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At least 541 records · Page 30

FAST DIFFERENTIAL EMISSION MEASURE INVERSION OF SOLAR CORONAL DATA

We present a fast method for reconstructing differential emission measures (DEMs) using solar coronal data. The method consists of a fast, simple regularized inversion in conjunction with an iteration scheme for removal of residual negative emission measure. On average, it computes over 1000 DEMs s{sup -1} for a sample active region observed by the Atmospheric Imaging Assembly (AIA) on the Solar Dynamics Observatory, and achieves reduced chi-squared of order unity with no negative emission in all but a few test cases. The high performance of this method is especially relevant in the context of AIA, which images of order one million solar pixels per second. This paper describes the method, analyzes its fidelity, compares its performance and results with other DEM methods, and applies it to an active region and loop observed by AIA and by the Extreme-ultraviolet Imaging Spectrometer on Hinode.

79 ASTRONOMY AND ASTROPHYSICS↗

A Compressed Sensing-based Image Reconstruction Algorithm for Solar Flare X-Ray Observations

One way of imaging X-ray emission from solar flares is to measure Fourier components of the spatial X-ray source distribution. We present a new compressed sensing-based algorithm named VIS-CS, which reconstructs the spatial distribution from such Fourier components. We demonstrate the application of the algorithm on synthetic and observed solar flare X-ray data from the Reuven Ramaty High Energy Solar Spectroscopic Imager satellite and compare its performance with existing algorithms. VIS-CS produces competitive results with accurate photometry and morphology, without requiring any algorithm- and X-ray-source-specific parameter tuning. Its robustness and performance make this algorithm ideally suited for the generation of quicklook images or large image cubes without user intervention, such as for imaging spectroscopy analysis.

79 ASTRONOMY AND ASTROPHYSICS↗

c-KIT signaling is targeted by pathogenic Yersinia to suppress the host immune response

Background: The pathogenic Yersinia species exhibit a primarily extracellular lifestyle through manipulation of host signaling pathways that regulate pro-inflammatory gene expression and cytokine release. To identify host genes that are targeted by Yersinia during the infection process, we performed an RNA interference (RNAi) screen based on recovery of host NF-κB-mediated gene activation in response to TNF-α stimulation upon Y. enterocolitica infection. Results: We screened shRNAs against 782 genes in the human kinome and 26 heat shock genes, and identified 19 genes that exhibited ≥40% relative increase in NF-κB reporter gene activity. The identified genes function in multiple cellular processes including MAP and ERK signaling pathways, ion channel activity, and regulation of cell growth. Pre-treatment with small molecule inhibitors specific for the screen hits c-KIT and CKII recovered NF-κB gene activation and/or pro-inflammatory TNF-α cytokine release in multiple cell types, in response to either Y. enterocolitica or Y. pestis infection. Conclusions: We demonstrate that pathogenic Yersinia exploits c-KIT signaling in a T3SS-dependent manner to downregulate expression of transcription factors EGR1 and RelA/p65, and pro-inflammatory cytokines. This study is the first major functional genomics RNAi screen to elucidate virulence mechanisms of a pathogen that is primarily dependent on extracellular-directed immunomodulation of host signaling pathways for suppression of host immunity.

59 BASIC BIOLOGICAL SCIENCES↗

NCSP FY 2015 AMPX Annual Report

The objective of the Nuclear Criticality Safety Program (NCSP) Analytical Methods program element is to sustain state-of-the-art radiation transport modeling capabilities and the expertise necessary to develop, maintain, and disseminate the analytical tools and data libraries in a manner that is responsive to the needs of those responsible for developing, implementing, and maintaining criticality safety. To this end, the objective of the AMPX Development and Maintenance Subtask is to ensure that the AMPX cross-section processing system is available to prepare cross-section and covariance libraries that are needed by SCALE and other radiation transport packages to support criticality safety analyses of systems with fissionable material. Moreover, the task ensures that the cross-section processing software is current and up-to-date with the Evaluated Nuclear Data File (ENDF/B) formats and procedures for disseminating evaluated cross-section data provided through new measurement and evaluation work efforts. The AMPX subtask provides for the production of data libraries needed for criticality safety analyses. As such, the task provides the “bridge” between the nuclear data evaluations and the radiation transport software. In the absence of the AMPX cross-section processing task, the ability to maintain and update the SCALE nuclear data libraries (cross-section and covariance data) would be hindered. Therefore, the AMPX Development and Maintenance Subtask ensures that SCALE is up-to-date with the latest cross-section data for supporting criticality safety analyses. This letter report provides a summary of the FY 2015 AMPX development and maintenance activities that have been performed in support of the NCSP. Specifically, the report summarizes the AMPX code system updates and modernization accomplishments that have been made to the software package. Also, the report documents the cross-section library updates that have been made for the SCALE radiation transport package. In addition, the report documents testing activities that have been performed to process available cross-section and covariance data files to ensure the latest ENDF/B data files can be processed properly. This report satisfies the following reporting milestone in the NCSP FY16-20 Five Year Plan: Document AMPX modernization and technical support for SCALE continuous energy (CE), multigroup (MG), and covariance libraries and report status annually to the NCSP Manager (AM3: Q2)

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Progression of Safe and Compliant Demolition of Hanford's Plutonium Finishing Plant - 16566

Department of Energy contractor CH2M HILL Plateau Remediation Company (CH2M) is about to begin demolition of the Plutonium Finishing Plant (PFP). The facility is located on the Hanford Site and produced plutonium metal during the Cold War. Production was stopped in 1988, the facility was formally shut-down in 1996 and material processing completed in 2004. The project team, partnering with DOE-Richland Operations Office (DOE-RL), is in the final stages of preparing to demolish the building by the Tri-Party Agreement Milestone date of September 30, 2016. Since 2008, employees have prepared approximately 85 percent of the building for demolition. All of the 52 pencil-shaped processing tanks and 95 percent of the 238 glove boxes have been removed. Work is progressing on dispositioning remaining glove boxes, filter boxes and ventilation ducts and chemical and drain lines. Demolition is scheduled to start in early 2016. In addition to wrapping up tasks like source term removal (or preparation for removal during pre-demolition) and decontamination, the project is also developing the strategy and process to perform physical open air demolition, including the use of 3D renderings and computer generated illustrations of building infrastructure to safely and compliantly demolish the building. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Sci-Thur AM: YIS – 08: Automated Imaging Quality Assurance for Image-Guided Small Animal Irradiators

Purpose: To develop quality assurance (QA) standards and tolerance levels for image quality of small animal irradiators. Methods: A fully automated in-house QA software for image analysis of a commercial microCT phantom was created. Quantitative analyses of CT linearity, signal-to-noise ratio (SNR), uniformity and noise, geometric accuracy, modulation transfer function (MTF), and CT number evaluation was performed. Phantom microCT scans from seven institutions acquired with varying parameters (kVp, mA, time, voxel size, and frame rate) and five irradiator units (Xstrahl SARRP, PXI X-RAD 225Cx, PXI X-RAD SmART, GE explore CT/RT 140, and GE Explore CT 120) were analyzed. Multi-institutional data sets were compared using our in-house software to establish pass/fail criteria for each QA test. Results: CT linearity (R2>0.996) was excellent at all but Institution 2. Acceptable SNR (>35) and noise levels (<55HU) were obtained at four of the seven institutions, where failing scans were acquired with less than 120mAs. Acceptable MTF (>1.5 lp/mm for MTF=0.2) was obtained at all but Institution 6 due to the largest scan voxel size (0.35mm). The geometric accuracy passed (<1.5%) at five of the seven institutions. Conclusion: Our QA software can be used to rapidly perform quantitative imaging QA for small animal irradiators, accumulate results over time, and display possible changes in imaging functionality from its original performance and/or from the recommended tolerance levels. This tool will aid researchers in maintaining high image quality, enabling precise conformal dose delivery to small animals.

60 APPLIED LIFE SCIENCES↗

Godiva IV Burst Reproducibility and Diagnostic Testing

Godiva IV is a fast burst critical assembly located at the Nation Criticality Experiment Research Center (NCERC) in the Nevada National Security Site (NNSS). It is constructed of approximately 65 kg of highly enriched uranium (HEU) fuel alloyed with 1.5% molybdenum for strength. The assembly can be operated at delayed critical or can be used to perform super-prompt critical bursts with temperature rises of up to 250 °C. Several projects with the objective of characterizing Go diva IV are ongoing including characterizations of its radiation emission and thermomechanics. One of the characterization projects is a study of the variability in the relative source emission (or fluence in absolute terms) between bursts that are nominally the same size. There is some inherent variation in the number of fissions, or "size" of the burst, even for bursts where the operators perform identical processes. The source of the variation can be attributed to several factors. The largest contributor is the precision with which the operators are able to determine delayed critical (DC). Operators find DC for every burst operation. The impact of being slightly above or below DC can change the super-prompt critical reactivity and therefore the source term. The temperature of the fuel is another factor. Establishing delayed critical prior to performing a burst act as a control of the bulk temperature coefficient of reactivity.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Scalability under a Power Bound using the GREMLINs Framework

With the move towards exascale, system and software developers will have to deal with issues of extreme parallelism. The system properties affected most by the increase in node and core count are the shared resources on node and across the system. The increase in parallelism leads to reduced memory and bandwidth when regarding individual cores. Since power is a limiting factor for supercomputers, and power is not fully utilized in current systems, overprovisioning compute resources is a viable approach to maximized power utilization. To maximize system performance in regard to these changing conditions, it is necessary to understand how resource restrictions impact performance and system behavior. For the purpose of understanding anticipated system properties the GREMLINs Framework was developed. The framework gives the opportunity to add power restrictions, hinder memory properties and introduce faults to study resilience, among others. These features give the opportunity to use current petascale technology to study problems system designers and software developers will have to face when moving towards exascale and beyond. This work describes the initial release of the GREMLINs Framework, developed for this work, and shows how it can be used to study the scaling behavior of proxy applications. These proxy applications represent a selection of HPC workloads important to the scientific community. The proxy applications studied are AMG2013, an algebraic multi-grid linear system solver, CoMD, a classical molecular dynamics proxy application and NEKBONE, an application that uses a high order spectral element method to solve the Navier-Stokes equations. The main interest of these studies lies in analysis regarding their power behavior at scale under a power bound. These findings show how the GREMLINs Framework can help systems and software designers to attain better application performance and can also be used as basis for CPU power balancing tools to use power more efficiently.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

A mathematical framework for thermodynamic computing with applications to chemical reaction networks

The widespread adoption of energy-intensive computing applications has led to a growing need for energy-efficient computing approaches. Thermodynamic computing offers a promising approach for low-energy computation by leveraging the intrinsic computational capabilities of physical, chemical, or biological systems. However, the mathematical foundations of thermodynamic computing require further development to fully realize the potential energy efficiencies, as well as to assess factors like noise and operational speed. In this paper, we establish a mathematical framework for utilizing thermodynamic processes to perform fundamental operations, including addition, subtraction, multiplication, and division. We highlight the use of chemical reactions as potential computational units and explore synthetic chemical and biochemical systems as practical implementations. Additionally, we demonstrate how these principles can be applied to solving complex mathematical problems, such as ordinary differential equations (ODEs) and suggest the necessary components to implement the thermodynamic computing framework using chemical reactions based in a microfluidic device. This work enhances our understanding of thermodynamic processes for natural computing as a basis for scalable, energy-efficient computation in paradigm disruptive next-generation systems.

Cannon, William R. [Pacific Northwest National Lab↗

Automated Inspection of Criticality Control Overpacks for Surplus Plutonium Disposition: Qualification Update – 25313

In an effort to reduce the amount of nuclear waste in South Carolina, the Department of Energy (DOE) tasked the Savannah River Site (SRS) with diluting and disposing of the amount of plutonium in the state. This process involves the movement and shipment of over 100,000 criticality control overpacks (CCOs) throughout the project lifespan, lending itself to the use of automation to reduce worker radiation exposure and more efficiently utilize human capital. Due to the large scope, this overarching process was broken down into several different “automation projects” to be developed. The first opportunity pursued was the receipt and inspection of empty CCO drums coming into SRS, identified as Automation Project 1 (AP1), and is the focus of this paper. AP1 was developed to unpack incoming CCOs and inspect them for unwanted foreign objects and any damage to the drum or its contents. This process is accomplished by the combination of an automated guided vehicle (AGV) that delivers CCOs to a robotic arm which uses a suite of custom tools to disassemble a CCO, inspect the inside and outside of the CCO and its inner criticality control container (CCC), reassemble the CCC and CCO, and apply a tamper indicating device (TID) to the inspected drum. In past years, the robotic work cell had been developed in a small-scale testing facility for proof-of-concept. This year, major improvements were made to the robotic work cell to perform the process, including integration into the final facility where CCOs will be inspected. Other technical improvements include the implementation of sensor feedback and safety relays into the control system to allow the state of the work cell to be better tracked, and additional development of the TID application process to complete the robotic inspection. Further enhancements were made to the robotic vision processes and robot pathing, as well as development on a computer vision inspection process to detect inspection criteria anomalies in CCOs. In addition to developmental improvements, the work cell underwent a six-month testing period to ensure the project requirements were met. Results of this testing period demonstrate the work cell’s capability to meet project throughput goals at an acceptable level, successfully document the status of each CCO inspected, and reduce the toll on technical operations’ human power by two thirds. At the time of this paper, the work cell is capable of autonomously handling up to eight CCOs with an AGV, delivering CCOs to and from the robot work cell, and having a robotic arm perform a full receipt and inspection procedure on each CCO. Moving forward, repeatability will be improved so that these CCOs can be run back-to-back seamlessly, as well as improving the system to handle more significant edge cases and failure modes.

Spivey, Nicholas↗

Scalable Parallel Methods for Analyzing Metagenomics Data at Extreme Scale

The field of bioinformatics and computational biology is currently experiencing a data revolution. The exciting prospect of making fundamental biological discoveries is fueling the rapid development and deployment of numerous cost-effective, high-throughput next-generation sequencing technologies. The result is that the DNA and protein sequence repositories are being bombarded with new sequence information. Databases are continuing to report a Moore’s law-like growth trajectory in their database sizes, roughly doubling every 18 months. In what seems to be a paradigm-shift, individual projects are now capable of generating billions of raw sequence data that need to be analyzed in the presence of already annotated sequence information. While it is clear that data-driven methods, such as sequencing homology detection, are becoming the mainstay in the field of computational life sciences, the algorithmic advancements essential for implementing complex data analytics at scale have mostly lagged behind. Sequence homology detection is central to a number of bioinformatics applications including genome sequencing and protein family characterization. Given millions of sequences, the goal is to identify all pairs of sequences that are highly similar (or “homologous”) on the basis of alignment criteria. While there are optimal alignment algorithms to compute pairwise homology, their deployment for large-scale is currently not feasible; instead, heuristic methods are used at the expense of quality. In this dissertation, we present the design and evaluation of a parallel implementation for conducting optimal homology detection on distributed memory supercomputers. Our approach uses a combination of techniques from asynchronous load balancing (viz. work stealing, dynamic task counters), data replication, and exact-matching filters to achieve homology detection at scale. Results for a collection of 2.56M sequences show parallel efficiencies of ~75-100% on up to 8K cores, representing a time-to-solution of 33 seconds. We extend this work with a detailed analysis of single-node sequence alignment performance using the latest CPU vector instruction set extensions. Preliminary results reveal that current sequence alignment algorithms are unable to fully utilize widening vector registers.

59 BASIC BIOLOGICAL SCIENCES↗

Optimization Methodology of Polar Direct-Drive Illumination for the National Ignition Facility

Improved laser illumination uniformity drives shocks and implosions to create more extreme high energy density environments. Predominantly, the geometry of experiments that can be performed is dictated by the layout of beams at laser facilities, limiting inter-facility and multiscale investigations. This Letter presents the first automated, algorithmic approach for generating illumination configurations for high energy density experiments. The method is demonstrated in comparison to a polar direct drive solid target experiment at the National Ignition Facility. The new illumination configuration is simulated to create greater than ×3 higher peak pressure and almost ×2 higher density by maintaining better shock uniformity. Furthermore, the optimization process is performed with reduced computational expense and isotropic plasma profiles, while accounting for the impact of cross-beam energy transfer.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

IMAGING ANALYSIS OF THE HARD X-RAY TELESCOPE ProtoEXIST2 AND NEW TECHNIQUES FOR HIGH-RESOLUTION CODED-APERTURE TELESCOPES

Wide-field (≳100 deg{sup 2}) hard X-ray coded-aperture telescopes with high angular resolution (≲2′) will enable a wide range of time domain astrophysics. For instance, transient sources such as gamma-ray bursts can be precisely localized without the assistance of secondary focusing X-ray telescopes to enable rapid followup studies. On the other hand, high angular resolution in coded-aperture imaging introduces a new challenge in handling the systematic uncertainty: the average photon count per pixel is often too small to establish a proper background pattern or model the systematic uncertainty in a timescale where the model remains invariant. We introduce two new techniques to improve detection sensitivity, which are designed for, but not limited to, a high-resolution coded-aperture system: a self-background modeling scheme which utilizes continuous scan or dithering operations, and a Poisson-statistics based probabilistic approach to evaluate the significance of source detection without subtraction in handling the background. We illustrate these new imaging analysis techniques in high resolution coded-aperture telescope using the data acquired by the wide-field hard X-ray telescope ProtoEXIST2 during a high-altitude balloon flight in fall 2012. We review the imaging sensitivity of ProtoEXIST2 during the flight, and demonstrate the performance of the new techniques using our balloon flight data in comparison with a simulated ideal Poisson background.

79 ASTRONOMY AND ASTROPHYSICS↗

Math processing by detection of elementary valued operands

One embodiment of the present invention includes a method for simplifying arithmetic operations by detecting operands with elementary values such as zero or 1.0. Computer and graphics processing systems perform a great number of multiply-add operations. In a significant portion of these operations, the values of one or more of the operands are zero or 1.0. By detecting the occurrence of these elementary values, math operations can be greatly simplified, for example by eliminating multiply operations when one multiplicand is zero or 1.0 or eliminating add operations when one addend is zero. The simplified math operations resulting from detecting elementary valued operands provide significant savings in overhead power, dynamic processing power, and cycle time.

Finchelstein, Daniel Frederic↗

Orientation transitions during the growth of imine covalent organic framework thin films

Oriented growth of thin films of covalent organic frameworks (COFs) has attracted significant interest as the anisotropically aligned channels provide ideal nanoscopic domains that can facilitate mass transport or charge percolation. Despite some experimental progress in achieving oriented COF thin films, little is known about the kinetics and thermodynamics associated with the orientation or control over the solution-based growth process. We performed a systematic study of the thin film growth of an imine-based COF as a function of concentration and growth time. Grazing incidence wide-angle X-ray scattering (GIWAXS) was used to reveal the orientation and evolution of crystallization within the thin films at sequential growth stages. Here, an unusual re-entrant transition from an oriented to disoriented to reoriented state was discovered, which correlates with the kinetics associated with independent surface- and solution-based nucleation and growth processes, as well as reorganization of disoriented COF crystallites.

36 MATERIALS SCIENCE↗

Making coordination networks ionic: a unique strategy to achieve solution-processable hybrid semiconductors

The development of high-performance, solution-processable semiconducting materials is crucial for the advancement of emerging clean-energy technologies such as light-emitting diodes and photovoltaics. While hybrid perovskites have shown considerable promise for implementation in these technologies, their reliance on toxic metals and relatively low stability towards moisture and chemical environments remain to be addressed. In this Chemistry Frontiers article, we describe a unique strategy to build nontoxic, robust and solution-processable hybrid semiconductors based on copper halide by incorporating ionic bonds in coordination complexes (molecular or extended network structures). Specifically, these compounds are made of anionic copper(I) halide and cationic organic ligands that form both coordinate and ionic bonds at the inorganic/organic interfaces and are referred to as all-in-one (AIO)-type structures. Here, the unique bonding nature renders the AIO-type structures with greatly enhanced solubility, excellent optical tunability and remarkable framework stability, all highly desirable for thin-film based optoelectronic devices. We will highlight the most recent progress in the development of this material group, including their design strategies, important properties and potential for clean-energy related applications. We will also briefly discuss the existing challenges and future outlook of these materials.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Evolution of AISI 304L stainless steel part properties due to powder recycling in laser powder-bed fusion

Selective laser melting (SLM) is a powder-bed fusion process in Additive Manufacturing (AM) that uses a laser beam to selectively fuse layers of powder into near net-shape components with little porosity. However, inconsistencies in the part properties due to the presence of defects in as-built components has hindered the widespread adoption of SLM for industrial applications forcing researchers to study the sources of variation for quality control purposes. A critical area suspected of creating variation in the part properties is the feedstock, where batch-to-batch differences as well as changes in the powder properties with reuse have the potential to affect performance. During processing, laser spatter and condensate eject from the melt pool and deposit into the powder-bed surrounding the parts. These particulates, more commonly known as ejecta, differ morphologically and chemically from the virgin powder compromising its reusability. In this study, 304L stainless steel powder was recycled for a total of 5 times through a systematic approach aimed at accelerating powder degradation to reveal the influence on both the tensile and impact toughness properties. Through analysis of variance (ANOVA), it was found that tensile properties did not change with reuse, while the impact toughness showed a steady decline illustrating the differences in static and dynamic part properties due to powder recycling.

36 MATERIALS SCIENCE↗