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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 541 records · Page 30
All sourcesNASA NTRSDOE OSTI
DOE OSTI2014

bantam miRNA is important for Drosophila blood cell homeostasis and a regulator of proliferation in the hematopoietic progenitor niche

Highlights: • bantam miRNA is endogenously expressed in the hematopoietic progenitor niche. • bantam is necessary and sufficient to induce cellular proliferation in the PSC. • bantam is upstream of the Insulin Receptor signaling pathway. • A model for positive regulation of hematopoietic niche growth is proposed. - Abstract: The Drosophila hematopoietic system is utilized in this study to gain novel insights into the process of growth control of the hematopoietic progenitor niche in blood development. The niche microenvironment is an essential component controlling the balance between progenitor populations and differentiated, mature blood cells and has been shown to lead to hematopoietic malignancies in humans when misregulated. MicroRNAs are one class of regulators associated with blood malignancies; however, there remains a relative paucity of information about the role of miRNAs in the niche. Here we demonstrate that bantam miRNA is endogenously active in the Drosophila hematopoietic progenitor niche, the posterior signaling center (PSC), and functions in the primary hematopoietic organ, the lymph gland, as a positive regulator of growth. Loss of bantam leads to a significant reduction in the PSC and overall lymph gland size, as well as a loss of the progenitor population and correlative premature differentiation of mature hemocytes. Interestingly, in addition to being essential for proper lymph gland development, we have determined bantam to be a novel upstream component of the insulin signaling cascade in the PSC and have unveiled dMyc as one factor central to bantam activity. These important findings identify bantam as a new hematopoietic regulator, place it in an evolutionarily conserved signaling pathway, present one way in which it is regulated, and provide a mechanism through which it facilitates cellular proliferation in the hematopoietic niche.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2014

Evolving Role of the Power Sector Regulator: A Clean Energy Regulators Initiative Report

This paper seeks to briefly characterize the evolving role of power sector regulation. Given current global dynamics, regulation of the power sector is undergoing dramatic changes. This transformation is being driven by various factors including technological advances and cost reductions in renewable energy, energy efficiency, and demand management; increasing air pollution and climate change concerns; and persistent pressure for ensuring sustainable economic development and increased access to energy services by the poor. These issues add to the already complex task of power sector regulation, of which the fundamental remit remains to objectively and transparently ensure least-cost service delivery at high quality. While no single regulatory task is trivial to undertake, it is the prioritization and harmonization of a multitude of objectives that exemplifies the essential challenge of power sector regulation. Evolving regulatory roles can be understood through the concept of existing objectives and an additional layer of emerging objectives. Following this categorization, we describe seven existing objectives of power sector regulators and nine emerging objectives, highlighting key challenges and outlining interdependencies. This essay serves as a preliminary installment in the Clean Energy Regulatory Initiative (CERI) series, and aims to lay the groundwork for subsequent reports and case studies that will explore these topics in more depth.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2019

Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

G protein-coupled receptor (GPCR) kinases (GRKs) are responsible for initiating desensitization of activated GPCRs. GRK5 is potently inhibited by the calcium-sensing protein calmodulin (CaM), which leads to nuclear translocation of GRK5 and promotion of cardiac hypertrophy. In this paper, we report the architecture of the Ca 2+ ·CaM– GRK5 complex determined by small-angle X-ray scattering and negative-stain electron microscopy. Ca 2+ ·CaM binds primarily to the small lobe of the kinase domain of GRK5 near elements critical for receptor interaction and membrane association, thereby inhibiting receptor phosphorylation while activating the kinase for phosphorylation of soluble substrates. To define the role of each lobe of Ca 2+ ·CaM, we utilized the natural product malbrancheamide as a chemical probe to show that the C-terminal lobe of Ca 2+ ·CaM regulates membrane binding while the N-terminal lobe regulates receptor phosphorylation and kinase domain activation. In cells, malbrancheamide attenuated GRK5 nuclear translocation and effectively blocked the hypertrophic response, demonstrating the utility of this natural product and its derivatives in probing Ca 2+ ·CaM-dependent hypertrophy.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2013

Treatment of Solar Generation in Electric Utility Resource Planning

Today's utility planners have a different market and economic context than their predecessors, including planning for the growth of renewable energy. State and federal support policies, solar photovoltaic (PV) price declines, and the introduction of new business models for solar PV 'ownership' are leading to increasing interest in solar technologies (especially PV); however, solar introduces myriad new variables into the utility resource planning decision. Most, but not all, utility planners have less experience analyzing solar than conventional generation as part of capacity planning, portfolio evaluation, and resource procurement decisions. To begin to build this knowledge, utility staff expressed interest in one effort: utility exchanges regarding data, methods, challenges, and solutions for incorporating solar in the planning process. Through interviews and a questionnaire, this report aims to begin this exchange of information and capture utility-provided information about: 1) how various utilities approach long-range resource planning; 2) methods and tools utilities use to conduct resource planning; and, 3) how solar technologies are considered in the resource planning process.

14 SOLAR ENERGY↗
NASA NTRS1991

Issues associated with establishing control zones for international space operations

Cooperative missions in Earth orbit can be facilitated by developing a strategy to regulate the manner in which vehicles interact in orbit. One means of implementing such a strategy is to utilize a control zones technique that assigns different types of orbital operations to specific regions of space surrounding a vehicle. Considered here are issues associated with developing a control zones technique to regulate the interactions of spacecraft in proximity to a manned vehicle. Technical and planning issues, flight hardware and software issues, mission management parameter, and other constraints are discussed. Also covered are manned and unmanned vehicle operations, and manual versus automated flight control. A review of the strategies utilized by the Apollo Soyuz Test Project and the Space Station Freedom Program is also presented.

Nader, Blair A.↗
NASA NTRS1992

Issues in developing control zones for international space operations

Cooperative missions in earth orbit can be facilitated by developing a strategy to regulate the manner in which vehicles interact in orbit. One means of implementing such a strategy is to utilize a control zones technique that assigns different types of orbital operations to specific regions of space surrounding a vehicle. Considered here are issues associated with developing a control zones technique to regulate the interactions of spacecraft in proximity to a manned vehicle. Technical and planning issues, flight hardware and software issues, mission management parameter, and other constraints are discussed. Also covered are manned and unmanned vehicle operations, and manual versus automated flight control. A review of the strategies utilized by the Apollo Soyuz Test Project and the Space Station Freedom Program is also presented.

Nader, Blair A.↗
DOE OSTI2014

A PerR-like protein involved in response to oxidative stress in the extreme bacterium Deinococcus radiodurans

Highlights: • We report a novel PerR-like protein of Fur family in D. radiodurans that is not annotated in the current database. • drperR responses to H{sub 2}O{sub 2} and functions as a negative regulator of katE and dps. • We provided implications on how to utilize sequenced genome data and the importance of genome data mining. • This study adds knowledge to complicated regulatory network that responds to ROS stress in D. radiodurans. - Abstract: Response and defense systems against reactive oxygen species (ROS) contribute to the remarkable resistance of Deinococcus radiodurans to oxidative stress induced by oxidants or radiation. However, mechanisms involved in ROS response and defense systems of D. radiodurans are not well understood. Fur family proteins are important in ROS response. Only a single Fur homolog is predicted by sequence similarity in the current D. radiodurans genome database. Our bioinformatics analysis demonstrated an additional guanine nucleotide in the genome of D. radiodurans that is not in the database, leading to the discovery of another Fur homolog DrPerR. Gene disruption mutant of DrPerR showed enhanced resistance to hydrogen peroxide (H{sub 2}O{sub 2}) and increased catalase activity in cell extracts. Real-time PCR results indicated that DrPerR functions as a repressor of the catalase gene katE. Meanwhile, derepression of dps (DNA-binding proteins from starved cells) gene under H{sub 2}O{sub 2} stress by DrPerR point to its regulatory role in metal ions hemostasis. Thus, DrPerR might function as a Fur homolog protein which is involved in ROS response and defense. These results help clarify the complicated regulatory network that responds to ROS stress in D. radiodurans.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

miR-1306–3p targets FBXL5 to promote metastasis of hepatocellular carcinoma through suppressing snail degradation

Highlights: • miR-1306–3p may be potential biomarker for the clinical prognosis of HCC. • miR-1306–3p may be effective target for the treatment of HCC. • miR-1306–3p regulates Snail-mediated metastasis through targeting FBXL5. • miR-1306–3p is transcripted by FOXM1 to promote HCC progression. This study aimed to elucidate the effect of miR-1306–3p on metastasis of hepatocellular carcinoma (HCC) and potential mechanism involved. miR-1306–3p promoted migration and invasion of HCC in vivo and in vitro. Moreover, miR-1306–3p inhibited snail to enhance its expression via directly targeting FBXL5, thus inducing the epithelial-mesenchymal transition (EMT) in HCC. Intriguingly, miR-1306–3p expression was transcriptionally enhanced by FoxM1. Consistently, miR-1306–3p was upregulated in HCC compared with paracarcinoma and correlated with poor prognosis of HCC patients. Our researches suggest that miR-1306–3p is a tumor enhancer in regulating of HCC metastasis, and miR-1306–3p may be clinically utilized as a factor for the clinical diagnosis and prognosis of HCC.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2019

Robust control of the current profile and plasma energy in EAST

Integrated control of the toroidal current density profile, or alternatively the q-profile, and plasma stored energy is essential to achieve advanced plasma scenarios characterized by high plasma confinement, magnetohydrodynamics stability, and noninductively driven plasma current. The q-profile evolution is closely related to the evolution of the poloidal magnetic flux profile, whose dynamics is modeled by a nonlinear partial differential equation (PDE) referred to as the magnetic-flux diffusion equation (MDE). The MDE prediction depends heavily on the chosen models for the electron temperature, plasma resistivity, and non-inductive current drives. To aid control synthesis, control-oriented models for these plasma quantities are necessary to make the problem tractable. However, a relatively large deviation between the predictions by these control-oriented models and experimental data is not uncommon. For this reason, the electron temperature, plasma resistivity, and non-inductive current drives are modeled for control synthesis in this work as the product of an “uncertain” reference profile and a nonlinear function of the different auxiliary heating and current-drive (H&CD) source powers and the total plasma current. The uncertainties are quantified in such a way that the family of models arising from the modeling process is able to capture the q-profile and plasma stored energy dynamics from a typical EAST shot. A control-oriented nonlinear PDE model is developed by combining the MDE with the “uncertain” models for the electron temperature, plasma resistivity, and non-inductive current drives. This model is then rewritten into a control framework to design a controller that is robust against the modeled uncertainties. The resulting controller utilizes EAST's H&CD powers and total plasma current to regulate the q profile and plasma stored energy even when mismatches between modeled and actual dynamics are present. The effectiveness of the controller is demonstrated through nonlinear simulations.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2015

Decentralized Optimal Dispatch of Photovoltaic Inverters in Residential Distribution Systems

Summary form only given. Decentralized methods for computing optimal real and reactive power setpoints for residential photovoltaic (PV) inverters are developed in this paper. It is known that conventional PV inverter controllers, which are designed to extract maximum power at unity power factor, cannot address secondary performance objectives such as voltage regulation and network loss minimization. Optimal power flow techniques can be utilized to select which inverters will provide ancillary services, and to compute their optimal real and reactive power setpoints according to well-defined performance criteria and economic objectives. Leveraging advances in sparsity-promoting regularization techniques and semidefinite relaxation, this paper shows how such problems can be solved with reduced computational burden and optimality guarantees. To enable large-scale implementation, a novel algorithmic framework is introduced - based on the so-called alternating direction method of multipliers - by which optimal power flow-type problems in this setting can be systematically decomposed into sub-problems that can be solved in a decentralized fashion by the utility and customer-owned PV systems with limited exchanges of information. Since the computational burden is shared among multiple devices and the requirement of all-to-all communication can be circumvented, the proposed optimization approach scales favorably to large distribution networks.

14 SOLAR ENERGY↗
DOE OSTI2025

RB-TnSeq elucidates dicarboxylic-acid-specific catabolism in β-proteobacteria for improved plastic monomer upcycling

Dicarboxylic acids are key components of many polymers and plastics, making them a target for both engineered microbial degradation and sustainable bioproduction. In this study, we generated a comprehensive data set of functional evidence for the genetic basis of dicarboxylic and fatty acid metabolism using randomly barcoded transposon sequencing (RB-TnSeq). We identified four β-proteobacteria that displayed robust growth with dicarboxylic acid sole carbon source and cultured their mutant libraries with dicarboxylic and fatty acids with carbon chain lengths from C3 to C12. The resulting fitness data suggested that dicarboxylic and fatty acid metabolisms are largely distinct, and different sets of β-oxidation genes are required for catabolizing dicarboxylic versus fatty acids of the same carbon chain lengths. In addition, we identified transcriptional regulators and transporters with strong fitness phenotypes related to dicarboxylic acid utilization. In Ralstonia sp. UNC404CL21Col (R. CL21), we deleted two transcriptional repressors to improve its utilization of short-chain dicarboxylic acids. We exploited the diacid-utilizing catabolism of R. CL21 to upcycle a mock mixture of the dicarboxylic acids produced when polyethylene is oxidized. After introducing a heterologous indigoidine production pathway, this engineered Ralstonia produced 0.56 ± 0.02 g/L indigoidine from a mixture of dicarboxylic acids as a carbon source, demonstrating the potential of R. CL21 to upcycle plastic wastes to products derived from tricarboxylic acid (TCA) cycle intermediates. IMPORTANCE: Upcycling the carbon in plastic wastes to value-added products is a promising approach to address the plastic waste and climate crises, and dicarboxylic acid metabolism is an important facet of several approaches. Improving our understanding of the genetic basis of this metabolism has the potential to uncover new enzymes and genetic parts for engineered pathways involving dicarboxylic acids. Our data set is the most comprehensive interrogation of dicarboxylic acid catabolism to date, and this work will be of utility to researchers interested in both plastics bioproduction and upcycling applications.

Pearson, Allison N↗
DOE OSTI2014

Sensitive Multi-Species Emissions Monitoring: Infrared Laser-Based Detection of Trace-Level Contaminants

This report summarizes our development of spectroscopic chemical analysis techniques and spectral modeling for trace-gas measurements of highly-regulated low-concentration species present in flue gas emissions from utility coal boilers such as HCl under conditions of high humidity. Detailed spectral modeling of the spectroscopy of HCl and other important combustion and atmospheric species such as H 2 O, CO 2 , N 2 O, NO 2 , SO 2 , and CH 4 demonstrates that IR-laser spectroscopy is a sensitive multi-component analysis strategy. Experimental measurements from techniques based on IR laser spectroscopy are presented that demonstrate sub-ppm sensitivity levels to these species. Photoacoustic infrared spectroscopy is used to detect and quantify HCl at ppm levels with extremely high signal-to-noise even under conditions of high relative humidity. Additionally, cavity ring-down IR spectroscopy is used to achieve an extremely high sensitivity to combustion trace gases in this spectral region; ppm level CH 4 is one demonstrated example. The importance of spectral resolution in the sensitivity of a trace-gas measurement is examined by spectral modeling in the mid- and near-IR, and efforts to improve measurement resolution through novel instrument development are described. While previous project reports focused on benefits and complexities of the dual-etalon cavity ring-down infrared spectrometer, here details on steps taken to implement this unique and potentially revolutionary instrument are described. This report also illustrates and critiques the general strategy of IR- laser photodetection of trace gases leading to the conclusion that mid-IR laser spectroscopy techniques provide a promising basis for further instrument development and implementation that will enable cost-effective sensitive detection of multiple key contaminant species simultaneously.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2021

Peer-to-peer Communication Control Architecture for Engaging Ubiquitous DERs to Support Distribution System Resiliency

In this project, we developed a leader-follower consensus (LFC) control architecture to coordinate between GFM and GFL inverters with the former being leaders and the latter being followers. The objective is to simultaneously achieve a fast frequency and voltage regulation along with accurate real power and var sharing among all inverters under various disturbances. The distinction of our work is that we consider both GFM and GFL inveters for frequency and voltage regulations. In addition, rather than a standard consensus algorithm, our work utilized a leader-follower consensus algorithm which exploits the physical characteristics of GFM-GFL inverters: (i) the GFM inverters directly control frequency and voltage, and hence, serve as leaders, (ii) the GFL inverters measure frequency/voltage to modulate their outputs, and hence, they should serve as followers. The effectiveness of the proposed LFC coordination was tested on a networked microgrid test system under different disturbances and communication degradation events. We demonstrated that the proposed fully coordinated control is robust to disturbances, while outperforming uncoordinated and GFM-only coordinated approaches. Overall, this work emphasized the necessity and benefits of the GFMGFL coordination in the secondary control of microgrids.

24 POWER TRANSMISSION AND DISTRIBUTION↗
DOE OSTI2024

LINAC Longitudinal Simulation and Measurement of Output Energy

The Fermilab Linac, a pivotal and historic accelerator at Fermilab, is crucial to the laboratory's operations, supplying a 400 MeV beam to various acceleration facilities. Due to daily variations in the Linac's output energy, precise monitoring and machine tuning are important to ensure the exiting energy meets the Booster's acceptance criteria. To address this, Beam Position Monitors (BPMs) are employed to assess and adjust the beam's energy, providing essential data on both the transverse position and longitudinal phase of the beam. We also aim to regulate the longitudinal phase profile to match our simulation predictions. By utilizing a Python-based simulation and beam data from three BPMs, we can determine the optimal phasing correction required for the final RF stage to achieve the desired energy. Currently, the calculations of longitudinal phase profile are based on simulations, so additional research is needed to verify if the predicted longitudinal phase distribution aligns with actual real-world data.

Safaryan, Milena↗
DOE OSTI2023

Precursor Analysis Report: SQL Slammer Worm Infection of Davis-Besse Nuclear Power Plant 2003

The SQL Slammer Worm Infection of Davis-Besse Nuclear Power Plant 2003 Precursor Analysis Report leverages publicly available information about Davis-Besse’s 2003 cyber attack and catalogs anomalous observables for each technique employed in the attack. This analysis is based upon the methodology of the Cybersecurity for the Operational Technology Environment (CyOTE) program. On 25 January 2003, the SQL Slammer worm infected more than 90% of vulnerable hosts and crashed the internet in 10 to 15 minutes, making it one of the fastest spreading worms in history. SQL Slammer is a fileless, memory-resident worm that remotely exploits a stack-based buffer overflow vulnerability on local hosts to intensively scan and rapidly self-propagate across the internet. The worm infected approximately 300,000 unpatched hosts running Microsoft Structured Query Language (SQL) Server 2000 or Microsoft Desktop Engine (MSDE) 2000 with SQL Server Resolution Service. The SQL Slammer worm indirectly infected FirstEnergy’s Davis-Besse nuclear power plant by first infecting a consultant’s company network server and then propagating through an external misconfigured connection into Davis-Besse’s site network. The infection caused major network congestion, slow performance, data overloads, and the inability of local hosts to communicate with each other, which eventually caused a loss of availability and a loss of view when the Safety Parameter Display System (SPDS) and Plant Process Computer (PPC) crashed. At the time of the infection, the plant was already offline, the digital monitoring systems had redundant analog backups, and the plant control and safety functions were not affected, so there were no concerns of a safety breach. However, this incident resulted in many lessons learned and spawned important discussions about cybersecurity’s role in nuclear safety and electric power reliability regulation, policy, and guidance. Researchers and analysts identified 10 unique techniques utilized during the attack with a total of 640 observables using MITRE ATT&CK® for Industrial Control Systems. The CyOTE program assesses observables accompanying techniques used prior to the triggering event to identify opportunities to detect malicious activity. If observables accompanying the attack techniques are perceived and investigated prior to the triggering event, earlier comprehension of malicious activity can take place. Eight of the identified techniques used during Davis-Besse cyber attack were precursors to the triggering event. Analysis identified 596 observables associated with these precursor techniques, 428 of which were assessed to have an increased likelihood of being perceived in the 331 days preceding the triggering event. The response and comprehension time could have been reduced if the observables had been identified earlier. The information gathered in this report contributes to a library of observables tied to a repository of artifacts, data sources, and technique detection references for practitioners and developers to support the comprehension of indicators of attack. Asset owners and operators can use these products if they experience similar observables or to prepare for comparable scenarios.

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEF↗
NASA NTRS1974

Power processor design considerations for a solar electric propulsion spacecraft

Propulsion power processor design options are described. The propulsion power processor generated the regulated dc voltages and currents from a solar array source of a solar electric propelled spacecraft. The power processor consisted of 12 power supplies that provide the regulated voltages and currents necessary to power a 30-cm mercury ion thruster. The design options for processing unregulated solar array power and for generating the regulated power required by each supply are studied. The technical approaches utilized in the developed design and the technological limitation of the identified design options are discussed. Alternate approaches for delivering power to a number of mercury ion thrusters and methods of optimizing are described. It was concluded that this power processor design should be considered for application in solar electric propulsion missions of the future.

Costogue, E. N.↗
NASA NTRS1977

Battery life test using reconditioning

A discussion is presented on nickel cadmium battery life tests using reconditioning and some comparative tests not using reconditioning. The discussion is aimed at the program application part of the testing. The goals of the program were to get an increased utilization out of the battery system in geosynchronous orbit. An attempt was made to push the depth of discharge operation up around 80 to 85 percent and the intent with the reconditioning program was to extend this type of utilization out towards a 10-year life and attune the voltage regulation.

Sparks, R. H.↗
DOE OSTI2015

Site closeout of the Linde FUSRAP Site, Tonawanda, New York - 15441

The US Army Corps of Engineers (USACE) Buffalo District, with assistance from Argonne National Laboratory (Argonne), prepared a Site Closeout Report (SCOR) for the Linde Formerly Utilized Sites Remedial Action Program (FUSRAP) Site in accordance with Engineer Regulation (ER) 200-1-4 [1]. Under FUSRAP, USACE is authorized to investigate, and clean up or control sites contaminated as the result of actions by the Atomic Energy Commission (AEC) and its predecessor, the Manhattan Engineer District (MED), in support of the nation's early atomic energy and weapons program. The SCOR documents response actions conducted at the Linde FUSRAP Site between 1996 and 2013. These response actions include two non-time-critical removal actions and long-term remedies associated with the three operable units (OUs) at the site: 1) soils and structure surfaces (except Building 14), 2) Building 14, and 3) groundwater. The report summarizes the site history, previous investigations, selected remedies, remedial actions, waste disposal, community involvement, monitoring results, recycling, quality assurance/quality control practices, post-remediation dose assessment, remedial costs, and five year review requirements. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗