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At least 559 records · Page 31

Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening

Osteosarcoma (OS) is the most common primary malignant bone cancer in children and adolescents. While numerous other cancers now have promising therapeutic advances, treatment options for OS have remained unchanged since the advent of standard chemotherapeutics and offer less than a 25% 5-y survival rate for those with metastatic disease. This dearth of clinical progress underscores a lack of understanding of OS progression and necessitates the study of this disease in an innovative system. Here, we adapt a previously described engineered bone marrow (eBM) construct for use as a three-dimensional platform to study how microenvironmental and immune factors affect OS tumor progression. We form eBM by implanting acellular bone-forming materials in mice and explanting the cellularized constructs after 8 wk for study. We interrogate the influence of the anatomical implantation site on eBM tissue quality, test ex vivo stability under normoxic (5% O 2 ) and standard (21% O 2 ) culture conditions, culture OS cells within these constructs, and compare them to human OS samples. We show that eBM stably recapitulates the composition of native bone marrow. OS cells exhibit differential behavior dependent on metastatic potential when cultured in eBM, thus mimicking in vivo conditions. Furthermore, we highlight the clinical applicability of eBM as a drug-screening platform through doxorubicin treatment and show that eBM confers a protective effect on OS cells that parallel clinical responses. Combined, this work presents eBM as a cellular construct that mimics the complex bone marrow environment that is useful for mechanistic bone cancer research and drug screening.

59 BASIC BIOLOGICAL SCIENCES↗

Human Capabilities Assessments for Autonomous Missions: A Multi-Team Research Effort to Reduce Risk in the Human-System Integration Architecture for Future Deep-Space Missions

In future exploration missions beyond low earth-orbit, crew will have to execute complex operations and respond to off-nominal events, without real-time support from Mission Control. It is anticipated that increased reliance on automated systems, including human-centric vehicle and information architecture, will need to be designed to support the crew; increased risk to performance, health, and safety may occur if these are not implemented appropriately. The Human Factors and Behavioral Performance Element (HFBP) in the NASA Human Research Program supports research to characterize and mitigate such human health and performance risks, including the Risk of Adverse Outcome Due to Inadequate Human Systems Integration Architecture (HSIA). The HSIA risk addresses the integration of onboard capability and the crew roles and responsibilities necessary to enable the crew to respond effectively and efficiently in the increasingly autonomous mission operations environment. In 2017, HFBP released the “Human Capabilities Assessments for Autonomous Missions” (HCAAM) research topic to address HSIA related questions. HCAAM is a major NASA research effort that has assembled a multidisciplinary team from seven institutions to work closely with design and engineering efforts on research towards developing and refining human performance standards, guidelines and automation tools. The scientific focus is on quantitative assessment of human capabilities relevant to future deep-space missions during which earth/spacecraft communication is so delayed and intermittent that the crew must be able to function autonomously. The integrated strategy of the HCAAM project characterizes human capabilities and limitations related to potential performance decrements during long duration exploration mission spaceflight as relevant to both routine and complex task performance; defines system characteristics that reduce the likelihood or impact of potential decrements in human performance capabilities; performs integrated assessment of intelligent system responses within the context of an operational environment with relevant NASA tools, systems, and data structures in order to determine positive or negative interactions and validate recommended approaches; and proposes specific updates to existing standards and guidelines for inclusion in NASA handbooks for the design of future spacecraft intelligent systems that provide crew performance assessment/feedback, and to also serve as decision-support aids for the onboard crew (i.e., NASA-STD-3001, and NASA/SP-Human Integration Design Handbook (HIDH)). The scientific research vectors being addressed by the seven HCAAM teams include: - crew task performance (accuracy, efficiency) (crew + automation) - crew performance (accuracy, efficiency) - crew Situation Awareness - procedure design and multi-modal enhancement - concurrent tasking (mixed manual + some level of autonomy) - task handover - crew self-planning and time-lining - task design - trust in automation, real-time calibration - human multi-sensory feedback and guidance - human trust in on-board software-based intelligent assistants - virtual assistants The presentation will highlight plans and progress made in each of these research areas as well as the methods by which surrogate astronaut crews in the NASA JSC HERA spaceflight analog facility will function as human test subjects for all of the HCAAM research projects.

HCAAM VNSCOR↗

Evolving Trust in Robots: Specification Through Sequential and Comparative Meta-Analyses

Objective The objectives of this meta-analysis are to explore the presently available empirical findings on the antecedents of trust in robots and use this information to expand upon a previous meta-analytic review of the area. Background Human–robot interaction (HRI) represents an increasingly important dimension of our everyday existence. Currently, the most important element of these interactions is proposed to be whether the human trusts the robot or not. We have identified three overarching categories that exert effects on the expression of trust. These consist of factors associated with (a) the human, (b) the robot, and (c) the context in which any specific HRI event occurs. Method The current body of literature was examined and all qualifying articles pertaining to trust in robots were included in the meta-analysis. A previous meta-analysis on HRI trust was used as the basis for this extended, updated, and evolving analysis. Results Multiple additional factors, which have now been demonstrated to significantly influence trust, were identified. The present results, expressed as points of difference and points of commonality between the current and previous analyses, are identified, explained, and cast in the setting of the emerging wave of HRI. Conclusion The present meta-analysis expands upon previous work and validates the overarching categories of trust antecedent (human-related, robot-related, and contextual), as well as identifying the significant individual precursors to trust within each category. A new and updated model of these complex interactions is offered. Application The identified trust factors can be used in order to promote appropriate levels of trust in robots.

Behavioral Sciences↗

Bio-inspired strategies for next-generation perovskite solar mobile power sources

Smart electronic devices are becoming ubiquitous due to many appealing attributes including portability, long operational time, rechargeability and compatibility with the user-desired form factor. Integration of mobile power sources (MPS) based on photovoltaic technologies with smart electronics will continue to drive improved sustainability and independence. With high efficiency, low cost, flexibility and lightweight features, halide perovskite photovoltaics have become promising candidates for MPS. Realization of these photovoltaic MPS (PV-MPS) with unconventionally extraordinary attributes requires new ‘out-of-box’ designs. Natural materials have provided promising designing solutions to engineer properties under a broad range of boundary conditions, ranging from molecules, proteins, cells, tissues, apparatus to systems in animals, plants, and humans optimized through billions of years of evolution. Applying bio-inspired strategies in PV-MPS could be biomolecular modification on crystallization at the atomic/meso-scale, bio-structural duplication at the device/system level and bio-mimicking at the functional level to render efficient charge delivery, energy transport/utilization, as well as stronger resistance against environmental stimuli (e.g., self-healing and self-cleaning). In this paper, we discuss the bio-inspired/-mimetic structures, experimental models, and working principles, with the goal of revealing physics and bio-microstructures relevant for PV-MPS. Here the emphasis is on identifying the strategies and material designs towards improvement of the performance of emerging halide perovskite PVs and strategizing their bridge to future MPS.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Empirical Tests of the Predicted Footprint for Uncontrolled Satellite Reentry Hazards

A number of statistical tools have been developed over the years for assessing the risk of reentering object to human populations. These tools make use of the characteristics (e.g., mass, material, shape, size) of debris that are predicted by aerothermal models to survive reentry. The statistical tools use this information to compute the probability that one or more of the surviving debris might hit a person on the ground and cause one or more casualties. The statistical portion of the analysis relies on a number of assumptions about how the debris footprint and the human population are distributed in latitude and longitude, and how to use that information to arrive at realistic risk numbers. Because this information is used in making policy and engineering decisions, it is important that these assumptions be tested using empirical data. This study uses the latest database of known uncontrolled reentry locations measured by the United States Department of Defense. The predicted ground footprint distributions of these objects are based on the theory that their orbits behave basically like simple Kepler orbits. However, there are a number of factors in the final stages of reentry - including the effects of gravitational harmonics, the effects of the Earth s equatorial bulge on the atmosphere, and the rotation of the Earth and atmosphere - that could cause them to diverge from simple Kepler orbit behavior and possibly change the probability of reentering over a given location. In this paper, the measured latitude and longitude distributions of these objects are directly compared with the predicted distributions, providing a fundamental empirical test of the model assumptions.

Matney, Mark↗

Statistical Issues for Uncontrolled Reentry Hazards Empirical Tests of the Predicted Footprint for Uncontrolled Satellite Reentry Hazards

A number of statistical tools have been developed over the years for assessing the risk of reentering objects to human populations. These tools make use of the characteristics (e.g., mass, material, shape, size) of debris that are predicted by aerothermal models to survive reentry. The statistical tools use this information to compute the probability that one or more of the surviving debris might hit a person on the ground and cause one or more casualties. The statistical portion of the analysis relies on a number of assumptions about how the debris footprint and the human population are distributed in latitude and longitude, and how to use that information to arrive at realistic risk numbers. Because this information is used in making policy and engineering decisions, it is important that these assumptions be tested using empirical data. This study uses the latest database of known uncontrolled reentry locations measured by the United States Department of Defense. The predicted ground footprint distributions of these objects are based on the theory that their orbits behave basically like simple Kepler orbits. However, there are a number of factors in the final stages of reentry - including the effects of gravitational harmonics, the effects of the Earth s equatorial bulge on the atmosphere, and the rotation of the Earth and atmosphere - that could cause them to diverge from simple Kepler orbit behavior and possibly change the probability of reentering over a given location. In this paper, the measured latitude and longitude distributions of these objects are directly compared with the predicted distributions, providing a fundamental empirical test of the model assumptions.

Matney, Mark↗

Feasibility of Large High-Powered Solar Electric Propulsion Vehicles: Issues and Solutions

Human exploration beyond low Earth orbit will require the use of enabling technologies that are efficient, affordable, and reliable. Solar electric propulsion (SEP) has been proposed by NASA s Human Exploration Framework Team as an option to achieve human exploration missions to near Earth objects (NEOs) because of its favorable mass efficiency as compared to traditional chemical systems. This paper describes the unique challenges and technology hurdles associated with developing a large high-power SEP vehicle. A subsystem level breakdown of factors contributing to the feasibility of SEP as a platform for future exploration missions to NEOs is presented including overall mission feasibility, trip time variables, propellant management issues, solar array power generation, array structure issues, and other areas that warrant investment in additional technology or engineering development.

Capadona, Lynn A.↗

Thrust Vector Control for Nuclear Thermal Rockets

Future space missions may use Nuclear Thermal Rocket (NTR) stages for human and cargo missions to Mars and other destinations. The vehicles are likely to require engine thrust vector control (TVC) to maintain desired flight trajectories. This paper explores requirements and concepts for TVC systems for representative NTR missions. Requirements for TVC systems were derived using 6 degree-of-freedom models of NTR vehicles. Various flight scenarios were evaluated to determine vehicle attitude control needs and to determine the applicability of TVC. Outputs from the models yielded key characteristics including engine gimbal angles, gimbal rates and gimbal actuator power. Additional factors such as engine thrust variability and engine thrust alignment errors were examined for impacts to gimbal requirements. Various technologies are surveyed for TVC systems for the NTR applications. A key factor in technology selection is the unique radiation environment present in NTR stages. Other considerations including mission duration and thermal environments influence the selection of optimal TVC technologies. Candidate technologies are compared to see which technologies, or combinations of technologies best fit the requirements for selected NTR missions. Representative TVC systems are proposed and key properties such as mass and power requirements are defined. The outputs from this effort can be used to refine NTR system sizing models, providing higher fidelity definition for TVC systems for future studies.

Ensworth, Clinton B. F.↗

Implementing Artificial Thinking Autonomy with Model-Based System Engineering

Complex autonomous systems capable of successfully operating independently under ‘known unknowns’ and harsh conditions require paradigm innovation in modern development strategies. In the field of autonomy, developing a system-of-systems which can ostensibly think for itself in the face of ‘unknown unknowns’ is still a field of ongoing research. Maturing the systems architecting and modeling methodologies for developing henceforth named Thinking Autonomous Systems, which are verified with digital mission simulation, can potentially usher in the next generation of artificial intelligence for space exploration. The concept presented in this paper incorporates multiple Model-Based Systems Engineering and simulation methodologies combined as a new paradigm to design a novel, biomimetic thinking autonomy strategy. Anachronistic concepts from classical Kantian philosophy will be leveraged to inspire architectural designs that could be used for complex distributed systems in deep space. To accomplish this, digital transformation of a document-based implementation plan for Thinking Autonomous Systems, generated by experienced NASA software engineers, is implemented for NASA’s Platform for Autonomous Systems by creating descriptive and executable software models in SysML to prototype real-time operating capabilities. This conceptual implementation has been developed by incorporating model-based digital simulations to theorize how a cyberphysical thinking system would achieve specific strategies without crew reliance, while simultaneously being resilient to all operating conditions and remaining functional when devoid of ground communication. Additionally, ensuring that an autonomous system framework is an ethical Artificial Intelligence requires careful consideration of system behavior and accountability, human factors for teaming with a thinking autonomous system, and comparison to other modern approaches used for implementing true autonomy. This paper presents the first steps in formalizing the metacognition required for instantiating a truly Thinking Autonomous System; the approach described symphonizes autonomy characteristics from classical philosophical into a unified software architecture describing human thought. In the future, the foundational models described in this paper can be further leveraged to help advance research into thinking autonomy requirements for future deep space missions as well as for current near-term applications, i.e., living aboard crewed spacecraft like a NASA Gateway cislunar habitat.

Artificial Thought↗

Intentional Collaboration & Innovation Spaces at NASA

Collaboration and Innovation (C&I) are extremely popular terms in corporate jargon, and institutions with reputations for creativity often have clever and fun spaces set aside for hatching ideas and developing products or services. In and of themselves, a room full of "collaboration furniture" and electronics can't make C&I happen, any more than oil makes a gas or diesel engine run. As with the engine, though, quality lubrication is a huge factor in the smooth operation, power, and longevity of C&I activity. This paper describes spaces deliberately set up at numerous NASA field centers to support collaborative and creative thinking and processes. (Sometimes support is not so much a matter of doing things to spark discussion as it is removing constraints imposed by traditional settings and making information sharing as easy as possible.) Some spaces are rooms or suites dedicated to C&I, with significant electronic support and/or intentional lack thereof (to emphasize the human element). Others are small, comfortable "roosting places" that invite conversations of opportunity. Descriptions include the sponsoring organization, underlying goals and philosophies, lessons learned, and opportunities to excel. There is discussion about how such areas might interconnect within centers, across NASA, and with external entities using current technology and what tools and approaches may be in our future.

Scott, David W.↗

A Rapid Assessment of a Lunar Surface Laboratory Module

Johnson Space Center has piloted an innovation team known as the Forge to perform rapid turnaround, concurrent engineering studies. The Forge is intended to be able to pull together a team of strategically selected domain experts to innovatively solve a specified problem within a short period of time. The Forge’s inaugural project was the development of a Lunar Surface Laboratory Module concept. The lab module is intended as an option for the NASA Lunar Architecture Team and may allow for increased science productivity and return on investment than with only the Surface Habitat. The Forge team developed two concepts, a stationary laboratory and a mobile laboratory. Human factors evaluations have been conducted to determine the acceptability of the resulting design concepts. The human factors evaluations conducted include a card sort evaluation of the laboratories by science discipline and the System Usability Scale (SUS). The card sort focused subject matter expert expectations for the relative positioning of the laboratory functional areas, determining whether a given lab area should be adjacent to, or separated from, another. The SUS focused on layout efficiency. Both used human factors personnel and both life and physical scientists as subject matter experts. Each of these evaluations will focus primarily on objective data with limited subjective comments, reducing the time required for processing responses. The results of the card sort and SUS evaluations and their implications will be discussed. Based on the evaluation data, an overall acceptability of the Lunar Surface Laboratory Module produced by the Forge study can be determined. Lessons learned and recommendations for future use of human factors rapid assessment processes in early design trades will also be provided.

Forge↗

Rapid Assessment of a Lunar Surface Laboratory Module

Johnson Space Center has piloted an innovation team known as the Forge to perform rapid turnaround, concurrent engineering studies. The Forge is intended to be able to pull together a team of strategically selected domain experts to innovatively solve a specified problem within a short period of time. The Forge’s inaugural project was the development of a Lunar Surface Laboratory Module concept. The lab module is intended as an option for the NASA Lunar Architecture Team and may allow for increased science productivity and return on investment than with only the Surface Habitat. The Forge team developed two concepts, a stationary laboratory and a mobile laboratory. Human factors evaluations have been conducted to determine the acceptability of the resulting design concepts. The human factors evaluations conducted include a card sort evaluation of the laboratories by science discipline and the System Usability Scale (SUS). The card sort is focused subject matter expert expectations for the relative positioning of the laboratory functional areas, determining whether a given lab area should be adjacent to, or separated from, another. The SUS will focus on layout efficiency. Both will use human factors personnel and both life and physical scientists as subject matter experts. Each of these evaluations will focus primarily on objective data with limited subjective comments, reducing the time required for processing responses. The results of the card sort and SUS evaluations and their implications will be discussed. Based on the evaluation data, an overall acceptability of the Lunar Surface Laboratory Module produced by the Forge study can be determined. Lessons learned and recommendations for future use of human factors rapid assessment processes in early design trades will also be provided.

Human Factors↗

Recent trends in digital human modeling and the concurrent issues that face human modeling approach

Tremendous strides have been made in the recent years to digitally represent human beings in computer simulation models ranging from assembly plant maintenance operations to occupants getting in and out of vehicles to action movie scenarios. While some of these tools are being actively pursued by the engineering communities, there is still a lot of work that remains to be done for the newly planned planetary exploration missions. For example, certain unique and several common challenges are seen in developing computer generated suited human models for designing the next generation space vehicle. The purpose of this presentation is to discuss NASA s potential needs for better human models and to show also many of the inherent yet not too obvious pitfalls that still are left unresolved in this new arena of digital human modeling. As part of NASA s Habitability and Human Factors Branch, the Anthropometry and Biomechanics Facility has been engaged in studying the various facets of computer generated human physical performance models; for instance, it has been engaged in utilizing three-dimensional laser scan data along with three dimensional video based motion and reach data to gather suited anthropometric and shape and size information that are not available yet in the form of computer mannequins. Our goal is to bring in new approaches to deal with heavily clothed humans (such as, suited astronauts) and to overcome the current limitations of wrongly identifying humans (either real or virtual) as univariate percentiles. We are looking at whole-body posture based anthropometric models as a means to identify humans of significantly different shapes and sizes to arrive at mathematically sound computer models for analytical purposes.

Rajulu, Sudhakar↗

Operational Considerations and Comparisons of the Saturn, Space Shuttle and Ares Launch Vehicles

The United States (U.S.) space exploration policy has directed the National Aeronautics and Space Administration (NASA) to retire the Space Shuttle and to replace it with a new generation of space transportation systems for crew and cargo travel to the International Space Station, the Moon, Mars, and beyond. As part of the Constellation Program, engineers at NASA's Marshall Space Flight Center in Huntsville, Alabama are working to design and build the Ares I, the first of two large launch vehicles to return humans to the Moon. A deliberate effort is being made to ensure a high level of operability in order to significantly increase safety and availability as well as reduce recurring costs of this new launch vehicle. It is the Ares Project's goal to instill operability as part of the requirements development, design and operations of the vehicle. This paper will identify important factors in launch vehicle design that affect the operability and availability of the system. Similarities and differences in operational constraints will also be compared between the Saturn V, Space Shuttle and current Ares I design. Finally, potential improvements in operations and operability for large launch vehicles will be addressed. From the examples presented, the paper will discuss potential improvements for operability for future launch vehicles.

Cruzen, Craig↗

Understanding the Effects of Vehicle Platoons on Crash Type and Severity

Crash type is an informative indicator to infer driving behaviors and conditions that cause a crash. For example, rear-end and side-swipe crashes are typically caused by improper vehicle interaction such as sudden lane-changing or speed control while hit-object crashes are likely the result of a single driver’s mistake. This study investigated the impact of vehicles travelling as a group (platoon) and its configuration (i.e., types of vehicles consisting of the platoon) on crash type and severity since the vehicles could affect each other when travelling in close proximity. This study applied Generalized Structure Equation Modeling (GSEM) to capture the complex relationships among the various crash factors such as traffic condition, driver characteristics, environmental conditions, and vehicle interaction to the crash attributes including type and severity. This study collected over 3 million individual vehicle data from 39 traffic count sites in California to estimate the vehicle interactions and driving behaviors. The microscopic traffic data are matched to 1417 crash reports. Results showed that vehicles traveling in platoons are associated with more rear-end and side-swipe crashes. Speed difference in the platoon had a positive effect on hit-object crashes if the platoon comprises vehicles of homogeneous type – either trucks or non-trucks. In addition, human factors such as age and gender were identified as significant influential factors in all type of crashes, however truck involvement particularly played an important role amongst side-swipe crashes. Crash severity was negatively affected by total flow, and rear-end crashes were more likely to be severe compared with hit-object crashes. Based on findings, this study suggests practical operational strategies to reduce traffic instability associated with platooned vehicle patterns. Understanding the high-risk factors for different crash types and severities would provide valuable insights for decision-makers and transportation engineers to develop targeted intervention strategies in consideration of road users and traffic conditions such as fleet mix and speed.

ADVANCED PROPULSION SYSTEMS↗

Hardware Development Process for Human Research Facility Applications

The simple goal of the Human Research Facility (HRF) is to conduct human research experiments on the International Space Station (ISS) astronauts during long-duration missions. This is accomplished by providing integration and operation of the necessary hardware and software capabilities. A typical hardware development flow consists of five stages: functional inputs and requirements definition, market research, design life cycle through hardware delivery, crew training, and mission support. The purpose of this presentation is to guide the audience through the early hardware development process: requirement definition through selecting a development path. Specific HRF equipment is used to illustrate the hardware development paths. The source of hardware requirements is the science community and HRF program. The HRF Science Working Group, consisting of SCientists from various medical disciplines, defined a basic set of equipment with functional requirements. This established the performance requirements of the hardware. HRF program requirements focus on making the hardware safe and operational in a space environment. This includes structural, thermal, human factors, and material requirements. Science and HRF program requirements are defined in a hardware requirements document which includes verification methods. Once the hardware is fabricated, requirements are verified by inspection, test, analysis, or demonstration. All data is compiled and reviewed to certify the hardware for flight. Obviously, the basis for all hardware development activities is requirement definition. Full and complete requirement definition is ideal prior to initiating the hardware development. However, this is generally not the case, but the hardware team typically has functional inputs as a guide. The first step is for engineers to conduct market research based on the functional inputs provided by scientists. CommerCially available products are evaluated against the science requirements as well as modifications needed to meet program requirements. Options are consolidated and the hardware development team reaches a hardware development decision point. Within budget and schedule constraints, the team must decide whether or not to complete the hardware as an in-house, subcontract with vendor, or commercial-off-the-shelf (COTS) development. An in-house development indicates NASA personnel or a contractor builds the hardware at a NASA site. A subcontract development is completed off-site by a commercial company. A COTS item is a vendor product available by ordering a specific part number. The team evaluates the pros and cons of each development path. For example, in-bouse developments utilize existing corporate knowledge regarding bow to build equipment for use in space. However, technical expertise would be required to fully understand the medical equipment capabilities, such as for an ultrasound system. It may require additional time and funding to gain the expertise that commercially exists. The major benefit of subcontracting a hardware development is the product is delivered as an end-item and commercial expertise is utilized. On the other hand, NASA has limited control over schedule delays. The final option of COTS or modified COTS equipment is a compromise between in-house and subcontracts. A vendor product may exist that meets all functional requirements but req uires in-house modifications for successful operation in a space environment. The HRF utilizes equipment developed using all of the paths described: inhouse, subcontract, and modified COTS.

Bauer, Liz↗

Unifying Human Centered Design and Systems Engineering for Human Systems Integration

Despite the holistic approach of systems engineering (SE), systems still fail, and sometimes spectacularly. Requirements, solutions and the world constantly evolve and are very difficult to keep current. SE requires more flexibility and new approaches to SE have to be developed to include creativity as an integral part and where the functions of people and technology are appropriately allocated within our highly interconnected complex organizations. Instead of disregarding complexity because it is too difficult to handle, we should take advantage of it, discovering behavioral attractors and the emerging properties that it generates. Human-centered design (HCD) provides the creativity factor that SE lacks. It promotes modeling and simulation from the early stages of design and throughout the life cycle of a product. Unifying HCD and SE will shape appropriate human-systems integration (HSI) and produce successful systems.

Boy, Guy A.↗

Joint Optimization for Transport and Bucket Loading Phases of Automated Wheel Loaders

This article investigates optimization of fuel-efficiency and productivity for automated wheel loaders. A control-oriented model for both the transport phase and bucket loading phase is proposed. Here, the vehicle model includes an automatic gear shift schedule that can be incorporated into the optimization problem. Based on the model, the multistage optimization problem is formulated to simultaneously consider all phases of a short cycle with physical constraints. Cycle time and fuel efficiency are used as the weighted performance indexes in a multiobjective cost function. Bucket fill factor is included as a constraint during the bucket loading phase. A nonlinear programming problem is created with collocation using MATLAB and CasADi. The optimization solver IPOPT solves the problem to obtain the optimal state and control trajectories, which can be used as a reference for automated wheel loaders or even as a driver advisory for human-driven wheel loaders.

42 ENGINEERING↗