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NASA NTRS1997

Baroreflex regulation of blood pressure during dynamic exercise

From the work of Potts et al. Papelier et al. and Shi et al. it is readily apparent that the arterial (aortic and carotid) baroreflexes are reset to function at the prevailing ABP of exercise. The blood pressure of exercise is the result of the hemodynamic (cardiac output and TPR) responses, which appear to be regulated by two redundant neural control systems, "Central Command" and the "exercise pressor reflex". Central Command is a feed-forward neural control system that operates in parallel with the neural regulation of the locomotor system and appears to establish the hemodynamic response to exercise. Within the central nervous system it appears that the HLR may be the operational site for Central Command. Specific neural sites within the HLR have been demonstrated in animals to be active during exercise. With the advent of positron emission tomography (PET) and single-photon emission computed tomography (SPECT), the anatomical areas of the human brain related to Central Command are being mapped. It also appears that the Nucleus Tractus Solitarius and the ventrolateral medulla may serve as an integrating site as they receive neural information from the working muscles via the group III/IV muscle afferents as well as from higher brain centers. This anatomical site within the CNS is now the focus of many investigations in which arterial baroreflex function, Central Command and the "exercise pressor reflex" appear to demonstrate inhibitory or facilitatory interaction. The concept of whether Central Command is the prime mover in the resetting of the arterial baroreceptors to function at the exercising ABP or whether the resetting is an integration of the "exercise pressor reflex" information with that of Central Command is now under intense investigation. However, it would be justified to conclude, from the data of Bevegard and Shepherd, Dicarlo and Bishop, Potts et al., and Papelier et al. that the act of exercise results in the resetting of the arterial baroreflex. In addition, if, as we have proposed, the cardiopulmonary baroreceptors primarily monitors and reflexly regulates cardiac filling volume, it would seem from the data of Mack et al. and Potts et al. that the cardiopulmonary baroreceptor is also reset at the beginning of exercise. Therefore, investigations of the neural mechanisms of regulation involving Central Command and cardiopulmonary afferents, similar to those being undertaken for the arterial baroreflex, need to be established.

NASA Discipline Cardiopulmonary↗

NASA NTRS1999

A role for cysteine 3635 of RYR1 in redox modulation and calmodulin binding

Oxidation of the skeletal muscle Ca(2+) release channel (RYR1) increases its activity, produces intersubunit disulfide bonds, and blocks its interaction with calmodulin. Conversely, bound calmodulin protects RYR1 from the effects of oxidants (Zhang, J.-Z., Wu, Y., Williams, B. Y., Rodney, G., Mandel, F., Strasburg, G. M., and Hamilton, S. L. (1999) Am. J. Physiol. 276, Cell Physiol. C46-C53). In addition, calmodulin protects RYR1 from trypsin cleavage at amino acids 3630 and 3637 (Moore, C. P., Rodney, G., Zhang, J.-Z., Santacruz-Toloza, L., Strasburg, G. M., and Hamilton, S. L. (1999) Biochemistry 38, 8532-8537). The sequence between these two tryptic sites is AVVACFR. Alkylation of RYR1 with N-ethylmaleimide (NEM) blocks both (35)S-apocalmodulin binding and oxidation-induced intersubunit cross-linking. In the current work, we demonstrate that both cysteines needed for the oxidation-induced intersubunit cross-link are protected from alkylation with N-ethylmaleimide by bound calmodulin. We also show, using N-terminal amino acid sequencing together with analysis of the distribution of [(3)H]NEM labeling with each sequencing cycle, that cysteine 3635 of RYR1 is rapidly labeled by NEM and that this labeling is blocked by bound calmodulin. We propose that cysteine 3635 is located at an intersubunit contact site that is close to or within a calmodulin binding site. These findings suggest that calmodulin and oxidation modulate RYR1 activity by regulating intersubunit interactions in a mutually exclusive manner and that these interactions involve cysteine 3635.

Non-NASA Center↗

NASA NTRS2018

Robotic External Leak Locator (RELL) Leak Plume Field Detection on the International Space Station (ISS)

The Robotic External Leak Locator (RELL) was deployed to the International Space Station (ISS) with the objective of demonstrating the ability to detect and locate small leaks. On-orbit operations began in late November 2016 and following scanning activities to characterize the natural and induced environment of the ISS, RELL focused on the United States External Active Thermal Control System (EATCS). RELL successfully detected ammonia related to a known small ammonia leak in the port-side EATCS, with the highest pressure values around the inboard Radiator Beam Valve Module 1 (RBVM 1). An additional day of scanning was subsequently performed in December 2017 to focus on RBVM 1. RELL was approved for additional external operations in February 2017 with the goal of fine tuning the location of the leak. Using grid scanning patterns, RELL detected ammonia around RBVM 1 and located the approximate source of the leak. The potential leak site was inspected by a crew member during an Extravehicular Activity (EVA) in March 2017, and the suspected radiator-side lines were isolated from the port-side EATCS coolant loop in April 2017. Subsequent monitoring of the system pressures showed that the leak has stopped, indicating RELL accurately located the source of the EATCS leak. These activities verify that RELL enhances the ISS Program's ability to not only locate small leaks, but isolate the source with minimal impact to the entire ISS system.

External Active Thermal Control System↗

NASA NTRS1991

Lunar base siting

As with any planetary body, the lunar surface is quite heterogeneous. There are widely dispersed sites of particular interest for known and potential resource availability, selenology, and lunar observatories. Discriminating characteristics include solar illumination, view of earth, local topography, engineering properties of the regolith and certain geological features, and local mineralogy and petrology. Space vehicle arrival and departure trajectories constitute a minor consideration. Over time, a variety of base sites will be developed serving different purposes. Resource-driven sites may see the fastest growth during the first decades of lunar development, but selection of the most favorable sites is likely to be driven by suitability for a combination of activities. As on earth, later development may be driven by geographical advantages of surface transportation routes. With the availability of near-constant sunlight for power generation, as well as permanently shadowed areas at cryogenic temperatures, polar sites are attractive because they require substantially less earth-launched mass and lower equipment complexity for an initial permanent base. Discovery of accessible volatiles reservoirs, either in the form of polar permafrost or gas reservoirs at other locations, would dramatically increase the attractiveness of any site from a logistical support and selenological point of view. Amid such speculation, no reliable evidence of such volatiles exist. More reliable evidence exists for areas of certain mineral concentrations, such as ilmenite, which could form a feedstock for some proposed resource extraction schemes. While tentative selections of advantageous base sites are made, new data from lunar polar orbiters and the Galileo polar flybys would be very helpful.

Staehle, Robert L.↗

NASA NTRS1993

Illness/injury pattern complex 40 (Titan)

On July 31, 1991, EG&G Medical began providing medical support at the Titan Area Clinic (TAC). The hours of operation are 0700-2300, Monday through Friday, with Emergency Medical Services (EMS) provided 24-hours a day, seven days a week. The TAC consists of a 10 x 10 ft section of a trailer that also houses Bechtel Safety. Supplies consisted of an examining table, an eye wash chair, first aid equipment, over-the-counter medications, spine boards, a portable rescuscitator, etc. All of the nurses are Advanced Cardiac Life Support (ACLS) certified. Although the Titan Area Clinic is strictly a first-aid station with no ACLS facilities on-site, it is staffed with an Occupational Health Nurse with ACLS certification. If ACLS or additional help is needed, the nurse activates EMS by dialing 911. The nurse responds to any medical problems or emergencies on the complex, but activates EMS prior to leaving the TAC. A Bechtel Safety Representative accompanies the nurse to the site and assists as needed. Other aspects of the complex and its functions are presented.

Blasdell, Sharon↗

NASA NTRS1981

Solar flare acceleration of solar wind - Influence of active region magnetic field

The direction of the photospheric magnetic field at the site of a solar flare is a good predictor of whether the flare will accelerate solar wind plasma. If the field has a southward component, high-speed solar wind plasma is usually observed near the earth about 4 days later. If the field has a northward component, such high-speed solar wind is almost never observed. Southward-field flares may then be expected to have much larger terrestrial effects than northward flares.

Lundstedt, H.↗

NASA NTRS1979

The association of coronal mass ejection transients with other forms of solar activity

Coronal mass-ejection transients observed with the white-light coronagraph on Skylab are found to be associated with several other forms of solar activity. There is a strong correlation between such mass-ejection transients and chromospheric H-alpha activity, with three-quarters of the transients apparently originating in or near active regions. It is inferred that 40% of transients are associated with flares, 50% are associated with eruptive prominences solely (without flares), and more than 70% are associated with eruptive prominences or filament disappearances (with or without flares). Nine of ten flares that displayed apparent mass ejections of H-alpha-emitting material from the flare site could be associated with coronal transients. Within each class of activity, the more energetic events are more likely to be associated with an observable mass ejection.

Munro, R. H.↗

NASA NTRS2024

The Analogs for VENus’ GEologically Recent Surfaces (AVENGERS) Initiative: Updates and New Target Areas

Several missions to Venus have been recently selected for launch, opening a new era for the exploration of the planet. One of the key questions that future missions need to address is the rate and style of present-day volcanic activity on Venus. To this regard, an important target on Venus is certainly represented by the young topographic rises, which can be interpreted as the surface expression of underlying mantle plumes. These areas can be considered as the geologically youngest regions of Venus, being characterized by recent volcanic and tectonic activity. Studying areas of active volcanism and tectonism on Venus is crucial as it can reveal clues to the geologic past of the planet, as well as provide information about the volatile content of its interior and about the formation of its dense atmosphere. The “Analogs for VENus’ GEologically Recent Surfaces” (AVENGERS) initiative aims to select and analyze a number of terrestrial analog sites for the comparative study of recent and possibly ongoing volcanic activity on Venus. In addition to its scientific importance, the AVENGERS initiative acts as a bridge for international scientific collaboration, including selected mission teams.

P D'Incecco↗

NASA NTRS1992

Nystagmus induced by electrical stimulation of the vestibular and prepositus hypoglossi nuclei in the monkey: evidence for site of induction of velocity storage

Electrical stimulation of the vestibular nuclei (VN) and prepositus hypoglossi nuclei (PPH) of alert cynomolgus monkeys evoked nystagmus and eye deviation while they were in darkness. At some sites in VN, nystagmus and after-nystagmus were induced with characteristics suggesting that velocity storage had been excited. We analyzed these responses and compared them to the slow component of optokinetic nystagmus (OKN) and to optokinetic after-nystagmus (OKAN). We then recorded unit activity in VN and determined which types of nystagmus would be evoked from the sites of recording. Nystagmus and eye deviations were also elicited by electrical stimulation of PPH, and we characterized the responses where unit activity was recorded in PPH. Horizontal slow phase velocity of the VN "storage" responses was contralateral to the side of stimulation. The rising time constants and peak steady-state velocities were similar to those of OKN, and the falling time constants of the after-nystagmus and of OKAN were approximately equal. Both the induced after-nystagmus and OKAN were habituated by stimulation of the VN. When horizontal after-nystagmus was evoked with animals on their sides, it developed yaw and pitch components that tended to shift the vector of the slow phase velocity toward the spatial vertical. Similar "cross-coupling" occurs for horizontal OKAN or for vestibular post-rotatory nystagmus elicited in tilted positions. Thus, the storage component of nystagmus induced by VN stimulation had the same characteristics as the slow component of OKN and the VOR. Positive stimulus sites for inducing nystagmus with typical storage components were located in rostral portions of VN. They lay in caudal ventral superior vestibular nucleus (SVN), dorsal portions of central medial vestibular nucleus (MVN) caudal to the abducens nuclei and in adjacent lateral vestibular nucleus (LVN). More complex stimulus responses, but with contralateral after-nystagmus, were induced from surrounding regions of ventral MVN and LVN, rostral descending vestibular nucleus and the marginal zone between MVN and PPH. Vestibular-only (VO), vestibular plus saccade (VPS) and tonic vestibular pause (TVP) units were identified by extracellular recording. Stimulation near type I lateral and vertical canal-related VO units elicited typical "storage" responses with after-nystagmus in 23 of 29 tracks (79%). Stimulus responses were more complex from the region of neurons with oculomotor-related signals, i.e., TVP or VPS cells, although after-nystagmus was also elicited from these sites. Effects of vestibular nerve and nucleus stimulation were compared.(ABSTRACT TRUNCATED AT 400 WORDS).

NASA Discipline Neuroscience↗

NASA NTRS1998

Muscle metaboreceptor modulation of cutaneous active vasodilation

PURPOSE: Isometric handgrip exercise in hyperthermia has been shown to reduce cutaneous vascular conductance (CVC) by inhibiting the cutaneous active vasodilator system. METHODS: To identify whether this response was initiated by muscle metaboreceptors, in seven subjects two 3-min bouts of isometric handgrip exercise in hyperthermia were performed, followed by 2 min of postexercise ischemia (PEI). An index of forearm skin blood flow (laser-Doppler flowmetry) was measured on the contralateral arm at an unblocked site and at a site at which adrenergic vasoconstrictor function was blocked via bretylium iontophoresis to reveal active cutaneous vasodilator function unambiguously. Sweat rate was measured via capacitance hygrometry, CVC was indexed from the ratio of skin blood flow to mean arterial pressure and was expressed as a percentage of maximal CVC at that site. In normothermia, neither isometric exercise nor PEI affected CVC (P > 0.05). RESULTS: The first bout of isometric handgrip exercise in hyperthermia reduced CVC at control sites and this reduction persisted through PEI (pre-exercise: 59.8 +/- 5.4, exercise: 49.8 +/- 4.9, PEI: 49.7 +/- 5.3% of maximum; both P < 0.05), whereas there were no significant changes in CVC at the bretylium treated sites. The succeeding bout of isometric exercise in hyperthermia significantly reduced CVC at both untreated (pre-exercise: 59.0 +/- 4.8, exercise: 47.3 +/- 4.0, PEI: 50.1 +/- 4.1% of maximum; both P < 0.05) and bretylium treated sites (pre-exercise: 61.4 +/- 7.3, exercise: 50.6 +/- 5.1, PEI: 53.9 +/- 6.0% of maximum, both P < 0.05). At both sites, CVC during PEI was lower than during the pre-exercise period (P < 0.05). Sweat rate rose significantly during both bouts of isometric exercise and remained elevated during PEI. CONCLUSIONS: These data suggest that the reduction in CVC during isometric exercise in hyperthermia, including the inhibition of the active vasodilator system, is primarily mediated by muscle metaboreceptors, whereas central command or muscle mechanoreceptors have less influence.

Non-NASA Center↗

NASA NTRS1998

Long-Term file activity patterns in a UNIX workstation environment

As mass storage technology becomes more affordable for sites smaller than supercomputer centers, understanding their file access patterns becomes crucial for developing systems to store rarely used data on tertiary storage devices such as tapes and optical disks. This paper presents a new way to collect and analyze file system statistics for UNIX-based file systems. The collection system runs in user-space and requires no modification of the operating system kernel. The statistics package provides details about file system operations at the file level: creations, deletions, modifications, etc. The paper analyzes four months of file system activity on a university file system. The results confirm previously published results gathered from supercomputer file systems, but differ in several important areas. Files in this study were considerably smaller than those at supercomputer centers, and they were accessed less frequently. Additionally, the long-term creation rate on workstation file systems is sufficiently low so that all data more than a day old could be cheaply saved on a mass storage device, allowing the integration of time travel into every file system.

Gibson, Timothy J.↗

NASA NTRS2011

Assessing Spectral Evidence of Aqueous Activity in Two Putative Martian Paleolakes

We evaluate the evidence for the presence of mineral spectral signatures indicative of the past presence of water at two putative paleolakes on Mars using observations by the Mars Reconnaissance Orbiter (MRO) Compact Reconnaissance Image Spectrometer for Mars (CRISM). CRISM spectra of both sites are consistent with laboratory spectra of Mg-rich phyllosilicates. Our analysis represents the first detailed evaluation of these locations. The spatial occurrence and association with topographic features within the craters is distinctly different for the two sites. The occurrence of these minerals supports the conclusion that water was once active in the areas sampled by these craters. The distribution of the phyllosilicates in Luqa does not provide distinctive evidence for the presence of a previous standing body of water and is consistent with either impact emplacement or post-impact alteration. For Cankuzo, the phyllosilicate distribution provides evidence of a layer in the crater wall indicative of aqueous activity, but does not require a paleolake.

Mineralogy↗

NASA NTRS1995

Active Flow Control: Instrumentation Automation and Experimental Technique

In investigating the potential of a new actuator for use in an active flow control system, several objectives had to be accomplished, the largest of which was the experimental setup. The work was conducted at the NASA Langley 20x28 Shear Flow Control Tunnel. The actuator named Thunder, is a high deflection piezo device recently developed at Langley Research Center. This research involved setting up the instrumentation, the lighting, the smoke, and the recording devices. The instrumentation was automated by means of a Power Macintosh running LabVIEW, a graphical instrumentation package developed by National Instruments. Routines were written to allow the tunnel conditions to be determined at a given instant at the push of a button. This included determination of tunnel pressures, speed, density, temperature, and viscosity. Other aspects of the experimental equipment included the set up of a CCD video camera with a video frame grabber, monitor, and VCR to capture the motion. A strobe light was used to highlight the smoke that was used to visualize the flow. Additional effort was put into creating a scale drawing of another tunnel on site and a limited literature search in the area of active flow control.

Gimbert, N. Wes↗

NASA NTRS1999

Cloning the promoter for transforming growth factor-beta type III receptor. Basal and conditional expression in fetal rat osteoblasts

Transforming growth factor-beta binds to three high affinity cell surface molecules that directly or indirectly regulate its biological effects. The type III receptor (TRIII) is a proteoglycan that lacks significant intracellular signaling or enzymatic motifs but may facilitate transforming growth factor-beta binding to other receptors, stabilize multimeric receptor complexes, or segregate growth factor from activating receptors. Because various agents or events that regulate osteoblast function rapidly modulate TRIII expression, we cloned the 5' region of the rat TRIII gene to assess possible control elements. DNA fragments from this region directed high reporter gene expression in osteoblasts. Sequencing showed no consensus TATA or CCAAT boxes, whereas several nuclear factors binding sequences within the 3' region of the promoter co-mapped with multiple transcription initiation sites, DNase I footprints, gel mobility shift analysis, or loss of activity by deletion or mutation. An upstream enhancer was evident 5' proximal to nucleotide -979, and a silencer region occurred between nucleotides -2014 and -2194. Glucocorticoid sensitivity mapped between nucleotides -687 and -253, whereas bone morphogenetic protein 2 sensitivity co-mapped within the silencer region. Thus, the TRIII promoter contains cooperative basal elements and dispersed growth factor- and hormone-sensitive regulatory regions that can control TRIII expression by osteoblasts.

Non-NASA Center↗

NASA NTRS1990

Downward shortwave surface irradiance from 17 sites for the FIRE/SRB Wisconsin experiment

A field experiment was conducted in Wisconsin during Oct. to Nov. 1986 for purposes of both intensive cirrus cloud measurments and SRB algorithm validation activities. The cirrus cloud measurements were part of the FIRE. Tables are presented which show data from 17 sites in the First ISCCP (International Satellite Cloud Climatology Project) Regional Experiment/Surface Radiation Budget (FIRE/SRB) Wisconsin experiment region. A discussion of intercomparison results and calibration inconsistencies is also included.

Whitlock, Charles H.↗

NASA NTRS2010

Integration of In-Situ Resource Utilization Into Lunar/Mars Exploration Through Field Analogs

The NASA project to develop In-Situ Resource Utilization (ISRU) technologies, in partnership with commercial and international collaborators, has achieved full system demonstrations of oxygen production using native regolith simulants. These demonstrations included robotic extraction of material from the terrain, sealed encapsulation of material in a pressurized reactor; chemical extraction of oxygen from the material in the form of water, and the electrolysis of water into oxygen and hydrogen for storage and reuse. These successes have provided growing confidence in the prospects of ISRU oxygen production as a credible source for critical mission consumables in preparation for and during crewed missions to the moon and other destinations. Other ISRU processes, especially relevant to early lunar exploration scenarios, have also been shown to be practical, including the extraction of subsurface volatiles, especially water, and the thermal processing of surface materials for civil engineering uses and for thermal energy storage. This paper describes these recent achievements and current NASA ISRU development and demonstration activity. The ability to extract and process resources at the site of exploration into useful products such as propellants, life support and power system consumables; and radiation and rocket exhaust plume debris shielding, known as In-Situ Resource Utilization or ISRU, has the potential to significantly reduce the launch mass, risk, and cost of robotic and human exploration of space. The incorporation of ISRU into missions can also significantly influence technology selection and system development in other areas such as power, life support, and propulsion. For example. the ability to extract or produce large amounts of oxygen and/or water in-situ could minimize the need to completely close life support air and water processing system cycles, change thermal and radiation protection of habitats, and influence propellant selection for ascent vehicles and surface propulsive hoppers. While concepts and even laboratory work on evaluating and developing ISRU techniques such as oxygen extraction from lunar regolith have been going on since before the Apollo 11 Moon landing, no ISRU system has ever flown in space, and only recently have ISRU technologies been developed at a scale and at a system level that is relevant to actual robotic and human mission applications. Because ISRU hardware and systems have never been demonstrated or utilized before on robotic or human missions, architecture and mission planners and surface system hardware developers are hesitant to rely on ISRU products and services that are critical to mission and system implementation success. To build confidence in ISRU systems for future missions and assess how ISRU systems can best influence and integrate with other surface system elements, NASA, with international partners, are performing analog field tests to understand how to take advantage of ISRU capabilities and benefits with the minimum of risk associated with introducing this game-changing approach to exploration. This paper will describe and review the results of four analog field tests (Moses Lake in 6/08, Mauna Kea in 11/08. Flagstaff in 9/09; and Mauna Kea in 1/10) that have begun the process of integrating ISRU into robotic and human exploration systems and missions, and propose future ISRU-related analog field test activities that can be performed in collaboration with international space agencies.

Sanders, Gerald B.↗

NASA NTRS1977

Morphology and physical parameters of a solar flare

The chromospheric and coronal morphology of the flare of June 15, 1973, (1B/M3) in NOAA active region 131 (McMath 12379) is discussed, and results of quantitative analysis of Skylab soft X-ray observations of the event are presented. H-alpha and white-light observations reveal evidence of emerging flux near the site of the H-alpha flare onset. Preflare and early flare filament activity and its spatial and temporal correlation with the flare are discussed. Spatially resolved soft X-rays are compared with H-alpha and magnetic-field measurements. Full-disk high-temporal-resolution soft X-ray flux measurements and time profiles of the resultant temperature and density calculations are also presented which yield a peak temperature of about 14.2 million K and a peak electron density of approximately 3.5 deg 10 to the -10th power per cu cm and show a preflash-phase temperature rise to about 9 million K. The peak values should be compared with the respective values of approximately 25 million K and 4.5 by 10 to the -10th power per cu cm deduced from the spatially resolved data.

Smith, J. B., Jr.↗

NASA NTRS1986

Diurnal and spatial variability of lightning activity in northeastern Colorado and central Florida during the summer

Lightning location data from northeastern Colorado and central Florida for the summer months of 1983 have been studied to ascertain the diurnal development of spatial distributions of flash frequencies. The data sources are discussed, and for both investigated regions, the regional geographic and climatic characteristics, the day-to-day variability of lightning activity, the diurnal cycle over the entire region, the spatial distribution of lightning activity, the diurnal changes of spatial distribution, and the diurnal variation of lightning at individual sites are described in detail. In both regions, the time and space distributions of lightning are modulated by the topographic features and the contrasts of the terrain. Lightning activity is a relatively rare and variable phenomenon in both regions when day-to-day frequencies are considered. There thus must be meteorological parameters that determine the extent and frequency of lightning occurrence.

Lopez, R. E.↗