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At least 541 records · Page 30

IMPACTing Medical System Design with a Risk Analysis Tool

Background: Following the success of Artemis I, NASA is preparing for human extended duration missions. Ongoing efforts are focused on mitigating mission-related risks, including those affecting crew health and performance. Communication latency, logistics of resupply and time frame of medical evacuation are barriers to provision of healthcare for these missions, especially with respect to constraints in mass, volume, and crew training. An in-depth assessment of medical risks, capabilities and resources for a specific mission design is necessary to determine an optimal balance that maximizes likelihood of mission success. Overview: IMPACT (Informed Mission Planning via Analysis of Complex Tradespaces) is a dynamic tool designed to estimate medical risk and outcomes for a specific mission design. In its current iteration, a list of medical conditions selected based on likelihood of occurrence and/or consequence was linked to a set of clinical capabilities and resources necessary for diagnosis and management. A probabilistic risk analysis tool was then used to identify and estimate the likelihood and consequence of risks through the following outcome metrics: loss of crew life (inflight mortality due to medical conditions), need for medical evacuation (return to definitive care), and crew disability (task time affected based on how medical conditions influence the ability to perform specific exploration mission crew tasks). Finally, the model’s optimization algorithm provides recommendations for medical capabilities that maximize risk mitigation relative to mass and volume constraints. In the Spring of 2023, IMPACT was utilized to estimate outcome metrics for a design reference mission that would be representative of an extended duration Artemis mission. Notional data generated were then used to determine a recommended set of medical capabilities and resources relative to user-defined mass and volume constraints. A multidisciplinary team has also been updating IMPACT to strengthen the model’s fidelity. Figure 1 shows how updates to outcome metric inputs for the conditions resulted in different capability and resource allocation recommendations. Discussion: This presentation will discuss the IMPACT tool and share the latest data generated for a representative extended duration Artemis mission. Efforts to improve the fidelity of data generated by the model’s algorithm will also be discussed.

K A Shair↗

Lessons from Astrobiological Planetary Analogue Exploration in Iceland: Biomarker Assay Performance and Downselection

Understanding the sensitivity of biomarker assays to the local physicochemical environment, and the underlying spatial distribution of the target biomarkers in 'homogeneous' environments, can increase mission science return. We have conducted four expeditions to Icelandic Mars analogue sites in which an increasingly refined battery of physicochemical measurements and biomarker assays were performed, staggered with scouting of further sites. Completed expeditions took place in 2012 (location scouting and field assay use testing), 2013 (sampling of two major sites with three assays and observational physicochemical measurements), 2015 (repeat sampling of prior sites and one new site, scouting of new sites, three assays and three instruments), and 2016 (preliminary sampling of new sites with analysis of returned samples). Target sites were geologically recent basaltic lava flows, and sample loci were arranged in hierarchically nested grids at 10 cm, 1 m, 10 m, 100 m, and >1 km order scales, subject to field constraints. Assays were intended to represent a diversity of potential biomarker types (cell counting via nucleic acid staining and fluorescence microscopy, ATP quantification via luciferase luminescence, and relative DNA quantification with simple domain-level primers) rather a specific mission science target, and were selected to reduce laboratory overhead, require limited consumables, and allow rapid turnaround. All analytical work was performed in situ or in a field laboratory within a day's travel of the field sites unless otherwise noted. We have demonstrated the feasibility of performing ATP quantification and qPCR analysis in a field-based laboratory with single-day turnaround. The ATP assay was generally robust and reliable and required minimal field equipment and training to produce a large amount of useful data. DNA was successfully extracted from all samples, but the serial-batch nature of qPCR significantly limited the number of primers (hence classifications) and replicates that could be run in a single day. Fluorescence microscopy did not prove feasible under the same constraints, primarily due to the large number of person-hours required to view, analyze, and record results from the images; however, this could be mitigated with higher-quality imaging instruments and appropriate image analysis software.

Planetary↗

Recent developments with the ORSER system

Additions to the ORSER remote sensing data processing package are described. The ORSER package consists of about 35 individual programs that are grouped into preprocessing, data analysis, and display subsystems. Additional data formats and data management, data transformation, and geometric correlation programs were supplemented to the preprocessing subsystem. Enhancements to the data analysis techniques include a maximum likelihood classifier (MAXCLASS) and a new version of the STATS program which makes delineation of training areas easier and allows for detection of outlier points. Ongoing developments are also described.

Baumer, G. M.↗

FACE computer simulation

A computer simulation of the FACE (Flexible Arm Controls Experiment) was conducted to assess its design for use in the Space Shuttle. The FACE is supposed to be a 14-ft long articulate structure with 4 degrees of freedom, consisting of shoulder pitch and yaw, elbow pitch, and wrist pitch. Kinematics of the FACE was simulated to obtain data on arm operation, function, workspace and interaction. Payload capture ability was modeled. The simulation indicates the capability for detailed kinematic simulation and payload capture ability analysis, and the feasibility of real-time simulation was determined. In addition, the potential for interactive real-time training through integration of the simulation with various interface controllers was revealed. At this stage, the flexibility of the arm was not yet considered.

Sadeh, Willy Z.↗

Aerospace Safety Advisory Panel Annual Report for 1999

This report covers the activities of the Aerospace Safety Advisory Panel (ASAP) for the calendar year 1999.This was a year of notable achievements and significant frustrations. Both the Space Shuttle and International Space Station (ISS) programs were delayed.The Space Shuttle prudently postponed launches after the occurrence of a wiring short during ascent of the STS-93 mission. The ISS construction schedule slipped as a result of the Space Shuttle delays and problems the Russians experienced in readying the Service Module and its launch vehicle. Each of these setbacks was dealt with in a constructive way. The STS-93 short circuit led to detailed wiring inspections and repairs on all four orbiters as well as analysis of other key subsystems for similar types of hidden damage. The ISS launch delays afforded time for further testing, training, development, and contingency planning. The safety consciousness of the NASA and contractor workforces, from hands-on labor to top management, continues high. Nevertheless, workforce issues remain among the most serious safety concerns of the Panel. Cutbacks and reorganizations over the past several years have resulted in problems related to workforce size, critical skills, and the extent of on-the-job experience. These problems have the potential to impact safety as the Space Shuttle launch rate increases to meet the demands of the ISS and its other customers. As with last year's report, these work- force-related issues were considered of sufficient import to place them first in the material that follows. Some of the same issues of concern for the Space Shuttle and ISS arose in a review of the launch vehicle for the Terra mission that the Panel was asked by NASA to undertake. Other areas the Panel was requested to assess included the readiness of the Inertial Upper Stage for the deployment of the Chandra X-ray Observatory and the possible safety impact of electromagnetic effects on the Space Shuttle. The findings and recommendations in this report do not highlight any major, immediate issues that might compromise the safe pursuit of the various NASA programs. They do, however, cover concerns that the Panel believes should be addressed in the interest of maintaining NASA's excellent safety record.The Panel is pleased to note that remedial efforts for some of the findings raised are underway. Given appropriate funding and cooperative efforts among the Administration, the Congress and the various contractors, the Panel is convinced that safety problems can be avoided or solved resulting in lower risk for NASA's human space and aeronautics programs. Section II of this report contains specific findings and recommendations generated by Panel activities during the calendar year 1999. Section III presents more detailed information in support of these findings and recommendations. A current roster of Panel members, consultants, and staff is included as Appendix A. Appendix B contains NASA's response to the findings and recommendations from the 1998 annual report. It has been augmented this year to include brief explanations of why the Panel classified the NASA response as " open,""continuing," or "closed." Appendix C lists the fact-finding activities of the Panel in 1999.

Blomberg, Richard D.↗

Antarctic Space Analog Program

The primary aim of this project was to examine group dynamics and individual performance in extreme, isolated environments and identify human factors requirements for long-duration space missions using data collected in an analog environment. Specifically, we wished to determine: 1) the characteristics of social relations in small groups of individuals living and working together in extreme, isolated environments, and 2) the environmental, social and psychological determinants of performance effectiveness in such groups. These two issues were examined in six interrelated studies using data collected in small, isolated research stations in Antarctica from 1963 to the present. Results from these six studies indicated that behavior and performance on long-duration space flights is likely to be seasonal or cyclical, situational, social, and salutogenic in nature. The project responded to two NASA program emphases for FY 1997 as described in the NRA: 1) the primary emphasis of the Behavior and Performance Program on determining long-term individual and group performance responses to space, identifying critical factors affecting those responses and understanding underlying mechanisms involved in behavior and performance, and developing and using ground-based models and analogs for studying space-related behavior and performance; and 2) the emphasis of the Data Analysis Program on extended data analysis. Results from the study were used to develop recommendations for the design and development of pre-flight crew training and in-flight psychological countermeasures for long-duration manned space missions.

Palinkas, Lawrence A↗

Does CRM training work?

Formal cockpit resource management training in crew coordination concepts increases the percentage of crews rated as above average in performance and decreases the percentage of crews rated as below average.

NASA Discipline Space Human Factors↗

Open Microphone Speech Understanding: Correct Discrimination Of In Domain Speech

An ideal spoken dialogue system listens continually and determines which utterances were spoken to it, understands them and responds appropriately while ignoring the rest This paper outlines a simple method for achieving this goal which involves trading a slightly higher false rejection rate of in domain utterances for a higher correct rejection rate of Out of Domain (OOD) utterances. The system recognizes semantic entities specified by a unification grammar which is specialized by Explanation Based Learning (EBL). so that it only uses rules which are seen in the training data. The resulting grammar has probabilities assigned to each construct so that overgeneralizations are not a problem. The resulting system only recognizes utterances which reduce to a valid logical form which has meaning for the system and rejects the rest. A class N-gram grammar has been trained on the same training data. This system gives good recognition performance and offers good Out of Domain discrimination when combined with the semantic analysis. The resulting systems were tested on a Space Station Robot Dialogue Speech Database and a subset of the OGI conversational speech database. Both systems run in real time on a PC laptop and the present performance allows continuous listening with an acceptably low false acceptance rate. This type of open microphone system has been used in the Clarissa procedure reading and navigation spoken dialogue system which is being tested on the International Space Station.

Hieronymus, James↗

The Sensor Test for Orion RelNav Risk Mitigation Development Test Objective

The Sensor Test for Orion Relative-Navigation Risk Mitigation (STORRM) Development Test Objective (DTO) ew aboard the Space Shuttle Endeavour on STS-134, and was designed to characterize the performance of the ash LIDAR being developed for the Orion. This ash LIDAR, called the Vision Navigation Sensor (VNS), will be the primary navigation instrument used by the Orion vehicle during rendezvous, proximity operations, and docking. This paper provides an overview of the STORRM test objectives and the concept of operations. It continues with a description of the STORRM's major hardware compo nents, which include the VNS and the docking camera. Next, an overview of crew and analyst training activities will describe how the STORRM team prepared for flight. Then an overview of how insight data collection and analysis actually went is presented. Key ndings and results from this project are summarized, including a description of "truth" data. Finally, the paper concludes with lessons learned from the STORRM DTO.

Christian, John A.↗

Preliminary Results of a U.S. Deep South Modeling Experiment Using NASA SPoRT Initialization Datasets for Operational National Weather Service Local Model Runs

A joint collaborative modeling effort among the NWS offices in Mobile, AL, and Houston, TX, and NASA Short-term Prediction Research and Transition (SPoRT) Center began during the 2011-2012 cold season, and continued into the 2012 warm season. The focus was on two frequent U.S. Deep South forecast challenges: the initiation of deep convection during the warm season; and heavy precipitation during the cold season. We wanted to examine the impact of certain NASA produced products on the Weather Research and Forecasting Environmental Modeling System in improving the model representation of mesoscale boundaries such as the local sea-, bay- and land-breezes (which often leads to warm season convective initiation); and improving the model representation of slow moving, or quasi-stationary frontal boundaries (which focus cold season storm cell training and heavy precipitation). The NASA products were: the 4-km Land Information System, a 1-km sea surface temperature analysis, and a 4-km greenness vegetation fraction analysis. Similar domains were established over the southeast Texas and Alabama coastlines, each with an outer grid with a 9 km spacing and an inner nest with a 3 km grid spacing. The model was run at each NWS office once per day out to 24 hours from 0600 UTC, using the NCEP Global Forecast System for initial and boundary conditions. Control runs without the NASA products were made at the NASA SPoRT Center. The NCAR Model Evaluation Tools verification package was used to evaluate both the positive and negative impacts of the NASA products on the model forecasts. Select case studies will be presented to highlight the influence of the products.

Wood, Lance↗

Aerosol Data Assimilation at GMAO

This presentation presents an overview of the aerosol data assimilation work performed at GMAO. The GMAO Forward Processing system and the biomass burning emissions from QFED are first presented. Then, the current assimilation of Aerosol Optical Depth (AOD), performed by means of the analysis splitting method is briefly described, followed by some results on the quality control of observations using a Neural Network trained using AERONET AOD. Some applications are shown such as the Mount Pinatubo eruption in 1991 using the MERRA-2 aerosol dataset. Finally preliminary results on the EnKF implementation for aerosol assimilation are presented.

Splitting↗

Transcriptomics-based Machine Learning (ML) Analysis Predicts Space-Exposed Murine Livers

Limited sample sizes, high data dimensionality, and sensitivity to technical and biological variability of next generation sequencing (NGS), typically limits machine learning (ML) approaches in spaceflight studies that include radiation effects. However, pooling smaller studies while addressing intra- and inter-study variabilities allows for ML predictive modeling. Here, integration methods were applied to whole transcriptome shotgun sequencing (RNA-seq) data from six mouse liver GeneLab datasets (GLDS) (n ranging from 6 to 39 samples) from with a total of 81 spaceflight and ground-control samples to determine top features (i.e. genes) relevant to spaceflight including the effect of radiation exposure. RNASeq counts were normalized for each study, then merged and scaled across all datasets. Data dimensionality was reduced using a minimum redundancy maximum relevance (MRMR) methodology. Redundancy and relevance were computed using the Pearson correlation and F-statistic, respectively. The top 100 MRMR features were used to predict spaceflight vs. ground-control samples using Random Forest (RF), Support Vector Machine (SVM), and Linear Discriminant Analysis (LDA) classifiers with 5-fold cross validation (CV). Principal component analysis (PCA) on the complete feature set versus the MRMR features shows separation between spaceflight samples and ground controls (Figure 1A). The ML-based gene sets were compared against differential gene expression results obtained with DESeq2 from individual GLDS. Using all features or randomly sampled subsets at matching set sizes with MRMR, a maximum classifier accuracy of 69% on the test set over 5 folds. For all classifiers, CV training using at least the top 30 MRMR genes show minimum 89% accuracy and 0.95 AUC value on the test set over 5 folds (Figure 1B). Baseline set analysis on differentially expressed genes (DEGs) identified using padj ≤ 0.05 show 295 DEGs that overlap at least two studies and 13 DEGs that overlap three studies (Figure 1C). Set analysis between the top 100 MRMR features and the DEGs showed 47 genes that overlap at least one study and 24 genes that overlap two studies. Over-representation analysis showed overlapping biological processes related to fatty acid and lipid metabolism which may indicate these processes in the response to spaceflight stressors. MRMR feature selection for the selected ML methods improve performance relative to a classifier built on all features or randomly sampled subsets. Permutation feature importance within the decorrelated MRMR features showed concordance in feature ranking between ML methods. A challenge of applying ML methods across heterogeneous NGS data is accounting for signal:noise. Here, signal validation across studies was shown by intersecting sets between top MRMR genes and DEGs from DESeq2 analysis. Non-intersecting sets introduce opportunity to explore genes relevant to differentiating space flight exposed groups and implementing ML methods across existing NGS datasets may overcome sample size limitations.

Machine Learning↗

Transcriptomics-based Machine Learning Analysis Predicts Space-Exposed Murine Livers

Limited sample sizes, high data dimensionality, and sensitivity to technical and biological variability of next generation sequencing (NGS), typically limits machine learning (ML) approaches in spaceflight studies that include radiation effects. However, pooling smaller studies while addressing intra- and inter-study variabilities allows for ML predictive modeling. Here, integration methods were applied to whole transcriptome shotgun sequencing (RNA-seq) data from six mouse liver GeneLab datasets (GLDS) (n ranging from 6 to 39 samples) from with a total of 81 spaceflight and ground-control samples to determine top features (i.e. genes) relevant to spaceflight including the effect of radiation exposure. RNASeq counts were normalized for each study, then merged and scaled across all datasets. Data dimensionality was reduced using a minimum redundancy maximum relevance (MRMR) methodology. Redundancy and relevance were computed using the Pearson correlation and F-statistic, respectively. The top 100 MRMR features were used to predict spaceflight vs. ground-control samples using Random Forest (RF), Support Vector Machine (SVM), and Linear Discriminant Analysis (LDA) classifiers with 5-fold cross validation (CV). Principal component analysis (PCA) on the complete feature set versus the MRMR features shows separation between spaceflight samples and ground controls (Figure 1A). The ML-based gene sets were compared against differential gene expression results obtained with DESeq2 from individual GLDS. Using all features or randomly sampled subsets at matching set sizes with MRMR, a maximum classifier accuracy of 69% was shown on the test set over 5 folds. For all classifiers, CV training using at least the top 30 MRMR genes show minimum 89% accuracy and 0.95 AUC value on the test set over 5 folds (Figure 1B). Baseline set analysis on differentially expressed genes (DEGs) identified using padj ≤ 0.05 show 295 DEGs that overlap at least two studies and 13 DEGs that overlap three studies (Figure 1C). Set analysis between the top 100 MRMR features and the DEGs showed 47 genes that overlap at least one study and 24 genes that overlap two studies. Over-representation analysis showed overlapping biological processes related to fatty acid and lipid metabolism which may indicate these processes in the response to spaceflight stressors. MRMR feature selection for the selected ML methods improve performance relative to a classifier built on all features or randomly sampled subsets. Permutation feature importance within the decorrelated MRMR features showed concordance in feature ranking between ML methods. A challenge of applying ML methods across heterogeneous NGS data is accounting for signal:noise. Here, signal validation across studies was shown by intersecting sets between top MRMR genes and DEGs from DESeq2 analysis. Non-intersecting sets introduce opportunity to explore genes relevant to differentiating space flight exposed groups and implementing ML methods across existing NGS datasets may overcome sample size limitations.

Machine Learning↗

Transcriptomics-based Machine Learning Analysis Predicts Space-Exposed Murine Livers

Limited sample sizes, high data dimensionality, and sensitivity to technical and biological variability of next generation sequencing (NGS), typically limits machine learning (ML) approaches in spaceflight studies that include radiation effects. However, pooling smaller studies while addressing intra- and inter-study variabilities allows for ML predictive modeling. Here, integration methods were applied to whole transcriptome shotgun sequencing (RNA-seq) data from six mouse liver GeneLab datasets (GLDS) (n ranging from 6 to 39 samples) from with a total of 81 spaceflight and ground-control samples to determine top features (i.e. genes) relevant to spaceflight including the effect of radiation exposure. RNASeq counts were normalized for each study, then merged and scaled across all datasets. Data dimensionality was reduced using a minimum redundancy maximum relevance (MRMR) methodology. Redundancy and relevance were computed using the Pearson correlation and F-statistic, respectively. The top 100 MRMR features were used to predict spaceflight vs. ground-control samples using Random Forest (RF), Support Vector Machine (SVM), and Linear Discriminant Analysis (LDA) classifiers with 5-fold cross validation (CV). Principal component analysis (PCA) on the complete feature set versus the MRMR features shows separation between spaceflight samples and ground controls (Figure 1A). The ML-based gene sets were compared against differential gene expression results obtained with DESeq2 from individual GLDS. Using all features or randomly sampled subsets at matching set sizes with MRMR, a maximum classifier accuracy of 69% was shown on the test set over 5 folds. For all classifiers, CV training using at least the top 30 MRMR genes show minimum 89% accuracy and 0.95 AUC value on the test set over 5 folds (Figure 1B). Baseline set analysis on differentially expressed genes (DEGs) identified using padj ≤ 0.05 show 295 DEGs that overlap at least two studies and 13 DEGs that overlap three studies (Figure 1C). Set analysis between the top 100 MRMR features and the DEGs showed 47 genes that overlap at least one study and 24 genes that overlap two studies. Over-representation analysis showed overlapping biological processes related to fatty acid and lipid metabolism which may indicate these processes in the response to spaceflight stressors. MRMR feature selection for the selected ML methods improve performance relative to a classifier built on all features or randomly sampled subsets. Permutation feature importance within the decorrelated MRMR features showed concordance in feature ranking between ML methods. A challenge of applying ML methods across heterogeneous NGS data is accounting for signal:noise. Here, signal validation across studies was shown by intersecting sets between top MRMR genes and DEGs from DESeq2 analysis. Non-intersecting sets introduce opportunity to explore genes relevant to differentiating space flight exposed groups and implementing ML methods across existing NGS datasets may overcome sample size limitations.

Machine Learning↗

Crop identification and area estimation by computer-aided analysis of Landsat data

This report describes the results of a study involving the use of computer-aided analysis techniques applied to Landsat MSS data for identification and area estimation of winter wheat in Kansas and corn and soybeans in Indiana. Key elements of the approach included use of aerial photography for classifier training, stratification of Landsat data and extension of training statistics to areas without training data, and classification of a systematic sample of pixels from each county. Major results and conclusions are: (1) Landsat data was adequate for accurate identification and area estimation of winter wheat in Kansas, but corn and soybean estimates for Indiana were less accurate; (2) computer-aided analysis techniques can be effectively used to extract crop identification information from Landsat MSS data, and (3) systematic sampling of entire counties made possible by computer classification methods resulted in very precise area estimates at county as well as district and state levels.

Bauer, M. E.↗

Graphics enhanced computer emulation for improved timing-race and fault tolerance control system analysis

A computer simulation system has been developed for the Space Shuttle's advanced Centaur liquid fuel booster rocket, in order to conduct systems safety verification and flight operations training. This simulation utility is designed to analyze functional system behavior by integrating control avionics with mechanical and fluid elements, and is able to emulate any system operation, from simple relay logic to complex VLSI components, with wire-by-wire detail. A novel graphics data entry system offers a pseudo-wire wrap data base that can be easily updated. Visual subsystem operations can be selected and displayed in color on a six-monitor graphics processor. System timing and fault verification analyses are conducted by injecting component fault modes and min/max timing delays, and then observing system operation through a red line monitor.

Szatkowski, G. P.↗

Application of System-Theoretic Process Analysis (STPA) to a NASA Concept Electric Aircraft Battery System

System-Theoretic Process Analysis (STPA) is a systems-based hazard analysis method that identifies unsafe interactions and control deficiencies in complex systems but has been rarely used for NASA programs in favor of more well-established hazard analyses. To evaluate its applicability, a NASA Safety and Mission Assurance (SMA) team applied the STPA method to an early-stage hybrid electrified aircraft concept, focusing on the energy storage system and electric powertrain. Objectives include assessing STPA’s value relative to traditional methods and its suitability for early design phases. Activities include team training, system review, detailed STPA execution, and comparison with traditional analyses. Findings show STPA provides a structured, comprehensive hazard evaluation and can identify additional risks by expanding analysis boundaries. However, traditional methods can yield similar results when applied rigorously, though they typically require more mature designs. Overall, STPA is a valuable addition, particularly for early development, informing safety requirements and supporting preliminary hazard analyses. Further pilot applications are recommended.

Electric Aviation↗