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At least 559 records · Page 31
All sourcesNASA NTRSDOE OSTI
DOE OSTI2024

CO2 Transport Planning Database

The CO2 Transport Planning Database v3.0 is a geospatial resource, containing over 70 gigabytes of data representing critical considerations for the spatial routing of pipelines and transport of CO2, from source to sink. Considerations include state-specific legislation, land use requirements, existing infrastructure, and hazard prevention areas. Built to support strategic domestic energy transport planning and development, more than 60 layers of this database have been weighted (Weight fields) according to current legislation and pipeline construction recommendations. Weighted values range from zero to one, where zero represents potentially more acceptable areas for transport based on the various considerations, and a value of one represents areas that should be avoided. This geospatial database provides a baseline for the Smart CO2 Transport Planning Tool.

Boundaries↗
NASA NTRS1990

Windshear detection and avoidance - Airborne systems survey

Functional requirements for airborne windshear detection and warning systems are discussed in terms of the threat posed to civil aircraft operations. A preliminary set of performance criteria for predictive windshear detection and warning systems is defined. Candidate airborne remote sensor technologies based on microwave Doppler radar, Doppler laser radar (lidar), and infrared radiometric techniques are discussed in the context of overall system requirements, and the performance of each sensor is assessed for representative microburst environments and ground clutter conditions. Preliminary simulation results demonstrate that all three sensors show potential for detecting windshear, and provide adequate warning time to allow flight crews to avoid the affected area or escape from the encounter. Radar simulation and analysis show that by using bin-to-bin automatic gain control, clutter filtering, limited detection range, and suitable antenna tilt management, windshear from wet microbursts can be accurately detected. Although a performance improvement can be obtained at higher radar frequency, the baseline X-band system also detected the presence of windshear hazard for a dry microburst. Simulation results of end-to-end performance for competing coherent lidar systems are presented.

Bowles, Roland L.↗
NASA NTRS1978

The prediction of turbulence and wind shear associated with thunderstorm gust fronts

The parametric dependence of storm simulation is explored on the basis of the previously reported (1977) second-order closure model of turbulence designed to simulate a thunderstorm gust front. The model simulation results are intended for extrapolation to the conditions considered most hazardous to aircraft operation. It is shown that the presistence and strength of the gust front are enhanced significantly by increasing the spread of the downdraft shaft and the velocity at the top of the domain. Turbulence develops in the regions of high shear and is most intense near the corner and within the gust front itself. While the center shaft is certainly an area to be avoided, the gust front region is probably more critical because it may extend over a large region far from the center of the downdraft, in a highly transient state.

Teske, M. E.↗
NASA NTRS1973

General aviation air traffic pattern safety analysis

A concept is described for evaluating the general aviation mid-air collision hazard in uncontrolled terminal airspace. Three-dimensional traffic pattern measurements were conducted at uncontrolled and controlled airports. Computer programs for data reduction, storage retrieval and statistical analysis have been developed. Initial general aviation air traffic pattern characteristics are presented. These preliminary results indicate that patterns are highly divergent from the expected standard pattern, and that pattern procedures observed can affect the ability of pilots to see and avoid each other.

Parker, L. C.↗
DOE OSTI2019

Automated Vehicles in Hazardous Merging Traffic: A Chance-Constrained Approach

To realize the energy efficiency and productivity benefits of automated driving, control algorithms must function safely among conventional vehicles. Prototype tests on public roads have revealed a trend of human-driven vehicles rear-ending automated ones. A popular belief holds that unusually conservative control algorithms play a role in such collisions. In August 2018, an automated vehicle was rear-ended while waiting to merge. Inspired by that incident, this paper examines a resemblant scenario in simulation using model predictive control for the automated vehicle. Constraint setup alternatives to avoid collisions with inattentive following vehicles are proposed and assessed in this simulation environment. In one variant, imminent rear-end collisions are detected and constraints are modified to promote more aggressive merging during such an event. Results show that higher-performing chance constraint designs can reduce collision probability, but may have other adverse effects depending on the particular algorithm.

Dollar, R. Austin↗
NASA NTRS2019

Reinforcing Additives for Ice Adhesion Reduction Coatings

Adhesion of contaminants has been identified as a ubiquitous issue for aeronautic exterior surfaces. In-flight icing is particularly hazardous for all aircraft and can be experienced throughout the year under the appropriate environmental conditions. On larger vehicles, the accretion of ice could result in loss of lift, engine failure, and potentially loss of vehicle and life were it not for active deicing or anti-icing equipment. Smaller vehicles though cannot support the mass and mechanical complexity of active ice mitigating systems and thus must rely upon passive approaches or avoid icing conditions altogether. One approach that may be applicable to all aircraft is the use of coatings. Durability remains an issue and has prevented realization of coatings for leading edge contamination mitigation. In this work, epoxy coatings were generated as a passive approach for ice adhesion mitigation and methods to improve durability were evaluated. Highly cross-linked epoxy systems can be extremely rigid, which could have deleterious consequences regarding application as a leading edge coating. Incorporation of flexible species, such as poly(ethylene glycol) may improve coating toughness.8 Additionally, core-shell rubber (CSR) particles have been utilized to improve fracture toughness of epoxies.9 Both of these more established additives are investigated in this work. An emerging additive that is also evaluated here is holey graphene. This nanomaterial possesses many of the advantageous properties of graphene (excellent mechanical properties, thermal and electrical conductivity, large surface area, etc.) while also exhibiting behaviors associated with flexible, porous materials (i.e., compressibility, increased permeation, etc.). Holey graphene, HG, was synthesized by the oxidation of defect-rich sites on graphene sheets through controlled thermal expo-sure.10 It is envisioned that the porous nature of HG would allow resin penetration through the graphitic plane, resulting in better interfacial interaction and therefore better translation of the nanomaterial’s properties to the surrounding matrix.

Wohl, Christopher J↗
NASA NTRS2004

Monitoring the Hazards of Silicic Volcanoes with Remote Sensing

This report details the final progress on the Solid Earth and Natural Hazards project: Monitoring of Hazards of Silicic Volcanoes with Remote Sensing (SENH99-0000-0159). The original award went to Arizona State University (ASU) with Dr. Jonathan Fink as the P.I. and Dr. Michael Ramsey as the Co-I. In May 2000, Dr. Ramsey left ASU to take a tenure-track faculty position at the University of Pittsburgh. The principle investigators and NASA Headquarters agreed to split the grant award at the HQ level and therefore avoid the double overhead charges that would arise from a university subcontract. The objectives of the science were divided, and coordinated yearly progress reports have been submitted from each University. This report details the final progress on work carried out at Arizona State. A report by Dr. Ramsey at the University of Pittsburgh has already been submitted. The work from both institutions is closely related and this report will reflect that connection.

Fink, Jonathan↗
NASA NTRS2024

Computing Proximity to Threat Along Uncertain Trajectory to Support Urban Air Mobility

Many airspace threats affect the selection of a flight route, such as terrain, physical obstacles, adverse weather, and special-use airspace, among others. Threat avoidance during Urban Air Mobility (UAM) and Low Altitude Mobility (LAM) flights is especially challenging due to their lower cruising altitudes. These operations may be exposed to buildings, towers, trees, terrain undulations, etc., along much of their flight route. Moreover, these low-altitude flights in urban environments are expected to encounter very busy airspace, increasing the workload associated with threat avoidance. The Proximity to Threat (PtT) function aims to support onboard or remote pilots by computing the risk from geospatial threats in the airspace along an aircraft’s flight path. The threats are both static entities and dynamic airspace restrictions that have been modeled and stored in geo-referenced mapping databases. The flight path may be specified by waypoints, airways, or similar discrete route elements or by a time series of closely spaced position and altitude points. Flight path uncertainty can also be taken into account by assuming both the position and altitude to be sampled from two normal distributions, each being specified by a mean and variance. PtT uses this additional information to verify that the flight path remains clear of threats along a wider path or if a position is reached earlier or later than anticipated, assuring the pilot or operator that there will be an available safety margin even if the aircraft deviates due to one or more occurrences of unexpected wind gusts, mechanical failures, airspeed changes, collision avoidance maneuvers, etc. The client can specify an uncertainty confidence level to bound the set of trajectories evaluated for threats so that the confidence level corresponds to the client’s risk tolerance under the expected conditions. PtT can be used as a pre-flight planning tool to determine a safe route through known threats and in-flight to avoid emerging or changing threats. In this report, we present the PtT function, discuss how the trajectory uncertainty is incorporated into the PtT function, and describe the use of this PtT function in a representative scenario.

urban air mobility↗
DOE OSTI2018

Metals in paints on chopsticks: Solubilization in simulated saliva, gastric, and food solutions and implication for human health

Highlights: • Extremely high metal concentrations were observed in paints on some chopsticks. • Significantly higher metal concentration in paints on stainless steel than wood chopsticks. • Higher metal concentration in red and green paints. • Significantly higher metal migration in 0.07 M HCl and 1% citric acid than in saliva. • Extremely high Pb and Cd in stainless steel chopsticks were health risk. Paints are often used on chopsticks, however, a paucity of studies has assessed metals in the paints and the associated health risk. In this study, total Pb, Cd, Cr, Co, and Ni concentrations in paints were assessed for 72 wood and 29 stainless steel chopsticks with different colors while metal solubilization from paints in simulated saliva, 0.07 M HCl, and 1% citric acid solutions was measured for 9 samples having total Pb > 90 mg kg{sup –1}, representing exposure scenarios of mouthing, incidental paint ingestion, and metal migration in food. Results showed that Pb (0.12–500,000 mg kg{sup –1}), Cd (0.002–120,000 mg kg{sup –1}), Cr (2.2–8400 mg kg{sup –1}), Co (0.004–2600 mg kg{sup –1}), and Ni (0.10–150,000 mg kg{sup –1}) concentrations varied considerably among paint samples. Most samples showed low metal concentrations, however, high metal concentrations were observed in red and green paints on stainless steel chopsticks, while paints on wood chopsticks showed lower metal concentrations. Estimation of daily metal intakes incorporating metal solubilization data in saliva, 0.07 M HCl, and 1% citric acid solutions suggested that the health risk via saliva contact was negligible, while unacceptable health risk was observed for Pb and Cd via their solubilization in 0.07 M HCl and 1% citric acid solutions from paints with high Pb and Cd concentrations. To avoid Pb and Cd exposure, use of metal-based paints on chopsticks should be banned, particularly in countries where food is regularly consumed with chopsticks.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS2005

Dynamic wake prediction and visualization with uncertainty analysis

A dynamic wake avoidance system utilizes aircraft and atmospheric parameters readily available in flight to model and predict airborne wake vortices in real time. A novel combination of algorithms allows for a relatively simple yet robust wake model to be constructed based on information extracted from a broadcast. The system predicts the location and movement of the wake based on the nominal wake model and correspondingly performs an uncertainty analysis on the wake model to determine a wake hazard zone (no fly zone), which comprises a plurality of wake planes, each moving independently from another. The system selectively adjusts dimensions of each wake plane to minimize spatial and temporal uncertainty, thereby ensuring that the actual wake is within the wake hazard zone. The predicted wake hazard zone is communicated in real time directly to a user via a realistic visual representation. In an example, the wake hazard zone is visualized on a 3-D flight deck display to enable a pilot to visualize or see a neighboring aircraft as well as its wake. The system substantially enhances the pilot's situational awareness and allows for a further safe decrease in spacing, which could alleviate airport and airspace congestion.

Holforty, Wendy L.↗
DOE OSTI2017

Assessment on Transport of Radioactive Species from Nuclear Facilities - 17079

It is generally recognized that radioactive nuclides are most hazardous fission products that could be released in the event of reactor accidents. The reactor coolant system of a pressurized water reactor (PWR) nuclear plant exhibits radioactivity from various sources. These radiation sources consist of the fission products from fuel element and activated products from corrosion products. The complex infrastructure of the processes does not allow detailed measurement of activity until after the reactor is shutdown. All of the components that require dismantling will be radioactive which was caused by neutron activation during operation, contamination by corrosion products, contamination by damaged by fuel rods and leaks by equipment. Due mainly to the various operation modes and their aging, there are the increasing needs to carry out repair works that are not sufficiently provided for by the original design. Many difficulties are involved in these tasks, namely, high radiation doses, cramped areas, hard to reach components, coupled with stringent quality conditions. The need to simulate the behavior of corrosion products in a nuclear power plant environment has attracted many researchers' attention. It has performed the in-depth reviews of the various theories and physics associated with the corrosion products transportation, the laboratory loop testing, and the field measurements in operating plants. Before we start the decommissioning of nuclear power plants, workers, the public and the environment shall be properly protected from radiation hazards. For this purpose, a safety assessment should be carried out relating to the potential hazards that may occur during the decommissioning. The radiological hazards involved in the decommissioning activities also should be identified, and be taken into account in the safety assessment. The radiation conditions of the primary circuit are determined by the activity of corrosion and fission products that have accumulated on the internal surfaces of the components. Therefore the estimation of contamination on the components is very important and, may be the first step in the reactor operation and decommissioning of components. The predominant radionuclide in the PWR primary coolant is Co-60, although Co-58 contributes significantly to radioactivity level at the early stage of a reactor operation. Since Co-60 is produced from the in-core Co-58, which is the source of cobalt in a reactor coolant system, many researchers have investigated its transmutation in the core, its transport around the system, and its subsequent deposition on surfaces. The major parameter influencing the behavior of radioactivity, such as Co-60 in the coolant, is the corrosion product oxides. The objective of this work is to analyze the corrosion product activity transported in the primary circuit by using a multi-region model. This model, which is incorporated with the mass and activity transport between the dissolved corrosion products in the coolant and the surface, describes the specific activity of corrosion products in coolant and on the surfaces according to the operation modes as well as decommissioning stage. In order to evaluate the analysis of the corrosion products in an integral type reactor, a multi-region mass balance model is applied. The specific activities of the various species on the surface of core and steam generator throughout the effective full power hours, 15,000 hours, are simulated for the various modes of operations. As a result, the specific activities of corrosion products from the surface of primary circuit were shown as very low compared to those of other commercial nuclear power plants. In this simulated reactor, a significant reduction of specific activities from the activated corrosion products is obtained due to the introduction of titanium alloy to the steam generator tube and the avoidance of boric acid induced corrosion. From this result we conclude that we are able to predict the level of radioactive nuclides generated by corrosion products in a primary circuit according to the various modes of operations by using multi-region model. In this point of view it is concluded that this multi-region model can be used as an engineering tool for analysis of the corrosion products within the primary coolant for the nuclear power plants. It is also considered that it is possible to extend to a calculation tool for estimating the radiological hazards involved in the decommissioning activities in terms of safety assessment. (authors)

07 ISOTOPE AND RADIATION SOURCES↗
NASA NTRS1975

The high current transient generator, theory and operation for simulating lightning induced voltages into aerospace electrical circuits

Because of the difficulty, hazard, and cost of simulating full-scale lightning currents on flight vehicles, a nondestructive test technique using reduced-scale lightning currents was used to determine if threat level voltages will be induced into aircraft electrical circuits in the event the aircraft is actually struck by lightning. The reasoning and theory of selecting a particular simulated lightning waveshape and magnitude is given, showing that extrapolation of induced waveforms over several orders of magnitude should be avoided. The operation of high-current transient generators and hardware are described along with typical applications. The means by which voltages were generated, induced, and measured, as well as possible sources of error, are discussed.

Schulte, E. H.↗
NASA NTRS2012

The Economics of NASA Mission Cost Reserves

Increases in NASA mission costs are well-noted but not well-understood, and there is little evidence that they are decreasing in frequency or amount over time. The need to control spending has led to analysis of the causes and magnitude of historical mission overruns, and many program control efforts are being implemented to attempt to prevent or mitigate the problem (NPR 7120). However, cost overruns have not abated, and while some direct causes of increased spending may be obvious (requirements creep, launch delays, directed changes, etc.), the underlying impetus to spend past the original budget may be more subtle. Gaining better insight into the causes of cost overruns will help NASA and its contracting organizations to avoid .them. This paper hypothesizes that one cause of NASA mission cost overruns is that the availability of reserves gives project team members an incentive to make decisions and behave in ways that increase costs. We theorize that the presence of reserves is a contributing factor to cost overruns because it causes organizations to use their funds less efficiently or to control spending less effectively. We draw a comparison to the insurance industry concept of moral hazard, the phenomenon that the presence of insurance causes insureds to have more frequent and higher insurance losses, and we attempt to apply actuarial techniques to quantifY the increase in the expected cost of a mission due to the availability of reserves. We create a theoretical model of reserve spending motivation by defining a variable ReserveSpending as a function of total reserves. This function has a positive slope; for every dollar of reserves available, there is a positive probability of spending it. Finally, the function should be concave down; the probability of spending each incremental dollar of reserves decreases progressively. We test the model against available NASA CADRe data by examining missions with reserve dollars initially available and testing whether they are more likely to spend those dollars, and whether larger levels of reserves lead to higher cost overruns. Finally, we address the question of how to prevent reserves from increasing mission spending without increasing cost risk to projects budgeted without any reserves. Is there a "sweet spot"? How can we derive the maximum benefit associated with risk reduction from reserves while minimizing the effects of reserve spending motivation?

Whitley, Sally↗
DOE OSTI2017

Radiation-Induced Skin Injuries to Patients: What the Interventional Radiologist Needs to Know

For a long time, radiation-induced skin injuries were only encountered in patients undergoing radiation therapy. In diagnostic radiology, radiation exposures of patients causing skin injuries were extremely rare. The introduction of fast multislice CT scanners and fluoroscopically guided interventions (FGI) changed the situation. Both methods carry the risk of excessive high doses to the skin of patients resulting in skin injuries. In the early nineties, several reports of epilation and skin injuries following CT brain perfusion studies were published. During the same time, several papers reported skin injuries following FGI, especially after percutaneous coronary interventions and neuroembolisations. Thus, CT and FGI are of major concern regarding radiation safety since both methods can apply doses to patients exceeding 5 Gy (National Council on Radiation Protection and Measurements threshold for substantial radiation dose level). This paper reviews the problem of skin injuries observed after FGI. Also, some practical advices are given how to effectively avoid skin injuries. In addition, guidelines are discussed how to deal with patients who were exposed to a potentially dangerous radiation skin dose during medically justified interventional procedures.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI1994

Nuclear Safety [Vol. 35, No. 1, January-June 1994]

Nuclear Safety is a review journal that covers significant developments in the field of nuclear safety. Its scope includes the analysis and control of hazards associated with nuclear energy, operations involving fissionable materials, and the products of nuclear fission and their effects on the environment. Primary emphasis is on safety in reactor design, construction, and operation; however, the safety aspects of the entire fuel cycle, including fuel fabrication, spent-fuel processing, nuclear waste disposal, handling of radioisotopes, and environmental effects of these operations, are also treated. Table of Contents for this issue follows. THE CHERNOBYL ACCIDENT: 1 Chernobyl Accident Management Actions, A. R Sich; GENERAL SAFETY CONSIDERATIONS: 25 The IAEA-ASSET Approach to Avoiding Accidents is to Recognize the Precursors to Prevent Incidents, F. Reisch; ACCIDENT ANALYSIS: 36 A Review of the Available Information on the Triggering Stage of a Steam Explosion, D. F. Fletcher; 58 Analysis and Modeling of Flow-Blockage-Induced Steam Explosion Events in the High-Flux Isotope Reactor, R. P. Taleyarkhan, V. Georgevich, C. W. Nestor, U. Gat, B. L. Lepard, D. H. Cook, J. Freels, S. J. Chang, C. Luttrell, R. C. Gwaltney, and J. Kirkpatrick; 74 An Analysis of Disassembling the Radial Reflector of a Thermionic Space Nuclear Reactor Power System, M. S. El-Genk and D. V. Paramonov; CONTROL AND INSTRUMENTATION: 86 Standards for High-Integrity Software, D. R. Wallace, D. R. Kuhn, L M. Ippolito, and L. Beltracchi; DESIGN FEATURES: 98 Adoption of New Design Features for the Next Generation Nuclear Power Reactors, L. S. Tong; 114 Review of Nuclear Piping Seismic Design Requirements, G. C. Slagis and S. E. Moore; ENVIRONMENTAL EFFECTS: 128 PC-Based Probabilistic Safety Assessment Study for a Geological Waste Repository Placed in a Bedded Salt Formation, S. A. Khan; OPERATING EXPERIENCES: 142 Managing Aging in Nuclear Power Plants: Insights from NRC’s Maintenance Team Inspection Reports, A. Fresco and M. Subudhi; 150 Reactor Shutdown Experience, Compiled by J. W. Cletcher; 153 Selected Safety-Related Events, Compiled by G. A. Murphy; RECENT DEVELOPMENTS: 158 Reports, Standards, and Safety Guides, D. S. Queener; 168 Proposed Rule Changes as of Dec. 31, 1993; ANNOUNCEMENTS: 177 Symposium on Radioactive and Mixed Waste—Risk as a Basis for Waste Classification; 177 1995 Incineration Conference 178 Ninth Power Plant Dynamics Control and Testing Symposium; 174 The Authors

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2015

Acute Superior Mesenteric Venous Thrombosis: Transcatheter Thrombolysis and Aspiration Thrombectomy Therapy by Combined Route of Superior Mesenteric Vein and Artery in Eight Patients

PurposeTo assess the feasibility, effectiveness, and safety of catheter-directed thrombolysis and aspiration thrombectomy therapy by combined route of superior mesenteric vein and artery (SMV+SMA) for acute superior mesenteric venous thrombosis (ASMVT).MethodsThis retrospective study reviewed eight ASMVT patients with transcatheter direct thrombolysis and aspiration thrombectomy therapy via SMV and indirect thrombolysis via SMA during a period of 14 months. The demographics, etiology, risk factors, therapeutic effect, complications, mortality, and follow-up of the study population were assessed. Anatomic and imaging classification of location and extent of thrombus at diagnosis and degree of thrombus lysis were described.ResultsTechnical success was achieved with substantial improvement in symptoms and thrombus resolution after thrombolytic therapy in all patients. The local urokinase infusion by SMA and SMV was performed for 5–7 (6.13 ± 0.83) and 7–15 (12 ± 2.51) days. Anticoagulation was performed catheter-directed and then orally throughout hospitalization and after discharge. Four patients required delayed localized bowel resection after thrombolytic therapy with no death. Thrombolytic therapy was not interrupted despite minor bleeding at the puncture site in two patients and sepsis in another two postoperatively. Nearly complete removal of thrombus was demonstrated by contrast-enhanced CT scan and portography before discharge. Patients were discharged in 10–27 (19.25 ± 4.89) days after admission. No recurrence developed during the follow-up of 10–13 (12.13 ± 0.99) months.ConclusionsCatheter-directed thrombolytic and aspiration therapy via SMV+SMA is beneficial for ASMVT in avoiding patient death, efficient resolving thrombus, rapid improving symptoms, reversing extensive intestinal ischemia, averting bowel resection, or localizing infarcted bowel segment and preventing short bowel syndrome.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2015

Technique for comprehensive head and neck irradiation using 3-dimensional conformal proton therapy

Owing to the technical and logistical complexities of matching photon and proton treatment modalities, we developed and implemented a technique of comprehensive head and neck radiation using 3-dimensional (3D) conformal proton therapy. A monoisocentric technique was used with a 30-cm snout. Cervical lymphatics were treated with 3 fields: a posterior-anterior field with a midline block and a right and a left posterior oblique field. The matchline of the 3 cervical nodal fields with the primary tumor site fields was staggered by 0.5 cm. Comparative intensity-modulated photon plans were later developed for 12 previously treated patients to provide equivalent target coverage, while matching or improving on the proton plans' sparing of organs at risk (OARs). Dosimetry to OARs was evaluated and compared by treatment modality. Comprehensive head and neck irradiation using proton therapy yielded treatment plans with significant dose avoidance of the oral cavity and midline neck structures. When compared with the generated intensity-modulated radiation therapy (IMRT) plans, the proton treatment plans yielded statistically significant reductions in the mean and integral radiation dose to the oral cavity, larynx, esophagus, and the maximally spared parotid gland. There was no significant difference in mean dose to the lesser-spared parotid gland by treatment modality or in mean or integral dose to the spared submandibular glands. A technique for cervical nodal irradiation using 3D conformal proton therapy with uniform scanning was developed and clinically implemented. Use of proton therapy for cervical nodal irradiation resulted in large volume of dose avoidance to the oral cavity and low dose exposure to midline structures of the larynx and the esophagus, with lower mean and integral dose to assessed OARs when compared with competing IMRT plans.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2015

SU-E-J-33: Comparison Between Soft Tissue Alignment and Bony Alignment for Pancreatic Cancer Radiotherapy

Purpose An IGRT modality for pancreatic cancer treatment with dose escalation at our institution is in-room daily CT imaging. The purpose of this study is to assess the difference between soft tissue alignment and bony alignment for pancreatic tumor localization. Methods Eighteen patients with pancreatic tumors who underwent IMRT treatment with an inspiration breath-hold technique between July 2012 and February 2015 are included in this study. Prior to each treatment, a CT scan was acquired. The CT image guidance started with auto-alignment to either the bony anatomy (vertebral bodies) or fiducials (for the six patients with the stent in/near the tumor) and then, when necessary, manual adjustments were made based on soft tissue alignment using clinical software (CT-Assisted Targeting system). The difference between soft tissue alignment and bony/fiducial alignment was evaluated. Results Of all 380 treatments, manual adjustment was made in 225 treatments, ranging from 11% (3 treatments out of 28) to 96% (27 treatments out of 28) per patient. The mean of the difference between soft tissue alignment and bony/fiducial alignment per patient ranged from −3.6 to 0.3 mm, −1.5 to 2.8 mm, and −3.3 to 3.4 mm in the AP, SI, and RL directions, respectively. The maximum difference over all treatments was −9.5, −14.6, and −14.6 mm in the AP, SI, and RL directions, respectively. Conclusion About 60% of the time, manual adjustment based on soft tissue alignment was required. The extent of manual adjustment was usually small but varied significantly from patient to patient. The ultimate goal of the IGRT modality using daily CT imaging is not to fully cover the target but to spare organs-at-risk as much as possible to avoid them moving into higher dose gradients than accepted in the treatment plan. To this end, manual adjustment based on soft tissue alignment is critically important.

60 APPLIED LIFE SCIENCES↗