Effective Model for Prediction of N2O and NH3 Formation During the Regeneration of NOx Storage Catalyst
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Koci, Petr↗
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Results for “REGENERATION”
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On the Road to Regeneration: “Tools” and “Routes” Towards Efficient Cardiac Cell Therapy for Ischemic Cardiomyopathy
Purpose of Review: Cardiac regenerative medicine is a field bridging together biotechnology and surgical science. In this review, we present the explored surgical roads to cell delivery and the known effects of each delivery method on cell therapy efficiency. We also list the more recent clinical trials, exploring the safety and efficacy of delivery routes used for cardiac cell therapy approaches. Recent Findings: There is no consensus in defining which way is the most suitable for the delivery of the different therapeutic cell types to the damaged heart tissue. In addition, it emerged that the “delivery issue” has not been systematically addressed in each clinical trial and for each and every cell type capable of cardiac repair. Summary: Cardiac damage occurring after an ischemic insult triggers a cascade of cellular events, eventually leading to heart failure through fibrosis and maladaptive remodelling. None of the pharmacological or medical interventions approved so far can rescue or reverse this phenomenon, and cardiovascular diseases are still the leading cause of death in the western world. Therefore, for nearly 20 years, regenerative medicine approaches have focused on cell therapy as a promising road to pursue, with numerous preclinical and clinical testing of cell-based therapies being studied and developed. Nonetheless, consistent clinical results are still missing to reach consensus on the most effective strategy for ischemic cardiomyopathy, based on patient selection, diagnosis and stage of the disease, therapeutic cell type, and delivery route.
62 RADIOLOGY AND NUCLEAR MEDICINE↗
Sulfur poisoning and regeneration of the Ag/γ-Al2O3 catalyst for H2-assisted SCR of NOx by ammonia
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Doronkin, Dmitry E.↗
Numerical simulation and optimization of an industrial fluid catalytic cracking regenerator
Not Available
Tang, Guangwu↗
Modeling and experimental testing of periodic flow regenerators for sCO2 cycles
Not Available
Hinze, Jacob (ORCID:000000018687235X)↗
Assessment of three different gadolinium-based regenerators in a rotary-type magnetic refrigerator
Not Available
Li, Zhenxing↗
In vitro prominent bone regeneration by release zinc ion from Zn-modified implant
Highlights: {yields} We isolated the Zn{sup 2+} ions (eluted Zn{sup 2+} ion; EZ) from zinc-incorporated titanium implant. {yields} The EZ promoted the cell viability in hBMCs. {yields} The EZ stimulated preosteoblast and osteoblast marker gene expression in hBMCs. {yields} The hBMCs supplemented with EZ showed typically cell morphology when osteoblast maturing. {yields} It is revealed that the EZ also stimulates the calcium deposition of hBMCs. -- Abstract: Zinc is one of the trace elements which induce the proliferation and the differentiation of the osteoblast. In the previous study, we found that zinc ions (Zn{sup 2+} ion)-releasing titanium implants had excellent bone fixation using a rabbit femurs model. In this study, we isolated the Zn{sup 2+} ions (eluted Zn{sup 2+} ion; EZ) released from the implant surface, and evaluated the effect of EZ on the osteogenesis of human bone marrow-derived mesenchymal cells (hBMCs). In the result, it was found that the EZ stimulated cell viability, osteoblast marker gene (type I collagen, osteocalcin (OC), alkaline phosphatase (ALP) and bone sialoprotein (BSP)) expressions and calcium deposition in hBMCs.
60 APPLIED LIFE SCIENCES↗
Regeneration of the oesophageal muscle layer from oesophagus acellular matrix scaffold using adipose-derived stem cells
Highlights: • Production of acellular matrix was achieved with complete removal of nuclear material but retaining collagen. • Human adipose-derived stem cells could attach and adhere to decellularized oesophageal acellular matrix. • Cells survived and proliferated for at least 7 days and oxygen level did not affect the proliferative capacity. This study explored the feasibility of constructing a tissue engineered muscle layer in the oesophagus using oesophageal acellular matrix (OAM) scaffolds and human aortic smooth muscle cells (hASMCs) or human adipose-derived stem cells (hASCs). The second objective was to investigate the effect of hypoxic preconditioning of seeding cells on cell viability and migration depth. Our results demonstrated that hASMCs and hASCs could attach and adhere to the decellularized OAM scaffold and survive and proliferate for at least 7 days depending on the growth conditions. This indicates adipose-derived stem cells (ASCs) have the potential to substitute for smooth muscle cells (SMCs) in the construction of tissue engineered oesophageal muscle layers.
60 APPLIED LIFE SCIENCES↗