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At least 577 records · Page 32

Flightcrew Thrust Control and Engine Display Concepts for the Subsonic Single Aft Engine (SUSAN) Transport Aircraft

NASA is developing a new hybrid-electric aircraft concept called the SUbsonic Single Aft eNgine (SUSAN) Electrofan. The SUSAN airplane is being designed as a 180-passenger commercial regional jet and is expected to fly in the 2040 time frame. The flight deck of the SUSAN airplane is expected to resemble a typical two flightcrew transport. Research issues include pilot control and the display elements needed for the hybrid-electric propulsion system. This paper describes a research study conducted in a high-fidelity simulator where 14 commercial pilots evaluated throttle controls and engine display concepts for a proposed SUSAN flight deck. The results showed that the number of throttle levers did not affect pilot’s situation awareness, workload, or speed control.

hybrid electric aircraft↗

Human Modeling Evaluations in Microgravity Workstation and Restraint Development

The International Space Station (ISS) will provide long-term missions which will enable the astronauts to live and work, as well as, conduct research in a microgravity environment. The dominant factor in space affecting the crew is "weightlessness" which creates a challenge for establishing workstation microgravity design requirements. The crewmembers will work at various workstations such as Human Research Facility (HRF), Microgravity Sciences Glovebox (MSG) and Life Sciences Glovebox (LSG). Since the crew will spend considerable amount of time at these workstations, it is critical that ergonomic design requirements are integral part of design and development effort. In order to achieve this goal, the Space Human Factors Laboratory in the Johnson Space Center Flight Crew Support Division has been tasked to conduct integrated evaluations of workstations and associated crew restraints. Thus, a two-phase approach was used: 1) ground and microgravity evaluations of the physical dimensions and layout of the workstation components, and 2) human modeling analyses of the user interface. Computer-based human modeling evaluations were an important part of the approach throughout the design and development process. Human modeling during the conceptual design phase included crew reach and accessibility of individual equipment, as well as, crew restraint needs. During later design phases, human modeling has been used in conjunction with ground reviews and microgravity evaluations of the mock-ups in order to verify the human factors requirements. (Specific examples will be discussed.) This two-phase approach was the most efficient method to determine ergonomic design characteristics for workstations and restraints. The real-time evaluations provided a hands-on implementation in a microgravity environment. On the other hand, only a limited number of participants could be tested. The human modeling evaluations provided a more detailed analysis of the setup. The issues identified during the real-time testing were investigated in the human modeling analyses. In some cases, the opposite was true where preliminary human modeling analyses provided the design engineers with critical issues that needed to be addressed further. This extensive approach provided an effective means to fully address ergonomic design considerations and accurately identify critical issues.

Whitmore, Mihriban↗

Predicting transport of intra-articularly injected growth factor fusion proteins into human knee joint cartilage

There are no drugs or treatment methods known to prevent the development of post-traumatic osteoarthritis (PTOA), a type of osteoarthritis (OA) that is triggered by traumatic joint injuries and accounts for ~12% of the nearly 600 million OA cases worldwide. Lack of effective drug delivery techniques remains a major challenge in developing clinically effective treatments, but cationic delivery carriers can help overcome this challenge. Scaling up treatments that are effective in in vitro models to achieve success in preclinical in vivo models and clinical trials is also a challenging problem in the field. Here we use a cationic green fluorescent protein (GFP) as a carrier to deliver Insulin-Like Growth Factor 1 (IGF-1), a drug considered as a potential therapeutic for PTOA. GFP-IGF-1 conjugates were first synthesized as fusion proteins with different polypeptide linkers, and their transport properties were characterized in human cartilage explants. In vitro experimental data were used to develop a predictive mathematical transport model that was validated using an independent in vitro experimental data set. In this study, the model was used to predict the transport of these fusion proteins upon intra-articular injection into human knee joints. The predictions included results for the rate and extent of fusion protein penetration into cartilage, and the maximum levels of fusion proteins that would escape into systemic circulation through the joint capsule. Together, our transport measurements and model set the stage for translation of such explant culture studies to in vivo preclinical studies and potentially clinical application.

36 MATERIALS SCIENCE↗

Suited and Unsuited Hybrid III Impact Testing and Finite Element Model Characterization

NASA spacecraft design requirements for occupant protection are a combination of the Brinkley Dynamic Response Criteria and injury assessment reference values (IARV) extracted from anthropomorphic test devices (ATD). For the ATD IARVs, the requirements specify the use of the 5th percentile female Hybrid III and the 95th percentile male Hybrid III. Each of these ATDs is required to be fitted with an articulating pelvis (also known as the aerospace pelvis) and a straight spine. The articulating pelvis is necessary for the ATD to fit into spacecraft seats, while the straight spine is required as injury metrics for vertical accelerations are better defined for this configuration. Sled testing of the Hybrid III 5th Percentile Female Anthropomorphic Test Device (ATD) was performed at Wright-Patterson Air Force Base (WAPFB). Two 5th Percentile ATDs were tested, the Air Force Research Lab (AFRL) and NASA owned Hybrid III ATDs with aerospace pelvises. Testing was also conducted with a NASA-owned 95th Percentile Male Hybrid III with aerospace pelvis at WPAFB. Testing was performed using an Orion seat prototype provided by Johnson Space Center (JSC). A 5-point harness comprised of 2 inch webbing was also provided by JSC. For suited runs, a small and extra-large Advanced Crew Escape System (ACES) suit and helmet were also provided by JSC. Impact vectors were combined frontal/spinal and rear/lateral. Some pure spinal and rear axis testing was also performed for model validation. Peak accelerations ranged between 15 and 20-g. This range was targeted because the ATD responses fell close to the IARV defined in the Human-Systems Integration Requirements (HSIR) document. Rise times varied between 70 and 110 ms to assess differences in ATD responses and model correlation for different impact energies. The purpose of the test series was to evaluate the Hybrid III ATD models in Orion-specific landing orientations both with and without a spacesuit. The results of these tests were used by the NASA Engineering and Safety Center (NESC) to validate the finite element model (FEM) of the Hybrid III 5th Percentile Female ATD. Physical test data was compared to analytical predictions from simulations, and modelling uncertainty factors have been determined for each injury metric. Additionally, the test data has been used to further improve the FEM, particularly in the areas of the ATD preload, harness, and suit and helmet effects.

Lawrence, C.↗

Uptake, Efflux, and Sequestration of Mercury in the Asian Clam, Corbicula fluminea , at Environmentally Relevant Concentrations, and the Implications for Mercury Remediation

(1) Mercury (Hg) is a persistent, ubiquitous contaminant that readily biomagnifies into higher trophic level species in aquatic environments across the globe. It is crucial to understand the movement of environmentally relevant concentrations of Hg in impacted freshwater streams to minimize risks to ecological and human health. (2) The bioconcentration kinetics of aqueous Hg exposure (20, 100, and 200 ng/L) in the invasive Asian Clam, Corbicula fluminea, were measured. A toxicokinetic model, the first parameterized for Hg accumulation in freshwater clams, was developed to estimate uptake and efflux parameters and compared to previous parameter values estimated for other mollusk species. (3) Results demonstrated that even at low Hg concentrations, Corbicula record signals of contamination through bioconcentration, and both direct measurement and toxicokinetic models demonstrate large Hg bioconcentration factors (as high as 1.34 × 10 5 mL/g dry tissue), similar to partitioning coefficients seen in engineered Hg sorbents. (4) Our study found that Corbicula accumulated Hg at aqueous concentrations relevant to impacted streams, but well below regulatory drinking water limits, demonstrating their utility as a sensitive sentinel species and potential bioremediator.

bioaccumulation↗

A Chess-Like Game for Teaching Engineering Students to Solve Large System of Simultaneous Linear Equations

Solving large (and sparse) system of simultaneous linear equations has been (and continues to be) a major challenging problem for many real-world engineering/science applications [1-2]. For many practical/large-scale problems, the sparse, Symmetrical and Positive Definite (SPD) system of linear equations can be conveniently represented in matrix notation as [A] {x} = {b} , where the square coefficient matrix [A] and the Right-Hand-Side (RHS) vector {b} are known. The unknown solution vector {x} can be efficiently solved by the following step-by-step procedures [1-2]: Reordering phase, Matrix Factorization phase, Forward solution phase, and Backward solution phase. In this research work, a Game-Based Learning (GBL) approach has been developed to help engineering students to understand crucial details about matrix reordering and factorization phases. A "chess-like" game has been developed and can be played by either a single player, or two players. Through this "chess-like" open-ended game, the players/learners will not only understand the key concepts involved in reordering algorithms (based on existing algorithms), but also have the opportunities to "discover new algorithms" which are better than existing algorithms. Implementing the proposed "chess-like" game for matrix reordering and factorization phases can be enhanced by FLASH [3] computer environments, where computer simulation with animated human voice, sound effects, visual/graphical/colorful displays of matrix tables, score (or monetary) awards for the best game players, etc. can all be exploited. Preliminary demonstrations of the developed GBL approach can be viewed by anyone who has access to the internet web-site [4]!

Nguyen, Duc T.↗

Engineered Nanoporous Frameworks for Adsorption Cooling Applications

The energy demand for traditional vapor-compressed technology for space cooling continues to soar year after year due to global warming and the increasing human population’s need to improve living and working conditions. Thus, there is a growing demand for eco-friendly technologies that use sustainable or waste energy resources. Here this review discusses the properties of various refrigerants used for adsorption cooling applications followed by a brief discussion on the thermodynamic cycle. Next, sorbents traditionally used for cooling are reviewed to emphasize the need for advanced capture materials with superior properties to improve refrigerant sorption. The remainder of the review focus on studies using engineered nanoporous frameworks (ENFs) with various refrigerants for adsorption cooling applications. The effects of the various factors that play a role in ENF–refrigerant pair selection, including pore structure/dimension/shape, morphology, open-metal sites, pore chemistry and possible presence of defects, are reviewed. Next, in-depth insights into the sorbent–refrigerant interaction, and pore filling mechanism gained through a combination of characterization techniques and computational modeling are discussed. Finally, we outline the challenges and opportunities related to using ENFs for adsorption cooling applications and provide our views on the future of this technology.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Inverted Outflow Ground Testing of Cryogenic Propellant Liquid Acquisition Devices

NASA is currently developing propulsion system concepts for human exploration. These propulsion concepts will require the vapor free acquisition and delivery of the cryogenic propellants stored in the propulsion tanks during periods of microgravity to the exploration vehicles engines. Propellant management devices (PMDs), such as screen channel capillary liquid acquisition devices (LADs), vanes and sponges have been used for earth storable propellants in the Space Shuttle Orbiter and other spacecraft propulsion systems, but only very limited propellant management capability currently exists for cryogenic propellants. NASA is developing PMD technology as a part of their cryogenic fluid management (CFM) project. System concept studies have looked at the key factors that dictate the size and shape of PMD devices and established screen channel LADs as an important component of PMD design. Modeling validated by normal gravity experiments is examining the behavior of the flow in the LAD channel assemblies (as opposed to only prior testing of screen samples) at the flow rates representative of actual engine service (similar in size to current launch vehicle upper stage engines). Recently testing of rectangular LAD channels has included inverted outflow in liquid oxygen and liquid hydrogen. This paper will report the results of liquid oxygen testing compare and contrast them with the recently published hydrogen results; and identify the sensitivity these results to flow rate and tank internal pressure.

Liquid Oxygen↗

Development of Human System Integration at NASA

Human Systems Integration seeks to design systems around the capabilities and limitations of the humans which use and interact with the system, ensuring greater efficiency of use, reduced error rates, and less rework in the design, manufacturing and operational deployment of hardware and software. One of the primary goals of HSI is to get the human factors practitioner involved early in the design process. In doing so, the aim is to reduce future budget costs and resources in redesign and training. By the preliminary design phase of a project nearly 80% of the total cost of the project is locked in. Potential design changes recommended by evaluations past this point will have little effect due to lack of funding or a huge cost in terms of resources to make changes. Three key concepts define an effective HSI program. First, systems are comprised of hardware, software, and the human, all of which operate within an environment. Too often, engineers and developers fail to consider the human capacity or requirements as part of the system. This leads to poor task allocation within the system. To promote ideal task allocation, it is critical that the human element be considered early in system development. Poor design, or designs that do not adequately consider the human component, could negatively affect physical or mental performance, as well as, social behavior. Second, successful HSI depends upon integration and collaboration of all the domains that represent acquisition efforts. Too often, these domains exist as independent disciplines due to the location of expertise within the service structure. Proper implementation of HSI through participation would help to integrate these domains and disciplines to leverage and apply their interdependencies to attain an optimal design. Via this process domain interests can be integrated to perform effective HSI through trade-offs and collaboration. This provides a common basis upon which to make knowledgeable decisions. Finally, HSI must be considered early in the requirements development phase of system design and acquisition. This will provide the best opportunity to maximize return on investment (ROI) and system performance. HSI requirements must be developed in conjunction with capability ]based requirements generation through functional. HSI requirements will drive HSI metrics and embed HSI issues within the system design. After a system is designed, implementation of HSI oversights can be very expensive. An HSI program should be included as an integral part of a total system approach to vehicle and habitat development. This would include, but not limited to, workstation design, D&C development, volumetric analysis, training, operations, and human -robotic interaction. HSI is a necessary process for Human Space Flight programs to meet the Agency Human ]System standards and thus mitigate human risks to acceptable levels. NASA has been involved in HSI planning, procedures development, process, and implementation for many years, and has been building several internal and publicly accessible products to facilitate HSI fs inclusion in the NASA Systems Engineering Lifecycle. Some of these products include: NASA STD 3001 Volumes 1 and 2, Human Integration Design Handbook, NASA HSI Implementation Plan, NASA HSI Implementation Plan Templates, NASA HSI Implementation Handbook, and a 2 ]hour short course on HSI delivered as part of the NASA Space and Life Sciences Directorate Academy. These products have been created leveraging industry best practices and lessons learned from other Federal Government agencies.

Whitmore, Mihriban↗

Inverted Outflow Ground Testing of Cryogenic Propellant Liquid Acquisition Devices

NASA is currently developing propulsion system concepts for human exploration. These propulsion concepts will require the vapor free acquisition and delivery of the cryogenic propellants stored in the propulsion tanks during periods of microgravity to the exploration vehicles engines. Propellant management devices (PMD's), such as screen channel capillary liquid acquisition devices (LAD's), vanes and sponges have been used for earth storable propellants in the Space Shuttle Orbiter and other spacecraft propulsion systems, but only very limited propellant management capability currently exists for cryogenic propellants. NASA is developing PMD technology as a part of their cryogenic fluid management (CFM) project. System concept studies have looked at the key factors that dictate the size and shape of PMD devices and established screen channel LADs as an important component of PMD design. Modeling validated by normal gravity experiments is examining the behavior of the flow in the LAD channel assemblies (as opposed to only prior testing of screen samples) at the flow rates representative of actual engine service (similar in size to current launch vehicle upper stage engines). Recently testing of rectangular LAD channels has included inverted outflow in liquid oxygen and liquid hydrogen. This paper will report the results of liquid oxygen testing compare and contrast them with the recently published hydrogen results; and identify the sensitivity of these results to flow rate and tank internal pressure.

Microgravity↗

Habitat Utilization Assessment - Building in Behaviors

Habitability, and the associated architectural and design attributes of an environment, is a powerful performance shaping factor. By identifying how inhabitants use an area, we can draw conclusions about what design or architectural attributes cause what behaviors and systematically design in desired human performance. We are analyzing how a crew uses a long duration habitat and work environment during a four-day underwater mission and identifying certain architectural and design attributes that are related to, and potential enablers of, certain crew behaviors. By identifying how inhabitants use the habitat, we can draw conclusions about what habitability attributes cause what behaviors and systematically design in desired human performance (applicable to NASA's Bioastronautics Human Behavior and Performance Critical Path Roadmap question 6.12). This assessment replicates a methodology reported in a chapter titled "Sociokinetic Analysis as a Tool for Optimization of Environmental Design" by C. Adams.' That study collected video imagery of certain areas of a closed habitat during a 91 day test and from that data calculated time spent in different volumes during the mission, and characterized the behaviors occurring in certain habitat volumes thus concluding various rules for design of such habitats. This study assesses the utilization of the Aquarius Habitat, an underwater station, which will support six Aquanauts for a fourteen-day mission during which the crew will perform specific scientific and engineering studies. Video is recorded for long uninterrupted periods of time during the mission and from that data the time spent in each area is calculated. In addition, qualitative and descriptive analysis of the types of behaviors in each area is performed with the purpose of identifying any behaviors that are not typical of a certain area. If a participant uses an area in a way different from expected, a subsequent analysis of the features of that area may result in conclusions of performance shaping factors. With the addition of this study, we can make comparisons between the two different habitats and begin drawing correlation judgments about design features and behavior. Ideally, this methodology should be repeated in additional Aquarius missions and other analog environments because the real information will come from comparisons between habitats.

Whitmore, Mihriban↗

Evidence Report: Risk Factor of Inadequate Nutrition

The importance of nutrition in exploration has been documented repeatedly throughout history, where, for example, in the period between Columbus' voyage in 1492 and the invention of the steam engine, scurvy resulted in more sailor deaths than all other causes of death combined. Because nutrients are required for the structure and function of every cell and every system in the body, defining the nutrient requirements for spaceflight and ensuring provision and intake of those nutrients are primary issues for crew health and mission success. Unique aspects of nutrition during space travel include the overarching physiological adaptation to weightlessness, psychological adaptation to extreme and remote environments, and the ability of nutrition and nutrients to serve as countermeasures to ameliorate the negative effects of spaceflight on the human body. Key areas of clinical concern for long-duration spaceflight include loss of body mass (general inadequate food intake), bone and muscle loss, cardiovascular and immune system decrements, increased radiation exposure and oxidative stress, vision and ophthalmic changes, behavior and performance, nutrient supply during extravehicular activity, and general depletion of body nutrient stores because of inadequate food supply, inadequate food intake, increased metabolism, and/or irreversible loss of nutrients. These topics are reviewed herein, based on the current gap structure.

Smith, Scott M.↗

Manned Mars mission crew factors

Crew factors include a wide range of concerns relating to the human system and its role in a Mars mission. There are two important areas which will play a large part in determining the crew for a Mars mission. The first relates to the goals and priorities determined for such a vast endeavor. The second is the design of the vehicle for the journey. The human system cannot be separated from the other systems in that vehicle. In fact it will be the human system which drives the development of many of the technical breakthroughs necessary to make a Mars mission successful. As much as possible, the engineering systems must adapt to the needs of the human system and its individual components.

Santy, Patricia A.↗

The Need for Analogue Missions in Scientific Human and Robotic Planetary Exploration

With the increasing challenges of planetary missions, and especially with the prospect of human exploration of the moon and Mars, the need for earth-based mission simulations has never been greater. The current focus on science as a major driver for planetary exploration introduces new constraints in mission design, planning, operations, and technology development. Analogue missions can be designed to address critical new integration issues arising from the new science-driven exploration paradigm. This next step builds on existing field studies and technology development at analogue sites, providing engineering, programmatic, and scientific lessons-learned in relatively low-cost and low-risk environments. One of the most important outstanding questions in planetary exploration is how to optimize the human and robotic interaction to achieve maximum science return with minimum cost and risk. To answer this question, researchers are faced with the task of defining scientific return and devising ways of measuring the benefit of scientific planetary exploration to humanity. Earth-based and spacebased analogue missions are uniquely suited to answer this question. Moreover, they represent the only means for integrating science operations, mission operations, crew training, technology development, psychology and human factors, and all other mission elements prior to final mission design and launch. Eventually, success in future planetary exploration will depend on our ability to prepare adequately for missions, requiring improved quality and quantity of analogue activities. This effort demands more than simply developing new technologies needed for future missions and increasing our scientific understanding of our destinations. It requires a systematic approach to the identification and evaluation of the categories of analogue activities. This paper presents one possible approach to the classification and design of analogue missions based on their degree of fidelity in ten key areas. Various case studies are discussed to illustrate the approach.

Snook, K. J.↗

Response time effects of alerting tone and semantic context for synthesized voice cockpit warnings

Some handbooks and human factors design guides have recommended that a voice warning should be preceded by a tone to attract attention to the warning. As far as can be determined from a search of the literature, no experimental evidence supporting this exists. A fixed-base simulator flown by airline pilots was used to test the hypothesis that the total 'system-time' to respond to a synthesized voice cockpit warning would be longer when the message was preceded by a tone because the voice itself was expected to perform both the alerting and the information transfer functions. The simulation included realistic ATC radio voice communications, synthesized engine noise, cockpit conversation, and realistic flight routes. The effect of a tone before a voice warning was to lengthen response time; that is, responses were slower with an alerting tone. Lengthening the voice warning with another work, however, did not increase response time.

Simpson, C. A.↗

Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role of translation initiation in the early induction of specific genes remains unclear. Here, we show human translation initiation factor eIF3 interacts with select immune system related mRNAs including those encoding the T cell receptor (TCR) subunits TCRA and TCRB. Binding of eIF3 to the TCRA and TCRB mRNA 3’-untranslated regions (3’-UTRs) depends on CD28 coreceptor signaling and regulates a burst in TCR translation required for robust T cell activation. Use of the TCRA or TCRB 3’-UTRs to control expression of an anti-CD19 chimeric antigen receptor (CAR) improves the ability of CAR-T cells to kill tumor cells in vitro. These results identify a new mechanism of eIF3-mediated translation control that can aid T cell engineering for immunotherapy applications.

59 BASIC BIOLOGICAL SCIENCES↗

System-Theoretic Analysis of Unsafe Collaborative Control in Teaming Systems

The interactions that occur in human-teaming are inspiring novel aerospace designs aimed at improving how humans and machines, or multiple machines, work together. Unfortunately, current Systems Engineering processes are ill-equipped to handle these complex relationships and are unable to design and assure the safety for these systems. To close part of this gap, this paper introduces a novel system-theoretic analytical process to identify unsafe collaborative control actions. It is part of a broader set of techniques that extend the state-of-the-art in hazard analysis, System Theoretic Process Analysis (STPA), to systematically address collaboration. The method rigorously expresses the different ways multiple commands may be unsafe together. Using Systems Theory, it employs abstraction to manage the combinatorial complexity in enumerating control contributions from multiple collaborating components. An algorithm integrates these concepts into an end-to-end process and is supported by automation to enumerate, refine, prune, and prioritize unsafe combinations of control actions. The output of the method feeds the specification of system requirements to implement safety-guided design starting early in concept development. The process is demonstrated on a manned-unmanned aircraft teaming case study and finds new causal factors that were not previously found in a past hazard analysis of the same system.

System Safety↗

Structural Requirements for the Space Propulsion Engine Systems

In January 2004, the National Aeronautics and Space Administration (NASA) was given a vision for Space Exploration by President Bush, setting our sight on a bold new path to go back to the Moon, then to Mars and beyond. As NASA gets ready to meet the vision set by President Bush, failures are not an option. Reliability of the propulsion engine systems will play an important role in establishing an overall safe and reliable operation of these new space systems. A new standard, NASA-STD-5012, Strength and Life Assessment for Space Propulsion System Engines, has been developed to provide structural requirements for assessment of the propulsion systems engine. This standard is a complement to the current NASA-wide standard NASA-STD-5001, Structural Design and Test Factors of Safety for Spaceflight Hardware, which excluded the requirement for the engine systems (rotatory structures) along with pressure vessels. As developed, this document builds on the heritage of the multiple industrial standards related to strength and life assessment of the structures. For assuring a safe and reliable operation of a product and/or mission, establishing a set of structural assessment requirements is a key ingredient. Hence, a concentrated effort was made to improve the requirements where there are known lessons learned during the design, test, and operation phases of the Space Shuttle Main Engine (SSME) and other engine development programs. Requirements delineated in this standard are also applicable for the reusable and/or human missions. It shall be noted that "reliability of a system cannot be tested and inspected but can only be achieved if it is first designed into a system." Hence, these strength and life assessment requirements for the space propulsion system engines shall be used along with other good engineering practices, requirements, and policies.

Aggarwal, Pravin K.↗