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At least 595 records · Page 33

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NASA NTRS2014

On Parametric Sensitivity of Reynolds-Averaged Navier-Stokes SST Turbulence Model: 2D Hypersonic Shock-Wave Boundary Layer Interactions

Examined is sensitivity of separation extent, wall pressure and heating to variation of primary input flow parameters, such as Mach and Reynolds numbers and shock strength, for 2D and Axisymmetric Hypersonic Shock Wave Turbulent Boundary Layer interactions obtained by Navier-Stokes methods using the SST turbulence model. Baseline parametric sensitivity response is provided in part by comparison with vetted experiments, and in part through updated correlations based on free interaction theory concepts. A recent database compilation of hypersonic 2D shock-wave/turbulent boundary layer experiments extensively used in a prior related uncertainty analysis provides the foundation for this updated correlation approach, as well as for more conventional validation. The primary CFD method for this work is DPLR, one of NASA's real-gas aerothermodynamic production RANS codes. Comparisons are also made with CFL3D, one of NASA's mature perfect-gas RANS codes. Deficiencies in predicted separation response of RANS/SST solutions to parametric variations of test conditions are summarized, along with recommendations as to future turbulence approach.

Hypersonic↗

NASA NTRS2019

Mars Phoenix EDL Trajectory and Atmosphere Reconstruction Using NewSTEP

This document describes the trajectory and atmosphere reconstruction of the Mars Phoenix Entry, Descent, and Landing using the New Statistical Trajectory Estimation Program. The approach utilizes a Kalman filter to blend inertial measurement unit data with initial conditions and radar altimetry to obtain the inertial trajectory of the entry vehicle. The nominal aerodynamic database is then used in combination with the sensed accelerations to obtain estimates of the atmosphere-relative state. The reconstructed atmosphere pro le is then blended with pre-flight models to construct an estimate of the as-flown atmosphere.

Karlgaard, Christopher D.↗

NASA NTRS2016

The Global Infrared Energy Budget of the Thermosphere from 1947 to 2016 and Implications for Solar Variability

We present an empirical model of the global infrared energy budget of the thermosphere over the past 70 years. The F(sub 10.7), Ap, and Dst indices are used in linear regression fits to the 14.5 year time series of radiative cooling by carbon dioxide and nitric oxide measured by the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument on the TIMED satellite. Databases of these indices are used to develop the radiative cooling time series from 1947. No consistent relation between the occurrence of peak sunspot number and peak infrared cooling is found over the past six solar cycles. The total infrared energy radiated by the thermosphere, integrated over a solar cycle, is nearly constant over five complete solar cycles studied. This is a direct consequence of the geoeffective solar energy also being nearly constant over the same intervals. These results provide a new metric for assessing the terrestrial context of the long‐term record of solar‐related indices.

Mlynczak, Martin G.↗

NASA NTRS2021

Mars Exploration Rovers EDL Trajectory and Atmosphere Reconstruction using NewSTEP

This document describes the trajectory and atmosphere reconstruction of the Mars Exploration Rovers (Spirit and Opportunity) Entry, Descent, and Landing using the New Statistical Trajectory Estimation Program. The approach utilizes a Kalman filter to blend inertial measurement unit data with initial conditions and radar altimetry to obtain the inertial trajectory of the entry vehicle. The nominal aerodynamic database is then used in combination with the sensed accelerations to obtain estimates of the atmosphere-relative state. The reconstructed atmosphere profile is then blended with pre-flight models to construct an estimate of the as-flown atmosphere.

EDL↗

NASA NTRSDate not supplied

Oregon Wildfires: Integrating ECOSTRESS to Map & Analyze Vegetation Moisture for Wildfire Modeling

Wildfire season in the western USA is starting earlier and gaining in intensity. The Bootleg Fire in Southern Oregon began on July 6th, 2021, and burned over 1675 km2 before it was fully contained on August 15th, 2021. Evapotranspiration (ET) is one indicator of vegetation moisture and there is interest in using high-resolution ET products from ECOsystem and Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) in future wildfire modeling. In partnership with the Pacific Northwest National Laboratory and US Forest Service, the team examined ECOSTRESS ET for the two years before the Bootleg Fire and assessed the relationship between ET, topography, and vegetation. Remotely sensed data from Shuttle Radar Topography Mission (SRTM) and Global Ecosystem Dynamics Investigation (GEDI) along with ancillary data from the National Land Cover Database (NLCD) and Landscape Fire Resource Management Planning Tools (LANDFIRE) were incorporated. The team examined data in relation to soil burn severity from the Burned Area Emergency Response (BAER) program. From ET median composites for April 1st – July 5th, 2021 and 2019, the Bootleg Fire area showed a 7 mm/day decrease in ET and a relative 75% decrease in ET between 2019 and 2021. Approximately 6% of the Bootleg Fire area was identified as having a high soil burn severity and these areas were found predominantly in the evergreen forest land cover class and northward facing slopes with a mean ET decrease of 3 mm/day between 2019 and 2021. The team also analyzed ECOSTRESS Water Use Efficiency products as an additional vegetation moisture indicator of pre-fire conditions in the study area. The end products will allow the partners to assess if higher resolution vegetation moisture datasets from ECOSTRESS will improve wildfire modeling for other susceptible areas.

Brenna Hatch↗

NASA NTRSDate not supplied

Future Improvements to Impact for Long Duration Exploration Spaceflight

BACKGROUND: While NASA currently uses the Integrated Medical Model (IMM) to model spaceflight medical risk for Low Earth Orbit missions, IMPACT (Informing Mission Planning via Analysis of Complex Tradespaces) was created to improve the fidelity of medical risk analysis for exploration missions involving the Lunar surface and beyond. OVERVIEW: While completion work continues on the initial version of the IMPACT tool, work has already begun to investigate ways to further enhance the fidelity of the model and its utility to stakeholders. DISCUSSION: Future additions leveraging the more robust and flexible IMPACT architecture include analyzing mission segments to account for segment-specific environments (ie. Lunar surface or microgravity), clinically tracible outcomes based on partial treatment of conditions, the ability to model mission outcomes based on provider Knowledge, Skills, and Abilities (KSAs), and the ability to affect the incidence of conditions based on the occurrence of related conditions (e.g. UTI progressing to sepsis). IMPACT also enables the addition of new conditions to its database as required to meet future risk assessment needs. Ultimately, the desire is to broaden IMPACT from a tool that models/trades medical risk to one that does so for all crew health and performance relevant systems (e.g., food, exercise, etc.).

E Stratton↗

DOE OSTI2021

Intervening alcohol marketing to reduce harmful alcohol use and lessons learned from the theory of changes: Case studies in Thailand

Objectives Globally, the burden of disease caused by alcohol use has been steadily increasing, including in Thailand. In this study, we aim to test the effectiveness of Anderson et al.‘s suggested three approaches to change the collective social norms, which comprise of: (1) providing information and an understanding about alcohol use behaviour, its causes and distribution; (2) focusing strategies on groups rather than individuals; and (3) strengthening supportive laws, regulations and approaches. Study design We employed a mixed-methods approach. Evidence was gathered from literature review and in-depth interviews with key individuals who are responsible for community-based interventions to alcohol marketing strategies in Thailand. Methods We chose to focus on two case studies in Nan and Surin provinces, where hospital-based longitudinal data (8 years) were available. Changes in casualties related to the harmful use of alcohol, resulting from interactions between community-based interventions and alcohol marketing during the time of annual festivals were investigated. We employed the theory of change (ToC) defined by Vogel to guide the data collection and analysis. We reviewed literature from online databases and grey literature to generate causal-loop diagrams. Results We created a causal-loop diagram to describe the complexity of harmful alcohol use, its related factors, context, interventions and outcomes. Over the decade between 2006 and 2015, community-based strategies led to a substantial reduction of casualties (initially a 50% reduction, rising to an 80–90% reduction by the end of the study period) during the time of the festivals. Conclusions The reduction in injuries and fatalities could be a result of the concerted actions, including legal sanctions of alcohol beverage sales and advertisement, and public education to raise awareness and impart knowledge of the harmful use of alcohol. The actions were organised by a coalition of civil society, health professionals, public authorities and community leaders using hospital-based data on the adverse effects of harmful alcohol use to mobilise political support at the provincial level. The availability of long-term financial support as a catalytic source of funds and the presence of a comprehensive alcohol control act enabled framing and mobilisation of local resources and political support.

60 APPLIED LIFE SCIENCES↗

NASA NTRS1987

The development of a prototype intelligent user interface subsystem for NASA's scientific database systems

The National Space Science Data Center (NSSDC) has initiated an Intelligent Data Management (IDM) research effort which has as one of its components the development of an Intelligent User Interface (IUI).The intent of the latter is to develop a friendly and intelligent user interface service that is based on expert systems and natural language processing technologies. The purpose is to support the large number of potential scientific and engineering users presently having need of space and land related research and technical data but who have little or no experience in query languages or understanding of the information content or architecture of the databases involved. This technical memorandum presents prototype Intelligent User Interface Subsystem (IUIS) using the Crustal Dynamics Project Database as a test bed for the implementation of the CRUDDES (Crustal Dynamics Expert System). The knowledge base has more than 200 rules and represents a single application view and the architectural view. Operational performance using CRUDDES has allowed nondatabase users to obtain useful information from the database previously accessible only to an expert database user or the database designer.

Campbell, William J.↗

DOE OSTI2021

Survival of Snow in the Melting Layer: Relative Humidity Influence

This study quantifies how far snow can fall into the melting layer (ML) before all snow has melted by examining a combination of in-situ observations from aircraft measurements in Lagrangian spiral descents from above through the ML and descents and ascents into the ML, as well as an extensive database of NOAA surface observer reports during the past 50 years. The airborne data contain information on the particle phase (solid, mixed, or liquid), population size distributions and shapes, along with temperature, relative humidity, and vertical velocity. A wide range of temperatures and ambient relative humidities are used for both the airborne and ground-based data. It is shown that an ice bulb temperature of 0°C, together with the air temperature and pressure (altitude), are good first order predictors of the highest temperature snowflakes can survive in the melting layer before completely melting. Particle size is also important, as is whether the particles are graupel or hail. If the relative humidity is too low, the particles will sublimate completely as they fall into the melting layer. Snow as warm as +7°C is observed from aircraft measurements and surface observations. Snow pellets survive to even warmer temperatures. Relationships are developed to represent the primary findings.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

NASA NTRS2002

A Data Management System for International Space Station Simulation Tools

Groups associated with the design, operational, and training aspects of the International Space Station make extensive use of modeling and simulation tools. Users of these tools often need to access and manipulate large quantities of data associated with the station, ranging from design documents to wiring diagrams. Retrieving and manipulating this data directly within the simulation and modeling environment can provide substantial benefit to users. An approach for providing these kinds of data management services, including a database schema and class structure, is presented. Implementation details are also provided as a data management system is integrated into the Intelligent Virtual Station, a modeling and simulation tool developed by the NASA Ames Smart Systems Research Laboratory. One use of the Intelligent Virtual Station is generating station-related training procedures in a virtual environment, The data management component allows users to quickly and easily retrieve information related to objects on the station, enhancing their ability to generate accurate procedures. Users can associate new information with objects and have that information stored in a database.

Betts, Bradley J.↗

DOE OSTI2023

Exposing new taxonomic variation with inflammation — a murine model-specific genome database for gut microbiome researchers

The murine CBA/J mouse model widely supports immunology and enteric pathogen research. This model has illuminated Salmonella interactions with the gut microbiome since pathogen proliferation does not require disruptive pretreatment of the native microbiota, nor does it become systemic, thereby representing an analog to gastroenteritis disease progression in humans. Despite the value to broad research communities, microbiota in CBA/J mice are not represented in current murine microbiome genome catalogs. Here we present the first microbial and viral genomic catalog of the CBA/J murine gut microbiome. Using fecal microbial communities from untreated and Salmonella-infected, highly inflamed mice, we performed genomic reconstruction to determine the impacts on gut microbiome membership and functional potential. From high depth whole community sequencing (~ 42.4 Gbps/sample), we reconstructed 2281 bacterial and 4516 viral draft genomes. Salmonella challenge significantly altered gut membership in CBA/J mice, revealing 30 genera and 98 species that were conditionally rare and unsampled in non-inflamed mice. Additionally, inflamed communities were depleted in microbial genes that modulate host anti-inflammatory pathways and enriched in genes for respiratory energy generation. Our findings suggest decreases in butyrate concentrations during Salmonella infection corresponded to reductions in the relative abundance in members of the Alistipes. Strain-level comparison of CBA/J microbial genomes to prominent murine gut microbiome databases identified newly sampled lineages in this resource, while comparisons to human gut microbiomes extended the host relevance of dominant CBA/J inflammation-resistant strains. This CBA/J microbiome database provides the first genomic sampling of relevant, uncultivated microorganisms within the gut from this widely used laboratory model. Using this resource, we curated a functional, strain-resolved view on how Salmonella remodels intact murine gut communities, advancing pathobiome understanding beyond inferences from prior amplicon-based approaches. Salmonella-induced inflammation suppressed Alistipes and other dominant members, while rarer commensals like Lactobacillus and Enterococcus endure. The rare and novel species sampled across this inflammation gradient advance the utility of this microbiome resource to benefit the broad research needs of the CBA/J scientific community, and those using murine models for understanding the impact of inflammation on the gut microbiome more generally.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2021

Novel compound heterozygous CPLANE1 variants identified in a Chinese family with Joubert syndrome

Abstract Joubert syndrome (JS) and JS‐related disorders (JSRD) are a group of neurodevelopmental diseases that share the “molar tooth sign” on axial brain magnetic resonance imaging (MRI), accompanied by cerebellar vermis hypoplasia, ataxia, hypotonia, and developmental delay. To identify variants responsible for the clinical symptoms of a Chinese family with JS and to explore the genotype–phenotype associations, we conducted a series of clinical examinations, including blood tests, brain MRI scans, ultrasound imaging, and ophthalmologic examination. Genomic DNA was extracted from the peripheral blood of the six‐person family, and the pathogenic variants were detected by whole‐exome sequencing (WES) and verified by Sanger sequencing. WES revealed two novel compound heterozygous variants in CPLANE1 : c.1270C>T (p.Arg424*) in exon 10 and c.8901C>A (p.Tyr2967*) in exon 48 of one child, inherited from each parent. Both variants were absent in ethnically matched Chinese control individuals and were either absent or present at very low frequencies in public databases, suggesting that these variants could be the pathogenic triggers of the JS phenotype. Notably, these CPLANE1 sequence variants were related to the pathogenesis of autosomal recessive JS in this study. The newly discovered variants expand the mutation spectrum of CPLANE1 , which assists in understanding the molecular mechanism underlying JS and improving the recognition of genetic counseling, particularly for families with a history of autosomal recessive JS.

Zhang, Cheng↗

DOE OSTI2022

MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses

Complex morphological traits are the product of many genes with transient or lasting developmental effects that interact in anatomical context. Mouse models are a key resource for disentangling such effects, because they offer myriad tools for manipulating the genome in a controlled environment. Unfortunately, phenotypic data are often obtained using laboratory-specific protocols, resulting in self-contained datasets that are difficult to relate to one another for larger scale analyses. To enable meta-analyses of morphological variation, particularly in the craniofacial complex and brain, we created MusMorph, a database of standardized mouse morphology data spanning numerous genotypes and developmental stages, including E10.5, E11.5, E14.5, E15.5, E18.5, and adulthood. To standardize data collection, we implemented an atlas-based phenotyping pipeline that combines techniques from image registration, deep learning, and morphometrics. Alongside stage-specific atlases, we provide aligned micro-computed tomography images, dense anatomical landmarks, and segmentations (if available) for each specimen (N = 10,056). Our workflow is open-source to encourage transparency and reproducible data collection.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS2015

High-Latitude Topside Ionospheric Vertical Electron-Density-Profile Changes in Response to Large Magnetic Storms

Large magnetic-storm induced changes have been detected in high-latitude topside vertical electron-density profiles Ne(h). The investigation was based on the large database of topside Ne(h) profiles and digital topside ionograms from the International Satellites for Ionospheric Studies (ISIS) program available from the NASA Space Physics Data Facility (SPDF) at http://spdf.gsfc.nasa.gov/isis/isis-status.html. This large database enabled Ne(h) profiles to be obtained when an ISIS satellite passed through nearly the same region of space before, during, and after a major magnetic storm. A major goal was to relate the magnetic-storm induced high-latitude Ne(h) profile changes to solar-wind parameters. Thus an additional data constraint was to consider only storms where solar-wind data were available from the NASA/SPDF OMNIWeb database. Ten large magnetic storms (with Dst less than -100 nT) were identified that satisfied both the Ne(h) profile and the solar-wind data constraints. During five of these storms topside ionospheric Ne(h) profiles were available in the high-latitude northern hemisphere and during the other five storms similar ionospheric data were available in the southern hemisphere. Large Ne(h) changes were observed during each one of these storms. Our concentration in this paper is on the northern hemisphere. The data coverage was best for the northern-hemisphere winter. Here Ne(h) profile enhancements were always observed when the magnetic local time (MLT) was between 00 and 03 and Ne(h) profile depletions were always observed between 08 and 10 MLT. The observed Ne(h) deviations were compared with solar-wind parameters, with appropriate time shifts, for four storms.

solar wind↗

NASA NTRS1994

Space flight risk data collection and analysis project: Risk and reliability database

The focus of the NASA 'Space Flight Risk Data Collection and Analysis' project was to acquire and evaluate space flight data with the express purpose of establishing a database containing measurements of specific risk assessment - reliability - availability - maintainability - supportability (RRAMS) parameters. The developed comprehensive RRAMS database will support the performance of future NASA and aerospace industry risk and reliability studies. One of the primary goals has been to acquire unprocessed information relating to the reliability and availability of launch vehicles and the subsystems and components thereof from the 45th Space Wing (formerly Eastern Space and Missile Command -ESMC) at Patrick Air Force Base. After evaluating and analyzing this information, it was encoded in terms of parameters pertinent to ascertaining reliability and availability statistics, and then assembled into an appropriate database structure.

Source record↗

DOE OSTI2023

Dataset of theoretical multinary perovskite oxides

Perovskite oxides (ternary chemical formula ABO 3 ) are a diverse class of materials with applications including heterogeneous catalysis, solid-oxide fuel cells, thermochemical conversion, and oxygen transport membranes. However, their multicomponent (chemical formula $A_xA^{'}_{1-x}B_yB^{'}_{1-y}O_3$) chemical space is underexplored due to the immense number of possible compositions. To expand the number of computed $A_xA^{'}_{1-x}B_yB^{'}_{1-y}O_3$ compounds we report a dataset of 66,516 theoretical multinary oxides, 59,708 of which are perovskites. First, 69,407 $A_{0.5}A^{'}_{0.5}B_{0.5}B^{'}_{0.5}O_3$ compositions were generated in the a - b + a - Glazer tilting mode using the computationally-inexpensive Structure Prediction and Diagnostic Software (SPuDS) program. Next, we optimized these structures with density functional theory (DFT) using parameters compatible with the Materials Project (MP) database. Our dataset contains these optimized structures and their formation (ΔH f ) and decomposition enthalpies (ΔH d ) computed relative to MP tabulated elemental references and competing phases, respectively. This dataset can be mined, used to train machine learning models, and rapidly and systematically expanded by optimizing more SPuDS-generated $A_{0.5}A^{'}_{0.5}B_{0.5}B^{'}_{0.5}O_3$ perovskite structures using MP-compatible DFT calculations.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2020

Topological Analysis of The SPOKE Graph

The SPOKE graph [2, 6] is a sparse decorated semantic graph representing a collection of knowledge collected in many scientific databases from the fields of healthcare, biochemistry, chemistry, biology, et cetera. This knowledge graph is stored as a relational dataset decorated with metadata on each constituent vertex and edge. Formally, the graph is G(V, E, D), where V is a set of n vertices V := {1, ..., n} and edges of the form (i, j) ϵ E for i, j ϵ V, and table D that for any item in V υ E stores unstructured data such as vertex/edge type, nature of a relationship, et cetera. D(i) = {data involving vertex i ϵ V}, and D(i, j) = {data involving edge (i, j) ϵ E}. Here, we treat the graph as undirected in the sense that a direct relationship for (i, j) causes a (possibly opposite) reverse direct relationship for (j, i). The SPOKE graph G(V, E, D) is formed by processing a collection of relational datasets from medicine, chemistry, and biology, connecting many entities. Here, we analyze an instance from 2019, Spoke-20190707, where a graph file contains 6.16M edges and associated metadata and a vertex file contains 2.15M vertices and the associated metadata. There are 12 different types of vertex entities; all edge types used are implicit (see §2). There is other metadata in D on edges and vertices, but we just use the topology and the vertex labels in this report. SPOKE is growing as more knowledge is gained and more datasets are added. SPOKE is likely to grow 10x during the next phase of this project, and we therefore would like to consider topoligical analysis techniques that are scalable to several orders of magnitude larger than the current dataset (say >1B edges).

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS1995

Tests and consequences of disk plus halo models of gamma-ray burst sources

The gamma-ray burst observations made by the Burst and Transient Source Experiment (BATSE) and by previous experiments are still consistent with a combined Galactic disk (or Galactic spiral arm) plus extended Galactic halo model. Testable predictions and consequences of the disk plus halo model are discussed here; tests performed on the expanded BATSE database in the future will constrain the allowed model parameters and may eventually rule out the disk plus halo model. Using examples, it is shown that if the halo has an appropriate edge, BATSE will never detect an anisotropic signal from the halo of the Andromeda galaxy. A prediction of the disk plus halo model is that the fraction of the bursts observed to be in the 'disk' population rises as the detector sensitivity improves. A careful reexamination of the numbers of bursts in the two populations for the pre-BATSE databases could rule out this class of models. Similarly, it is predicted that different satellites will observe different relative numbers of bursts in the two classes for any model in which there are two different spatial distribiutions of the sources, or for models in which there is one spatial distribution of the sources that is sampled to different depths for the two classes. An important consequence of the disk plus halo model is that for the birthrate of the halo sources to be small compared to the birthrate of the disk sources, it is necessary for the halo sources to release many orders of magnitude more energy over their bursting lifetime than the disk sources. The halo bursts must also be much more luminous than the disk bursts; if this disk-halo model is correct, it is necessary to explain why the disk sources do not produce halo-type bursts.

Smith, I. A.↗