freezable Radiator Testing and Model Correlation

Freezable radiators offer an attractive solution to the issue of thermal control system scalability. As thermal environments change, a freezable radiator will effectively scale the total heat rejection it is capable of as a function of the thermal environment and flow rate through the radiator. Scalable thermal control systems are a critical technology for spacecraft that will endure missions with widely varying thermal requirements. These changing requirements are a result of the spacecraft s surroundings and because of different thermal loads rejected during different mission phases. However, freezing and thawing (recovering) a freezable radiator is a process that has historically proven very difficult to predict through modeling, resulting in highly inaccurate predictions of recovery time. These predictions are a critical step in gaining the capability to quickly design and produce optimized freezable radiators for a range of mission requirements. This paper builds upon previous efforts made to correlate a Thermal Desktop(TradeMark) model with empirical testing data from two test articles, with additional model modifications and empirical data from a sub-component radiator for a full scale design. Two working fluids were tested, namely MultiTherm WB-58 and a 50-50 mixture of DI water and Amsoil ANT.

Lillibridge, Sean↗

Six Degrees-of-Freedom Ascent Control for Small-Body Touch and Go

A document discusses a method of controlling touch and go (TAG) of a spacecraft to correct attitude, while ensuring a safe ascent. TAG is a concept whereby a spacecraft is in contact with the surface of a small body, such as a comet or asteroid, for a few seconds or less before ascending to a safe location away from the small body. The report describes a controller that corrects attitude and ensures that the spacecraft ascends to a safe state as quickly as possible. The approach allocates a certain amount of control authority to attitude control, and uses the rest to accelerate the spacecraft as quickly as possible in the ascent direction. The relative allocation to attitude and position is a parameter whose optimal value is determined using a ground software tool. This new approach makes use of the full control authority of the spacecraft to correct the errors imparted by the contact, and ascend as quickly as possible. This is in contrast to prior approaches, which do not optimize the ascent acceleration.

Blackmore, Lars James C.↗

Six-Tube Freezable Radiator Testing and Model Correlation

Freezable Radiators offer an attractive solution to the issue of thermal control system scalability. As thermal environments change, a freezable radiator will effectively scale the total heat rejection it is capable of as a function of the thermal environment and flow rate through the radiator. Scalable thermal control systems are a critical technology for spacecraft that will endure missions with widely varying thermal requirements. These changing requirements are a result of the spacecraft?s surroundings and because of different thermal loads rejected during different mission phases. However, freezing and thawing (recov ering) a freezable radiator is a process that has historically proven very difficult to predict through modeling, resulting in highly inaccurate predictions of recovery time. These predictions are a critical step in gaining the capability to quickly design and produce optimized freezable radiators for a range of mission requirements. This paper builds upon previous efforts made to correlate a Thermal Desktop(TM) model with empirical testing data from two test articles, with additional model modifications and empirical data from a sub-component radiator for a full scale design. Two working fluids were tested: MultiTherm WB-58 and a 50-50 mixture of DI water and Amsoil ANT.

Lilibridge, Sean T.↗