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At least 577 records · Page 32

Search for decays of the Higgs boson into pair-produced pseudoscalar particles decaying into τ+τ−τ+τ− using pp collisions at s=13 TeV with the ATLAS detector

A search for a pair of low-mass pseudoscalars a that promptly decay into τ-leptons is presented using 140 fb −1 of proton–proton collision data at 13 TeV centre-of-mass energy recorded with the ATLAS detector at the Large Hadron Collider. The result is used to place constraints on exotic decays of the Higgs boson into four τ-leptons, H→aa→τ+τ−τ+τ−. This search focuses on events with either one or two τ-leptons decaying into hadrons and neutrinos, and the remaining three or two τ-leptons decaying into either electron or muon and neutrinos. No significant excess is observed above the expected Standard Model background and upper limits at the 95% confidence level on B(H→aa→τ+τ−τ+τ−) are set ranging from 0.06 to 0.23, depending on the mass ma ranging from 15 to 60 GeV.

Source record↗

Searches for neutrinos from cosmic-ray interactions in the Sun using seven years of IceCube data

Cosmic-ray interactions with the solar atmosphere are expected to produce particle showers which in turn produce neutrinos from weak decays of mesons. These solar atmospheric neutrinos (SAνs) have never been observed experimentally. A detection would be an important step in understanding cosmic-ray propagation in the inner solar system and the dynamics of solar magnetic fields. SAνs also represent an irreducible background to solar dark matter searches and a detection would allow precise characterization of this background. In this work, we present the first experimental search based on seven years of data collected from May 2010 to May 2017 in the austral winter with the IceCube Neutrino Observatory. An unbinned likelihood analysis is performed for events reconstructed within 5 degrees of the center of the Sun. No evidence for a SAν flux is observed. After inclusion of systematic uncertainties, we set a 90% upper limit of 1.02 +0.20 -0.18 ·10 -13 GeV-1cm -2 s -1 at 1 TeV.

79 ASTRONOMY AND ASTROPHYSICS↗

A search for ultrahigh-energy neutrinos associated with astrophysical sources using the third flight of ANITA

The ANtarctic Impulsive Transient Antenna (ANITA) long-duration balloon experiment is sensitive to interactions of ultrahigh-energy (E>10 18 eV) neutrinos in the Antarctic ice sheet. The third flight of ANITA, lasting 22 days, began in December 2014. We develop a methodology to search for energetic neutrinos spatially and temporally coincident with potential source classes in ANITA data. This methodology is applied to several source classes: the potential IceCube-identified neutrino sources TXS 0506+056 and NGC 1068, flaring high-energy blazars reported by the Fermi All-Sky Variability Analysis, gamma-ray bursts, and supernovae. Among searches within the five source classes, one candidate was identified as associated with SN 2015D, although not at a statistically significant level. Finally, we proceed to place upper limits on the source classes. We further comment on potential application of this methodology to more sensitive future instruments.

79 ASTRONOMY AND ASTROPHYSICS↗

Bayesian forecasts for dark matter substructure searches with mock pulsar timing data

Dark matter substructure, such as primordial black holes (PBHs) and axion miniclusters, can induce phase shifts in pulsar timing arrays (PTAs) measurements due to gravitational effects. In order to gain a more realistic forecast for the detectability of such models of dark matter with PTAs, we propose a Bayesian inference framework to search for phase shifts generated by PBHs and perform the analysis on mock PTA data. Furthermore, for most PBH masses the constraints on the dark matter abundance agree with previous (frequentist) analyses (without mock data) to $\mathcal{O}$(1) factors. This further motivates a dedicated search for PBHs (and dense small scale structures) in the mass range from 10 -8 M ⊙ to well above 10 2 M ⊙ with the Square Kilometer Array. Moreover, with a more optimistic set of timing parameters, future PTAs are predicted to constrain PBHs down to 10 -11 M ⊙ . Lastly, we discuss the impact of backgrounds, such as Supermassive Black Hole Mergers, on detection prospects, suggesting a future program to separate a dark matter signal from other astrophysical sources.

79 ASTRONOMY AND ASTROPHYSICS↗

Searching for velocity-dependent dark matter annihilation signals from extragalactic halos

For this work, we consider gamma-ray signals of dark matter annihilation in extragalactic halos in the case where dark matter annihilates from a p-wave or d-wave state. In these scenarios, signals from extragalactic halos are enhanced relative to other targets, such as the Galactic Center or dwarf spheroidal galaxies, because the typical relative speed of the dark matter is larger in extragalactic halos. We perform a mock data analysis of gamma rays produced by dark matter annihilation in halos detected by the Sloan Digital Sky Survey. We include a model for uncorrelated galactic and extragalactic gamma ray backgrounds, as well as a simple model for backgrounds due to astrophysical processes in the extragalactic halos detected by the survey. We find that, for models which are still allowed by other gamma ray searches, searches of extragalactic halos with the current Fermi exposure can produce evidence for dark matter annihilation, though it is difficult to distinguish the p-wave and d-wave scenarios. With a factor 10x larger exposure, though, discrimination of the velocity-dependence is possible.

79 ASTRONOMY AND ASTROPHYSICS↗

Search For Electron-Antineutrinos Associated With 2 Gravitational-Wave Events GW150914, GW151012, GW151226, 3 GW170104, GW170608, GW170814, and GW170817 at Daya Bay

Providing a possible connection between neutrino emission and gravitational-wave (GW) bursts is important to our understanding of the physical processes that occur when black holes or neutron stars merge. In the Daya Bay experiment, using the data collected from December 2011 to August 2017, a search has been performed for electron-antineutrino signals coinciding with detected GW events, including GW150914, GW151012, GW151226, GW170104, GW170608, GW170814, and GW170817. We used three time windows of ±10 s, ±500 s, and ±1000 s relative to the occurrence of the GW events, and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino candidates. The detected electron-antineutrino candidates are consistent with the expected background rates for all the three time windows. Assuming monochromatic spectra, we found upper limits (90% confidence level) on electron-antineutrino fluence of (1.13 - 2.44)×1011 cm-2 at 5 MeV to 8.0×107cm-2at 100 MeV for the three timewindows. Under the assumption of a Fermi-Dirac spectrum, the upper limits were found to be (5.4 - 7.0)×109 cm-2 for the three time windows.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Search for the doubly heavy baryons $ {{{{\varOmega}_{bc}^{0}}}} $ and $ {{{{\varXi}_{bc}^{0}}}} $ decaying to $ {{{{\varLambda}^+_c}}} {{{{\pi}^-}}} $ and $ {{{{\varXi}^+_c}}} {{{{\pi}^-}}} $ *

The first search for the doubly heavy $ {{{{\varOmega}_{bc}^{0}}}} $ baryon and a search for the $ {{{{\varXi}_{bc}^{0}}}} $ baryon are performed using $ pp $ collision data collected via the $ {\rm{LHCb}} $ experiment from 2016 to 2018 at a centre-of-mass energy of $ 13 \;{\rm{TeV}} $, corresponding to an integrated luminosity of 5.2 $ \;{\rm{f}}{{\rm{b}}^{ - 1}} $. The baryons are reconstructed via their decays to $ {{{{\varLambda}^+_c}}} {{{{\pi}^-}}} $ and $ {{{{\varXi}^+_c}}} {{{{\pi}^-}}} $. No significant excess is found for invariant masses between 6700 and 7300 $ \;{\rm{MeV}}/{c^2} $, in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 $ \;{\rm{MeV}}/{c} $. Upper limits are set on the ratio of the $ {{{{\varOmega}_{bc}^{0}}}} $ and $ {{{{\varXi}_{bc}^{0}}}} $ production cross-section times the branching fraction to $ {{{{\varLambda}^+_c}}}{{{{\pi}^-}}} $ ( $ {{{{\varXi}^+_c}}}{{{{\pi}^-}}} $) relative to that of the $ {{{{\varLambda}^0_b}}} $ ( $ {{{{\varXi}_{b}^{0}}}} $) baryon, for different lifetime hypotheses, at 95% confidence level. The upper limits range from $ 0.5\times10^{-4} $ to $ 2.5\times10^{-4} $ for the $ {{{{{{{{\varOmega}_{bc}^{0}}}}{{\rightarrow }}{{{{\varLambda}^+_c}}}{{{{\pi}^-}}}}}}} $ ( $ {{{{{{{{\varXi}_{bc}^{0}}}}{{\rightarrow }}{{{{\varLambda}^+_c}}}{{{{\pi}^-}}}}}}} $) decay, and from $ 1.4\times10^{-3} $ to $ 6.9\times10^{-3} $ for the $ {{{{{{{{\varOmega}_{bc}^{0}}}}{{\rightarrow }}{{{{\varXi}^+_c}}}{{{{\pi}^-}}}}}}} $ ( $ {{{{{{{{\varXi}_{bc}^{0}}}}{{\rightarrow }}{{{{\varXi}^+_c}}}{{{{\pi}^-}}}}}}} $) decay, depending on the considered mass and lifetime of the $ {{{{\varOmega}_{bc}^{0}}}} $ ( $ {{{{\varXi}_{bc}^{0}}}} $) baryon.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Search for the rare decays $W^+ → D^+_s \gamma$ and $Z → D^0 \gamma$ at LHCb

A search for the rare decays $W^+ → D^+_s \gamma$ and $Z → D^0 \gamma$ is performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of 13TeV, corresponding to an integrated luminosity of 2.0fb -1 . No significant signal is observed for either decay mode and upper limits on their branching fractions are set using W⁺ → μ⁺v and Z → μ⁺μ⁻ decays as normalization channels. The upper limits are 6.5 x 10 -4 and 2.1 x 10 -3 at 95% confidence level for the $W^+ → D^+_s \gamma$ and $Z → D^0 \gamma$ decay modes, respectively. This is the first reported search for the $Z → D^0 \gamma$ decay, while the upper limit on the branching fraction $W^+ → D^+_s \gamma$ improves upon the previous best limit.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Search for two-neutrino double-beta decay of 136 Xe to the $0$$^{+}_{1}$ excited state of 136 Ba with the complete EXO-200 dataset*

A new search for two-neutrino double-beta (2νββ) decay of 136 Xe to the $0$$^{+}_{1}$ excited state of 136 Ba is performed with the full EXO-200 dataset. A deep learning-based convolutional neural network is used to discriminate signal from background events. Signal detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of two. With the addition of the Phase II dataset taken with an upgraded detector, the median 90% confidence level half-life sensitivity of 2νββ decay to the $0$$^{+}_{1}$ state of 136 Ba is 2.9 x 10 24 yr using a total 136 Xe exposure of 234.1 kg yr. Furthermore, no statistically significant evidence for 2νββ decay to the $0$$^{+}_{1}$ state is observed, leading to a lower limit of $T$$^{2v}_{1/2}$(0 + → $0$$^{+}_{1}$) > 1.4 x 10 24 yr at 90% confidence level, improved by 70% relative to the current world's best constraint.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

The FRB-searching Pipeline of the Tianlai Cylinder Pathfinder Array

This paper presents the design, calibration, and survey strategy of the Fast Radio Burst (FRB) digital backend and its real-time data processing pipeline employed in the Tianlai Cylinder Pathfinder Array. The array, consisting of three parallel cylindrical reflectors and equipped with 96 dual-polarization feeds, is a radio interferometer array designed for conducting drift scans of the northern celestial semi-sphere. The FRB digital backend enables the formation of 96 digital beams, effectively covering an area of approximately 40 square degrees with the 3 dB beam. Our pipeline demonstrates the capability to conduct an automatic search of FRBs, detecting at quasi-real-time and classifying FRB candidates automatically. The current FRB searching pipeline has an overall recall rate of 88%. During the commissioning phase, we successfully detected signals emitted by four well-known pulsars: PSR B0329+54, B2021+51, B0823+26, and B2020+28. We report the first discovery of an FRB by our array, designated as FRB 20220414A. We also investigate the optimal arrangement for the digitally formed beams to achieve maximum detection rate by numerical simulation.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Skipper CCDs for the search of a daily modulation of Dark Matter signal in the DMSQUARE experiment

The Dark Matter Daily Modulation experiment (DMSQUARE) seeks for dark matter interactions with a Skipper CCD. It is currently running at surface level in Bariloche, Argentina, and will be moved to a shallow underground site at Sierra Grande, Argentina in November 2021. The low threshold achieved by Skipper CCDs allows to search for electron recoil events with an ionization energy down to 1.2 eV. In order to extract a potential dark matter signal from noise at the single electron level, we propose to search for a diurnal modulation of events, resulting from the potential interaction of the dark matter wind with the particles in the Earth. Depending on the model, mass and cross-section, this modulation can be maximum at 40deg of latitude in the Southern Hemisphere, where DMSQUARE is operated. In this article we present the experiment, report preliminary results with a prototype Skipper CCD taking data at surface level and comment on future prospects.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

On the use of dielectric elements in axion searches with microwave resonant cavities

This study explores the primary effects of dielectric materials in a resonant cavity-based search for axion dark matter. While dielectrics prove beneficial in numerous cases, their incorporation may lead to less-than-optimal performance, especially for the lowest TM mode. Additionally, the stronger confinement of the electric field inside the dielectrics can exacerbate mode mixings, in particular for higher-order modes. Case studies have been carried out using a combination of analytical solutions and numerical simulations. The findings indicate dielectric cavities employing the TM 010 mode experience a significant reduction in sensitivity when compared to a similar search conducted in a cavity at equivalent frequency using no dielectrics.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

NASMDR: a framework for miRNA-drug resistance prediction using efficient neural architecture search and graph isomorphism networks

Abstract As a frontier field of individualized therapy, microRNA (miRNA) pharmacogenomics facilitates the understanding of different individual responses to certain drugs and provides a reasonable reference for clinical treatment. However, the known drug resistance-associated miRNAs are not yet sufficient to support precision medicine. Although existing methods are effective, they all focus on modelling miRNA-drug resistance interaction graphs, making their performance bounded by the interaction density. In this study, we propose a framework for miRNA-drug resistance prediction through efficient neural architecture search and graph isomorphism networks (NASMDR). NASMDR uses attribute information instead of the commonly used interactive graph information. In the cross-validation experiment, the proposed framework can achieve an AUC of 0.9468 on the ncDR dataset, which is 2.29% higher than the state-of-the-art method. In addition, we propose a novel sequence characterization approach, k-mer Sparse Nonnegative Matrix Factorization (KSNMF). The results show that NASMDR provides novel insights for integrating efficient neural architecture search and graph isomorphic networks into a unified framework to predict drug resistance-related miRNAs. The codes for NASMDR are available at https://github.com/kaizheng-academic/NASMDR.

Zheng, Kai↗

RCSB Protein Data Bank: improved annotation, search and visualization of membrane protein structures archived in the PDB

Abstract Motivation Membrane proteins are encoded by approximately one fifth of human genes but account for more than half of all US FDA approved drug targets. Thanks to new technological advances, the number of membrane proteins archived in the PDB is growing rapidly. However, automatic identification of membrane proteins or inference of membrane location is not a trivial task. Results We present recent improvements to the RCSB Protein Data Bank web portal (RCSB PDB, rcsb.org) that provide a wealth of new membrane protein annotations integrated from four external resources: OPM, PDBTM, MemProtMD and mpstruc. We have substantially enhanced the presentation of data on membrane proteins. The number of membrane proteins with annotations available on rcsb.org was increased by ∼80%. Users can search for these annotations, explore corresponding tree hierarchies, display membrane segments at the 1D amino acid sequence level, and visualize the predicted location of the membrane layer in 3D. Availability and implementation Annotations, search, tree data and visualization are available at our rcsb.org web portal. Membrane visualization is supported by the open-source Mol* viewer (molstar.org and github.com/molstar/molstar). Supplementary information Supplementary data are available at Bioinformatics online.

59 BASIC BIOLOGICAL SCIENCES↗

Searching for quasar candidates with periodic variations from the Zwicky Transient Facility: results and implications

ABSTRACT We conduct a systematic search for quasars with periodic variations from the archival photometric data of the Zwicky Transient Facility by cross-matching with the quasar catalogues of the Sloan Digital Sky Survey and Véron-Cetty and Véron. We first select out 184 primitive periodic candidates using the generalized Lomb–Scargle periodogram and autocorrelation function and then estimate their statistical significance of periodicity based on two red-noise models, i.e. damped random walk (DRW) and single power-law (SPL) models. As such, we finally identify 106 (DRW) and 86 (SPL) candidates with the most significant periodic variations out of 143 700 quasars. We further compare DRW and SPL models using Bayes factors, which indicate a relative preference of the SPL model for our primitive sample. We thus adopt the candidates identified with SPL as the final sample and summarize its basic properties. We extend the light curves of the selected candidates by supplying other archival survey data to verify their periodicity. However, only three candidates (with 6–8 cycles of periods) meet the selection criteria. This result clearly implies that, instead of being strictly periodic, the variability must be quasi-periodic or caused by stochastic red-noise. This exerts a challenge to the existing search approaches and calls for developing new effective methods.

Chen, Yong-Jie (ORCID:0000000342807673)↗

Search for subsolar-mass black hole binaries in the second part of Advanced LIGO’s and Advanced Virgo’s third observing run

ABSTRACT We describe a search for gravitational waves from compact binaries with at least one component with mass $0.2$–$1.0 \, \mathrm{M}_\odot$ and mass ratio q ≥ 0.1 in Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) and Advanced Virgo data collected between 2019 November 1, 15:00 utc and 2020 March 27, 17:00 utc. No signals were detected. The most significant candidate has a false alarm rate of $0.2 \, \rm {yr}^{-1}$. We estimate the sensitivity of our search over the entirety of Advanced LIGO’s and Advanced Virgo’s third observing run, and present the most stringent limits to date on the merger rate of binary black holes with at least one subsolar-mass component. We use the upper limits to constrain two fiducial scenarios that could produce subsolar-mass black holes: primordial black holes (PBH) and a model of dissipative dark matter. The PBH model uses recent prescriptions for the merger rate of PBH binaries that include a rate suppression factor to effectively account for PBH early binary disruptions. If the PBHs are monochromatically distributed, we can exclude a dark matter fraction in PBHs $f_\mathrm{PBH} \gtrsim \, 0.6$ (at 90 per cent confidence) in the probed subsolar-mass range. However, if we allow for broad PBH mass distributions, we are unable to rule out fPBH = 1. For the dissipative model, where the dark matter has chemistry that allows a small fraction to cool and collapse into black holes, we find an upper bound fDBH < 10−5 on the fraction of atomic dark matter collapsed into black holes.

79 ASTRONOMY AND ASTROPHYSICS↗

The Atacama cosmology telescope: flux upper limits from a targeted search for extragalactic transients

ABSTRACT We have performed targeted searches of known extragalactic transient events at millimetre wavelengths using nine seasons (2013–2021) of 98, 150, and 229 GHz Atacama Cosmology Telescope (ACT) observations that mapped ∼40 per cent of the sky for most of the data volume. Our data cover 88 gamma-ray bursts (GRBs), 12 tidal disruption events (TDEs), and 203 other transients, including supernovae (SNe). We stack our ACT observations to increase the signal-to-noise ratio of the maps. In all cases but one, we do not detect these transients in the ACT data. The single candidate detection (event AT2019ppm), seen at ∼5σ significance in our data, appears to be due to active galactic nuclei activity in the host galaxy coincident with a transient alert. For each source in our search we provide flux upper limits. For example, the medians for the 95 per cent confidence upper limits at 98 GHz are 15, 18, and 16 mJy for GRBs, SNe, and TDEs, respectively, in the first month after discovery. The projected sensitivity of future wide-area cosmic microwave background surveys should be sufficient to detect many of these events using the methods described in this paper.

Hervías-Caimapo, Carlos↗

BioPortal: an open community resource for sharing, searching, and utilizing biomedical ontologies

Abstract BioPortal (https://bioportal.bioontology.org) is the world’s most comprehensive repository of biomedical ontologies. It provides infrastructure for finding, sharing, searching, and utilizing biomedical ontologies. Launched in 2005, BioPortal now includes 1549 ontologies (1182 of them public). Its open, freely accessible website enables anyone (i) to browse the ontology library, (ii) to search for terms across ontologies, (iii) to browse mappings between terms, (iv) to see popularity ratings and recommendations on which ontologies are most relevant to their use cases, (v) to annotate text with ontology terms, (vi) to submit an ontology, and (vii) to request ontology changes. The library of ontologies can be accessed programmatically via a REST application programming interface (API). Recent enhancements include a BioPortal knowledge graph that integrates knowledge from multiple ontologies; a unified data model for interoperability with other knowledge sources; ontology popularity ratings and recommendations for relevant ontologies; and the ability to request ontology changes via a simple user interface that automatically converts user change requests to GitHub Pull Requests that specify the edits that will be made to the ontology upon approval.

Vendetti, Jennifer↗