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At least 541 records · Page 30

Dose Summation Strategies for External Beam Radiation Therapy and Brachytherapy in Gynecologic Malignancy: A Review from the NRG Oncology and NCTN Medical Physics Subcommittees

Definitive, nonsurgical management of gynecologic malignancies involves external beam radiation therapy (EBRT) and/or brachytherapy (BT). Summation of the cumulative dose is critical to assess the total biologic effective dose to targets and organs at risk. Cumulative dose calculation from EBRT and BT can be performed with or without image registration (IR) and biologic dose summation. Among these dose summation strategies, linear addition of dose-volume histogram (DVH) parameters without IR is the global standard for composite dose reporting. This approach stems from an era without image guidance and simple external beam and brachytherapy treatment approaches. With technological advances, EBRT and high-dose-rate BT have evolved to allow for volume-based treatment planning and delivery. Modern conformal therapeutic radiation involves volumetric or intensity modulated EBRT, capable of simultaneously treating multiple targets at different specified dose levels. Therefore, given the complexity of modern radiation treatment, the linear addition of DVH parameters from EBRT and high-dose-rate BT is challenging to represent the combined dose distribution. Deformable image registration (DIR) between EBRT and image guided brachytherapy (IGBT) data sets may provide a more nuanced calculation of multimodal dose accumulation. However, DIR is still nascent in this regard, and needs further development for accuracy and efficiency for clinical use. Biologic dose summation can combine physical dose maps from EBRT and each IGBT fraction, thereby generating a composite DVH from the biologic effective dose. However, accurate radiobiologic parameters are tissue-dependent and not well characterized. A combination of voxel-based DIR and biologic weighted dose maps may be the best approximation of dose accumulation but remains invalidated. The purpose of this report is to review dose summation strategies for EBRT and BT, including conventional equivalent dose in 2-Gy fractions dose summation without image registration, physical dose summation using 3-dimensional rigid IR and DIR, and biologic dose summation. We also provide general clinical workflows for IGBT with a focus on cervical cancer.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Hantavirus is Associated With Open Developed Areas and Arid Climates, Highlighting Increased Risk in the Western United States

In the United States, hantaviruses can cause hantavirus pulmonary syndrome (HPS) in humans, an acute respiratory illness with a high mortality rate. Most people contract HPS from exposure to infected rodent excrement. The interannual dynamics of hantavirus transmission are tied to both environmental and human-related factors, including changes in annual climate conditions, rodent populations, and the built environment in which humans are more likely to be exposed. Similar environmental conditions and socioeconomic factors also likely determine the long-term risk of hantavirus exposure. Here, we use ecological niche models and human cases of HPS in the U.S. from 1993 to 2022 to assess hantavirus risk using four socioeconomic variables, 17 land use variables, one variable of rodent richness, and seven climate variables to determine both the geographical locations of highest exposure risk and leading environmental predictors. We found that areas with higher relative risk tend to be where it is drier, higher social vulnerability, increased rodent richness, and more open to low levels of development—this largely mapped to the western U.S. We found evidence that fringe ecosystems may be important areas of hantavirus transmission, similar to other emerging diseases. Increased rodent richness was associated with increased hantavirus risk, warranting further investigation into how the abundance and community composition of rodents could impact long-term risk. These risk maps can help public health officials develop plans for mitigating hantavirus, especially for the most susceptible populations. They can also be used to further investigate regions estimated to be at high risk for hantavirus where disease cases have not been as common but may be underreported.

54 ENVIRONMENTAL SCIENCES↗

Topographic Characterization

The National Aeronautics and Space Administration (NASA), other government agencies, and private industry have requirements to map and analyze 3-dimensional surfaces of varying regularity and material composition. This requires a high fidelity, 3-dimensional description of the work space. In cases where complete and current information about the space is not available, topographic characterization allows on-line initialization and/or modification of the work space database. The mapping environment is often challenging with regard to lighting, radiation, temperature, atmosphere, and causticity. This paper describes a system that provides topographic characterization based on fusing intensity and depth information, and describes the application of this technique for inspection of Shuttle thermal tiles.

Goode, Plesent W.↗

Self-absorption correction on 2D X-ray fluorescence maps

Abstract X-ray fluorescence mapping (XRF) is a highly efficient and non-invasive technique for quantifying material composition with micro and nanoscale spatial resolutions. Quantitative XRF analysis, however, confronts challenges from the long-lasting problem called self-absorption. Moreover, correcting two-dimensional XRF mapping datasets is particularly difficult because it is an ill-posed inverse problem. Here we report a semi-empirical method that can effectively correct 2D XRF mapping data. The correction error is generally less than 10% from a comprehensive evaluation of the accuracy in various configurations. The proposed method was applied to quantify the composition distribution around the grain boundaries in an electrochemically corroded stainless steel sample. Highly localized Cr enrichment was found around the crack sites, which was invisible before the absorption correction.

36 MATERIALS SCIENCE↗

Direct Measurement of the Composition of Aqueous Fluids from the Parent Body of Asteroid 162173 Ryugu

Imaging using X-ray absorption contrast by synchrotron nano-computed tomography (47.4 nm/voxel, 7keV) of a Ryugu pyrrhotite crystal (C0002-FC012-from the second touch-down site) revealed probable fluid inclusions (Fig. 1A,B) [1]. The inclusions were completely encapsuled in pyrrhotite, suggesting the fluids were trapped in the early stages of crystal growth, and filled with low-Z material. We performed Time-of Flight-Secondary Ion Mass Spectrometry (TOF-SIMS) depth profiling and high-resolution map-ping at -120°C to exposure and measure the composition of the trapped fluids in a frozen state.

M Zolensky↗

Computational Design of Interlayers for Thermally Stable Compositionally Graded Coatings on Nickel Alloys

To extend the service life of Ni-based superalloys, refractory metal coatings are often used. However, direct bonding between metals with dissimilar crystal structure promotes brittle intermetallic phase formation. This work presents a computational thermodynamic framework for high throughput design of functionally graded interlayers to suppress deleterious phases that may form at the interlayer. The Thermo-Calc software package was used to screen candidate metallic interlayer elements based on stability of solid-solution phases. Vanadium was identified as a promising interlayer due to its consistent suppression of intermetallic phases. Temperature-dependent phase diagram mapping between 600 and 1000 °C guided selection of a compositional pathway that significantly reduced intermetallic formation compared to directly joining the Ni-based and Nb refractory alloys. Time–temperature–transformation analysis was performed to assess whether equilibrium-predicted phases are kinetically accessible along regions of the graded path where non-solid-solution phases are not fully suppressed. The methodology was further applied to additional Ni-based alloy and coating systems, illustrating its transferability as an approach for rapid computational design of graded interlayers in dissimilar high-temperature materials.

36 MATERIALS SCIENCE↗

Investigation of the Ignition and Burning of Materials in Space Cabin Atmospheres. Part 1: Ignition and Burning of Material

An analytical study of the theory of ignition and burning of a plastic material immersed in an atmosphere of a space cabin which may be subjected to gravity force changes is considered. The hazardous condition in a space cabin environment where the changes of gravity may effect the combustion process is evaluated. The model considered the analysis of the coupled gas and solid phases and is based on the premise that material heating leads to the formation of pyrolysis gases from the decomposed solid which then react with the ambient oxidizer to further the combustion process. Moreover, free convection plays a dominant role in transporting these hot gases to the virgin material. A time-dependent study of the coupled gas-solid model as required for ignition processes with emphasis on the surface energy interchange of the gas and solid phases has been made. Detailed distribution of species composition and temperature patterns provide a spatial and time map of the evolving gases from the material combustion.

Lew, H. G.↗

The Apollo 15 X-ray fluorescence experiment.

The prime purpose of the X-ray fluorescence spectrometer carried in the Scientific Instrument Module of the Command-Service Module was to map the lunar surface with respect to its chemical composition. Results are presented for Al, Mg, and Si as Al/Si and Mg/Si ratios for the various features overflow by the spacecraft. The lunar surface measurements involved observations of the intensity and characteristic energy distribution of the secondary or fluorescent X rays produced by the interaction of solar X rays with the lunar surface. The results showed that the highlands and maria are chemically different, with the highlands having considerably more Al and less Mg than the maria. The mare-highland contact is quite sharp and puts a limit on the amount of horizontal transport of material. The X-ray data suggest that the dominant rock type of the lunar highlands is a plagioclase-rich pyroxene bearing rock probably anorthositic gabbro or feldspathic basalt.

Adler, I.↗

Annual review of earth observations from space

An overview is given of the present state of satellites making observations of the earth. Satellite systems discussed include the NOAA series of Synchronous Meteorological Satellites (SMS) and sun-synchronous satellites, the two LANDSATS (formerly called ERTS), and the NIMBUS series. Examples are presented of the types of observations being made as well as their purposes. These include observations of synoptic and mesoscale atmospheric processes for daily weather forecasting, global atmospheric processes for long-range weather forecasting, planetary radiation budget and ocean circulation for monitoring climatic trends, earth dynamics and tectonic structure for mineral exploration and assessing earthquake hazards, atmospheric composition and water quality for environment monitoring, and thematic mapping for monitoring land use, managing crops and water resources, and assessing environmental impacts.

Nordberg, W.↗

Investigation of remote sensing techniques as inputs to operational resource management models

The author has identified the following significant results. Successful operational applications of LANDSAT data were found for level 1 land use mapping, drainage network delineation, and aspen mapping. Visual LANDSAT interpretation using 1:125,000 color composite imagery was the least expensive method of obtaining timely level 1 land use data. With an average agricultural/rangeland interpretation accuracy in excess of 80%, such a data source was considered the most cost effective of those sources available to state agencies. Costs do not compare favorably with those incurred using the present method of extracting land use data from historical tabular summaries. The cost increase in advancing from the present procedure to a satellite-based data source was justified in terms of expanded data content.

Schmer, F. A.↗

Regional distribution of mineral and matrix in the femurs of rats flown on Cosmos 1887 biosatellite

The location and nature of the defect in mineralization known to occur in growing animals after spaceflight are studied. The distribution of bone mineral density in situ is mapped, and these images are correlated with the chemical composition of the diaphyseal bone. Concentrations of mineral and osteocalcin are found to be low in the distal half of the diaphysis and concentrations of collagen to be low with evidence of increased synthesis in the proximal half of the diaphysis of the flight bones. X-ray microtomography indicates a longitudinal gradient of decreasing mineralization toward the distal diaphysis. Analysis of embedded sections by backscattered electrons reveals patterns of mineral distribution in the proximal, central, and distal regions of the diaphysis and also shows a net reduction in mineral levels toward the distal shaft. Increases in mineral density to higher fractions in controls are less in the flight bones at all three levels.

Mechanic, Gerald L.↗

One-Dimensional Coupled Ecosystem-Carbon Flux Model for the Simulation of Biogeochemical Parameters at Ocean Weather Station P

In this Technical Publication, we describe the model functionality and analyze its application to the seasonal and interannual variations of phytoplankton, nutrients, pCO2 and CO2 concentrations in the eastern subarctic Pacific at Ocean Weather Station P (OWSP, 50 deg. N 145 deg. W). We use a verified one-dimensional ecosystem model, coupled with newly incorporated carbon flux and carbon chemistry components, to simulate 22 years (1958-1980) of pCO2 and CO2 variability at Ocean Weather Station P (OWS P). This relatively long period of simulation verifies and extends the findings of previous studies using an explicit approach for the biological component and realistic coupling with the carbon flux dynamics. The slow currents and the horizontally homogeneous ocean in the subarctic Pacific make OWS P one of the best available candidates for modeling the chemistry of the upper ocean in one dimension. The chlorophyll and ocean currents composite for 1998 illustrates this premise. The chlorophyll concentration map was derived from SeaWiFS data and the currents are from an OGCM simulation (from R. Murtugudde).

Signorini, S.↗

The Atmospheres of Titan and Saturn in the Infrared from Cassini: The Interplay Between Observation and Laboratory Studies

The Composite Infrared Spectrometer (CIRS) aboard the Cassini spacecraft has been recording spectra of Saturn and Titan since its arrival in the Saturn system in 2004. CIRS, a Fourier transform spectrometer, observes the thermal infrared spectrum of both atmospheres from 10 to 1500/cm with resolutions up to 0.5/cm (Flasar et al. 2004). From these data CIRS provides global coverage of the molecular composition of the stratosphere and troposphere, as well as maps of temperature and winds. From such studies CIRS helps reveal the chemistry and evolutionary history of Saturn and Titan and their relationships to other Solar System bodies. The Cassini mission is continuing until 2017, permitting CIRS to search for atmospheric changes during more than a Saturnian season. By combining with results from Voyager (1980, 1981) the baseline becomes more than one Saturnian year (Coustenis et al. 2011). CIRS spectroscopy of the atmospheres of Saturn and Titan has raised a variety of questions that require new laboratory studies. A complete understanding of the CIRS high-resolution atmospheric spectra cannot be fully achieved without new or improved line positions and intensities for some trace molecules (e.g., Nixon et al. 2009). Isotopic variants of some of the more abundant species often need improved line parameters in order to derive isotopic ratios (e.g., Coustenis et al. 2008 and Fletcher et a!. 2009). Isotopic ratios contain information about the history of an atmosphere if experimental fractionation rates are available (Jennings et al. 2009). Some aerosol and haze features continue to defy identification and will not be explained without better knowledge of how these materials are formed and until we obtain their laboratory spectra. The interaction between CIRS investigations and laboratory research has been productive and has already led to new discoveries.

Jennings, D. E.↗

Characterization of Mineralogy Across Vesta

Dawn VIR spectra are characterized by pyroxene absorptions and no clear evidence for abundant other minerals are observed at the scale of the present measurements. Even though Vesta spectra are dominated by pyroxenes, spectral variation at regional and local scales are evident and distinct color units are identified. Although almost all of the surface materials exhibit spectra like those of howardites, some large units can be interpreted to be material richer in diogenite (based on pyroxenes band depths and band centers) and some others like eucrite-rich howardite units. VIR data strongly indicate that the south polar region (Rheasilvia) has its own spectral characteristics, indicating the presence of Mg-pyroxene-rich terrains (diogenite-like), while the equatorial areas have swallower band depths and average band centers at slightly longer wavelengths, consistent with more eucrite rich materials. Vesta surface shows considerable diversity at smaller scales (tens of km), in terms of spectral reflectance and emission, band depths and slopes. Many bright and dark spots are present on Vesta. Dark spots have low reflectance at visible wavelengths and are spectrally characterized by shallower 1 and 2 micron bands with respect the surrounding terrains. Bright materials have high reflectance and are often spectrally characterized by deep pyroxenes absorption bands. Vesta presents complex geology/topography and the mineral distribution is often correlated with geological and topographical structures. Ejecta from large craters have distinct spectral behaviors, and materials exposed in the craters show distinct spectra on floors and rims. VIR reveals the mineralogical variation of Vesta s crustal stratigraphy on local and global scales. Maps of spectral parameters show surface and subsurface unit compositions in their stratigraphic context. The hypothesis that Vesta is the HED parent body is consistent with, and strengthened by, the geologic and spectral context for pyroxene distribution provided by Dawn.

De Sanctis, M. C.↗

Integrated laboratory, modeling and observational investigations of the condensation of benzene on Titan's stratospheric aerosols

Aerosols in Titan’s atmosphere play an important role in determining its thermal structure and can act as condensation nuclei for the formation of clouds. The global circulation of Titan’s atmosphere reversed within the two years following the northern spring equinox in August 2009, increasing the mixing ratios of benzene (C6H6) and other species at the South pole. A simultaneous strong cooling above the south pole (dropping temperatures below 120 K) resulted in conditions where molecules could condense at unusually high altitudes (>250 km). C6H6 and HCN ices have been detected by the Composite Infrared Spectrometer (CIRS) and the Visible and Infrared Mapping Spectrometer (VIMS), respectively, in the South polar cloud system, but the existing laboratory data is insufficient to allow models to reproduce the formation of the observed cloud system. We will present the preliminary results and the overall scope of a newly funded NASA SMD Cassini Data Analysis Program (CDAP) project which proposes to combine laboratory, modeling and observational studies to investigate the condensation of benzene on Titan’s aerosol as an important component of the cloud system that appeared during the autumn at 300 km above Titan’s South pole.

E. Sciamma-O’Brien↗

Direct Analyses of Aqueous Fluids from C-Class Asteroid 162173 Ryugu

Imaging using X-ray absorption contrast by synchrotron nano-computed tomography (47.4 nm/voxel, 7keV) of a Ryugu pyrrhotite crystal revealed probable fluid inclusions. The inclusions were completely encapsuled in pyrrhotite, suggesting the fluids were trapped in the early stages of crystal growth, and filled with low-Z material. We performed Time-of Flight-Secondary Ion Mass Spectrometry (TOF-SIMS) depth profiling and high-resolution mapping at -120°C to exposure and measure the composition of the trapped fluids in a frozen state. These measurements revealed that the ancient, trapped fluids on Ryugu’s parent asteroid were saline aqueous solutions containing H2O, CO2, sulfur species, and nitrogen- and chlorine-bearing organic compounds identified by representative secondary ion species including O(-), OH(-), CO(-), S(-), Cl(-), C2(-), C2H(-), and CN(-). The inferred presence of CO2 indicates formation of the sulfides, and by implication the Ryugu parent body, beyond the H2O and CO2 snow lines of the early solar system, i.e. > 3-4 au from the Sun.

M Zolensky↗

The Science Case for Spacecraft Exploration of the Uranian Satellites: Candidate Ocean Worlds in an Ice Giant System

The 27 satellites of Uranus are enigmatic, with dark surfaces coated by material that could be rich in organics. Voyager 2 imaged the southern hemispheres of Uranus’s five largest “classical” moons—Miranda, Ariel, Umbriel, Titania, and Oberon, as well as the largest ring moon, Puck—but their northern hemispheres were largely unobservable at the time of the flyby and were not imaged. Additionally, no spatially resolved data sets exist for the other 21 known moons, and their surface properties are essentially unknown. Because Voyager 2 was not equipped with a near-infrared mapping spectrometer, our knowledge of the Uranian moons’ surface compositions, and the processes that modify them, is limited to disk-integrated data sets collected by ground- and space-based telescopes. Nevertheless, images collected by the Imaging Science System on Voyager 2 and reflectance spectra collected by telescope facilities indicate that the five classical moons are candidate ocean worlds that might currently have, or had, liquid subsurface layers beneath their icy surfaces. To determine whether these moons are ocean worlds, and to investigate Uranus’s ring moons and irregular satellites, close-up observations and measurements made by instruments on board a Uranus orbiter are needed.

Richard J. Cartwright↗