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At least 577 records · Page 32

TH-CD-BRA-02: 3D Remote Dosimetry for MRI-Guided Radiation Therapy: A Hybrid Approach

Purpose: To validate the dosimetric accuracy of a commercially available MR-IGRT system using a combination of 3D dosimetry measurements (with PRESAGE(R) radiochromic plastic and optical-CT readout) and an in-house developed GPU-accelerated PENELOPE Monte-Carlo dose calculation system. Methods: {sup 60}Co IMRT subject to a 0.35T lateral magnetic field has recently been commissioned in our institution following AAPM’s TG-119 recommendations. We performed PRESAGE(R) sensitivity studies in 4ml cuvettes to verify linearity, MR-compatibility, and energy-independence. Using 10cm diameter PRESAGE(R), we delivered an open calibration field to examine the percent depth dose and a symmetrical 3-field plan with three adjacent regions of varying dose to determine uniformity within the dosimeter under a magnetic field. After initial testing, TG-119 plans were created in the TPS and then delivered to 14.5cm 2kg PRESAGE(R) dosimeters. Dose readout was performed via optical-CT at a second institution specializing in remote 3D dosimetry. Absolute dose was measured using an IBA CC01 ion chamber and the institution standard patient-specific QA methods were used to validate plan delivery. Calculated TG-119 plans were then compared with an independent Monte Carlo dose calculation (gPENELOPE). Results: PRESAGE(R) responds linearly (R{sup 2}=0.9996) to {sup 60}Co irradiation, in the presence of a 0.35T magnetic field, with a sensitivity of 0.0305(±0.003)cm{sup −1}Gy{sup −1}, within 1% of a 6MV non-MR linac irradiation (R{sup 2}=0.9991) with a sensitivity of 0.0302(±0.003)cm{sup −1}Gy{sup −1}. Analysis of TG-119 clinical plans using 3D-gamma (3%/3mm, 10% threshold) give passing rates of: HN 99.1%, prostate 98.0%, C-shape 90.8%, and multi-target 98.5%. The TPS agreed with gPENELOPE with a mean gamma passing rate of 98.4±1.5% (2%/2mm) with the z-score distributions following a standard normal distribution. Conclusion: We demonstrate for the first time that 3D remote dosimetry using both experimental and computational methods is a feasible and reliable approach to commissioning MR-IMRT, which is particularly useful for less specialized clinics in adopting this new treatment modality.

60 APPLIED LIFE SCIENCES↗

TH-CD-201-05: Characterization of a Novel Light-Collimating Tank Optical-CT System for 3D Dosimetry

Purpose: Comprehensive 3D dosimetry is highly desirable for advanced clinical QA, but costly optical readout techniques have hindered widespread implementation. Here, we present the first results from a cost-effective Integrated-lens Dry-tank Optical Scanner (IDOS), designed for convenient 3D dosimetry readout of radiochromic plastic dosimeters (e.g. PRESAGE). Methods: The scanner incorporates a novel transparent light-collimating tank, which collimates a point light source into parallel-ray CT geometry. The tank was designed using an in-house Monte-Carlo optical ray-tracing simulation, and was cast in polyurethane using a 3D printed mould. IDOS spatial accuracy was evaluated by imaging a set of custom optical phantoms, with comparison to x-ray CT images. IDOS dose measurement performance was assessed by imaging PRESAGE dosimeters irradiated with simple known dose distributions (e.g., 4 field box 6MV treatment with Varian Linac). Direct comparisons were made to images from our gold standard DLOS scanner and calculated dose distributions from a commissioned Eclipse planning system. Results: All optical CT images were reconstructed at 1mm isotropic resolution. Comparison of IDOS and x-ray CT images of the geometric phantom demonstrated excellent IDOS geometric accuracy (sub-mm) throughout the dosimeter. IDOS measured 3D dose distribution agreed well with prediction from Eclipse, with 95% gamma pass rate at 3%/3mm. Cross-scanner dose measurement gamma analysis shows >90% of pixels passing at 3%/3mm. Conclusion: The first prototype of the IDOS system has demonstrated promising performance, with accurate dosimeter readout and negligible spatial distortion. The use of optical simulations and 3D printing to create a light collimating-tank has dramatically increased convenience and reduced costs by removing the need for expensive lenses and large volumes of refractive matching fluids.

60 APPLIED LIFE SCIENCES↗

Hydraulic Cylinder With an Integral Position Indicator

Linear variable differential transformer (LVDT) incorporated within cylinder of hydraulic actuator gives precise readout of position of piston relative to cylinder. LVDT contained completely within actuator. System requires precise positioning and position readout for computer control of model motions. Minimal space available for motion cylinders, and precise, continuous position readout (with no steps or pulses) required. Device provides continuous and accurate position indication of a hydraulic cylinder by means of integral, coaxially mounted LVDT.

Goodwin, G. O.↗

On readout of vibrational qubits using quantum beats

Readout of the final states of qubits is a crucial step towards implementing quantum computation in experiment. Although not scalable to large numbers of qubits per molecule, computational studies show that molecular vibrations could provide a significant (factor 2–5 in the literature) increase in the number of qubits compared to two-level systems. In this theoretical work, we explore the process of readout from vibrational qubits in thiophosgene molecule, SCCl{sub 2}, using quantum beat oscillations. The quantum beats are measured by first exciting the superposition of the qubit-encoding vibrational states to the electronically excited readout state with variable time-delay pulses. The resulting oscillation of population of the readout state is then detected as a function of time delay. In principle, fitting the quantum beat signal by an analytical expression should allow extracting the values of probability amplitudes and the relative phases of the vibrational qubit states. However, we found that if this procedure is implemented using the standard analytic expression for quantum beats, a non-negligible phase error is obtained. We discuss the origin and properties of this phase error, and propose a new analytical expression to correct the phase error. The corrected expression fits the quantum beat signal very accurately, which may permit reading out the final state of vibrational qubits in experiments by combining the analytic fitting expression with numerical modelling of the readout process. The new expression is also useful as a simple model for fitting any quantum beat experiments where more accurate phase information is desired.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

A flexible data acquisition system architecture for the Nab experiment

Here, the Nab experiment will measure the electron–neutrino correlation and Fierz interference term in free neutron beta decay to test the Standard Model and probe Beyond the Standard Model physics. Using National Instrument’s PXIe-5171 Reconfigurable Oscilloscope module, we have developed a data acquisition system that is not only capable of meeting Nab’s specifications, but flexible enough to be adapted in situ as the experimental environment dictates. The L1 and L2 trigger logic can be reconfigured to optimize the system for coincidence event detection at runtime through configuration files and LabVIEW controls. This system is capable of identifying L1 triggers at a rate of at least 1 MHz, while reading out a peak signal rate of approximately 2 GB/s. During the commissioning phase of the experiment, the system ran at a sustained readout rate of 400 MB/s of detector signal data originating from roughly 6 kHz L2 triggers, well within the peak performance of the system.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

TH-C-19A-12: Two-Dimensional High Spatial-Resolution Dosimeter Using Europium Doped Potassium Chloride

Purpose: Recent research has shown that KCl:Eu2+ has great potential for use in megavoltage radiation therapy dosimetry because this material exhibits excellent storage performance and is reusable due to strong radiation hardness. This work reports our attempts to fabricate 2D KCl:Eu2+ storage phosphor films (SPFs) using both a physical vapor deposition (PVD) method and a tape casting method. Methods: A thin layer of KCl:Eu2+ was deposited on a substrate of borosilicate glass (e.g., laboratory slides) with a PVD system. For tape casting, a homogenous suspension containing storage phosphor particles, liquid vehicle and polymer binder was formed and subsequently cast by doctor-blade onto a polyethylene terephthalate substrate to form a 150 μm thick SPF. Results: X ray diffraction analysis showed that a 10 μm thick PVD sample was composed of highly crystalline KCl. No additional phases were observed, suggesting that the europium activator had completed been incorporated into the KCl matrix. Photostimulated luminescence and photoluminescence spectra suggested that F (Cl−) centers were the electron storage centers post x ray irradiation and that Eu2+ cations acted as luminescence centers in the photostimulation process. The 150 μm thick casted KCl:Eu2+ SPF showed sub-millimeter spatial resolution. Monte Carlo simulations further demonstrated that the admixture of 20% KCl:Eu2+ and 80% low Z polymer binder exhibited almost no energy dependence in a 6 MV beam. KCl:Eu2+ pellet samples showed a large dynamic range from 0.01 cGy to 60 Gy dose-to-water, and saturated at approximately 500 Gy as a Result of its intrinsic high radiation hardness. Conclusions: This discovery research provides strong evidence that KCl:Eu2+ based SPF with associated readout apparatus could Result in a novel electronic film system that has all the desirable features associated with classic radiographic film and, importantly, water equivalence and the capability of permanent identification of each detector. This work was supported in part by NIH Grant No. R01CA148853. The authors would like to thank Paul Leblans (AGFA Healthcare, Belgium) for many helpful discussions on this topic.

61 RADIATION PROTECTION AND DOSIMETRY↗

Quantum simulation of boson-related Hamiltonians: techniques, effective Hamiltonian construction, and error analysis

Elementary quantum mechanics proposes that a closed physical system consistently evolves in a reversible manner. However, control and readout necessitate the coupling of the quantum system to the external environment, subjecting it to relaxation and decoherence. Consequently, system-environment interactions are indispensable for simulating physically significant theories. A broad spectrum of physical systems in condensed-matter and high-energy physics, vibrational spectroscopy, and circuit and cavity QED necessitates the incorporation of bosonic degrees of freedom, such as phonons, photons, and gluons, into optimized fermion algorithms for near-future quantum simulations. In particular, when a quantum system is surrounded by an external environment, its basic physics can usually be simplified to a spin or fermionic system interacting with bosonic modes. Nevertheless, troublesome factors such as the magnitude of the bosonic degrees of freedom typically complicate the direct quantum simulation of these interacting models, necessitating the consideration of a comprehensive plan. This strategy should specifically include a suitable fermion/boson-to-qubit mapping scheme to encode sufficiently large yet manageable bosonic modes, and a method for truncating and/or downfolding the Hamiltonian to the defined subspace for performing an approximate but highly accurate simulation, guided by rigorous error analysis. In this pedagogical tutorial review, we aim to provide such an exhaustive strategy, focusing on encoding and simulating certain bosonic-related model Hamiltonians, inclusive of their static properties and time evolutions. Specifically, we emphasize two aspects: (1) the discussion of recently developed quantum algorithms for these interacting models and the construction of effective Hamiltonians, and (2) a detailed analysis regarding a tightened error bound for truncating the bosonic modes for a class of fermion-boson interacting Hamiltonians.

bosonic Hamiltonian↗

Systematic calibration of an integrated x-ray and optical tomography system for preclinical radiation research

Purpose: The cone beam computed tomography (CBCT) guided small animal radiation research platform (SARRP) has been developed for focal tumor irradiation, allowing laboratory researchers to test basic biological hypotheses that can modify radiotherapy outcomes in ways that were not feasible previously. CBCT provides excellent bone to soft tissue contrast, but is incapable of differentiating tumors from surrounding soft tissue. Bioluminescence tomography (BLT), in contrast, allows direct visualization of even subpalpable tumors and quantitative evaluation of tumor response. Integration of BLT with CBCT offers complementary image information, with CBCT delineating anatomic structures and BLT differentiating luminescent tumors. This study is to develop a systematic method to calibrate an integrated CBCT and BLT imaging system which can be adopted onboard the SARRP to guide focal tumor irradiation. Methods: The integrated imaging system consists of CBCT, diffuse optical tomography (DOT), and BLT. The anatomy acquired from CBCT and optical properties acquired from DOT serve as a priori information for the subsequent BLT reconstruction. Phantoms were designed and procedures were developed to calibrate the CBCT, DOT/BLT, and the entire integrated system. Geometrical calibration was performed to calibrate the CBCT system. Flat field correction was performed to correct the nonuniform response of the optical imaging system. Absolute emittance calibration was performed to convert the camera readout to the emittance at the phantom or animal surface, which enabled the direct reconstruction of the bioluminescence source strength. Phantom and mouse imaging were performed to validate the calibration. Results: All calibration procedures were successfully performed. Both CBCT of a thin wire and a euthanized mouse revealed no spatial artifact, validating the accuracy of the CBCT calibration. The absolute emittance calibration was validated with a 650 nm laser source, resulting in a 3.0% difference between simulated and measured signal. The calibration of the entire system was confirmed through the CBCT and BLT reconstruction of a bioluminescence source placed inside a tissue-simulating optical phantom. Using a spatial region constraint, the source position was reconstructed with less than 1 mm error and the source strength reconstructed with less than 24% error. Conclusions: A practical and systematic method has been developed to calibrate an integrated x-ray and optical tomography imaging system, including the respective CBCT and optical tomography system calibration and the geometrical calibration of the entire system. The method can be modified and adopted to calibrate CBCT and optical tomography systems that are operated independently or hybrid x-ray and optical tomography imaging systems.

60 APPLIED LIFE SCIENCES↗

A radioxenon detection system using PIPS and CZT

This paper introduces and describes the initial characterizations of a prototype beta gamma coincidence detection system that utilizes a PIPSBox and two coplanar CdZnTe detectors for atmospheric radioxenon identification and nuclear test ban treaty verification. Coincidences between four independent detecting bodies are identified in real time via a custom coincidence module implemented in a field-programmable gate array (FPGA). The system is compact, maintains simple readout electronics, and provides high resolution radiation detection at room temperature operation. Preliminary measurements using 137 Cs and 131m Xe were conducted to optimize various system parameters to achieve optimal energy resolution of key spectral features. The purpose of this research was to explore the utility of these materials and methods for radioxenon monitoring in the International Monitoring System (IMS).

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Semi-automatic aircraft control system

A flight control type system which provides a tactile readout to the hand of a pilot for directing elevator control during both approach to flare-out and departure maneuvers. For altitudes above flare-out, the system sums the instantaneous coefficient of lift signals of a lift transducer with a generated signal representing ideal coefficient of lift for approach to flare-out, i.e., a value of about 30% below stall. Error signals resulting from the summation are read out by the noted tactile device. Below flare altitude, an altitude responsive variation is summed with the signal representing ideal coefficient of lift to provide error signal readout.

Gilson, Richard D.↗

Impact of light output on the timing resolution of organic glass scintillator bars in a dual-ended readout configuration

The effectiveness of detector system modeling and validation depends on the quality of characterization performed on the system. For nuclear nonproliferation applications, which require detectors to address complex and variable field conditions, access to accurate system models is essential. This study presents the timing characterization of organic glass scintillator bars used in an imaging system developed at the University of Michigan. 137 Cs and 60 Co gamma-ray sources were used to determine the coincidence time resolution as a function of measured light output for two Compton scatter events between two organic glass scintillator bars. Timing resolution for two events, each with light output ranging from 100 to 1100 keVee were characterized. The resulting data were fit to a parametric function that was validated to agree with experimental results within ±25 ps. Simulations were performed to establish appropriate calibration points for each organic scintillator, thereby ensuring accurate calibration of light output values during analysis. This work successfully characterized the light output dependence of the coincidence timing resolution of a pair of organic glass detectors for use in an imaging system. Depending on the amount of scintillation light output from the events, the full width at half maximum of the measured coincidence time resolution ranged from 653.2 ± 16.1 ps for low light yields, 100 keVee, to 121.0 ± 8.4 ps for higher yields at 1100 keVee. The insights obtained from the timing resolution behavior will allow for accurate simulation capabilities in future security and verification efforts using scatter-based imaging systems.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Back-side readout semiconductor photomultiplier

This disclosure provides systems, methods, and apparatus related to semiconductor photomultipliers. In one aspect, a device includes a p-type semiconductor substrate, the p-type semiconductor substrate having a first side and a second side, the first side of the p-type semiconductor substrate defining a recess, and the second side of the p-type semiconductor substrate being doped with n-type ions. A conductive material is disposed in the recess. A p-type epitaxial layer is disposed on the second side of the p-type semiconductor substrate. The p-type epitaxial layer includes a first region proximate the p-type semiconductor substrate, the first region being implanted with p-type ions at a higher doping level than the p-type epitaxial layer, and a second region disposed on the first region, the second region being doped with p-type ions at a higher doping level than the first region.

42 ENGINEERING↗

Commissioning of the Mu2e Data AcQuisition System and the Vertical Slice Test of the Straw Tracker

The report discusses the commissioning of the DAQ system of the Mu2e experiment. We studied how the tracker works and especially the tracker readout. We used a generator to send pulses and we tried to understand the output and non-output of the DTC, in order to validate the event and run format and all the failure modes. In section one, we describe Charged Lepton Flavour Violation, the main purpose of Mu2e, in section two we describe Mu2e experiment. Section three presents the tracker description and readout, meanwhile section four the DAQ system and event building. In section five, we start explaining the analysis we have done on events and all the failure modes we discovered. In section six, we have done an analysis of the logger and boardreader rate, we validated the generator frequency in section seven and studied the number of hits in function of the channel number in section eight. To conclude we investigated the channel to channel time differences in section nine and in section ten we explain our Monte Carlo simulation, reproducing ROCs readout.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Wide field imaging of solar system objects with an 8192 x 8192 CCD mosaic

As part of this program, we successfully completed the construction of the world's largest CCD camera, an 8192 x 8192 CCD mosaic. The system employs 8 2K x 4K 3-edge buttable CCDs arranged in a 2 x 4 chip mosaic. The focal plane has small gaps (less than 1 mm) between mosaic elements and measures over 120 mm x 120 mm. The initial set of frontside illuminated CCDs were developed with Loral-Fairchild in a custom foundry run. The initial lots yielded of order 20 to 25 functional devices, of which we selected the best eight for inclusion for the camera. We have designed a custom 3-edge-buttable package that ensures the CCD dies are mounted flat to plus or minus 10 microns over the entire area of the mosaic. The mosaic camera system consists of eight separate readout signal chains controlled by two independent DSP microcontrollers. These are in turn interfaced to a Sun Sparc-10 workstation through two high speed fiber optic interfaces. The system saw first-light on the Canada-France-Hawaii Telescope on Mauna Kea in March 1995. First-light on the University of Hawaii 2.2-M Telescope on Mauna Kea was in July 1995. Both runs were quite successful. A sample of some of the early science from the first light run is reported in the publication, 'Observations of Weak Lensing in Clusters with an 8192 x 8192 CCD Mosaic Camera'.

Hall, Donald N. B.↗

High Pressure Sensing and Dynamics Using High Speed Fiber Bragg Grating Interrogation Systems

Fiber Bragg gratings (FBGs) are developing into useful sensing tools for measuring high pressure dynamics in extreme environments under shock loading conditions. Approaches using traditional diode array coupled FBG interrogation systems are often limited to readout speeds in the sub-MHz range. For shock wave physics, required detection speeds approaching 100 MHz are desired. We explore the use of two types of FBG sensing systems that are aimed at applying this technology as embedded high pressure probes for transient shock events. Both approaches measure time resolved spectral shifts in the return light from short (few mm long) uniform FBGs at 1550 nm. In the first approach, we use a fiber coupled spectrometer to demultiplex spectral channels into an array (up to 12) of single element InGaAs photoreceivers. By monitoring the detectors during a shock impact event with high speed recording, we are able to track the pressure induced spectral shifting in FBG down to a time resolution of 20 ns. In the second approach, developed at the Special Technologies Lab, a coherent mode-locked fiber laser is used to illuminate the FBG sensor. After the sensor, wavelength-to-time mapping is accomplished with a chromatic dispersive element, and entire spectra are sampled using a single detector at the modelocked laser repetition rate of 50 MHz. By sampling with a 12 GHz InGaAs detector, direct wavelength mapping in time is recorded, and the pressure induced FBG spectral shift is sampled at 50 MHz. Here, the sensing systems are used to monitor the spectral shifts of FBGs that are immersed into liquid water and shock compressed using explosives. In this configuration, the gratings survive to pressures approaching 50 kbar. We describe both approaches and present the measured spectral shifts from the shock experiments.

fiber Bragg grating sensors, shockwave diagnostics↗

An 82 to 84 percent efficient, small size, 2 and 4 stage depressed collector for octave bandwidth high performance TWT's

Improvements were carried out on a TWT (traveling wave tube) for use in EMC (electronic countermeasure) systems by applying MDC (multi-stage depressed collector) and spent-beam refocusing techniques. The MDC geometric design consists of six collecting elements (electrodes) at ground and cathode potentials operating in 2 or 4 stage configuration. The refocusing system designed allows a controlled beam expansion to the point that space charge becomes negligible at the MDC entrance. Simultaneously, the standard deviation of the radial velocity (angular spread) is reduced. This system provides an analog real time readout of P(recovered). Data on all tests is obtained with an automated data acquisition system.

Kosmahl, H.↗

Multi-purpose γ-Ray Interface to Auxiliary Detectors (MyRIAD) User Manual

The MyRIAD (Multipurpose γ-Ray Interface to Auxiliary Detectors) module provides a general-purpose interface to allow other detector systems that work in concert with the digital data acquisition (DAQ) sytems of Digital Gammasphere (DGS) and GRETINA to receive the timestamp and triggering information from those systems to synchronize the data acquisition system of an auxiliary detector used in concert with these large detector arrays. Additionally the MyRIAD may be used to transmit time-stamped trigger messages from the auxiliary detector to the main system so that the main system may filter its event readout based upon the presence or absence of a local trigger in the auxiliary detector. Finally, the MyRIAD provides signal interface capabilities designed to allow legacy CAMAC-based detector DAQ systems to be directly controlled and interfaced by the DAQ system of DGS or GRETINA.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Double Image Polarimeter—Ultra Fast: Simultaneous Three-color (BVR) Polarimeter with Electron-multiplying Charge-coupled Devices

We describe a new instrument capable of high-precision (10{sup −5}) polarimetric observations simultaneously in three passbands (BVR). The instrument utilizes electron-multiplying charge-coupled device (EM CCD) cameras for high efficiency and fast image readout. The key features of the Double Image Polarimeter—Ultra Fast (DIPol-UF) are: (i) the optical design with high throughput and inherent stability; (ii) great versatility, which makes the instrument optimally suitable for observations of bright and faint targets; and (iii) a control system, which allows the use of the polarimeter remotely. Examples are given of the first results obtained from high signal-to-noise observations of bright nearby stars and of fainter sources such as X-ray binaries in their quiescent states.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗