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At least 559 records · Page 31

Microfluidic Extraction of Biomarkers using Water as Solvent

A proposed device, denoted a miniature microfluidic biomarker extractor (mu-EX), would extract trace amounts of chemicals of interest from samples, such as soils and rocks. Traditionally, such extractions are performed on a large scale with hazardous organic solvents; each solvent capable of dissolving only those molecules lying within narrow ranges of specific chemical and physical characteristics that notably include volatility, electric charge, and polarity. In contrast, in the mu-EX, extractions could be performed by use of small amounts (typically between 0.1 and 100 L) of water as a universal solvent. As a rule of thumb, in order to enable solvation and extraction of molecules, it is necessary to use solvents that have polarity sufficiently close to the polarity of the target molecules. The mu-EX would make selection of specific organic solvents unnecessary, because mu-EX would exploit a unique property of liquid water: the possibility of tuning its polarity to match the polarity of organic solvents appropriate for extraction of molecules of interest. The change of the permittivity of water would be achieved by exploiting interactions between the translational states of water molecules and an imposed electromagnetic field in the frequency range of 300 to 600 GHz. On a molecular level, these interactions would result in disruption of the three-dimensional hydrogen-bonding network among liquid-water molecules and subsequent solvation and hydrolysis of target molecules. The mu-EX is expected to be an efficient means of hydrolyzing chemical bonds in complex macromolecules as well and, thus, enabling analysis of the building blocks of these complex chemical systems. The mu-EX device would include a microfluidic channel, part of which would lie within a waveguide coupled to an electronically tuned source of broad-band electromagnetic radiation in the frequency range from 300 to 600 GHz (see figure). The part of the microfluidic channel lying in the waveguide would constitute an interaction volume. The dimensions of the interaction volume would be chosen in accordance with the anticipated amount of solid sample material needed to ensure extraction of sufficient amount of target molecules for detection and analysis. By means that were not specified at the time of reporting the information for this article, the solid sample material would be placed in the interaction volume. Then the electromagnetic field would be imposed within the waveguide and water would be pumped through the interaction volume to effect the extraction.

Amashukeli, Xenia↗

Investigation of International Space Station Major Constituent Analyzer Anomalous ORU 02 Performance

The Major Constituent Analyzer (MCA) is a mass spectrometer-based instrument designed to provide critical monitoring of six major atmospheric constituents; nitrogen, oxygen, hydrogen, carbon dioxide, methane, and water vapor on-board the International Space Station. It is an integral part of the Environmental Control and Life Support System (ECLSS). The MCA system is comprised of seven orbit-replaceable units (ORUs) that provide flexibility in maintaining the MCA. Of these, ORU 02, the analyzer assembly requires replacement every 1 to 2 years due to the consumption of limited life components including the ion pump and ion source filaments. Typically, ORU 02s that reach end of life are swapped out of the MCA on orbit and replaced with the on-orbit spare. The replaced ORU 02 is then returned to the OEM for refurbishment and is then return to service. Recently, 2 refurbished ORU 02s, serial numbers F0001 and F0003, failed on orbit shortly after being installed into the MCA. Both ORU 02s have been returned to ground for TT&E, and a failure investigation is underway. The failure signatures have been reproduced on the ground and an initial investigation has determined that both ORU 02 failures involve either the ion source or the ion source control electronics. This paper discusses the results of the failure investigation, the steps required to refurbish the ORU 02s, and the risk mitigation steps that are being incorporated into the refurbishment process to preclude the reoccurrence of these failures in the future

Gardner, Ben D.↗

Investigation of International Space Station Major Constituent Analyzer Anomalous ORU 02 Performance

The Major Constituent Analyzer (MCA) is a mass spectrometer-based instrument designed to provide critical monitoring of six major atmospheric constituents; nitrogen, oxygen, hydrogen, carbon dioxide, methane, and water vapor on-board the International Space Station. It is an integral part of the Environmental Control and Life Support System (ECLSS). The MCA system is comprised of seven orbit-replaceable units (ORUs) that provide flexibility in maintaining the MCA. Of these, ORU 02, the analyzer assembly requires replacement every 1 to 2 years due to the consumption of limited life components including the ion pump and ion source filaments. Typically, ORU 02s that reach end of life are swapped out of the MCA on orbit and replaced with the on-orbit spare. The replaced ORU 02 is then cycled through the OEM for refurbishment and returned to service. Recently, two refurbished ORU 02s, serial numbers F0001 and F0003, failed on orbit shortly after being installed into the MCA. Both ORU 02s were returned to ground for TT&E and a failure investigation. The failure signatures were reproduced on the ground and the investigation determined that both ORU 02 failures involve either the ion source or the ion source control electronics. This paper discusses the results of the failure investigation, the steps required to refurbish the ORU 02s, and the corrective actions that are being incorporated into the build and refurbishment process to preclude the reoccurrence of these failures in the future.

Gardner, Ben D.↗

High-Fidelity Flash Lidar Model Development

NASA's Autonomous Landing and Hazard Avoidance Technologies (ALHAT) project is currently developing the critical technologies to safely and precisely navigate and land crew, cargo and robotic spacecraft vehicles on and around planetary bodies. One key element of this project is a high-fidelity Flash Lidar sensor that can generate three-dimensional (3-D) images of the planetary surface. These images are processed with hazard detection and avoidance and hazard relative navigation algorithms, and then are subsequently used by the Guidance, Navigation and Control subsystem to generate an optimal navigation solution. A complex, high-fidelity model of the Flash Lidar was developed in order to evaluate the performance of the sensor and its interaction with the interfacing ALHAT components on vehicles with different configurations and under different flight trajectories. The model contains a parameterized, general approach to Flash Lidar detection and reflects physical attributes such as range and electronic noise sources, and laser pulse temporal and spatial profiles. It also provides the realistic interaction of the laser pulse with terrain features that include varying albedo, boulders, craters slopes and shadows. This paper gives a description of the Flash Lidar model and presents results from the Lidar operating under different scenarios.

Hines, Glenn D.↗

Oscillating heat pipe integrated thermal management system for power electronics

Disclosed is a thermal management system for removing heat from a power electronic heat source, the system comprising: a base plate having a plurality of fluid passages there through and extending between and inlet side of the base plate and an outlet side of the base plate; and a plurality of heat transfer pipe segments respectively attached to one or more of the plurality of fluid passages at the inlet side of the base plate and the outlet side of the base plate, the plurality of heat transfer pipe segments arranged adjacent one another, the plurality of heat transfer pipe segments containing a two-phase working fluid, and the plurality of heat transfer pipe segments forming a continuous flow path through and back into the base plate for the two-phase working fluid.

Wang, Jim↗

Measuring the neutrino-oxygen neutral current quasielastic cross section using the accelerator neutrino neutron interaction experiment

The Accelerator Neutrino Neutron Interaction Experiment (ANNIE) is a 26-ton gadolinium-doped water Cherenkov detector located on-axis to Fermilab’s Booster Neutrino Beam (BNB). ANNIE is uniquely positioned to perform high-statistics measurements of neutrino-nucleus interactions in water, benefiting from a large neutrino flux due to a short (100-meter) baseline. A central focus of ANNIE’s physics program is the measurement of both charged current (CC) and neutral current (NC) cross sections on water, including neutral current quasielastic (NCQE) and CC-inclusive channels. The NCQE measurement is particularly critical for constraining uncertainties in rare-event searches such as the Diffuse Supernova Neutrino Background (DSNB), where atmospheric $\nu$NCQE interactions constitute a significant and poorly constrained background. This dissertation presents a measurement of the flux-averaged neutrino-oxygen neutral current quasielastic ($\nu$NCQE) cross section using $2.573 \times 10^{20}$~POT of BNB exposure from the 2022 and 2023 beam years. The $\nu$NCQE interaction is identified through the primary $\gamma$-rays produced by nuclear de-excitation of the residual $^{15}$N$^*$ or $^{15}$O$^*$ nucleus following nucleon knockout from $^{16}$O. A dedicated Monte Carlo (MC) re-tuning campaign was conducted using an americium-beryllium (AmBe) calibration source, Michel electrons from stopped muons, and throughgoing dirt muons originating upstream of the detector. This multi-sample approach provided a wide-ranging $\mathcal{O}(\text{MeV})$--$\mathcal{O}(\text{GeV})$ dataset for tuning the simulated detector response, which was subsequently validated against AmBe neutron and Michel electron data for use in the $\nu$NCQE analysis. A dedicated laser calibration campaign was carried out to reduce timing uncertainties across the PMT system, enabling reconstruction of the BNB bunch substructure with sufficient resolution to serve as a background rejection tool. By selecting events in-time with individual neutrino bunches, beam-correlated $\nu$NCQE events are separated from diffuse and accelerator-induced backgrounds, notably skyshine neutrons and externally-originating events, that would otherwise dominate traditional charge-based selections within a small-scale, surface-level, short-baseline detector. A data-driven estimation of the skyshine neutron and external background rates was performed and incorporated into the systematic uncertainty budget. The flux-averaged $\nu$NCQE cross section on oxygen is measured to be $1.57 \pm 0.06\,(\text{stat.})$ $^{+0.91}_{-0.67}\,(\text{syst.})$ $\times 10^{-38}\ \text{cm}^{2}$. A full systematic budget is constructed by propagating uncertainties in the secondary hadronic interaction modeling, background cross section normalizations, detector response, neutrino flux, and the primary $\gamma$-ray emission probabilities from oxygen nuclear de-excitation. An idealized de-excitation model, constructed from existing measurements in the literature is developed to benchmark the predictions of the \textsc{GENIE} event generator. A comparison reveals that \textsc{GENIE} systematically overpredicts the primary $\gamma$-ray emission probability from oxygen de-excitation by a factor of $1.49\times$ for $E_\gamma > 6$~MeV and $3.07\times$ in the $3$--$6$~MeV band. This comparison motivates the dominant systematic uncertainty in this analysis, where a conservative uncertainty of $^{+39.9\%}_{-0\%}$ on the primary $\gamma$-ray signal prediction is assigned. The ANNIE result is consistent with and complementary to existing flux-averaged $\nu$NCQE cross section measurements from T2K and Super-Kamiokande, providing an independent measurement with a different detector, neutrino beam, and analysis methodology. Looking ahead, an upgrade to the ANNIE DAQ infrastructure enabling continuous extended readout will allow a complementary $\nu$NCQE neutron multiplicity measurement, directly relevant to constraining the NCQE background in DSNB searches, competitive with the recent T2K measurement at SK-Gd. The planned Super-SANDI upgrade, deploying a large Water-based Liquid Scintillator (WbLS) volume, will further extend ANNIE's reach to hadronic final states and exclusive NC channels, and enable joint measurements with liquid argon detectors sharing the BNB beamline ahead of DUNE and Hyper-Kamiokande.

Doran, Steven [Iowa State U.]↗

Magnetospheric electrons.

Aspects of convection dominated electrons in the auroral zone are considered, giving attention to the plasma sheet as the source of auroral electrons, the convection electron spatial distribution, the observed electron spatial distribution, and the coupling of convection and precipitation. Questions regarding geomagnetically trapped electrons are also investigated, taking into account the source of Van Allen electrons, the inward radial diffuse transport, the spatial structure of Van Allen electrons, electron slot formation, and the rapid loss of outer zone MeV electrons.

Coroniti, F. V.↗

Quiet Plasma Source

Synthesis of plasma from separate ion and electron emitters suppresses electromagnetic interference. Source employs separate emitters for electrons and ions. Plasma source used to simulate variety of astrophysical phenomena and space-plasma effects. For example, used in studies of propagation of electromagnetic waves in plasmas. Serves as interference-free charge neutralizer.

Leung, P. L.↗

Electron-beam instrumentation.

Use of controlled flow of electrons for analyzing and processing integrated circuits and focused electron beam as heat source for microwelding

INTEGRATED CIRCUIT↗

The electron-cyclotron maser instability as a source of plasma radiation

The generation of continuum bursts from the sun at dm and m wavelengths (in particular, type IV bursts) via the electron-cyclotron-maser instability is examined. The maser instability can be driven by an electron distribution with either a loss-cone anisotropy or a peak at large pitch angles. For omega(p)/Omega(e) much greater than 1, the maser emission is produced by electrons interacting through a harmonic (cyclotron) resonance and is electrostatic, being in the upper hybrid mode at frequencies approximately equal to omega(p). Coalescence processes are required to convert the electrostatic waves into transverse radiation which can escape from the source region. Whether the resultant spectrum is nearly a smooth continuum or has a zebra-stripe pattern (both of which occur in type IV bursts) depends on the form of the electron distribution, inhomogeneities in the density and magnetic field, and whether the maser reaches saturation. For at least the case of some type IV dm bursts with fine structure, comparison with observations seems to indicate that the electrons producing the emission are more likely to have a loss-cone distribution, and that the maser instability is not at saturation.

Winglee, R. M.↗

Electron velocity space hole modes

In space plasmas the local electron distribution is formed by ballistic motion from different source regions. Since electrons with positive and negative parallel (v-parallel) velocities have different sources and experience different interactions with the large-scale electromagnetic fields, the electron distribution function near v-parallel = 0 should possess considerable structure, including the possibility of velocity space holes, i.e., regions where the phase space density is zero, and sharp discontinuities. A particular hole distribution, which may occur upstream of slow shocks in the distant geomagnetic tail, is shown to support a nonstandard plasma wave mode with frequencies between the ion and electron plasma frequencies and parallel phase speed above the ion, but well below the electron, thermal speed. The hole mode can be destabilized by a positive slope in the low parallel velocity electron distribution, and the growth rate is strongly enhanced if the electron parallel temperature exceeds the perpendicular temperature; the mode can also be excited by a hot, fast ion beam. The hole modes exist only for a narrow range of propagation angles about the magnetic field direction.

Coroniti, Ferdinand V.↗

Direct comparison of wire, foil, and hybrid X-pinches on a 200 kA, 150 ns current driver

Wire X-pinches (WXPs) have been studied comprehensively as fast (~1 ns pulse width), small (~1 μm) x-ray sources, created by twisting two or more fine wires into an “X” to produce a localized region of extreme magnetic pressure at the cross-point. Recently, two alternatives to the traditional WXP have arisen: the hybrid X-pinch (HXP), composed of two conical electrodes bridged by a thin wire or capillary, and the laser-cut foil X-pinch (LCXP), cut from a thin foil using a laser. We present a comparison of copper wire, hybrid, and laser-cut foil X-pinches on a single experimental platform: UC San Diego’s ~200 kA, 150 ns rise time GenASIS driver. All configurations produced 1–2 ns pulse width, ≤5 μm soft x-ray (Cu L-shell, ~1 keV) sources (resolutions diagnostically limited) with comparable fluxes. WXP results varied with linear mass and wire count, but consistently showed separate pinch and electron-beam-driven sources. LCXPs produced the brightest (~1 MW), smallest (≤5 μm) Cu K-shell sources, and spectroscopic data showed both H-like Cu K α lines indicative of source temperatures ≥2 keV, and cold K α (~8050 eV) characteristic of electron beam generated sources, which were not separately resolved on other diagnostics (within 1–2 ns and ≤200 μm). HXPs produced minimal K-shell emission and reliably single, bright, and small L-shell sources after modifications to shape the early current pulse through them. Benefits and drawbacks for each configuration are discussed to provide potential X-pinch users with the information required to choose the configuration best suited to their needs.

42 ENGINEERING↗

Corotation of an intermittent solar wind source

The measured electron content of the solar wind in mid-1970 exhibited a region of relatively high electron density that reappeared at intervals of about 27.8 days. It is shown that the repeating event cannot be reconciled with the concept of a long-enduring steady flow, even though the recurrence period is close to the rotation period of the sun. This evidence of transients is inferred from the short duration of each appearance of the interval of higher density; each should last for roughly one corotation interval if it is caused by a steady stream. The radio path was approximately 0.8 AU long, and the corotation interval exceeded 3 days. Other aspects of the content data patterns support the view that such transient events are common in the solar wind. The mid-1970 repeating event is an unusually good example of the intermittent character of flow regions in the solar wind that fluctuate on a time scale of days but endure as identifiable regions for many months. A sputtering corotating source of thin solar plasma streams could explain this series of events; it could also be explained in terms of a stream that is steady in density and speed but undulating north-south so that it passes into and out of the 0.8 AU radio path in a matter of a day or less.

Croft, T. A.↗