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DOE OSTI2015

WE-EF-BRA-11: Precision Partial-Tumor Irradiation of Dorsal Rodent Mammary Tumors

Purpose: To introduce a pre-clinical treatment technique on a micro-irradiator to treat specific volumes of dorsal mammary tumors in BALB/c mice while sparing lungs and spine. This technique facilitates pre-clinical investigation of tumor response to sub-optimal radiation treatments in which a portion of the tumor is unirradiated, known as a “marginal miss”. In-vitro data suggests that partial tumor radiations trigger a more aggressive phenotype in non-irradiated, regional tumor cells via bystander effects. As the lung tissue is spared, the impact of marginal miss on the development of pulmonary metastasis may be assessed. Methods: End to end test was performed on three BALB/c mice as proof of concept for larger studies. 1Gy was delivered on the micro-irradiator employing previously unexplored lateral parallel-opposed diamond and/or triangle-shaped beams. The margins of the treatment beam were defined using a combination of tumor palpation, barium fiducial markers, and real-time fluoroscopic images. The dose distribution was independently verified with kilovoltage beam Monte Carlo dose calculations with 7% statistical uncertainty and double exposure images. As a final step, the technique was used in a larger pre-clinical study (15Gy, 36 BALB/c mice) and lung metastasis in response to tumor irradiation of 100%, 50% and 0% was quantified. Results: For the Monte-Carlo dose calculations, the dose volume histograms established a maximum dose within the un-irradiated and radiated portions of the mammary tumor of 0.3Gy and 1.5Gy respectively, with a sharp gradient at the boundary. 100% of the lung volume received less than 0.5Gy. This technique proved suitable for a pre-clinical marginal miss study with 50% more lung metastases in partially-radiated mouse models compared to completely. Conclusion: We have developed a novel treatment technique for partial or full irradiation of dorsal mammary tumors incorporating lung sparing.The technique will be useful for exploring the phenomena of aggressive tumor phenotype that may arise from miss-irradiation.

60 APPLIED LIFE SCIENCES↗

NASA NTRS2002

Charge Transfer Calculations and Database for Astrophysics

A variety of theoretical approaches, having different but overlapping energy ranges of applicability, are applied to investigate charge transfer processes for collisions of atomic ions with atoms and molecules. The methods include quantal molecular-orbital close-coupling, classical trajectory Monte Carlo, and continuum distorted wave methods. Recent collision systems studied include S(+4) + H, S(+4) + He, N(+7) + He, H2O, CO, and CO2, O(+q)(q = 1 - 8) + H, H2, and S(+q)(q = 1 - 16) + H2. The database effort is concentrating on astrophysically important reactions of atomic ions X(+q)(X=H-Zn, q=1-4, and selected higher charges) with H, He, various metal atoms, H2, and other selected molecular targets. Existing data, much of it produced by us, has been compiled and critically evaluated. Data for many reactions missing in the literature are estimated using the multichannel Landau-Zener approximation. Fits to cross sections and rate coefficients using standard functions are provided as well as tabulations of the raw data. The database is available on the World Wide Web at cfadc.phy.ornl.gov/astro/ps/data.

Wang, J. G.↗

NASA NTRSDate not supplied

EVA Planning: Using Neutral Buoyancy Laboratory (NBL) Training to Predict in-Flight Energy Expenditure

Metabolic rate (“met rate”) is the amount of energy expended over a period of time and is influenced by many factors including body composition, level of physical activity, resting metabolic rate, sex, age, and food intake. Met rate is measured during Extravehicular Activity (EVA) training at the Neutral Buoyancy Laboratory (NBL) and during in-flight EVAs through indirect calorimetry, calculating energy expenditure from respiratory measurements of O 2 consumption and/or CO 2 production. During Extravehicular Activity (EVA) planning, metabolic cost is important to consider and is used to inform EVA duration based on spacesuit consumables associated with life support systems. Currently, NBL and previous ISS EVA met rate data for specified crewmembers are utilized to predict in-flight EVA metabolic costs based on a proposed EVA timeline. Timeline data collected during training is used to relate met rates to specific EVA activities, which are in turn assigned to more generalized EVA task categories, categorizing by both task type and restraint type. EVA task categories include EVA Setup/Cleanup, Worksite Setup/Cleanup, Cable Routing, Bolts, Fluid Connectors, Electrical Connectors, R&R Work, Miscellaneous Work, Incapacitated Crew Rescue (being rescued or performing), Assisted Crew Rescue (being assisted or performing), and Translation. Restraint types consist of Free-Float, Body Restraint Tether (BRT), Articulating Portable Foot Restraint (APFR), and Space Station Remote Manipulator System (SSRMS). From a crewmember’s historical data, individualized 10th, 50th and 90th percentile met rate estimates are generated for each task category and used to estimate the proposed EVA timeline metabolic cost. In-flight metabolic data (“As-Executed”) from recent ISS US EVAs 85-88 (totaling eight EVA crewmember met rates) was compared with their predicted metabolic cost (“As-Planned”) to evaluate the accuracy of the current met rate estimation method. Across the four EVAs, As-Executed Cumulative EVA Total Metabolic Cost (M = 5893.78 BTU, SD = 816.60) was not significantly different compared to As-Planned Cumulative EVA Total Metabolic Cost (M = 6106.60 BTU, SD = 826.62; t(7) = 0.751 , p = .477). Though not a significant difference, generally, As-Planned total estimates were slightly higher than As-Executed total metabolic cost. Relative Error for Cumulative EVA Total Metabolic Cost ranged from -33% to 14.7%, depending on the crewmember and EVA. When comparing As-Planned to A-Executed EVA task categories for Bolts, Electrical Connectors, EVA Cleanup, EVA Setup, Miscellaneous Work, Translation, Worksite Cleanup, and Worksite Setup during these EVAs, no significant differences were observed, however, there was a significant difference in As-Planned (M = 783.71 BTU, SD = 408.88) compared to As-Executed (M = 608.87 BTU, SD = 425.29) metabolic cost for the task category of Repair-and-Replace (R&R) Work (t(17) = 3.21 , p = .005). Looking closer within the R&R Work task category, As-Executed R&R Work with Free-Float restraint type (M = 706.17 BTU, SD = 352.18) was significantly less than As-Planned R&R Work with Free-Float restraint type (M= 887.96 BTU, SD = 381.42; t(12) = 2.59, p < .024). As-Executed R&R Work with SSRMS Restraint type (M = 355.89 BTU, SD = 534.65) was not significantly different from As-Planned values (M = 512.69 BTU, SD = 383.34; t(4) = 1.88, p = 0.132). These findings suggest that the energy expended performing R&R Work (Free-Float) is lower in flight than predicted. Accurate predictions of the metabolic cost of EVA are essential for planning and executing successful ISS EVAs. Overall, the current met rate prediction method is similar to actual in-flight values, slightly erring on the side of overestimation. Future work includes analysis of more historical in-flight EVA data to increase the power of the analysis, evaluating the NBL-ISS met rate conversion factor between NBL and ISS tasks, as well as exploring methods of substitution when crewmembers are missing prior task category data.

Lauren Cox↗

NASA NTRSDate not supplied

Automating MISSE Specimens Image Analysis

The Materials International Space Station Experiment (MISSE) Project consists of experiments focused on the investigation of the effects that occur through the exposure of materials specimens in the space environment. To determine if there is a change in a specimen, the data obtained from the MISSE high-resolution photographic images can be monitored. For this, a compilation of folders was created to provide an organizational system. Each mission was divided into the specific direction in space, materials specimen, and date the image was taken. This organization helps to identify how a specimen behaves as a function of time in the space environment. Once the images were classified, a qualitative process was first used to detect an evolution in the materials of MISSE-9 - MISSE-14.

MISSE ISS Materials↗

DOE OSTI2025

The Missing Correlation Between the Potential Rate Impacts of Rooftop Solar and the Timing of State Net Metering Policy Revisions

Data supporting the article “The Missing Correlation Between the Potential Rate Impacts of Rooftop Solar and the Timing of State Net Metering Policy Revisions” (https://www.nlr.gov/docs/fy25osti/93543.pdf). Residential solar photovoltaic (PV) output in most states is credited at the retail electricity rate, a policy commonly known as net metering. Twelve states have replaced net metering with alternative rate structures that reduce PV adopter bill savings. Proponents of these revisions argue that net metering increases the electricity rates of customers without PV. Here, we analyze the degree to which the timelines of net metering revisions have correlated with potential electricity rate impacts. We estimate that potential rate impacts at the end of 2023 were less than 1% of typical customer bills in 37 of 44 states that have offered net metering. There are no statistically significant differences in average or median estimated rate impacts between states that have and have not revised net metering. Nine of the states that had revised net metering did so when estimated impacts were less than 1% of typical customer bills. Many states have retained net metering into higher PV deployment levels with increased risk of potential rate impacts. Only two states-California and Hawaii-retained net metering beyond estimated rate impacts of 5%, and both have revised net metering. These findings do not suggest a clear, consistent link between net metering revision timelines and potential rate impacts. The timing and nature of net metering revisions are ultimately policy decisions based on state-level priorities and considerations.

14 SOLAR ENERGY↗

DOE OSTI2020

RELAP5-3D Modeling of High Temperature Test Facility (HTTF) Test PG-26

The High Temperature Test Facility (HTTF) at Oregon State University (OSU) is a scaled integral effects experiment designed to investigate transient behavior in high-temperature gas-cooled nuclear reactors with prismatic fuel and reflector blocks. Several tests have been completed, and more are still planned to at the HTTF, including depressurized conduction cooldown (DCC) and pressurized conduction cooldown (PCC) transients. This report analyses test PG-26, a progression of the Double Ended Inlet-Outlet Crossover Duct Break transient that is referred to as a DCC. PG-26 has been performed at the HTTF between May 30 and June 30, 2019. Core initial conditions (i.e., before the DCC started) have been met using low power (<100 kW) and two of ten available electric heaters. The DCC transient was initiated during the 50 th hour of the test. The break valves were opened, and hot helium from the core and cold helium from the reactor cavity simulation tank (RCST) started mixing. The gases flowed in a countercurrent fashion, where the top half of the hot duct contained hot helium that flowed in one direction and cold helium that flowed in the other direction in the bottom half of the duct. After the pressure and density reached equilibrium, the event entered a diffusion mode. The onset of a reverse natural circulation was not observed during the DCC period of the test. Version 4.4.2ie of the RELAP5-3D computer code has been used to model the HTTF PG-26 test, and results have been compared to available high-quality measured data. The model used in this study is the quality-controlled HTTF RELAP5-3D model (HTTF base 2018-04-19 QA), originally developed by P. Bayless. The report includes RELAP5-3D results of the “base calculations” as well as some sensitivities to important uncertain model inputs, such as primary helium mass flow rate, core ceramic thermal properties, as well as heat evacuation and loop friction models. Using the base RELAP5-3D model predicts a countercurrent helium flow in the hot duct observed at the beginning of the DCC, but instead of going into a molecular diffusion mode, the model predicts the onset of natural convection. Increasing friction in the core and hot duct prevents the natural convection from happening in some of the simulations. Although some temperatures are well predicted (and even overpredicted), the general tendency is to underpredict the ceramic and helium temperatures and heat removal rates during the DCC, resulting in many of the assessment findings being in minimal or insufficient agreement with the data. It is worth noting that the described discrepancies between measured data and RELAP5-3D predictions are not RELAP5-3D code limitations. More so, they reflect limitations in boundary condition and thermal property knowledge. While the RELAP5-3D calculations of the test provide some insights into what happens during the transient, and point to missing or potentially uncertain data to which the experimenters can direct their attention, the principal conclusion is that the PG-26 test data are insufficient for a system code assessment.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

DOE OSTI2022

Enhancing Worker Safety During Off-Site Construction of Energy-Efficient, Low-Carbon Exterior Envelope

The construction industry is not doing enough to embrace off-site modular construction. It is a missed opportunity for optimized energy efficiency because prefabricated exterior wall envelopes are lower in cost and faster and easier to install. Factory off-site construction offers improved safety for construction workers because work is done in a controlled environment, but lack of intent, understanding, and data is also a missed opportunity for enhancing worker safety. This research looks specifically at the prefabricated wall exterior envelope in the context of safety. The research question is "off-site factories build with ease of energy efficiency and lowered carbon emissions, but is the process safer?" This research was funded by NREL Student Training in Applied Research (STAR) program, University Partnerships Program, and Wells Fargo Bank. Key finding is that modular and prefabricated construction are perceived to be safer, but the accident rates are much higher than in the general construction and manufacturing industries. Proposed solutions to decrease accidents in off-site prefabricated construction includes safety training for workers, provide movable kiosks with PPE at workstations, ensure tools are well-maintained and place safety posters in visible locations. Future work includes improving worker safety to increase worker productivity, perform pilot demonstration, work with factory designers for new modular layout for worker safety, i.e., easy access to PPE kiosks, and work closely with OSHA so that they take notice of this safety niche.

drywall↗

NASA NTRS2011

Characterization of Tactical Departure Scheduling in the National Airspace System

This paper discusses and analyzes current day utilization and performance of the tactical departure scheduling process in the National Airspace System (NAS) to understand the benefits in improving this process. The analysis used operational air traffic data from over 1,082,000 flights during the month of January, 2011. Specific metrics included the frequency of tactical departure scheduling, site specific variances in the technology's utilization, departure time prediction compliance used in the tactical scheduling process and the performance with which the current system can predict the airborne slot that aircraft are being scheduled into from the airport surface. Operational data analysis described in this paper indicates significant room for improvement exists in the current system primarily in the area of reduced departure time prediction uncertainty. Results indicate that a significant number of tactically scheduled aircraft did not meet their scheduled departure slot due to departure time uncertainty. In addition to missed slots, the operational data analysis identified increased controller workload associated with tactical departures which were subject to traffic management manual re-scheduling or controller swaps. An analysis of achievable levels of departure time prediction accuracy as obtained by a new integrated surface and tactical scheduling tool is provided to assess the benefit it may provide as a solution to the identified shortfalls. A list of NAS facilities which are likely to receive the greatest benefit from the integrated surface and tactical scheduling technology are provided.

Capps, Alan↗

NASA NTRSDate not supplied

Exposure of Plant Seeds to the Space Environment outside the International Space Station

If crop seeds are to be stored on space vehicles for long-duration missions, the effects of the space environment on the seeds must be understood for developing mitigation strategies to prevent seed degradation. The MISSE-Seed project was designed to investigate the effects of space exposure on seed quality and storage. The project also tested the Materials International Space Station Experiment (MISSE) platform for exposing biological samples to the space environment and evaluated the capability of a newly designed passive sample containment vessel for the provision of acceptable storage conditions for seeds, or other biological samples, to be preserved upon exposure to the space environment outside the ISS. The experiment was launched to the ISS on NG-15and returned to Earth aboard SpX-24. The specimens consisted of eleven seed varieties (Lettuce, Scarlet Frills, Amara, Garnet Giant, Pac Choi, Radish, Mizuna, Tomato, Cauliflower, Pepper, and Arabidopsis). The exposure lasted eight months outside the ISS in the MISSE hardware at the Zenith position. Data-loggers and thermoluminescent dosimeters (TLDs) were included in each container to record the environmental data. Temperature profiles and radiation/UV exposure data were also provided by Aegis Aerospace, the MISSE Implementation Partner. In this presentation, the hardware and experimental design, the environmental profiles, and the results of post-flight germination tests will be presented.

Jeffrey T Richards↗

NASA NTRSDate not supplied

Exposure of Plant Seeds to the Space Environment Outside the International Space Station

Jeffrey T Richards↗

DOE OSTI2021

Low-rank Tensor Completion for PMU Data Recovery

This paper proposes a tensor completion method for the recovery of missing phasor measurement unit (PMU) measurements. Tensor completion as the general case of matrix completion has attracted increasing attention in recent years. The imputation accuracy for the existing matrix completion methods may be significantly reduced when there are consecutive data losses across multiple data channels. To tackle this issue, we explore the multi-way characteristics of PMU measurements by using a tensor model. We leverage the low-rank property of the PMU measurements and formulate the missing PMU data recovery problem as a low-rank tensor completion problem. An efficient algorithm based on alternating direction method of multipliers (ADMM) is developed to solve the tensor completion problem. The experiments using the real PMU dataset show that the proposed method exhibits better imputation accuracy compared with the conventional data recovery methods.

Ghasemkhani, Amir↗

NASA NTRS2002

NASA Hybrid Reflectometer Project

Time-domain and frequency-domain reflectometry have been used for about forty years to locate opens and shorts in cables. Interpretation of reflectometry data is as much art as science. Is there information in the data that is being missed? Can the reflectometers be improved to allow us to detect and locate defects in cables that are not outright shorts or opens? The Hybrid Reflectometer Project was begun this year at NASA Ames Research Center, initially to model wire physics, simulating time-domain reflectometry (TDR) signals in those models and validating the models against actual TDR data taken on testbed cables. Theoretical models of reflectometry in wires will give us an understanding of the merits and limits of these techniques and will guide the application of a proposed hybrid reflectometer with the aim of enhancing reflectometer sensitivity to the point that wire defects can be detected. We will point out efforts by some other researchers to apply wire physics models to the problem of defect detection in wires and we will describe our own initial efforts to create wire physics models and report on testbed validation of the TDR simulations.

Lynch, Dana↗

DOE OSTI2014

A Chandra-HETG view of MCG +8-11-11

We present a spectral analysis of the 118 ks Chandra High Energy Transmission Gratings (HETG) observation of the X-ray bright Seyfert 1.5 galaxy MCG +8-11-11, in conjunction with 100 ks of archival Suzaku data, aimed at investigating the signatures of warm absorption and Compton reflection reported from previous Suzaku and XMM-Newton studies of the source. Contrary to previous results, we find that warm absorption is not required by the data. Instead, we report upper limits on absorption lines that are below previous (marginal) detections. Fe Kα line emission is clearly detected and is likely resolved with σ ∼ 0.02 keV with the HETG data. We applied self-consistent, broadband spectral-fitting models to the Chandra and Suzaku data to investigate this and other signatures of distant absorption and reflection. Utilizing in particular the MYTorus model, we find that the data are consistent with reprocessing by a distant, neutral torus that is marginally Compton-thick ( N {sub H} ∼10{sup 24}cm{sup –2}) and out of the line of sight. However, we do not find compelling evidence of a relativistically broadened Fe K emission line, which is often expected from type 1 active galactic nuclei. This is consistent with some, although not all, previous studies of MCG +8-11-11. A well-measured edge is identified by the HETG near 0.5 keV, indicating neutral absorption in the line of sight that is consistent with galactic absorption; however, the absorption may be partially intrinsic to the source. The HETG data are consistent with the presence of a soft excess, a feature that may be missed by considering the Suzaku data alone.

79 ASTRONOMY AND ASTROPHYSICS↗

DOE OSTI2020

In-Situ Inference: Bringing Advanced Data Science Into Exascale Simulations

As simulations generate ever-increasing amounts of data, there are correspondingly richer opportunities for analysis and scientific discovery - discoveries that will be missed if most of the data must be discarded before it is analyzed. Because future exascale architectures will be increasingly storage-limited, it will not be possible to save the vast majority of simulation data for later analysis, requiring analysis to occur “in-situ” within the simulation. However, existing in-situ data analysis frameworks provide little or no support for one of the most sophisticated forms of data science: probabilistic statistical modeling or uncertainty quantification (UQ), and the accompanying challenge of inference - fitting those statistical models to massive simulation output. Our goal is to develop the fundamental statistical algorithms and computer science needed to perform statistical inference in-situ (in HPC simulations) to the full stream of data those simulations generate.

97 MATHEMATICS AND COMPUTING↗

DOE OSTI2023

Search for flavor-changing neutral-current couplings between the top quark and the Z boson with proton-proton collisions at s = 13 TeV with the ATLAS detector

A search for flavor-changing neutral-current couplings between a top quark, an up or charm quark, and a $Z$ boson is presented, using proton-proton collision data at $\sqrt{s}$ = 13 TeV collected by the ATLAS detector at the Large Hadron Collider. The analyzed data set corresponds to an integrated luminosity of 139 fb -1 . The search targets both single-top-quark events produced as $gq$ → $tZ$ (with $q$ = $u, c$) and top-quark-pair events, with one top quark decaying through the $t$ → $Zq$ channel. The analysis considers events with three leptons (electrons or muons), a $b$-tagged jet, possible additional jets, and missing transverse momentum. The data are found to be consistent with the background-only hypothesis and 95% confidence-level limits on the $t$ → $Zq$ branching ratios, assuming only tensor operators of the Standard Model effective field theory framework contribute to the $tZq$ vertices. These are 6.2 x 10 -5 (13 x 10 -5 ) for $t$ → $Zu$ ($t$ → $Zc$) for a left-handed $tZq$ coupling, and 6.6 x 10 -5 (12 x 10 -5 ) in the case of a right-handed coupling. These results are interpreted as 95% CL upper limits on the strength of the corresponding couplings, yielding limits for |${C}^{(13)*}_{uW}$| and |${C}^{(13)*}_{uB}$| (|${C}^{(31)}_{uW}$| and |${C}^{(31)}_{uB}$|) of 0.15 (0.16), and limits for |${C}^{(23)*}_{uW}$| and |${C}^{(23)*}_{uB}$| (|${C}^{(32)}_{uW}$| and |${C}^{(32)}_{uB}$|) of 0.22 (0.21), assuming a new-physics energy scale Λ NP of 1 TeV.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

NASA NTRS1973

Estimation of rate constants of elementary processes - A review of the state of the art.

'Thermochemical kinetics,' the codification and extrapolation of empirical observations, as applied to certain elementary reactions of importance to combustion studies, is described. This approach allows the critical scrutiny of experimental data in areas where sufficient previous data exist, while, at the same time, illuminating those key areas where more experimentation is crucial. It is shown that combination of transition-state theory with an understanding of the molecular basis of entropy puts fairly rigid constraints on the values of the Arrhenius A-factor for most reactions. This, in turn, means that the activation energy is often the key datum that is missing, and that such data can be obtained with some degree of confidence, even from measurements of rate constants at only one temperature. In complex mechanisms, it is often possible to distinguish among alternate pathways and pinpoint key processes.

Golden, D. M.↗

DOE OSTI2021

Search for squarks and gluinos in final states with jets and missing transverse momentum using 139 fb -1 of $ \sqrt{s} $ = 13 TeV pp collision data with the ATLAS detector

A search for the supersymmetric partners of quarks and gluons (squarks and gluinos) in final states containing jets and missing transverse momentum, but no electrons or muons, is presented. The data used in this search were recorded by the ATLAS experiment in proton-proton collisions at a centre-of-mass energy of $\sqrt{s}$ = 13 TeV during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb -1 . The results are interpreted in the context of various R -parity-conserving models where squarks and gluinos are produced in pairs or in association and a neutralino is the lightest supersymmetric particle. An exclusion limit at the 95% confidence level on the mass of the gluino is set at 2.30 TeV for a simplified model containing only a gluino and the lightest neutralino, assuming the latter is massless. For a simplified model involving the strong production of mass-degenerate first- and second-generation squarks, squark masses below 1.85 TeV are excluded if the lightest neutralino is massless. These limits extend substantially beyond the region of supersymmetric parameter space excluded previously by similar searches with the ATLAS detector.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

DOE OSTI2016

Search for new physics in final states with two opposite-sign, same-flavor leptons, jets, and missing transverse momentum in pp collisions at sqrt(s) = 13 TeV

A search is presented for physics beyond the standard model in final states with two opposite-sign, same-flavor leptons, jets, and missing transverse momentum. The data sample corresponds to an integrated luminosity of 2.3 fb$^{−1}$ of proton-proton collisions at $ \sqrt{s}=13 $ TeV collected with the CMS detector at the LHC in 2015. The analysis uses the invariant mass of the lepton pair, searching for a kinematic edge or a resonant-like excess compatible with the Z boson mass. Both search modes use several event categories in order to increase the sensitivity to new physics. These categories are based on the rapidity of the leptons, the multiplicity of jets and b jets, the scalar sum of jet transverse momenta, and missing transverse momentum. The observations in all signal regions are consistent with the expectations from the standard model, and the results are interpreted in the context of simplified models of supersymmetry.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗