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At least 595 records · Page 33

Stellar Echo Imaging of Exoplanets

All stars exhibit intensity fluctuations over several timescales, from nanoseconds to years. These intensity fluctuations echo off bodies and structures in the star system. We posit that it is possible to take advantage of these echoes to detect, and possibly image, Earth-scale exoplanets. Unlike direct imaging techniques, temporal measurements do not require fringe tracking, maintaining an optically-perfect baseline, or utilizing ultra-contrast coronagraphs. Unlike transit or radial velocity techniques, stellar echo detection is not constrained to any specific orbital inclination. Current results suggest that existing and emerging technology can already enable stellar echo techniques at flare stars, such as Proxima Centauri, including detection, spectroscopic interrogation, and possibly even continent-level imaging of exoplanets in a variety of orbits. Detection of Earth-like planets around Sun-like stars appears to be extremely challenging, but cannot be fully quantified without additional data on micro- and millisecond-scale intensity fluctuations of the Sun. We consider survey missions in the mold of Kepler and place preliminary constraints on the feasibility of producing 3D tomographic maps of other structures in star systems, such as accretion disks. In this report we discuss the theory, limitations, models, and future opportunities for stellar echo imaging.

stellar↗

Cu and Ni Co-sputtered heteroatomic thin film for enhanced nonenzymatic glucose detection

Abstract In this work, we report a wafer-scale and chemical-free fabrication of nickel (Ni) and copper (Cu) heteroatomic Cu–Ni thin films using RF magnetron sputtering technique for non-enzymatic glucose sensing application. The as-prepared wafer-scale Cu–Ni thin films exhibits excellent electrocatalytic activity toward glucose oxidation with a 1.86 μM detection limit in the range of 0.01 mM to 20 mM range. The Cu–Ni film shows 1.3- and 5.4-times higher glucose oxidation activity in comparison to the Cu and Ni electrodes, respectively. The improved electrocatalytic activity is attributed to the synergistic effect of the bimetallic catalyst and high density of grain boundaries. The Cu–Ni electrodes also possessed excellent anti-interference characteristics. These results indicate that Cu–Ni heteroatomic thin film can be a potential candidate for the development of non-enzymatic glucose biosensor because of its chemical free synthesis, excellent reproducibility, reusability, and long-term stability.

59 BASIC BIOLOGICAL SCIENCES↗

A Leptonic Model for Neutrino Emission From Active Galactic Nuclei

It is often stated that the observation of high-energy neutrinos from an astrophysical source would constitute a smoking gun for the acceleration of hadronic cosmic rays. Here, we point out that there exists a purely leptonic mechanism to produce TeV-scale neutrinos in astrophysical environments. In particular, very high-energy synchrotron photons can scatter with X-rays, exceeding the threshold for muon-antimuon pair production. When these muons decay, they produce neutrinos without any cosmic-ray protons or nuclei being involved. In order for this mechanism to be efficient, the source in question must produce very high-energy photons which interact in an environment that is dominated by keV-scale radiation. As an example, we consider the active galaxy NGC 1068, which IceCube has recently detected as a source of TeV-scale neutrinos. We find that the neutrino emission observed from this source could potentially be generated through muon pair production for reasonable choices of physical parameters.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Detection of Critical Surface Features in PTLs and GDLs for Improved Device Performance and Manufacturing Reliability

High points, or features that protrude above the surface of the material, on porous transport layers (PTLs) and gas diffusion layers (GDLs) can be critical features that may affect the manufacturing process and the performance of the device containing the feature. High points on PTLs and GDLs may stress the membrane of a polymer electrolyte membrane (PEM) during lamination and cell operation of a PEM electrolyzer or fuel cell. Additionally, high points on GDLs may impact the reliability of the manufacturing process. Thus, understanding these critical features and developing procedures to detect them are a key part of developing quality control techniques for PTLs and GDLs. This work evaluates the effectiveness of the Keyence VR6200 benchtop-scale structured light optical profilometer for detection of surface protrusions on PTLs and GDLs. Standard testing procedures for detecting and measuring high points were created for use on both material types. These procedures were evaluated using Gage Repeatability and Reproducibility (Gage R&R), where the repeatability, reproducibility, and effectiveness of the system to detect and measure high points were quantified. We have shown with high statistical power that the system is very effective in detection and measurement of high points, with Gage R&R contributions measured to be 2.2% and 3.6% for PTLs and GDLs, respectively.

36 MATERIALS SCIENCE↗

Approximate Computing Techniques for Iterative Graph Algorithms

Approximate computing enables processing of large-scale graphs by trading off quality for performance. Approximate computing techniques have become critical not only due to the emergence of parallel architectures but also the availability of large scale datasets enabling data-driven discovery. Using two prototypical graph algorithms, PageRank and community detection, we present several approximate computing heuristics to scale the performance with minimal loss of accuracy. We present several heuristics including loop perforation, data caching, incomplete graph coloring and synchronization, and evaluate their efficiency. We demonstrate performance improvements of up to 83% for PageRank and up to 450x for community detection, with low impact of accuracy for both the algorithms. We expect the proposed approximate techniques will enable scalable graph analytics on data of importance to several applications in science and their subsequent adoption to scale similar graph algorithms.

Panyala, Ajay R.↗

Weakly supervised anomaly detection in the Milky Way

ABSTRACT Large-scale astrophysics data sets present an opportunity for new machine learning techniques to identify regions of interest that might otherwise be overlooked by traditional searches. To this end, we demonstrate how Classification Without Labels (CWoLa), a weakly supervised anomaly detection method, can help identify cold stellar streams within the more than one billion Milky Way stars observed by the Gaia satellite. CWoLa operates without the use of labelled streams or knowledge of astrophysical principles. Instead, it uses a classifier to distinguish between mixed samples for which the proportions of signal and background samples are unknown. As a proof of concept, we demonstrate that this computationally lightweight strategy is able to detect both simulated streams and the known stream GD-1 in data. Originally designed for high-energy collider physics, this technique may have broad applicability within astrophysics as well as other domains interested in identifying localized anomalies.

79 ASTRONOMY AND ASTROPHYSICS↗

High-significance detection of correlation between the unresolved gamma-ray background and the large-scale cosmic structure

Our understanding of the γ-ray sky has improved dramatically in the past decade, however, the unresolved γ-ray background (UGRB) still has a potential wealth of information about the faintest γ-ray sources pervading the Universe. Statistical cross-correlations with tracers of cosmic structure can indirectly identify the populations that most characterize the γ-ray background. In this study, we analyze the angular correlation between the γ-ray background and the matter distribution in the Universe as traced by gravitational lensing, leveraging more than a decade of observations from the Fermi-Large Area Telescope (LAT) and 3 years of data from the Dark Energy Survey (DES). We detect a correlation at signal-to-noise ratio of 8.9. Most of the statistical significance comes from large scales, demonstrating, for the first time, that a substantial portion of the UGRB aligns with the mass clustering of the Universe as traced by weak lensing. Blazars provide a plausible explanation for this signal, especially if those contributing to the correlation reside in halos of large mass (∼ 10 14 M ⊙ ) and account for approximately 30–40% of the UGRB above 10 GeV. Additionally, we observe a preference for a curved γ-ray energy spectrum, with a log-parabolic shape being favored over a power-law. We also discuss the possibility of modifications to the blazar model and the inclusion of additional γ-ray sources, such as star-forming galaxies, misalinged active galactic nuclei, or particle dark matter.

79 ASTRONOMY AND ASTROPHYSICS↗

Do responses to different anthropogenic forcings add linearly in climate models?

Many detection and attribution and pattern scaling studies assume that the global climate response to multiple forcings is additive: that the response over the historical period is statistically indistinguishable from the sum of the responses to individual forcings. Here, we use the NASA Goddard Institute for Space Studies (GISS) and National Center for Atmospheric Research Community Climate System Model (CCSM4) simulations from the CMIP5 archive to test this assumption for multi-year trends in global-average, annual-average temperature and precipitation at multiple timescales. We find that responses in models forced by pre-computed aerosol and ozone concentrations are generally additive across forcings. However, we demonstrate that there are significant nonlinearities in precipitation responses to different forcings in a configuration of the GISS model that interactively computes these concentrations from precursor emissions. We attribute these to differences in ozone forcing arising from interactions between forcing agents. Lastly, our results suggest that attribution to specific forcings may be complicated in a model with fully interactive chemistry and may provide motivation for other modeling groups to conduct further single-forcing experiments.

54 ENVIRONMENTAL SCIENCES↗

Epidemic failure detection and consensus for extreme parallelism

Future extreme-scale high-performance computing systems will be required to work under frequent component failures. The MPI Forum s User Level Failure Mitigation proposal has introduced an operation, MPI Comm shrink, to synchronize the alive processes on the list of failed processes, so that applications can continue to execute even in the presence of failures by adopting algorithm-based fault tolerance techniques. This MPI Comm shrink operation requires a failure detection and consensus algorithm. This paper presents three novel failure detection and consensus algorithms using Gossiping. The proposed algorithms were implemented and tested using the Extreme-scale Simulator. The results show that in all algorithms the number of Gossip cycles to achieve global consensus scales logarithmically with system size. The second algorithm also shows better scalability in terms of memory and network bandwidth usage and a perfect synchronization in achieving global consensus. The third approach is a three-phase distributed failure detection and consensus algorithm and provides consistency guarantees even in very large and extreme-scale systems while at the same time being memory and bandwidth efficient.

97 MATHEMATICS AND COMPUTING↗

A Cross-correlation Study of High-energy Neutrinos and Tracers of Large-scale Structure

The origin of the bulk of the astrophysical neutrinos detected by the IceCube Observatory remains a mystery. Previous source-finding analyses compared the directions of IceCube events and individual sources in astrophysical catalogs. The source association method is technically challenging when the number of source candidates is much larger than the number of the observed astrophysical neutrinos. In this paper, we show that in this large source number regime, a two-point cross-correlation analysis of neutrino data and source catalog can instead be used to constrain potential source populations for the high-energy astrophysical neutrinos, and provide spatial evidence for the existence of astrophysical neutrinos. We present an analysis of the cross-correlation of the IceCube 2010–2012 point-source data and a WISE–2MASS galaxy sample. While we find no significant detection of cross-correlation with the publicly available neutrino data set, we show that, when applied to the full IceCube data, which has a longer observation time and higher astrophysical neutrino purity, our method has sufficient statistical power to detect a cross-correlation signal if the neutrino sources trace the large-scale structure of the universe.

79 ASTRONOMY AND ASTROPHYSICS↗

Structural and functional features of lysine acetylation of plant and animal tubulins

Abstract The study of the genome and the proteome of different species and representatives of distinct kingdoms, especially detection of proteome via wide‐scaled analyses has various challenges and pitfalls. Attempts to combine all available information together and isolate some common features for determination of the pathway and their mechanism of action generally have a highly complicated nature. However, microtubule (MT) monomers are highly conserved protein structures, and microtubules are structurally conserved from Homo sapiens to Arabidopsis thaliana . The interaction of MT elements with microtubule‐associated proteins and post‐translational modifiers is fully dependent on protein interfaces, and almost all MT modifications are well described except acetylation. Crystallography and interactome data using different approaches were combined to identify conserved proteins important in acetylation of microtubules. Application of computational methods and comparative analysis of binding modes generated a robust predictive model of acetylation of the ϵ‐amino group of Lys40 in α‐tubulins. In turn, the model discarded some probable mechanisms of interaction between elements of interest. Reconstruction of unresolved protein structures was carried out with modeling by homology to the existing crystal structure (PDBID: 1Z2B) from B. taurus using Swiss‐model server, followed by a molecular dynamics simulation. Docking of the human tubulin fragment with Lys40 into the active site of α‐tubulin acetyltransferase, reproduces the binding mode of peptidomimetic from X‐ray structure (PDBID: 4PK3).

Rayevsky, Alexey V.↗

Magnetic monopoles and free fractionally charged states at accelerators and in cosmic rays

Unified theories of strong, weak and electromagnetic interactions which have electric charge quantization predict the existence of topologically stable magnetic monopoles. Intermediate scale monopoles are comparable with detection energies of cosmic ray monopoles at IceCube and other cosmic ray experiments. Magnetic monopoles in some models can be significantly lighter and carry two, three or possibly even higher quanta of the Dirac magnetic charge. They could be light enough for their effects to be detected at the LHC either directly or indirectly. An example based on a D-brane inspired SU(3) C × SU(3) L × SU(3) R (trinification) model with the monopole carrying three quanta of Dirac magnetic charge is presented. These theories also predict the existence of color singlet states with fractional electric charge which may be accessible at the LHC.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Capturing Hidden Geochemical Anomalies in Scarce Data by Fractal Analysis and Stochastic Modeling

Fractal/multifractal modeling is a widely used geomathematical approach to capturing different populations in geochemical mapping. The rationale of this methodology is based on empirical frequency density functions attained from global or local distributions. This approach is quite popular because of its simplicity and versatility; it accounts for the frequency and spatial distribution of geochemical data considering self-similarity across a range of scales. Using this technique for detection of geochemical anomalies in scarce data, however, is problematic and can lead to systematic bias in the characterization of the underlying populations. In this paper, an innovative technique is presented that provides good results without a priori assumptions. A simulation approach is adopted for fractal analysis by generating different possible distribution scenarios for the variable under study to reveal the underlying populations that are frequently hidden due to lack of data. The proposed technique is called the global simulated size–number method, and it is validated in a case study with two synthetic datasets and another case study with real dataset from the Ushtagan gold deposit in northeast Kazakhstan.

58 GEOSCIENCES↗

Effects of water addition on the combustion of iso -octane investigated in laminar flames, low-temperature reactors, and an HCCI engine

In this work, the effect of H 2 O injection on the combustion process of iso -octane was investigated with the aim to better understand the suitability of water addition as a potential engine control parameter for homogeneous-charge compression ignition (HCCI) combustion. Several experiments were combined including premixed low-pressure flames, a jet-stirred reactor (JSR) and a plug-flow reactor (PFR), both at atmospheric pressure, and a single-cylinder research engine (SCRE) operated with either iso -octane or RON 98 gasoline. The thermal effect of H 2 O addition was determined in laminar premixed iso -octane/O 2 /Ar flames (equivalence ratio $Φ$=1.4, 40 mbar) with H 2 O mole fractions of 0 to 0.22, where water addition reduced the temperature measured by laser-induced fluorescence (LIF) by up to 110 K. Speciation data were obtained from these flames as well as in the JSR ($Φ$=0.65, 933 mbar) and PFR experiments ($Φ$=0.65, 970 mbar) with and without H 2 O addition in the low- to intermediate temperature regime from 700–1100 K. The chemical analysis in these flame and reactor experiments was performed using molecular-beam mass spectrometry (MBMS) employing either electron ionization (EI) in the PFR and premixed flame or single-photon ionization (PI) by tunable vacuum-ultraviolet radiation in the JSR. The effects on species mole fractions were small which is supported by predictions from chemical-kinetic simulations. Quantitative speciation data of the exhaust gas of the SCRE were obtained by using Fourier-transform infrared (FTIR) spectroscopy. A very similar species pool was detected in the laboratory-scale experiments and for the engine operation. It is thus assumed that these results could assist in guiding both the improvement of fundamental chemical-kinetic as well as HCCI engine control models.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Phase 1/2 Trial of 5-Fraction Stereotactic Radiosurgery With 5-mm Margins With Concurrent and Adjuvant Temozolomide in Newly Diagnosed Supratentorial Glioblastoma: Health-Related Quality of Life Results

Purpose: We report a longitudinal assessment of health-related quality of life (HRQOL) in patients with glioblastoma (GBM) treated on a prospective dose escalation trial of 5-fraction stereotactic radiosurgery (25-40 Gy in 5 fractions) with concurrent and adjuvant temozolomide. Methods: HRQOL was assessed using the European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire core-30 (QLQ-C30) general, the EORTC quality of life questionnaire-brain cancer specific module (QLQ-BN20), and the M.D. Anderson Symptom Inventory–Brain Tumor (MDASI-BT). Questionnaires were completed at baseline and at every follow-up visit after completion of radiosurgery. Changes from baseline for 9 predefined HRQOL measures (global quality of life, physical functioning, social functioning, emotional functioning, motor dysfunction, communication deficit, fatigue, insomnia, and future uncertainty) were calculated at every time point. Results: With a median follow-up time of 10.4 months (range, 0.4-52 months), 139 total HRQOL questionnaires were completed by the 30 patients on trial. Compliance with HRQOL assessment was 76% at 12 months. Communication deficit significantly worsened over time, with a decline of 1.7 points per month (P=.008). No significant changes over time were detected in the other 8 scales of our primary analysis, including global quality of life. Although 8 patients (27%) experienced adverse radiation effects (ARE) on this dose escalation trial, it was not associated with a statistically significant decline in any of the primary HRQOL scales. Disease progression was associated with communication deficit, with patients experiencing an average worsening of 13.9 points per month after progression compared with 0.7 points per month before progression (P=.01). Conclusion: On this 5-fraction dose escalation protocol for newly diagnosed GBM, overall HRQOL remained stable and appears similar to historical controls of 30 fractions of radiation therapy. Tumor recurrence was associated with worsening communication deficit, and ARE did not correlate with a decline in HRQOL.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Mixing Matters: Nanoscale Heterogeneity and Stability in Metal Halide Perovskite Solar Cells

The structural stability of the metal halide perovskite (MHP) absorber material is crucial for the long-term solar cell stability in this thin-film photovoltaic technology. Here, we use mixed A-site FA0.83Cs0.17PbI3 to demonstrate that nanoscale compositional heterogeneity can serve as initiation sites for more macroscale, irreversible phase segregation, which causes device performance degradation. Probing compositional heterogeneity on length scales that has not been detected with conventional characterization techniques, we analyze the tetragonal to cubic phase transition behavior to indirectly determine the level of nanoscale compositional heterogeneity in the initial films. Further, we show that the thermal annealing conditions of the MHP layer during film processing influence the initial nanoscale compositional heterogeneity, and changing these processing conditions can be used to improve the device performance stability. The insights into structural degradation mechanisms initiated by nanoscale compositional heterogeneity and the proposed mitigation strategies will help guide the way toward long-term stable MHP solar cells.

14 SOLAR ENERGY↗

Full data acquisition in Kelvin Probe Force Microscopy: Mapping dynamic electric phenomena in real space

Kelvin probe force microscopy (KPFM) has provided deep insights into the role local electronic, ionic and electrochemical processes play on the global functionality of materials and devices, even down to the atomic scale. Conventional KPFM utilizes heterodyne detection and bias feedback to measure the contact potential difference (CPD) between tip and sample. This measurement paradigm, however, permits only partial recovery of the information encoded in bias- and time-dependent electrostatic interactions between the tip and sample and effectively down-samples the cantilever response to a single measurement of CPD per pixel. This level of detail is insufficient for electroactive materials, devices, or solid-liquid interfaces, where non-linear dielectrics are present or spurious electrostatic events are possible. Here, we simulate and experimentally validate a novel approach for spatially resolved KPFM capable of a full information transfer of the dynamic electric processes occurring between tip and sample. General acquisition mode, or G-Mode, adopts a big data approach utilising high speed detection, compression, and storage of the raw cantilever deflection signal in its entirety at high sampling rates (> 4 MHz), providing a permanent record of the tip trajectory. We develop a range of methodologies for analysing the resultant large multidimensional datasets involving classical, physics-based and information-based approaches. Physics-based analysis of G-Mode KPFM data recovers the parabolic bias dependence of the electrostatic force for each cycle of the excitation voltage, leading to a multidimensional dataset containing spatial and temporal dependence of the CPD and capacitance channels. We use multivariate statistical methods to reduce data volume and separate the complex multidimensional data sets into statistically significant components that can then be mapped onto separate physical mechanisms. Overall, G-Mode KPFM offers a new paradigm to study dynamic electric phenomena in electroactive interfaces as well as offer a promising approach to extend KPFM to solid-liquid interfaces.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗