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At least 577 records · Page 32

Assessment of internal mammary artery and saphenous vein graft patency and flow reserve using transthoracic Doppler echocardiography

OBJECTIVE: To investigate transthoracic Doppler echocardiography in the identification of coronary artery bypass graft (CABG) flow for assessing graft patency. DESIGN: The initial study group comprised 45 consecutive patients with previous CABG undergoing elective cardiac catheterisation for recurrent ischaemia. The Doppler variables best correlated with angiographic graft patency were then tested prospectively in a further 84 patients (test group). SETTING: Three tertiary referral centres. INTERVENTIONS: Flow velocities in grafts were recorded at rest and during hyperaemia induced by dipyridamole (0.56 mg/kg/4 min), under the guidance of transthoracic colour Doppler flow mapping. Findings on transthoracic Doppler were compared with angiography. MAIN OUTCOME MEASURES: Feasibility of identifying open grafts by Doppler and diagnostic accuracy for Doppler detection of significant (>/= 70%) graft stenosis. RESULTS: In the test group the identification rate for mammary artery grafts was 100%, for saphenous vein grafts to left anterior descending coronary artery 91%, for vein grafts to right coronary artery 96%, and for vein grafts to circumflex artery 90%. Coronary flow reserve (the ratio between peak diastolic velocity under hyperaemia and at baseline) of < 1.9 (95% confidence interval 1.83 to 2.08) had 100% sensitivity, 98% specificity, 87.5% positive predictive value, and 100% negative predictive value for mammary artery graft stenosis. Coronary flow reserve of < 1.6 (95% CI 1.51 to 1.73) had 91% sensitivity, 87% specificity, 85.4% positive predictive value, and 92.3% negative predictive value for significant vein graft stenosis. CONCLUSIONS: Transthoracic Doppler can provide non-invasive assessment of CABG patency.

Multicenter Study↗

Neural Networks for Rapid Design and Analysis

Artificial neural networks have been employed for rapid and efficient dynamics and control analysis of flexible systems. Specifically, feedforward neural networks are designed to approximate nonlinear dynamic components over prescribed input ranges, and are used in simulations as a means to speed up the overall time response analysis process. To capture the recursive nature of dynamic components with artificial neural networks, recurrent networks, which use state feedback with the appropriate number of time delays, as inputs to the networks, are employed. Once properly trained, neural networks can give very good approximations to nonlinear dynamic components, and by their judicious use in simulations, allow the analyst the potential to speed up the analysis process considerably. To illustrate this potential speed up, an existing simulation model of a spacecraft reaction wheel system is executed, first conventionally, and then with an artificial neural network in place.

Sparks, Dean W., Jr.↗

Oxygen desaturations triggered by partial seizures: implications for cardiopulmonary instability in epilepsy

PURPOSE: The occurrence of hypoxemia in adults with partial seizures has not been systematically explored. Our aim was to study in detail the temporal dynamics of this specific type of ictal-associated hypoxemia. METHODS: During long-term video/EEG monitoring (LTM), patients underwent monitoring of oxygen saturation using a digital Spo2 (pulse oximeter) transducer. Six patients (nine seizures) were identified with oxygen desaturations after the onset of partial seizure activity. RESULTS: Complex partial seizures originated from both left and right temporal lobes. Mean seizure duration (+/-SD) was 73 +/- 18 s. Mean Spo2 desaturation duration was 76 +/- 19 s. The onset of oxygen desaturation followed seizure onset with a mean delay of 43 +/- 16 s. Mean (+/-SD) Spo2 nadir was 83 +/- 5% (range, 77-91%), occurring an average of 35 +/- 12 s after the onset of the desaturation. One seizure was associated with prolonged and recurrent Spo2 desaturations. CONCLUSIONS: Partial seizures may be associated with prominent oxygen desaturations. The comparable duration of each seizure and its subsequent desaturation suggests a close mechanistic (possibly causal) relation. Spo2 monitoring provides an added means for seizure detection that may increase LTM yield. These observations also raise the possibility that ictal ventilatory dysfunction could play a role in certain cases of sudden unexpected death in epilepsy in adults with partial seizures.

NASA Program Biomedical Research and Countermeasur↗

Improving Performance of the System Safety Function at Marshall Space Flight Center

The Columbia Accident Investigation Board (CAIB) determined that organizational and management issues were significant contributors to the loss of Space Shuttle Columbia. In addition, the CAIB observed similarities between the organizational and management climate that preceded the Challenger accident and the climate that preceded the Columbia accident. To prevent recurrence of adverse organizational and management climates, effective implementation of the system safety function is suggested. Attributes of an effective system safety program are presented. The Marshall Space Flight Center (MSFC) system safety program is analyzed using the attributes. Conclusions and recommendations for improving the MSFC system safety program are offered in this case study.

Kiessling, Ed↗

UV Nebular Absorption in Eta Car and Weigelt D

Coronal Mass Ejections (CMEs) are a spectacular manifestation of solar activity. CMEs typically appear as looplike features that disrupt helmet streamers in the solar corona. They are believed to be the primary cause of large, non-recurrent geomagnetic storms. The goal of our research sponsored by NASA's Supporting Research and Technology Program in Solar Physics is to investigate how the corona evolves to produce these eruptions. In the following sections we describe the work performed under this contract.

Nielsen, K. E.↗

XMM TOO Observation

The primary research goal of this project is to perform follow-up observations of a recurrent ultraluminous supersoft X-ray source (SSS) in Ml0l. The source was first discovered by ROSAT and was confirmed as a SSS with a blackbody temperature of about l00eV by Chandra. During 2000 March, Chandra detected it at Lx=4e39 erg per second, and then in 2000 October, its luminosity dropped to around le39 erg per second. During 2004, Chandra is conducting a monitoring program for Ml0l. The SSS was near the detection limit during January, March, and May; the X-ray spectra were harder with a power-law shape, and the X-ray luminosity was about 3e37 erg/second, a factor of greater than 200 fainter than that in the previous high state. The source was found to be in outburst again during the July 5 observation, with an X-ray luminosity of about 7e39 erg/second. Data taken on July 6,7, and 8 show that the source was in a strong outburst with a peak bolometric luminosity of about 7e39 erg/second. In general, the X-ray spectra are best described with an absorbed blackbody model with temperatures of approximately 50-100eV. In addition, we found absorption edges at 0.33, 0.57, 0.66, and 0.88 keV in two of the high state spectra. These features may signal the presence of highly ionized gas in the vicinity of the accretor (e.g., warm absorber). In order to study an ultraluminous SSS in outburst in detail, we proposed a TOO XMM observation to observe the source. The observation was taken on July 23 and the source was fainter with a luminosity of 6e38 ergs, and a harder X-ray spectrum with a power-law tail seen up to 7 keV. This clearly indicates that the source was in the decline stage with spectral change. In addition to the XMM observation, we also arranged radio observation and a simultaneous CFHT observation. The X-ray results were published in ATel and ApJL. There were several more Chandra observations taken after 2004 July. The source was in a low luminosity state but it underwent another X-ray outburst in 2004 December. We are arranging more follow-up observations for this intriguing source.

Kong, Albert↗

Observations of Soft Gamma Repeaters

Magnetars (Soft Gamma Repeaters and Anomalous X-ray Pulsars) are a subclass of neutron stars characterized by their recurrent X-ray bursts. While in an active (bursting) state (lasting anywhere between days and years), they are emit&ng hundreds of predominantly soft (kT=30 kev), short (0.1-100 ms long) events. Their quiescent source x-ray light ewes exhibit puhlions rotational period rate changes (spin-down) indicate that their magnetic fields are extremely high, of the order of 10^14- 10^l5 G. Such high B-field objects, dubbed "magnetars", had been predicted to exist in 1992, but the first concrete observational evidence were obtained in 1998 for two of these sources. I will discuss here the history of Soft Gamma Repeaters, and their spectral, timing and flux characteristics both in the persistent and their burst emission.

Kouveliotou, Chryssa↗

Aspects of Neutron Star and Black Hole Transients in RXTE Observations

Scans of the the galactic center with the Proportional Counter Array on the Rossi X-ray Timing Explorer have discovered the outbursts of many neutron star and black hole binary transients early in the outbursts. We have had observations during the rise of the transients which allow us to study the spectral and timing characteristics. Some of the transients are also identified as radio sources, with compact cores and jet ejections. A recent example is H 1743-322, a recurrent black hole candidate, in which the ejection of radio emitting plasma is correlated with changes in the spectral characteristics. I will review the properties of black hole transients compare the characteristics of neutron star transients.

Swank, J.↗

Magnetars

"Magnetars (Soft Gamma Repeaters and Anomalous X-ray Pulsars) are a subclass of neutron stars characterized by their recurrent X-ray bursts. While in an active (bursting) state, they are emitting hundreds of predominantly soft (kT=30 keV), short (0.1-100 ms long) events. Active states last anywhere between days and years. Their quiescent source X-ray light curves exhibit pulsations in the narrow range of 5-11 s; estimates of these rotational period rate changes (spin-down) indicate that their magnetic fields are extremely high, of the order of 10^14-10^15 G. Such high B-field objects, dubbed "magnetars", had been predicted to exist in 1992, but the first concrete observational evidence was obtained in 1998 for two of these sources. I will discuss here the recent spectacular results from SGR 1806-20, as well as the history of magnetars, and their spectral, timing and flux characteristics both in the persistent and their burst emission."

Kouveliotou, Chryssa↗

Observations of Soft Gamma Repeaters

Magnetars (Soft Gamma Repeaters and Anomalous X-ray Pulsars) are a subclass of neutron stars characterized by their recurrent X-ray bursts. While in an active (bursting) state (lasting anywhere between days and years), they are emitting hundreds of predominantly soft (kl'=30 kev), short (0.1 - 100 ms long) events. Their quiescent source X-ray light curves exhibit pulsations in the narrow range of 5-1 1 s; estimates of these rotational period rate changes (spin-down) indicate that their magnetic fields are extremely high, of the order of 10A14-10A15 G. Such high B-field objects, dubbed "magnetars", had been predicted to exist in 1992, but the first concrete observational evidence was obtained in 1998 for two of these sources. Very recently, SGR1806-20 emitted a giant flare, which was detected in the radio with a multitude of telescopes under an extensive international campaign. These observations have revealed exciting new results, never seen before in any of the other magnetar sources. I will discuss here these results and their relevance to our understanding of the nature of magnetars.

Kouveliotou, Chryssa↗

INTEGRAL Observations of the Be/X-ray binary EX0 2030+375 During Outburst

We present a type-I outburst of the high-mass X-ray binary EX0 2030+375, detected during INTEGRAL'S Performance and Verification phase in December 2002 (on-source time about 10(exp 6) seconds). In addition, six more outbursts have been observed during INTEGRAL'S Galactic Plane Scans. X-ray pulsations have been detected with a pulse period of 41.691798 plus or minus 0.000016 s. The X-ray luminosity in the 5-300 keV energy range was 9.7 x 10 (exp 36) erg per second, for a distance of 7.1 kpc. Two unusual features were found in the light curve, with an initial peak before the main outburst and another possible spike after the maximum. RXTE observations confirm only the existence of the initial spike. Although the initial peak appears to be a recurrent feature, the physical mechanisms producing it and the possible second spike are unknown. Moreover, a four-day delay between periastron passage and the peak of the outburst is observed. We present for the first time a 5-300 keV broad-band spectrum of this source. It can be modelled by the sum of a disk black body (kT(sub BB) approximately 8 keV) and either with a power law model with Gamma=2.04 plus or minus 0.11 keV or a Comptonized component (spherical geometry, kT(sub e).=30 keV, tau = 2.64, kT(sub w)=1.5 keV).

Arranz, A. Camero↗

A New Variety of CMEs: Streamer Puffs from Compact Ejective Flares

We present SOHO EIT, UVCS and LASCO observations of recurrent (6 --- 8 events per day) narrow (angular widths of about 3 --- 10 degrees) Coronal Mass Ejections (CMEs) which occurred over 2002 November 26--29. The active region where the ejections originate is near the base of a coronal streamer that appears to be unperturbed by the events and keeps stable in time; hence we interpret the observed events as a new class of recursive narrow CMEs that we call "streamer puffs." EIT 304 angstrom (He II) images indicate that the puffs result from compact ejective flares embedded in the streamer, with the ejections from the flares having velocities 100 --- 200 kilometers per second. Most ejections are closely correlated with coronal "jets" seen at 1.7 solar radii in the UVCS data, and a subset of these ejections and jets correspond to streamer puffs observed in LASCO coronagraph images. There are, however, more compact flares and jets than streamer puffs during the observation period, indicating that only a subset of the flare-associated ejections are energetic enough to escape into the heliosphere.

Sterling, Alphonse C.↗

Magnetars

Magnetars (Soft Gamma Repeaters and Anomalous X-ray Pulsars) are a subclass of neutron stars characterized by their recurrent X-ray bursts. While in an active (bursting) state, they are emitting hundreds of predominantly soft (kT=30 keV), short (0.1-100 ms long) events. Active states last anywhere between days and years. Their quiescent source X-ray light curves exhibit pulsations in the narrow range of 5-11 s; estimates of their rotational period rate changes (spin-down) indicate that their magnetic fields are extremely high, of the order of 10^14-10^15 G. Such high B-field objects, dubbed "magnetars", had been predicted to exist in 1992, but the first ccncrete observational evidence was obtained in 1998 for two of these sources. I will discuss here the recent spectacular results from SGR 1806-20, as well as the history of magnetars, and their spectral, timing and flux characteristics both in the persistent and their burst emission.

Kouveliotou, Chryssa↗

X-Ray and Radio Studies of Black Hole X-Ray Transients During Outburst Decay

Black hole (BH) and black hole candidate (BHC) transients are X-ray binary systems that typically undergo bright outbursts that last a couple months with recurrence times of years to decades. For this ADP project, we are studying BH/BHC systems during the decaying phases of their outbursts using the Rossi X-ray Taming Explorer (RXTE), the Chandra X-ray Observatory, and multi-wavelength facilities. These systems usually undergo state transitions as they decay, and our observations are designed to catch the state transitions. The specific goals of this proposal include: 1. To determine the evolution of the characteristic frequencies present in the power spectrum (such as quasi-periodic oscillations, QPOs) during state transitions in order to place constraints on the accretion geometry; 2. To contemporaneously measure X-ray spectral and timing properties along with flux measurements in the radio band to determine the relationship between the accretion disk and radio jets; 3. To extend our studies of X-ray properties of BHCs to very low accretion rates using RXTE and Chandra. The work performed under this proposal has been highly successful, allowing the PI to lead, direct, or assist in the preparation of 7 related publications in refereed journals and 6 other conference presentations or reports. These items are listed below, and the abstracts for the refereed publications have also been included. Especially notable results include our detailed measurements of the characteristic frequencies and spectral parameters of BH/BHCs after the transition to the hard state (see All A3, and A5) and at low flux levels (see A4). Our measurements provide one of the strongest lines of evidence to date that the inner edge of the optically thick accretion disk gradually recedes from the black hole at low flux levels. In addition, we have succeeded in obtaining excellent multi-wavelength coverage of a BH system as its compact jet turned on (see Al). Our results show, somewhat unexpectedly, that the radio jet does not turn on until the hard X-ray emission is well past its peak hard state level, strongly constraining theoretical models for hard X-ray production and the spectrum emitted by the jet. Finally, the X-ray/radio results in A2 led us to propose a general picture about the relationship between jet production and X-ray spectral states .

Tomsick, John A.↗

On the Extraction of Angular Velocity from Attitude Measurements

In this paper we research the extraction of the angular rate vector from attitude information without differentiation, in particular from quaternion measurements. We show that instead of using a Kalman filter of some kind, it is possible to obtain good rate estimates, suitable for spacecraft attitude control loop damping, using simple feedback loops, thereby eliminating the need for recurrent covariance computation performed when a Kalman filter is used. This considerably simplifies the computations required for rate estimation in gyro-less spacecraft. Some interesting qualities of the Kalman filter gain are explored, proven and utilized. We examine two kinds of feedback loops, one with varying gain that is proportional to the well known Q matrix, which is computed using the measured quaternion, and the other type of feedback loop is one with constant coefficients. The latter type includes two kinds; namely, a proportional feedback loop, and a proportional-integral feedback loop. The various schemes are examined through simulations and their performance is compared. It is shown that all schemes are adequate for extracting the angular velocity at an accuracy suitable for control loop damping.

Bar-Itzhack, I. Y.↗

Rigid Body Rate Inference from Attitude Variation

In this paper we research the extraction of the angular rate vector from attitude information without differentiation, in particular from quaternion measurements. We show that instead of using a Kalman filter of some kind, it is possible to obtain good rate estimates, suitable for spacecraft attitude control loop damping, using simple feedback loops, thereby eliminating the need for recurrent covariance computation performed when a Kalman filter is used. This considerably simplifies the computations required for rate estimation in gyro-less spacecraft. Some interesting qualities of the Kalman filter gain are explored, proven and utilized. We examine two kinds of feedback loops, one with varying gain that is proportional to the well known Q matrix, which is computed using the measured quaternion, and the other type of feedback loop is one with constant coefficients. The latter type includes two kinds; namely, a proportional feedback loop, and a proportional-integral feedback loop. The various schemes are examined through simulations and their performance is compared. It is shown that all schemes are adequate for extracting the angular velocity at an accuracy suitable for control loop damping.

Bar-Itzhack, I. Y.↗

Evidence for a Binary Companion to the Enigmatic Compact Central Object 1E 1207.4-5209

Located in the supernova remnant G296.5+10.0, 1E 1207.4-5209 is a 0.424 s period X-ray pulsar that exhibits strong absorption lines in its energy spectrum. The physical origin of the spectral features in 1E 1207.4-5209 and more generally, the absence of similar features in other radio-quiet neutron stars remains a mystery. Another, possibly related, anomalous property of 1E 1207.4-5209 is its non-monotonic spin frequency evolution. Zavlin, Pavlov & Sanwal(2004) proposed that the irregular spin-down was caused by either (i) frequent, recurrent glitches, (ii) the presence of a fall-back disk or (iii) a binary companion. Here, we report on a sequence of seven XMM-Newton observations of 1E 1207.4-5209 performed during a 40 day window between 2005 June 22 and July 3 1. Due to unanticipated phase noise, we identified three statistically-acceptable phase-coherent timing solutions with frequency time derivatives of +0.9, -2.6, and +1.6 x 10-12 Hz/s (listed in descending order of significance). We concluded that the local frequency derivative during our XMM-Newton observing campaign differs from the long-term spin-down rate by more than an order of magnitude. This measurement strongly supports the binary interpretation for the observed spin irregularities in 1E 1207.4-5209. We identified a family of orbital solutions that are consistent with our phase-connected solution as well as all archival data. We will discuss possible orbital solutions, prospects for constraining binary parameters with future observations, and consequences for the nature of 1E 1207.4-5209.

Woods, P. M.↗

Marshall Space Flight Center Propulsion Systems Department (PSD) KM Initiative

NASA Marshall Space Flight Center s Propulsion Systems Department (PSD) is four months into a fifteen month Knowledge Management (KM) initiative to support enhanced engineering decision making and analyses, faster resolution of anomalies (near-term) and effective, efficient knowledge infused engineering processes, reduced knowledge attrition, and reduced anomaly occurrences (long-term). The near-term objective of this initiative is developing a KM Pilot project, within the context of a 3-5 year KM strategy, to introduce and evaluate the use of KM within PSD. An internal NASA/MSFC PSD KM team was established early in project formulation to maintain a practitioner, user-centric focus throughout the conceptual development, planning and deployment of KM technologies and capabilities with in the PSD. The PSD internal team is supported by the University of Alabama's Aging Infrastructure Systems Center Of Excellence (AISCE), Intergraph Corporation, and The Knowledge Institute. The principle product of the initial four month effort has been strategic planning of PSD KM implementation by first determining the "as is" state of KM capabilities and developing, planning and documenting the roadmap to achieve the desired "to be" state. Activities undertaken to support the planning phase have included data gathering; cultural surveys, group work-sessions, interviews, documentation review, and independent research. Assessments and analyses have been performed including industry benchmarking, related local and Agency initiatives, specific tools and techniques used and strategies for leveraging existing resources, people and technology to achieve common KM goals. Key findings captured in the PSD KM Strategic Plan include the system vision, purpose, stakeholders, prioritized strategic objectives mapped to the top ten practitioner needs and analysis of current resource usage. Opportunities identified from research, analyses, cultural/KM surveys and practitioner interviews include: executive and senior management sponsorship, KM awareness, promotion and training, cultural change management, process improvement, leveraging existing resources and new innovative technologies to align with other NASA KM initiatives (convergence: the big picture). To enable results based incremental implementation and future growth of the KM initiative, key performance measures have been identified including stakeholder value, system utility, learning and growth (knowledge capture, sharing, reduced anomaly recurrence), cultural change, process improvement and return-on-investment. The next steps for the initial implementation spiral (focused on SSME Turbomachinery) have been identified, largely based on the organization and compilation of summary level engineering process models, data capture matrices, functional models and conceptual-level systems architecture. Key elements include detailed KM requirements definition, KM technology architecture assessment, evaluation and selection, deployable KM Pilot design, development, implementation and evaluation, and justifying full implementation (estimated Return-on-Investment). Features identified for the notional system architecture include the knowledge presentation layer (and its components), knowledge network layer (and its components), knowledge storage layer (and its components), User Interface and capabilities. This paper provides a snapshot of the progress to date, the near term planning for deploying the KM pilot project and a forward look at results based growth of KM capabilities with-in the MSFC PSD.

Caraccioli, Paul↗