A digital parameter-identification technique applied to biological signals
Arterial circulatory system parameter identification from diastolic blood pressure curves by digital filter techniques
Burrus, C. S.↗
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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Blood gases in hibernating and active ground squirrels - HbO2 affinity at 6 and 38 C
Venous and arterial blood gases in hibernating and normothermic ground squirrels, showing venous oxygen and carbon dioxide partial pressures reduction in hibernation
Musacchia, X. J.↗
Experimental high performance heat pipes for the OAO-C spacecraft
Design and performance testing of arterial wick circular heat pipes for OAO-C spacecraft
Bienert, W.↗
Action of pharmacologic agents in experimental cardiac tamponade
Isoproterenol, atrial pacing, ouabain and methoxamine effects on dogs during experimental cardiac tamponade, observing arterial pressure, cardiac output and heart rate changes
Finegan, R. E.↗
Electronic circuit detects left ventricular ejection events in cardiovascular system
Electronic circuit processes arterial blood pressure waveform to produce discrete signals that coincide with beginning and end of left ventricular ejection. Output signals provide timing signals for computers that monitor cardiovascular systems. Circuit operates reliably for heart rates between 50 and 200 beats per minute.
Gebben, V. D.↗
Automated analysis of blood pressure measurements (Korotkov sound)
Automatic system for noninvasive measurements of arterial blood pressure is described. System uses Korotkov sound processor logic ratios to identify Korotkov sounds. Schematic diagram of system is provided to show components and method of operation.
Golden, D. P.↗
Study of a heat rejection system using capillary pumping
Results of an analytical study investigating the application of capillary pumping to the heat rejection loop of an advanced Rankine cycle power conversion system are presented. The feasibility of the concept of capillary pumping as an alternate to electromagnetic pumping is analytically demonstrated. Capillary pumping is shown to provide a potential for weight and electrical power saving and reliability through the use of redundant systems. A screen wick pump design with arterial feed lines was analytically developed. Advantages of this design are high thermodynamic and hydrodynamic efficiency, which provide a lightweight easily packaged system. Operational problems were identified which must be solved for successful application of capillary pumping. The most important are the development of start up and shutdown procedures, and development of a means of keeping noncondensibles from the system and of earth-bound testing procedures.
Neal, L. G.↗
Application of various elastic thin shell theories to blood flow problems
Some existing theories, on elastic thin shells, are reviewed to ascertain their influence on the computation of phase velocities in fluid filled cylinders representing certain aspects of the behavior of arteries and veins in vivo. For physiologically meaningful parameters, including moderately large in plane prestrain that occurs in mammals, the results suggest that with one exception, the small differences in the formulations exercise little influence on the phase velocities. However, it is demonstrated that inclusion of the forces induced by the rotation of the hydrostatic pressure is essential or significantly erroneous torsional wave speeds result. Also the introduction of moderate implane prestrains that are present in living mammals is shown to lead to nonselfadjoint differential equations of motion, whose biorthogonal eigenvectors differ slightly from each other.
Source record↗
Design of a specialized computer for on-line monitoring of cardiac stroke volume
The design of a specialized analog computer for on-line determination of cardiac stroke volume by means of a modified version of the pressure pulse contour method is presented. The design consists of an analog circuit for computation and a timing circuit for detecting necessary events on the pressure waveform. Readouts of arterial pressures, systolic duration, heart rate, percent change in stroke volume, and percent change in cardiac output are provided for monitoring cardiac patients. Laboratory results showed that computational accuracy was within 3 percent, while animal experiments verified the operational capability of the computer. Patient safety considerations are also discussed.
Webb, J. A., Jr.↗
Pressure ramp programmer; IMBLMS Phase B4 Additional Tasks: Task 3.0 pressure ramp programmer
A pressure ramp programmer model was designed, fabricated and tested. This model, in conjunction with an automatic blood pressure monitor, automatically controls the pressure in the blood pressure monitor arterial cuff. The cuff pressurization cycle is designed to maximize accuracy and repeatability of blood pressure measurements. The key feature of this automatic cycle is rapid blood pressure cuff bleed down from an initial setting until systolic (diastolic) pressure is encountered followed by a short repressurization and slow bleed, long enough to permit accurate systolic (diastolic) pressure determination. The system includes a pressure reservoir which bleeds the cuff through a precision needle valve; a solenoid valve which permits rapid pressurization from the reservoir; and a pressure sensor which provides information for bleed rate and set point controls. Korotkoff sound signals from a microphone in the blood pressure cuff (not part of the system) provide decision information to the digital control system. The system completed a series of engineering tests using simulated Korotkoff sound inputs. The system performed successfully in all cases and was stable over an extended period of time.
Fogal, G. L.↗
Effect of neck warming and cooling on thermal comfort
The potential use of local neck cooling in an area superficial to the cerebral arteries was evaluated by circulating cold or hot water through two copper disks held firmly against the neck. Subjective responses indicated that neck cooling improves the thermal comfort in a hot environment.
Williams, B. A.↗
Factors involved in the antinatriuretic effects of acute constriction of the thoracic and abdominal inferior vena cava.
Study of the antinatriuretic effect of acute thoracic inferior vena cava (TIVC) constriction in the absence of alterations in renal perfusion pressure. A comparison is made of the effects of equivalent degrees of TIVC and abdominal inferior vena cava constriction on arterial pressure, renal hemodynamics, and electrolyte excretion.
Schrier, R. W.↗
Splanchnic vasoconstriction in hyperthermic man - Role of falling blood pressure.
Results of a study in which six supine resting subjects, wearing water-perfused suits, had body skin temperature controlled at 35 C for 30 min (control period), then rapidly increased to 40.5 C for 43 to 50 min (heating period) in a two-part experiment. In the first part of the experiment arterial mean pressure (MP) in three men was increased back to, or above control levels at the 30 to 35th min of heating by total occlusion of both legs for 8 to 10 min. Splanchnic blood flow (SBF), which had fallen from 1.4 to 0.9 L/min at occlusion, rose only 0.05 L/min during occlusion. Splanchnic vascular resistance (SVR) rose throughout heating and occlusion. In the second part of the experiment (three men) SBF fell despite a spontaneous rise in MP and aortic pulse pressure prior to leg occlusion. Cardiac output (CO) was measured just before, during and after occlusion. Occlusion raised MP 10 to 15 mm Hg and reduced CO only slightly. It is concluded that falling MP or aortic pulse pressure are not major causes of the splanchnic vasoconstriction in response to heating man.
Rowell, L. B.↗
Effects of viscosity and constraints on the dispersion and dissipation of waves in large blood vessels. I.
Investigation of the effects of blood viscosity on dissipation as well as dispersion of small waves in arteries and veins by means of a parametric study. A linearized analysis of axisymmetric waves in a cylindrical membrane that contains a viscous fluid indicates that there are two families of waves: a family of slow waves and one of fast waves. The faster waves are shown to be more sensitive to variations in the elastic properties of the medium surrounding the blood vessels and at high values of the frequency parameter alpha. At low values of alpha the effects of viscosity on attenuation are reversed.
Jones, E.↗
Circulatory responses to hypoxia in experimental myocardial infarction.
Three levels of decreased arterial oxygen saturation elicited a graded circulatory response in dogs, manifested by stepwise increases in cardiac output, left ventricular dp/dt, and stroke volume, and decreases in systemic vascular resistance. Responses to similar hypoxia challenges after experimental myocardial infarction were qualitatively similar but quantitatively less. Although the circulatory compensation for hypoxia was less effective after myocardial infarction, no further deterioration of the haemodynamics was noted.
Schroll, M.↗
Importance of the splanchnic vascular bed in human blood pressure regulation.
Three-part experiment in which five subjects were exposed to lower body negative pressure (LBNP) at -50 mm Hg below the iliac crests. Duration of LBNP to earliest vagal symptoms was 7 to 21 min; all data are expressed as changes from control period to the last measurements before these symptoms. In part I, forearm blood flow (by Whitney gauge) fell 45% during LBNP. In part II, splanchnic blood flow (from arterial clearance hepatic extraction of indocyanine green) fell 32% and splanchnic vascular resistance rose 30%. In part III, cardiac output fell 28%, stroke volume 51%, and central blood volume 21%. Total peripheral resistance and heart rate rose 19% and 52%. Of the reduction in total vascular conductance, decreased splanchnic conductance accounted for approximately 33%; skin plus muscle conductance decreased similarly.
Rowell, L. B.↗
Action of acetylstrophanthidin on experimental myocardial infarction.
An experimental animal model with acute myocardial infarction of a size insufficient to produce profound heart failure or shock was used to study the effects of acute infarction on digitalis tolerance and the hemodynamic changes produced by moderate and large doses of acetylstrophanthidin. With acute myocardial infarction, digitalis toxic arrhythmias could be precipitated with significantly lower doses of digitalis than in animals without myocardial infarction. There was no precise correlation between the size of infarction and the toxic dose of glycoside. Coronary artery ligation produced a stable but relatively depressed circulatory state, as evidenced by lowered cardiac output and stroke volume and elevated systemic vascular resistance and left atrial mean pressure. When digitalis was infused, the following significant changes were observed at nontoxic doses: (1) elevation of aortic and left ventricular pressures; (2) further decline in cardiac output; and (3) decreased left atrial mean pressure.
Nola, G. T.↗
Development of a thermal diode heat pipe for the advanced thermal control flight experiment /ATFE/.
Description of the analysis, design, fabrication, and test of the engineering model of the ATFE diode. Included is a review of several diode concepts that led to selection of the liquid blockage technique for shut-off. The diode is made of stainless steel, 26 in. long, 0.375-in. nominal OD, with self-filling spiral artery wick and ammonia working fluid. In the normal heat pipe mode, at ambient temperatures, the diode capacity is 85 W. For flight, the pipe will deliver 20 W with a 9 F temperature difference between the external evaporator and condenser surfaces. Reverse mode conduction is less than 1.5 W with a 260 F temperature difference.
Swerdling, B.↗