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DOE OSTI2011

Proceedings of the Inaugural Meeting of the International Forum for Reactor Aging Management (IFRAM)

In almost all countries with nuclear power plants (NPPs), regulatory authorities and the nuclear industry are looking at some form of extended operating periods. To support life extension activities it is necessary to ensure the continued safety and reliability of system, structures, and components, and the component materials. Internationally, a variety of individual national and international activities have been initiated including Plant Life Management through the International Atomic Energy Agency, Electric Power Research Institute’s Long Term Operation program, and various national programs in managing materials degradation and related topics. The U.S. Nuclear Regulatory Commission (NRC) engaged the international community in workshops in 2005-2006 to identify research needs and to collect information in an expert panel report on Proactive Management of Materials Degradation (PMMD), which was reported in NUREG/CR-6923. These results are also available via an Information Tool on the internet at http://pmmd.pnl.gov. This information builds on the extensive compilations known as the GALL Report (Generic Aging Lessons Learned, NUREG-1801, Vols. 1 and 2). Pacific Northwest National Laboratory (PNNL) recently issued a report on the review of various international activities in PMMD (PNNL-17779). There have also been initiatives by Electricite de France, Tokyo Electric Power Company, EPRI, and others to establish a "Materials Aging Institute." Within the materials degradation research community there are also networks and technical meetings focused on some elements of PMMD. In spite of all these efforts, there is currently no forum to bring together these diverse activities and provide coordinated information exchange and prioritization of materials aging management/PMMD topics. It is believed that the International Forum for Reactor Aging Management (IFRAM) would be a good way to achieve this goal and help develop new approaches for ensuring continued safe operation in existing and future nuclear power plants. To begin addressing this need, NRC has established a Proactive Management of Materials Degradation Program for managing in-service degradation of metallic components in aging NPPs. The NRC is seeking to facilitate the establishment of IFRAM as a network of international experts who would exchange information on operating experience, best practices, and emerging knowledge. These experts would be willing to work jointly and leverage the separate efforts of existing national programs into a unified approach to enable the potential for the safe and economic life extension of NPPs. A proposal for establishing IFRAM was developed and presented at Engagement workshops in Seoul, Korea (October 2009) and Petten, The Netherlands (May 2010). Participants in both groups demonstrated strong interest in the establishment of IFRAM. Therefore the Global Steering Committee was formed to plan and carry out the start-up of IFRAM in 2011. This group finalized the documents for IFRAM and organized the kick-off meeting. This document records the contents of the inaugural meeting of IFRAM, which was held August 4-5, 2011, at the Cheyenne Mountain Resort in Colorado Springs, Colorado. Representatives from Asia, Europe, and the United States met to share information on reactor aging management and make plans for the future. Professor Tetsuo Shoji was elected chairperson of the Leadership Council. This kick-off event transformed the dream of an international forum into a reality. IFRAM has begun to achieve its mission.

Reactor Aging Management↗

DOE OSTI2021

Accelerated Aging of Fast Pyrolysis Bio-Oil Using Carbonyl Titration: Laboratory Analytical Procedure (LAP)

This laboratory analytical procedure covers the accelerated aging of fast pyrolysis bio-oils. Bio-oils undergo reactions that result in physical and chemical changes over time. These changes typically result in an increase in molecular weight, decrease in some functional groups such as carbonyls, and an increase in viscosity; additionally, the aging process often leads to phase separation. Studies have shown that accelerated aging of bio-oils using this method closely mimics room temperature aging for long periods of time (over 3 years). This procedure has been developed for the accelerated aging of fast pyrolysis bio-oils only. Fast pyrolysis bio-oils are more reactive than other bio-oils (e.g., catalytic fast pyrolysis) and undergo aging much more rapidly. Therefore, this procedure should only be used for fast pyrolysis bio-oil samples.

09 BIOMASS FUELS↗

DOE OSTI2017

Epigenetic Regulation of Cellular Senescence and Aging

Aging is characterized by functional decline of diverse organs and an increased risk for several diseases. Therefore, a high interest exists in understanding the molecular mechanisms that stimulate aging at all levels, from cells and tissues to organs and organisms, in order to develop ways to promote healthy aging. While many molecular and biochemical mechanisms are already understood in some detail, the role of changes in epigenetic regulation has only begun to be considered in recent years. The age-dependent global reduction in heterochromatin, along with site-specific changes in the patterns of DNA methylation and modification of histones, have been observed in several aging model systems. However, understanding of the precise role of such changes requires further research. In this review, we will discuss the role of epigenetic regulation in aging and indicate future research directions that will help elucidate the mechanistic details of it.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS2000

Validity of VO(2 max) in predicting blood volume: implications for the effect of fitness on aging

A multiple regression model was constructed to investigate the premise that blood volume (BV) could be predicted using several anthropometric variables, age, and maximal oxygen uptake (VO(2 max)). To test this hypothesis, age, calculated body surface area (height/weight composite), percent body fat (hydrostatic weight), and VO(2 max) were regressed on to BV using data obtained from 66 normal healthy men. Results from the evaluation of the full model indicated that the most parsimonious result was obtained when age and VO(2 max) were regressed on BV expressed per kilogram body weight. The full model accounted for 52% of the total variance in BV per kilogram body weight. Both age and VO(2 max) were related to BV in the positive direction. Percent body fat contributed <1% to the explained variance in BV when expressed in absolute BV (ml) or as BV per kilogram body weight. When the model was cross validated on 41 new subjects and BV per kilogram body weight was reexpressed as raw BV, the results indicated that the statistical model would be stable under cross validation (e.g., predictive applications) with an accuracy of +/- 1,200 ml at 95% confidence. Our results support the hypothesis that BV is an increasing function of aerobic fitness and to a lesser extent the age of the subject. The results may have implication as to a mechanism by which aerobic fitness and activity may be protective against reduced BV associated with aging.

NASA Discipline Cardiopulmonary↗

NASA NTRS1996

Changes in aerobic power of women, ages 20-64 yr

This study quantified and compared the cross-sectional and longitudinal influence of age, self-report physical activity (SR-PA), and body composition (%fat) on the decline of maximal aerobic power (VO2peak) of women. The cross-sectional sample consisted of 409 healthy women, ages 20-64 yr. The 43 women of the longitudinal sample were from the same population and examined twice, the mean time between tests was 3.7 (+/-2.2) yr. Peak oxygen uptake was determined by indirect calorimetry during a maximal treadmill test. The zero-order correlation of -0.742 between VO2peak and %fat was significantly (P < 0.05) higher then the SR-PA (r = 0.626) and age correlations (r = -0.633). Linear regression defined the cross-sectional age-related decline in VO2peak at 0.537 ml.kg-1.min-1.yr-1. Multiple regression analysis (R = 0.851) showed that adding %fat and SR-PA and their interaction to the regression model reduced the age regression weight of -0.537, to -0.265 ml.kg-1.min-1.yr-1. Statistically controlling for time differences between tests, general linear models analysis showed that longitudinal changes in aerobic power were due to independent changes in %fat and SR-PA, confirming the cross-sectional results. These findings are consistent with men's data from the same lab showing that about 50% of the cross-sectional age-related decline in VO2peak was due to %fat and SR-PA.

Aging/physiology↗

NASA NTRS1994

Cardiovascular responses to postural changes: differences with age for women and men

The cardiovascular responses to postural change, and how they are affected by aging, are inadequately described in women. Therefore, the authors examined the influence of age and sex on the responses of blood pressure, cardiac output, heart rate, and other variables to change in posture. Measurements were made after 10 minutes each in the supine, seated, and standing positions in 22 men and 25 women who ranged in age from 21 to 59 years. Several variables differed, both by sex and by age, when subjects were supine. On rising, subjects' diastolic and mean arterial pressures, heart rate, total peripheral resistance (TPR), and thoracic impedance increased; cardiac output, stroke volume, and mean stroke ejection rate decreased; and changes in all variables, except heart rate, were greater from supine to sitting than sitting to standing. The increase in heart rate was greater in the younger subjects, and increases in TPR and thoracic impedance were greater in the older subjects. Stroke volume decreased less, and TPR and thoracic impedance increased more, in the women than in the men. The increase in TPR was particularly pronounced in the older women. These studies show that the cardiovascular responses to standing differ, in some respects, between the sexes and with age. The authors suggest that the sex differences are, in part, related to greater decrease of thoracic blood volume with standing in women than in men, and that the age differences result, in part, from decreased responsiveness of the high-pressure baroreceptor system.

Posture/physiology↗

DOE OSTI2018

Insight into Thermal Aging of Jacket-bonded Ethylene-propylene Rubber Cable Insulation

Electrical cables are integral to nuclear power plant operation and control during power generation, during planned outages, and during design basis events. Polymeric insulation and jacketing used in cable construction does age over time as a function of environmental stresses including heat, moisture, and radiation. Degradation of polymer mechanical properties can lead to breaks in the insulation and consequent electrical shorting. In this work we consider the thermal aging behavior of one of the two most common insulation polymer classes in nuclear power plants, ethylene-propylene rubber (EPR), both as an independent material and within a cable in which the EPR is bonded to a chlorinated polyethylene (CPE) jacket. Understanding the changes in these two materials with aging, both independently and in concert, will allow the establishment of aging lifetime curves and enable the development of effective non-destructive methods for tracking the condition of installed cables composed of similar material systems. Additional and more effective methods for monitoring the condition of installed cables are needed as a technical basis for continued safe use of aging cables in long term operation and to minimize operating costs for cable aging management through better informed retain/repair/replace decisions.

Light Water Reactors, electrical cables, aging, EP↗

DOE OSTI2018

Aging Management Considerations for Dry Cask Storage Canisters - 18472

Dry cask storage systems (DCSSs) are used to store used nuclear fuel (UNF) at independent spent fuel storage installations (ISFSIs) prior to final geologic storage or reprocessing. As storage durations increase beyond the twenty-year period commonly implemented for licensing the storage sites, it is important to consider aging related degradation issues for DCSS components. A large portion of the DCSS designs used throughout the world employ a ventilated concrete overpack with a welded stainless steel canister that confines the UNF. This paper explores key issues related to aging management for these canister components, including: (1) canister environment, (2) inspection limitations, and (3) aging management program guidance and requirements. While the austenitic stainless steel used for the canisters are generally resistant to most forms of environmental attack, it is possible for conditions to arise that lead to pitting and even stress corrosion cracking of the canister systems. A large number of studies related to canister degradation have been performed by industry groups and government researchers, both in the US and worldwide. These advances in the collective knowledge provide insight into risk factors for DCSS. Such information is beneficial to improve ISFSI siting decisions and ensure successful relicensing of existing ISFSIs. This paper highlights relevant research and also discusses applicability to degradation of other equipment and containers used to process and isolate UNF and other nuclear waste streams from the public and the environment. Inspection of the canister surface is an important tool to investigate and evaluate the potential for degradation. Existing DCSS designs typically do not offer ready access to the canister surface in order to perform the inspection. Further complicating inspection efforts are the surface conditions present on the sheltered canisters after extended storage times, including atmospheric debris such as dust and pollen. Given ongoing development efforts, inspection capabilities and associated limitations should be assessed at multiple points in time over the course of an aging management program to incorporate new advances in the field. This paper explores the limitations of currently available capabilities in inspection and delivery, and provides insight into the gaps remaining to be filled to permit an effective inspection program. Recommendations and requirements related to programs for aging management of canisters have been published or are in progress from a variety of groups, including industry groups, regulatory authorities, and Codes and Standards. An effective aging management program should consider the technical bases of these various inputs and maintain compliance with requirements. Given multiple sources, decisions will be required when considering conflicting guidance, and this paper will include discussion of the relative merits of the various approaches. (author)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

DOE OSTI2019

Directed aging, memory, and nature’s greed

Disordered materials are often out of equilibrium and evolve very slowly in a rugged and tortuous energy landscape. This slow evolution, referred to as aging, is deemed undesirable as it often leads to material degradation. However, we show that aging also encodes a memory of the stresses imposed during preparation. Because of inhomogeneous local stresses, the material itself decides how to evolve by modifying stressed regions differently from those under less stress. Because material evolution occurs in response to stresses, aging can be “directed” to produce sought-after responses and unusual functionalities that do not inherently exist. Aging obeys a natural “greedy algorithm” as, at each instant, the material simply follows the path of most rapid and accessible relaxation. Our experiments and simulations illustrate directed aging in examples in which the material’s elasticity transforms as desired because of an imposed deformation.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

NASA NTRS1997

High resolution magnetic resonance imaging of the calcaneus: age-related changes in trabecular structure and comparison with dual X-ray absorptiometry measurements

A high-resolution magnetic resonance imaging (MRI) protocol, together with specialized image processing techniques, was applied to the quantitative measurement of age-related changes in calcaneal trabecular structure. The reproducibility of the technique was assessed and the annual rates of change for several trabecular structure parameters were measured. The MR-derived trabecular parameters were compared with calcaneal bone mineral density (BMD), measured by dual X-ray absorptiometry (DXA) in the same subjects. Sagittal MR images were acquired at 1.5 T in 23 healthy women (mean age: 49.3 +/- 16.6 [SD]), using a three-dimensional gradient echo sequence. Image analysis procedures included internal gray-scale calibration, bone and marrow segmentation, and run-length methods. Three trabecular structure parameters, apparent bone volume (ABV/TV), intercept thickness (I.Th), and intercept separation (I.Sp) were calculated from the MR images. The short- and long-term precision errors (mean %CV) of these measured parameters were in the ranges 1-2% and 3-6%, respectively. Linear regression of the trabecular structure parameters vs. age showed significant correlation: ABV/TV (r2 = 33.7%, P < 0.0037), I.Th (r2 = 26.6%, P < 0.0118), I.Sp (r2 = 28.9%, P < 0.0081). These trends with age were also expressed as annual rates of change: ABV/TV (-0.52%/year), I.Th (-0.33%/year), and I.Sp (0.59%/year). Linear regression analysis also showed significant correlation between the MR-derived trabecular structure parameters and calcaneal BMD values. Although a larger group of subjects is needed to better define the age-related changes in trabecular structure parameters and their relation to BMD, these preliminary results demonstrate that high-resolution MRI may potentially be useful for the quantitative assessment of trabecular structure.

NASA Discipline Number 26-10↗

DOE OSTI2024

Fluoro‐Ethylene‐Carbonate Plays a Double‐Edged Role on the Stability of Si Anode‐Based Rechargeable Batteries During Cycling and Calendar Aging

Abstract The energy storage density of Li‐ion batteries can be improved by replacing graphite anodes with high‐capacity Si‐based materials, though instabilities have limited their implementation. Performance degradation mechanisms that occur in Si anodes can be divided into cycling stability (capacity retention after repeated battery cycles) and calendar aging (shelf life). While cycling instabilities and improvement strategies have been researched intensively, there is little known about the underlying mechanisms that cause calendar aging. In this work, multiple electron microscope techniques are used to explore the mechanism that governs calendar aging from the sub‐nanometer‐to‐electrode scale. Plasma focused ion beam tomography is used to create 3D reconstructions of calendar aged electrodes and revealed the growth of a LiF‐rich layer at the interface between the copper current collector and the silicon material, which can lead to delamination and increased interfacial impendence. The LiF layer appeared to derive from the fluoro‐ethylene‐carbonate electrolyte additive, which is commonly used to improve cycling stability in Si‐based systems. The results reveal that additives necessary to improve cycling stability can cause performance degradation over the long‐term during calendar aging. The results show that high performing, stable systems require careful design to simultaneously mitigate both cycling and calendar aging instabilities.

25 ENERGY STORAGE↗

DOE OSTI2022

New Insights into Physical Aging‐Induced Structure Evolution in Carbon Molecular Sieve Membranes

Abstract Carbon molecular sieve (CMS) membranes offer the best available combination of scalable economical processability with excellent separation performance. Physical aging of CMS membranes causes pore structure changes over time that affect CMS membrane performance. To provide fundamental insights into the structure evolution in CMS membranes during physical aging, a combined dual‐mode sorption and transport model is used in this study to characterize the diffusion coefficients of gas molecules in fresh and 7‐day vacuum aged CMS membranes. The results show physical aging of CMS membrane is primarily “diffusion related” and such aging behavior simultaneously causes ultramicropore changes in the continuous phase and Langmuir phase of CMS membrane. The new insights offered in this study suggest strategies to control the physical aging of CMS membranes and even use it as a valuable tool to tune the separation performance of CMS membranes for demanding gas separations.

Liu, Zhongyun↗

DOE OSTI2021

Thirdhand cigarette smoke leads to age-dependent and persistent alterations in the cecal microbiome of mice

The gut microbiome composition is influenced by many factors including environmental exposures. Here, we investigated the effect of thirdhand cigarette smoke (THS) and exposure age on gut microbiome diversity. C57BL/6 mice were exposed to THS at human exposure relevant levels for three weeks during three different life stages: postnatal (0–3 weeks of age), pubescent (4–7 weeks of age), and adult (9–12 weeks of age), respectively. Cecal microbiome profiles were assessed at 17 weeks of age by 16S rRNA gene sequencing. We found that age at THS exposure strongly influenced the cecal microbiome composition. Although postnatal THS exposure significantly influenced the microbial composition, pubescent and adulthood exposures only had minor effects. The microbiome of postnatally THS-exposed mice significantly increased several degradation pathways that regulate glycolysis and pyruvate decarboxylation, and significantly decreased coenzyme A biosynthesis and pyrimidine deoxyribonucleoside salvage. Our results indicate that mouse postnatal development is particularly susceptible to persistent THS exposure effects on the gut microbiome.

16S rRNA gene sequencing↗

DOE OSTI2018

Effect of Thermal Aging and Test Temperatures on Fracture Toughness of SS 316(N) Welds

The effect of thermal aging and test temperatures on fracture toughness (J{sub 0.2}) of SS 316(N) weld material has been studied based on J-R curve evaluations. The aging of the welds was carried out at temperatures 370, 475 and 550 °C and for durations varying from 1000 to 20,000 h. The fracture toughness (J-R curve) tests were carried out at 380 and 550 °C for specimens after all aging conditions, including as-weld condition. The initiation fracture toughness (J{sub 0.2}) of the SS 316(N) weld material has shown degradation after 20,000-h aging durations and is reflected in all the test temperatures and aging temperatures. The fracture toughness after different aging conditions and test temperatures, including as-weld condition, was higher than the minimum specified value for this class of welds.

36 MATERIALS SCIENCE↗

DOE OSTI2022

Effect of thermal aging on corrosion behavior of duplex stainless steels

Abstract Despite their exceptional mechanical and corrosion properties, duplex stainless steels (DSS) have not found widespread use in high-temperature applications due to concerns over thermal aging and embrittlement at elevated operational temperatures (> 300 °C). The present study investigated the effect of thermal aging time on the electrochemical properties of lean and standard grade DSS that are exposed to a range of pressurized water reactors containing LiOH and H 3 BO 3 . The results indicated that the electrolyte chemistry plays a significant role in the corrosion behavior of the DSS alloys. Corrosion resistance decreased with thermal aging time for all DSS alloys; however, standard grade DSS (2205 and 2209-w) alloys showed better corrosion resistance than lean grades (2003, 2101, 2101-w). The presence of dissolved oxygen in the electrolytes resulted in a significant increase in corrosion rate for the DSS alloys, but it did not affect the general trend of corrosion rates with aging time. All DSS alloys became vulnerable to pitting corrosion due to chloride addition, but the pitting resistance decreased with increasing thermal aging time. Increased boron B content resulted in degradation of corrosion resistance of the DSS alloys, while minor changes in pH did not show a significant change in corrosion resistance. Mechanical and metallurgical characterization coupled with electrochemical characterization of the DSS alloys gave a comprehensive insight into the effects of thermal aging on the electrochemical response of the DSS. Graphical abstract

Murkute, Pratik (ORCID:0000000278636346)↗

DOE OSTI2016

Plasma acylcarnitines during insulin stimulation in humans are reflective of age-related metabolic dysfunction

The purpose of this study was to determine if plasma acylcarnitine (AC) profiling is altered under hyperinsulinemic conditions as part of the aging process. Fifteen young, lean (19–29 years) and fifteen middle-to older-aged (57–82 years) individuals underwent a 2-hr euglycemic-hyperinsulinemic clamp. Plasma samples were obtained at baseline, 20 min, 50 min, and 120 min for analysis of AC species and amino acids. Skeletal muscle biopsies were performed after 60 min of insulin-stimulation for analysis of acetyl-CoA carboxylase (ACC) phosphorylation. Insulin infusion decreased the majority of plasma short-, medium-, and long-chain (SC, MC, and LC, respectively) AC. However, during the initial 50 min, a number of MC and LC AC species (C10, C10:1, C12:1, C14, C16, C16:1, C18) remained elevated in aged individuals compared to their younger counterparts indicating a lag in responsiveness. Additionally, the insulin-induced decline in skeletal muscle ACC phosphorylation was blunted in the aged compared to young individuals (−24% vs. −56%, P < 0.05). These data suggest that a desensitization to insulin during aging, possibly at the level of skeletal muscle ACC phosphorylation, results in a diminished ability to transition to glucose oxidation indicative of metabolic inflexibility. - Highlights: • Plasma acylcarnitine profiling reveals metabolic inflexibility in aged individuals. • Time course acylcarnitine profiling is critical to identify metabolic dysfunction. • Acetyl-CoA carboxylase phosphorylation status is related to metabolic dysfunction.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2019

Effects of Thermal Aging on the Fracture Toughness of Cast Stainless Steel CF8

Cast stainless steels are widely used in the primary coolant systems of nuclear power plants because of their high strength, toughness, and corrosion resistance. Mechanical property degradation in the steels, primarily due to a thermally-embrittled ferrite, is of major concern in an extended-term operation. To investigate the aging-induced loss of fracture resistance in cast stainless steels, static fracture resistance (J-R) testing was performed for three different CF8 cast stainless steels with significantly different d-ferrite contents. The materials were thermally-aged at 290-400°C for up to 10kh and fracture-tested at 25-400°C. It was found that the fracture toughness in high-ferrite materials generally decreased with thermal aging while the relationship between aging and fracture toughness in low-ferrite materials was rather complicated, showing non-monotonic variation with the degree of aging. While significant degradation was observed for the highly-aged high-ferrite materials, no material was observed having a K0.2mm less than 100 MPavm.

Collins, David A.↗

DOE OSTI2013

Age and Comorbid Illness Are Associated With Late Rectal Toxicity Following Dose-Escalated Radiation Therapy for Prostate Cancer

Purpose: To assess the impacts of patient age and comorbid illness on rectal toxicity following external beam radiation therapy (EBRT) for prostate cancer and to assess the Qualitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) normal tissue complication probability (NTCP) model in this context. Methods and Materials: Rectal toxicity was analyzed in 718 men previously treated for prostate cancer with EBRT (≥75 Gy). Comorbid illness was scored using the Charlson Comorbidity Index (CCMI), and the NTCP was evaluated with the QUANTEC model. The influence of clinical and treatment-related parameters on rectal toxicity was assessed by Kaplan-Meier and Cox proportional hazards models. Results: The cumulative incidence of rectal toxicity grade ≥2 was 9.5% and 11.6% at 3 and 5 years and 3.3% and 3.9% at 3 and 5 years for grade ≥3 toxicity, respectively. Each year of age predicted an increasing relative risk of grade ≥2 (P<.03; hazard ratio [HR], 1.04 [95% confidence interval (CI), 1.01-1.06]) and ≥3 rectal toxicity (P<.0001; HR, 1.14 [95% CI,1.07-1.22]). Increasing CCMI predicted rectal toxicity where a history of either myocardial infarction (MI) (P<.0001; HR, 5.1 [95% CI, 1.9-13.7]) or congestive heart failure (CHF) (P<.0006; HR, 5.4 [95% CI, 0.6-47.5]) predicted grade ≥3 rectal toxicity, with lesser correlation with grade ≥2 toxicity (P<.02 for MI, and P<.09 for CHF). An age comorbidity model to predict rectal toxicity was developed and confirmed in a validation cohort. The use of anticoagulants increased toxicity independent of age and comorbidity. NTCP was prognostic for grade ≥3 (P=.015) but not grade ≥2 (P=.49) toxicity. On multivariate analysis, age, MI, CHF, and an NTCP >20% all correlated with late rectal toxicity. Conclusions: Patient age and a history of MI or CHF significantly impact rectal toxicity following EBRT for the treatment of prostate cancer, even after controlling for NTCP.

62 RADIOLOGY AND NUCLEAR MEDICINE↗