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At least 559 records · Page 31

Allostery and Hysteresis Are Coupled in Human UDP-Glucose Dehydrogenase

Human UDP-glucose dehydrogenase (hUGDH) is regulated by an atypical allosteric mechanism in which the feedback inhibitor UDP-xylose (UDP-Xyl) competes with the substrate for the active site. Binding of UDP-Xyl triggers the T131-loop/α6 allosteric switch, which converts the hexameric structure of hUGDH into an inactive, horseshoe-shaped complex (E Ω ). This allosteric transition buries residue A136 in the protein core to produce a subunit interface that favors the E Ω structure. Here we use a methionine substitution to prevent the burial of A136 and trap the T131-loop/α6 switch in the active conformation. We show that hUGDH A136M does not exhibit substrate cooperativity, which is strong evidence that the methionine substitution prevents the formation of the low-UDP-Glc-affinity E Ω state. In addition, the inhibitor affinity of hUGDH A136M is reduced 14-fold, which most likely represents the K i for competitive inhibition in the absence of the allosteric transition to the higher-affinity E Ω state. hUGDH also displays a lag in progress curves, which is caused by a slow, substrate-induced isomerization that activates the enzyme. Stopped-flow analysis shows that hUGDH A136M does not exhibit hysteresis, which suggests that the T131-loop/α6 switch is the source of the slow isomerization. This interpretation is supported by the 2.05 Å resolution crystal structure of hUGDH A136M , which shows that the A136M substitution has stabilized the active conformation of the T131-loop/α6 allosteric switch. Furthermore, this work shows that the T131-loop/α6 allosteric switch couples allostery and hysteresis in hUGDH.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

INSIGHTS INTO FILAMENT ERUPTION ONSET FROM SOLAR DYNAMICS OBSERVATORY OBSERVATIONS

We examine the buildup to and onset of an active region filament confined eruption of 2010 May 12, using EUV imaging data from the Solar Dynamics Observatory (SDO) Atmospheric Imaging Array and line-of-sight magnetic data from the SDO Helioseismic and Magnetic Imager. Over the hour preceding eruption the filament undergoes a slow rise averaging {approx}3 km s{sup -1}, with a step-like trajectory. Accompanying a final rise step {approx}20 minutes prior to eruption is a transient preflare brightening, occurring on loops rooted near the site where magnetic field had canceled over the previous 20 hr. Flow-type motions of the filament are relatively smooth with speeds {approx}50 km s{sup -1} prior to the preflare brightening and appear more helical, with speeds {approx}50-100 km s{sup -1}, after that brightening. After a final plateau in the filament's rise, its rapid eruption begins, and concurrently an outer shell 'cocoon' of the filament material increases in emission in hot EUV lines, consistent with heating in a newly formed magnetic flux rope. The main flare brightenings start {approx}5 minutes after eruption onset. The main flare arcade begins between the legs of an envelope-arcade loop that is nearly orthogonal to the filament, suggesting that the flare results from reconnection among the legs of that loop. This progress of events is broadly consistent with flux cancellation leading to formation of a helical flux rope that subsequently erupts due to onset of a magnetic instability and/or runaway tether cutting.

79 ASTRONOMY AND ASTROPHYSICS↗

Hubble Space Telescope Observations within the Sphere of Influence of the Powerful Supermassive Black Hole in PKS 0745-191

We present Space Telescope Imaging Spectrograph observations from the Hubble Space Telescope of the supermassive black hole (SMBH) at the center of PKS 0745-191, a brightest cluster galaxy (BCG) undergoing powerful radio-mode active galactic nucleus (AGN) feedback (P cav ~ 5 × 10 45 erg s -1 ). These high-resolution data offer the first spatially resolved map of gas dynamics within an SMBH's sphere of influence under such powerful feedback. Our results reveal the presence of highly chaotic, nondrotational ionized gas flows on subkiloparsec scales, in contrast to the more coherent flows observed on larger scales. While radio-mode feedback effectively thermalizes hot gas in galaxy clusters on kiloparsec scales, within the core, the hot gas flow may decouple, leading to a reduction in angular momentum and supplying ionized gas through cooling, which could enhance accretion onto the SMBH. This process could, in turn, lead to a self-regulating feedback loop. Compared to other BCGs with weaker radio-mode feedback, where rotation is more stable, intense feedback may lead to more chaotic flows, indicating a stronger coupling between jet activity and gas dynamics. Additionally, we observe a sharp increase in velocity dispersion near the nucleus, consistent with a very massive M BH ~ 1.5 × 10 10 M ⊙ SMBH. The density profile of the ionized gas is also notably flat, paralleling the profiles observed in X-ray gas around galaxies where the Bondi radius is resolved. These results provide valuable insights into the complex mechanisms driving galaxy evolution, highlighting the intricate relationship between SMBH fueling and AGN feedback within the host galaxy.

79 ASTRONOMY AND ASTROPHYSICS↗

How to sustain a CO 2 -thermosiphon in a partially saturated geothermal reservoir: Lessons learned from field experiment and numerical modeling

CO 2 has been proposed as a working fluid for geothermal energy production because of its ability to establish a self-sustaining CO 2 thermosiphon, taking advantage of the strong temperature dependence of CO 2 density. To test the concept of CO 2 heat extraction, in January 2015 a CO 2 thermosiphon was operated at the SECARB Cranfield Site, Cranfield, Mississippi, where a brine-saturated sand at a depth of 3.2 km has been under near continuous CO 2 flood since December 2009 as part of a U.S. Department of Energy demonstration of CO 2 sequestration, resulting in a partially saturated reservoir surrounding a well pair. The lateral distance between the producer and injector was 112 m at reservoir depth, a distance considered pre-commercial in scale, but great enough that thermal breakthrough was still not significant after several years of injection. Instead of producing power with a turbine, heat was extracted heat from recirculated fluid using a heat exchanger and portable chiller. The well field and surface equipment were instrumented to compare field observations with predicted responses from numerical models. Thermosiphon flow could be initiated by venting, but thereafter flow rate steadily declined, indicating that the thermosiphon was not sustainable. To model the system, the capability of T2Well, a fully coupled wellbore/reservoir numerical simulator, was expanded to enable simulation of the entire loop of fluid circulation in the fully-coupled system consisting of the injection/production wells, the reservoir, and the surface devices (heat exchanger, flow-rate regulator etc.). Combined with the newly developed TOUGH2 equation of state module called EOS7CMA, the enhanced T2 Well was used prior to the field experiment to simulate the circulation of a CO 2 -H 2 O-CH 4 mixture in a model geothermal system patterned after the Cranfield demonstration test. The model predicted that a sustainable thermosiphon could be achieved. After the field thermosiphon did not achieve the pre-test prediction of flow rates and thermosiphon sustainability, the numerical model was modified to improve realism and calibrate certain processes; it was then able to reproduce the major phenomena observed in the field. In a series of sensitivity studies, many factors were found that could potentially contribute to the failing of a sustainable thermosiphon. These factors could be categorized as two types: factors that increase the resistance to flow and factors that increase heat loss of the working fluid. In conclusion, the lessons learned can be applied to both future modeling and to achieving CO 2 -based geothermal reservoir exploitation.

15 GEOTHERMAL ENERGY↗

Tritium Module for Calculating the Behavior of Tritium in a Loop of a Reactor Installation with Sodium Coolant

A description of the models and the results of tests of the Tritium module, which is intended for modeling the transport of tritium in the loops of fast reactors, are presented. The characteristics features of the module are alienability, functional relation with other modules of the code, and calculation of model coefficients as a function of the temperature of the coolant and surface of the loops. The module makes it possible to perform calculations of the behavior of tritium, including transport along loops, penetrability through the channel walls, run-off in a cold trap, and flow through leaks in the reactor installation.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

A MECHANISM FOR HYSTERESIS IN BLACK HOLE BINARY STATE TRANSITIONS

We suggest that the hysteretic cycle of black hole state transitions arises from two established properties of accretion disks: the increase in turbulent stress in disks threaded by a net magnetic field and the ability of thick (but not thin) disks to advect such a field radially. During quiescence, magnetic field loops are generated by the magnetorotational instability at the interface between the inner hot flow and outer thin disk. Vertical flux is advected into and accumulates stochastically within the inner flow, where it stimulates the turbulence so that α ∼ 1. The transition to a geometrically thin inner disk occurs when L ∼ α{sup 2} L {sub Edd} ∼ L {sub Edd}, and the first ''thin'' disk to form is itself moderately thick, strongly magnetized, and able to advect field inward. These properties favor episodic jet production. As the accretion rate declines magnetic flux escapes, α decreases to α ∼ 0.01-0.1, and a hot inner flow is not re-established until L << L {sub Edd}. We discuss possible observational consequences of our scenario.

79 ASTRONOMY AND ASTROPHYSICS↗

Component and Technology Development for Advanced Liquid Metal Reactors

The following report details the significant developments to Sodium Fast Reactor (SFR) technologies made throughout the course of this funding. This report will begin with an overview of the sodium loop and the improvements made over the course of this research to make it a more advanced and capable facility. These improvements have much to do with oxygen control and diagnostics. Thus a detailed report of advancements with respect to the cold trap, plugging meter, vanadium equilibration loop, and electrochemical oxygen sensor is included. Further analysis of the university’s moving magnet pump was performed and included in a section of this report. A continuous electrical resistance based level sensor was built and tested in the sodium with favorable results. Materials testing was done on diffusion bonded samples of metal and the results are presented here as well. A significant portion of this work went into the development of optical fiber temperature sensors which could be deployed in an SFR environment. Thus, a section of this report presents the work done to develop an encapsulation method for these fibers inside of a stainless steel capillary tube. High temperature testing was then done on the optical fiber ex situ in a furnace. Thermal response time was also explored with the optical fiber temperature sensors. Finally these optical fibers were deployed successfully in a sodium environment for data acquisition. As a test of the sodium deployable optical fiber temperature sensors they were installed in a sub-loop of the sodium facility which was constructed to promote the thermal striping effect in sodium. The optical fibers performed exceptionally well, yielding unprecedented 2 dimensional temperature profiles with good temporal resolution. Finally, this thermal striping loop was used to perform cross correlation velocimetry successfully over a wide range of flow rates.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Editorial: Linking Hydrological and Biogeochemical Processes in Riparian Corridors

The riparian corridor is a key component of the critical zone and an essential component of watershed systems. According to Merriam-Webster Dictionary, the word riparian is derived from the Latin word riparius, meaning “existing alongside a river.” Riparian corridors typically extend from a few meters to hundreds of meters adjacent to a river and are marked by rich biodiversity, vegetation, and intense biogeochemical activity. They act as integrators of watershed processes and constitute the primary pathways for the subsurface geochemical exports from the watershed. Although riparian corridors comprise only 2–10% of a watershed's area, as much as 90–98% of biogeochemical processing in watersheds occurs in this region, thereby affecting the subsurface geochemical exports and downstream river water quality. Indeed, the riparian corridor is a good example of the Pareto principle. This outsized contribution occurs at the interface between aquatic (river) and terrestrial (land) environments, where interactions between hydrologic and biogeochemical processes are intensified. Variations in the river corridor over time can thus also have outsize impacts. Therefore, it is important to understand the hydrological and biogeochemical linkages in riparian corridors to determine water availability and quality for sustainable management.

54 ENVIRONMENTAL SCIENCES↗

Shallow Geothermal Resources for Cooling Applications at the University of Hawai‘i

Scientists at Berkeley Lab have teamed up with The University of Hawai‘i at Manoa (UH Manoa) through the U.S. Department of Energy’s (DOE’s) Energy Transitions Initiative Partnership Project (ETIPP) to evaluate the technological and market feasibility of shallow geothermal heat exchanger (GHE) technology for building cooling, energy efficiency, and emissions reduction applications in Hawai’i. The team is assessing the data necessary to model the feasibility of deploying this technology, the actual models that will be used, and what hurdles need to be overcome to install a demonstration case. UH has an abundance of geologic and geothermal data and is looking to the national labs’ expertise to execute this analysis. UH is also interested in investigating policy, regulatory, and business conditions advantageous for implementation of a pilot project, and more broad deployment of this technology in Hawai‘i. In many locations around the world, the demands for heating and cooling are roughly balanced over the course of the year, so GHEs do not cause significant long-term changes in subsurface temperature. This is not the case in Hawai’i, where the demand for heating is very small, meaning that over time, GHEs will add heat to the subsurface. If temperatures increase significantly, GHE systems will not work as designed. Regional groundwater flow has the potential to sweep heated water away from boreholes, thereby maintaining the functionality of the GHE system. Significant regional groundwater flow requires two things: a sufficiently large driving hydraulic head gradient (usually closely related to surface topography), and sufficient porosity and permeability to enable groundwater to flow in large enough quantities to enable near-borehole temperatures to be maintained at ambient values. Hawai‘i’s volcanic terrain offers ample surface topographic variation. The lava itself shows an extremely large range of porosity and permeability, making it crucial to select sites with large enough values of these properties. Numerical modeling of coupled groundwater and heat flow can be used to determine how large is large enough. Both closed-loop and open-loop systems are being investigated. Another option being considered is using cool seawater as the source of chill. Currently work is progressing on two fronts. A hydrogeologic model for a closed-loop system is being developed for the Stan Sheriff Center at the UH Manoa campus, where a subsurface karst system immediately downgradient of the borefield may provide efficient removal of heated groundwater. The team will also develop a technoeconomic model for this site to compare the cost of cooling using a GHE system with the costs of operating the current air conditioning system. At the state scale, geographic information system (GIS) layers of various attributes relevant for GHE are being combined to develop an overall favorability map for employing GHE in Hawai‘i.

Doughty, C↗

DNB evaluation of PWR steam-line break event using Westinghouse and CASL coupled code systems

ANCKVIPRE and the VERA-CS code systems have been successfully applied to predicting PWR core response with respect to departure from nucleate boiling (DNB) at the limiting time step of a postulated hot zero power (HZP) main steam-line break (MSLB) event with and without offsite power available. ANCKVIPRE links the ANC code with the VIPRE-W code. ANC is Westinghouse's multi-dimensional nodal diffusion code for all nuclear core design calculations. It predicts core reactivity, assembly power, rod power, detector thimble flux, and other relevant core characteristics. VIPRE-W is the Westinghouse version of a thermalhydraulic subchannel code developed for light water reactor core design applications. The reactor core simulation was based on input of the core boundary conditions from RETRAN system transient and STAR-CCM+ CFD core inlet distribution calculations. To account for the asymmetric power distribution in the reactor core due to the broken steam pipe in one loop and the stuck RCCA, both ANCKVIPRE and the VERA-CS models were set up for the whole reactor core. The advanced modeling and simulations confirmed that the HZP MSLB high-flow case with offsite power available is more limiting with respect to the DNB acceptance criterion, consistent with the limiting case analyzed in the 4-loop plant Safety Analysis Report (SAR). The results also demonstrated that the currently NRC-approved Westinghouse coupled code system such as ANCKVIPRE remains conservative.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Full-Loop Simulation of the Combustion of Biomass in a Circulating Fluidized Bed Combustor

Interest in circulating fluidized bed (CFB) boilers as a power generation technology has skyrocketed in recent years because of several advantages this technology offers over conventional boilers, such as increased gas-solid mixing, which results in higher combustion efficiency, and the ability to use lower rank fuels. CFB combustors are operated at lower temperatures than conventional thermal power generation combustors, thus reducing NO x emissions, while SO 2 emissions can be conveniently controlled through the addition of Ca-based sulfur sorbents within the combustor. This report summarizes the development of a comprehensive computational fluid dynamics (CFD) model for biomass combustion in a 50 kW th CFB combustor employing the multiphase particle-in-cell (PIC) approach in the open-source Multiphase Flow with Interphase eXchanges (MFiX) Software Suite at the U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL). The experimental combustor was designed, built, and operated at CanmetENERGY, Natural Resources Canada in Ottawa, Canada. This work is the culmination of a multi-year collaboration between NETL and CanmetENERGY. The hydrodynamics in the full loop are validated against cold-flow experiments conducted at CanmetENERGY. To mimic the dense packing in the standpipe in the absence of a collisional model in the MFiX-PIC approach, the ram valve in the return leg is partially closed to obstruct the flow. A combustion reaction scheme was developed that considers the volatiles released by the fuel as a lumped species that fully converts to CO 2 and H 2 O. The so-called enhanced simplified combustion scheme produces an excellent match with experimental data in terms of the species concentrations of CO 2 and O 2 at the outlet and the freeboard, demonstrating the utility of the comprehensive model for a range of flow conditions and operating temperatures. Furthermore, the model can be readily adapted to simulate combustion of a variety of biomass fuels as well as co-fired systems under air and oxy-fuel conditions.

09 BIOMASS FUELS↗

Plasma-assisted chemical-looping combustion: Mechanistic insights into low temperature methane oxidation with CuO

The low-temperature oxidation of CH 4 by CuO in a coaxial, fixed bed, double dielectric barrier discharge (DBD) reactor was investigated with time-dependent species measurements by an electron-ionization molecular beam mass spectrometer (EI-MBMS). In the experiment, 10% methane carried by noble gasses was flown at 50 sccm through 1 g CuO dispersed in quartz wool both under plasma and non-plasma conditions, while time-dependent gas-phase species profiles were collected. Plasma conditions were explored from 300 to 600 °C while the non-plasma conditions were set from 300 to 900 °C. Mechanistic insights into the oxidation of CH 4 by CuO with plasma discharge at lower temperatures (≤ 600 °C) were obtained by quantifying the fuel oxidation, intermediate species, and CO 2 production in comparison to the non-plasma conditions. Here, we observed significant enhancement of fuel oxidation from the plasma discharge between 400 and 500 °C. The CO 2 production at 500 °C with plasma was greater than that at 700 °C without plasma, reducing fuel oxidation temperature by 200+ °C. During tests, three distinct reaction stages were observed: a gas-phase transport limited stage, a surface reaction limited kinetic stage, and an oxygen ion diffusion limited stage. It was observed that plasma greatly improved the reactivity of the second stage at low temperature. In addition, no carbon deposits were observed on the resultant particles, even under the presence of plasma. M. species such as C 4 H 2 and C 6 H 6 not previously observed or predicted in CuO/CH 4 chemical looping were observed, with some species such as CH 3 OH only becoming detectable as total flowrate was increased from 50 to 1500sccm. A non-plasma reaction pathway for CH 4 based the observed species from the MBMS spectrum and previous predictions from reactive molecular dynamics simulations was created, providing a framework from which more complex plasma CuO mechanisms can be crafted from.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

QUANTITATIVE EXAMINATION OF A LARGE SAMPLE OF SUPRA-ARCADE DOWNFLOWS IN ERUPTIVE SOLAR FLARES

Sunward-flowing voids above post-coronal mass ejection flare arcades were first discovered using the soft X-ray telescope aboard Yohkoh and have since been observed with TRACE (extreme ultraviolet (EUV)), SOHO/LASCO (white light), SOHO/SUMER (EUV spectra), and Hinode/XRT (soft X-rays). Supra-arcade downflow (SAD) observations suggest that they are the cross-sections of thin flux tubes retracting from a reconnection site high in the corona. Supra-arcade downflowing loops (SADLs) have also been observed under similar circumstances and are theorized to be SADs viewed from a perpendicular angle. Although previous studies have focused on dark flows because they are easier to detect and complementary spectral data analysis reveals their magnetic nature, the signal intensity of the flows actually ranges from dark to bright. This implies that newly reconnected coronal loops can contain a range of hot plasma density. Previous studies have presented detailed SAD observations for a small number of flares. In this paper, we present a substantial SADs and SADLs flare catalog. We have applied semi-automatic detection software to several of these events to detect and track individual downflows thereby providing statistically significant samples of parameters such as velocity, acceleration, area, magnetic flux, shrinkage energy, and reconnection rate. We discuss these measurements (particularly the unexpected result of the speeds being an order of magnitude slower than the assumed Alfven speed), how they were obtained, and potential impact on reconnection models.

79 ASTRONOMY AND ASTROPHYSICS↗

Discovery of a new class of coronal structures in white light eclipse images

White light images of the solar corona, taken during total solar eclipses, capture the complex dynamic relationship between the coronal plasma and the magnetic field. This relationship can be recorded on timescales of seconds to minutes, within a few solar radii above the solar surface. Rays, large-scale loops, and streamers, which are the brightest structures in these images, have shaped current models of the coronal magnetic field and solar wind flow. We show in this work how the application of novel image processing techniques to unique high-resolution white light eclipse images reveals the presence of a new class of structures, reminiscent of smoke rings, faint nested expanding loops, expanding bubbles, and twisted helical structures. These features are interpreted as snapshots of the dynamical evolution of instabilities developing at prominence-corona interfaces and propagating outward with the solar wind.

79 ASTRONOMY AND ASTROPHYSICS↗

Process and control variables from the mercury loop at the SNS's mercury target

Set of process and control variables corresponding to the mercury process loop at the Spallation Neutron Source's (SNS) mercury target. The data corresponds to 36 measurement signals (pressure, temperature, flows, valve position, etc.) spanning from 2017/01/01 to 2023/12/31. Each signal is broken intro three-month intervals, resulting in a total of 28 files per signal during the aforementioned period of time.

mercury loop↗

Advanced High-Temperature Reactor Dynamic System Model Development: April 2012 Status

The Advanced High-Temperature Reactor (AHTR) is a large-output fluoride-salt-cooled high-temperature reactor (FHR). An early-phase preconceptual design of a 1500 MW(e) power plant was developed in 2011 [Refs. 1 and 2]. An updated version of this plant is shown as Fig. 1. FHRs feature low-pressure liquid fluoride salt cooling, coated-particle fuel, a high-temperature power cycle, and fully passive decay heat rejection. The AHTR is designed to be a “walk away” reactor that requires no action to prevent large off-site releases following even severe reactor accidents. This report describes the development of dynamic system models used to further the AHTR design toward that goal. These models predict system response during warmup, startup, normal operation, and limited off-normal operating conditions. Severe accidents that include a loss-of-fluid inventory are not currently modeled. The scope of the models is limited to the plant power system, including the reactor, the primary and intermediate heat transport systems, the power conversion system, and safety-related or auxiliary heat removal systems. The primary coolant system, the intermediate heat transport system and the reactor building structure surrounding them are shown in Fig. 2. These systems are modeled in the most detail because the passive interaction of the primary system with the surrounding structure and heat removal systems, and ultimately the environment, protects the reactor fuel and the vessel from damage during severe reactor transients. The reactor silo also plays an important role during system warmup. The dynamic system modeling tools predict system performance and response. The goal is to accurately predict temperatures and pressures within the primary, intermediate, and power conversion systems and to study the impacts of design changes on those responses. The models are design tools and are not intended to be used in reactor qualification. The important details to capture in the primary system relate to flows within the reactor vessel during severe events and the resulting temperature profiles (temperature and duration) for major components. Critical components include the fuel, reactor vessel, primary piping, and the primary-to-intermediate heat exchangers (P-IHXs). The major AHTR power system loops are shown in Fig. 3. The intermediate heat transfer system is a group of three pumped salt loops that transports the energy produced in the primary system to the power conversion system. Two dynamic system models are used to analyze the AHTR. A Matlab/Simulink-based model initiated in 2011 has been updated to reflect the evolving design parameters related to the heat flows associated with the reactor vessel. The Matlab model utilizes simplified flow assumptions within the vessel and incorporates an empirical representation of the Direct Reactor Auxiliary Cooling System (DRACS). A Dymola/Modelica model incorporates a more sophisticated representation of primary coolant flow and a physics-based representation of the three-loop DRACS thermal hydraulics. This model is not currently operating in a fully integrated mode. The Matlab model serves as a prototype and provides verification for the Dymola model, and its use will be phased out as the Dymola model nears completion. The heat exchangers in the system are sized using spreadsheet-based, steady-state calculations. The detail features of the heat exchangers are programmed into the dynamic models, and the overall dimensions are used to generate realistic plant designs. For the modeling cases where the emphasis is on understanding responses within the intermediate and primary systems, the power conversion system may be modeled as a simple boundary condition at the intermediate-to-power conversion system heat exchangers.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Improvement of Stent Retriever Design and Efficacy of Mechanical Thrombectomy in a Flow Model

In vitro experiments were performed to evaluate the efficacy of mechanical intracranial thrombectomy comparing the newly developed Aperio stent retriever and standard devices for stroke treatment. The Aperio (A), with an increased working length of 4 cm and a special cell design for capturing and withholding clots, was compared to three benchmark devices: the Solitaire retrievable stent (B), the Merci X6 (C), and the Merci L5 retriever (D). In a vascular glass model with pulsatile flow, reminiscent of the M1 segment of the middle cerebral artery, we repeatedly induced occlusion by generating thrombi via a modified Chandler loop system. The numbers of recanalization attempts, peripheral embolizations, and recanalizations at the site of occlusion were recorded during 10 retrieval experiments with each device. Eleven devices were able to remove the blood clots from the occluded branch. In 34 of 40 experiments, restoration of flow was obtained in 1-3 attempts. The main differences between the study devices were observed in terms of clot withholding and fragmentation during retrieval. Although there was only one fragmentation recorded for device A, disengagement of the whole clot or peripheral embolization of fragments occurred more frequently (5-7 times) with devices B, C, and D. In a vascular model, the design of device A was best at capturing and withholding thrombi during retrieval. Further study will be necessary to see whether this holds true in clinical applications.

42 ENGINEERING↗

Understanding the role of flow dynamics in thermoacoustic combustion instability

Thermoacoustic combustion instability is one of the most challenging operational issues in several high-performance, low-emissions combustion technologies, including gas turbines, aircraft engines, rockets, and industrial boilers. Driven by the coupling between combustor acoustics and flame heat release rate fluctuations, thermoacoustic combustion instability can lead to reduced operability, increased emissions, and, in the most extreme cases, catastrophic failure of combustor components. The feedback loop between acoustics and combustion is often facilitated by fluid mechanic oscillations, referred to as “velocity coupling,” whereby acoustic oscillations drive flow fluctuations, which in turn create fluctuations in the flame. The character of these fluid mechanic oscillations is highly dependent on the structure of the flow field and the receptivity of the flow to external excitation. Combustor flow fields use features like fluid recirculation and shear to enhance flame holding and reduce emissions, but these are also the same features that can make the flow receptive to acoustic excitation or even drive self-excited oscillations. Here, in this paper, we discuss the basics of thermoacoustic instability with a focus on the role of hydrodynamic oscillations in typical combustor flows. To facilitate this discussion, we explore the hydrodynamic instability characteristics of several key combustor unit flows (wakes, swirling jets, etc.) and show how the hydrodynamic stability of a flow is an important consideration in determining a combustor’s propensity for thermoacoustic oscillations. Several examples of coupling between hydrodynamics and thermoacoustics are discussed to illustrate this important link. The paper concludes by discussing the potential for designing flow fields that are thermoacoustic instability resistant, either through a reduction in the receptivity of the flow or through nonlinear coupling mechanisms by which self-excited flow instabilities can suppress velocity-coupled combustion oscillations.

42 ENGINEERING↗