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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 595 records · Page 33
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

RMEM-REMOTE MEMORY

RMEM - a prototyping platform to explore the usage of RMA-based strategies in GPU-to-GPU communication. The implementation relies on libfabric (BSD-2 or GNUv2) to explore different synchronization approach and their associated performance. It is compatible with different network technologies such as InfiniBand, SlingShot-11, and TCP. It provides to the user host-to-host and device-to-device communication. The latter can be initiated either from the host, or from the device.

Gillis, Thomas↗
DOE OSTI2021

The role of memory in non-genetic inheritance and its impact on cancer treatment resistance

Intra-tumour heterogeneity is a leading cause of treatment failure and disease progression in cancer. While genetic mutations have long been accepted as a primary mechanism of generating this heterogeneity, the role of phenotypic plasticity is becoming increasingly apparent as a driver of intra-tumour heterogeneity. Consequently, understanding the role of this plasticity in treatment resistance and failure is a key component of improving cancer therapy. We develop a mathematical model of stochastic phenotype switching that tracks the evolution of drug-sensitive and drug-tolerant subpopulations to clarify the role of phenotype switching on population growth rates and tumour persistence. By including cytotoxic therapy in the model, we show that, depending on the strategy of the drug-tolerant subpopulation, stochastic phenotype switching can lead to either transient or permanent drug resistance. We study the role of phenotypic heterogeneity in a drug-resistant, genetically homogeneous population of non-small cell lung cancer cells to derive a rational treatment schedule that drives population extinction and avoids competitive release of the drug-tolerant sub-population. This model-informed therapeutic schedule results in increased treatment efficacy when compared against periodic therapy, and, most importantly, sustained tumour decay without the development of resistance.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2024

Magnetic shape memory alloy Ni45Co5Mn36.6In13.4 measured on ARCS at 300 K and 450 K

These sqw files were generated by combining all of the individual crystal angles scans using the HORACE software package (https://pace-neutrons.github.io/Horace/unstable/user_guide/Getting_started.html). The neutron incident energy for both temperatures was 50 meV. The file labeled 50meV_450K_All.sqw is the 450 K data and the file labeled 50meV_RT_All.sqw is for the 300 K data. The crystal was oriented such that HHL is in the scattering plane.

excitations↗
DOE OSTI2024

Strain glass state of magnetic shape memory alloy Ni45Co5Mn36.6In13.4 measured on ARCS at 300 K

Combined inelastic neutron scattering data from ARCS on the strain glass state of Ni45Co5Mn36.6In13.4 measured at 300 K. Crystal was oriented with HHL in the scattering plane. To obtain a large Q-E volume the crystal was rotated in the beam and the individual angles were combined using the HORACE software package (https://pace-neutrons.github.io/Horace/unstable/user_guide/Getting_started.html).

excitations↗
DOE OSTI2024

Strain glass state of magnetic shape memory alloy Ni45Co5Mn36.6In13.4 measured on SEQUOIA at 5 K

Combined inelastic neutron scattering data from SEQUOIA on the strain glass state of Ni45Co5Mn36.6In13.4 measured at 5 K. Crystal was oriented with HHL in the scattering plane. To obtain a large Q-E volume the crystal was rotated in the beam and the individual angles were combined using the HORACE software package (https://pace-neutrons.github.io/Horace/unstable/user_guide/Getting_started.html).

excitations↗