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At least 541 records · Page 30

A mixed formulation of the plane-stress problem to facilitate reuse of constitutive models in finite-element programs

Here, the plane-stress assumption can be challenging to support in a finite element program because it traditionally requires separate implementations of constitutive models than those intended for three-dimensional or two-dimensional plane-strain simulations. As a solution to this issue, this paper presents a method to solve the plane-stress problem using a mixed formulation. In this formulation, the out-of-plane strain is treated as a field variable that is solved for in addition to the standard in-plane displacement variables, in a manner that weakly enforces the condition that the out-of-plane stress is zero. The proposed formulation is non-intrusive, requiring no modifications to the constitutive models in contrast to the conventional plane-stress formulation. The proposed mixed formulation has been benchmarked against analytical solutions and numerical solutions, with good performance and accuracy.

97 MATHEMATICS AND COMPUTING↗

Volumetric modulated arc radiotherapy for esophageal cancer

A treatment planning study was performed to evaluate the performance of volumetric arc modulation with RapidArc (RA) against 3D conformal radiation therapy (3D-CRT) and conventional intensity-modulated radiation therapy (IMRT) techniques for esophageal cancer. Computed tomgraphy scans of 10 patients were included in the study. 3D-CRT, 4-field IMRT, and single-arc and double-arc RA plans were generated with the aim to spare organs at risk (OAR) and healthy tissue while enforcing highly conformal target coverage. The planning objective was to deliver 54 Gy to the planning target volume (PTV) in 30 fractions. Plans were evaluated based on target conformity and dose-volume histograms of organs at risk (lung, spinal cord, and heart). The monitor unit (MU) and treatment delivery time were also evaluated to measure the treatment efficiency. The IMRT plan improves target conformity and spares OAR when compared with 3D-CRT. Target conformity improved with RA plans compared with IMRT. The mean lung dose was similar in all techniques. However, RA plans showed a reduction in the volume of the lung irradiated at V{sub 20Gy} and V{sub 30Gy} dose levels (range, 4.62-17.98%) compared with IMRT plans. The mean dose and D{sub 35%} of heart for the RA plans were better than the IMRT by 0.5-5.8%. Mean V{sub 10Gy} and integral dose to healthy tissue were almost similar in all techniques. But RA plans resulted in a reduced low-level dose bath (15-20 Gy) in the range of 14-16% compared with IMRT plans. The average MU needed to deliver the prescribed dose by RA technique was reduced by 20-25% compared with IMRT technique. The preliminary study on RA for esophageal cancers showed improvements in sparing OAR and healthy tissue with reduced beam-on time, whereas only double-arc RA offered improved target coverage compared with IMRT and 3D-CRT plans.

61 RADIATION PROTECTION AND DOSIMETRY↗

A dosimetric comparison of whole-lung treatment techniques in the pediatric population

To demonstrate the dosimetric advantages and disadvantages of standard anteroposterior-posteroanterior (S-AP/PA{sub AAA}), inverse-planned AP/PA (IP-AP/PA) and volumetry-modulated arc (VMAT) radiotherapies in the treatment of children undergoing whole-lung irradiation. Each technique was evaluated by means of target coverage and normal tissue sparing, including data regarding low doses. A historical approach with and without tissue heterogeneity corrections is also demonstrated. Computed tomography (CT) scans of 10 children scanned from the neck to the reproductive organs were used. For each scan, 6 plans were created: (1) S-AP/PA{sub AAA} using the anisotropic analytical algorithm (AAA), (2) IP-AP/PA, (3) VMAT, (4) S-AP/PA{sub NONE} without heterogeneity corrections, (5) S-AP/PA{sub PB} using the Pencil-Beam algorithm and enforcing monitor units from technique 4, and (6) S-AP/PA{sub AAA[FM]} using AAA and forcing fixed monitor units. The first 3 plans compare modern methods and were evaluated based on target coverage and normal tissue sparing. Body maximum and lower body doses (50% and 30%) were also analyzed. Plans 4 to 6 provide a historic view on the progression of heterogeneity algorithms and elucidate what was actually delivered in the past. Averages of each comparison parameter were calculated for all techniques. The S-AP/PA{sub AAA} technique resulted in superior target coverage but had the highest maximum dose to every normal tissue structure. The IP-AP/PA technique provided the lowest dose to the esophagus, stomach, and lower body doses. VMAT excelled at body maximum dose and maximum doses to the heart, spine, and spleen, but resulted in the highest dose in the 30% body range. It was, however, superior to the S-AP/PA{sub AAA} approach in the 50% range. Each approach has strengths and weaknesses thus associated. Techniques may be selected on a case-by-case basis and by physician preference of target coverage vs normal tissue sparing.

61 RADIATION PROTECTION AND DOSIMETRY↗

Reconstructing cerebrovascular networks under local physiological constraints by integer programming

We introduce a probabilistic approach to vessel network extraction that enforces physiological constraints on the vessel structure. The method accounts for both image evidence and geometric relationships between vessels by solving an integer program, which is shown to yield the maximum a posteriori (MAP) estimate to the probabilistic model. Starting from an over-connected network, it is pruning vessel stumps and spurious connections by evaluating the local geometry and the global connectivity of the graph. We utilize a high-resolution micro computed tomography (µCT) dataset of a cerebrovascular corrosion cast to obtain a reference network and learn the prior distributions of our probabilistic model. As a result, we perform experiments on micro magnetic resonance angiography (µMRA) images of mouse brains and discuss properties of the networks obtained under different tracking and pruning approaches.

59 BASIC BIOLOGICAL SCIENCES↗

Estimation of process steady state with autoregressive models and Bayesian inference

To improve efficiency, separations engineers will typically design process circuits containing recirculating streams, which mix one or more of the process outputs with the feed material. Doing so can improve efficiency, but will cause a delay in the system reaching steady state conditions until the recirculating load mass flows stabilize. In testing separation circuits, engineers will often test a variety of factors and complete an analysis from sample results. Knowledge of if a process is at steady state, as well as the steady state conditions of a process, is essential for a valid techno-economic analysis. However, the definition of process steady state is often poorly defined, or does not include uncertainty quantification. If the performance of a process operating under two different sets of conditions are compared, an engineer who does not test for steady state or quantify steady state conditions risks producing a faulty analysis. In this work, a Bayesian statistical method for testing if all streams are at steady state is further motivated and then derived. Then after testing for steady state, the same model is used with a prior distribution that enforces a steady state assumption to estimate steady state conditions. Further, these methods were validated in a solvent extraction pilot plant where steady state conditions for all outflows were inferred with uncertainty quantification. Analysis is completed with functions available to the reader as part of the BayesMassBal (V 1.1.0) software package written in R.

01 COAL, LIGNITE, AND PEAT↗

The CLAS12 Micromegas Vertex Tracker

The Micromegas Vertex Tracker was designed to improve upon the tracking capabilities of the baseline design of the CLAS12 spectrometer in Hall~B at Jefferson Laboratory. A Barrel Micromegas Tracker made with six concentric cylinders, each made of three 120$^\circ$-sector tiles, surrounds the Silicon Vertex Tracker, and a Forward Micromegas Tracker composed of 6 disks is placed 30~cm downstream of the liquid-hydrogen target. Both trackers sit in a 5~T solenoid magnetic field. All Micromegas elements are based on resistive technology to withstand luminosities up to $10^{35}$~cm$^{-2}$s$^{-1}$, as well as on bulk technology to enforce gain uniformity and mechanical robustness. Due to the high magnetic field, dedicated electronics have been designed and displaced $\sim$2~m away from the detectors. The electronics readout is based on the DREAM ASICs that allow sustained operation up to 20~kHz trigger rate at the maximum luminosity.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Sensitivity of the active neutron coincidence collar response during simulated and experimental fresh fuel assay

Verification of the fissile (and fertile) content in fresh nuclear fuel assemblies is conducted by the IAEA to enforce the Nuclear Non-Proliferation Treaty using the UNCL (Uranium Neutron Collar — Light Water Reactor Fuel). The UNCL uses an uncorrelated AmLi neutron source to interrogate the fuel, producing a signal of coincident fission neutrons (Doubles rate) used to assay 235 U content of the fuel. The cost of producing calibration assemblies and limited availability of diverse commercial assemblies at any one time historically restricted the ability to explore the full parameter space experimentally. Monte Carlo simulations can overcome this, but introduce additional sources of uncertainty. In this work, the sensitivity of simulations and measurements to various parameters is assessed for a reference 1616 PWR assembly of uniform 3.2% enrichment. Uncertainty contributions in this evaluation include: simulated AmLi neutron source spectrum, AmLi neutron emission rate, AmLi anisotropicity, high density polyethylene (HDPE) density, the precise position of the fuel assembly within the detector, and experimentally the statistical uncertainty. The overall total systematic uncertainty estimate for the simulation of the absolute/relative Doubles rates responses are estimated to be approximately 2.0%/1.5%, and for experimental measurements systematic uncertainty reduces to 1.1%. This analysis supports further work using the relative Doubles rates in place of measurements for updating and extending the UNCL analysis methodology as systematic uncertainty is reasonably small.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Advanced storage ring lattice options based on hybrid six-bend achromat for Stanford Synchrotron Radiation Lightsource upgrade

Three storage ring lattices have been designed as options for a future upgrade of the Stanford synchrotron radiation lightsource (SSRL). The three options differ in circumference and targeted future site, with one to be built in the tunnel of the present SPEAR3 ring, one as a green field ring on the SLAC campus, and the third in the tunnel of the decommissioned PEP-II ring. The lattices are based on the newly proposed hybrid 6-bend achromat (H6BA) lattice cells, which is ideal for pushing the photon beam brightness while achieving excellent nonlinear dynamics performance. The transparent matching conditions are enforced to minimize the negative impact of the loss of periodicity due to insertion of various long straight sections. Numerical optimization is performed to further improve the nonlinear dynamics. Finally, in addition to reaching very low emittances, the lattices can accommodate traditional off-axis injection and achieve beam lifetimes similar to or exceeding that of typical third generation rings.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

To thread or not to thread: Reaction of uranyl (UO 2 2+ ) with two Aza-crown macrocycles

The complexation of the uranyl ion (UO 2 2+ ) by macrocyclic ligands is hindered by the rigidly enforced trans orientation of its oxo ligands. To further investigate this coordination chemistry challenge, here we investigate the reactivity of UO 2 2+ with two different 18-membered aza-crown macrocycles, diaza-dibenzo-18-crown-6 (DADBC) and 7,16-bis(N-methylacetamide)diaza-18-crown-6 (BAM). The reaction of uranyl triflate, [UO 2 (OTf) 2 (THF) 3 ], with DADBC in toluene afforded [UO 2 (DADBC)][OTf] 2 , in which the UO 2 2+ ion is fully encapsulated by the macrocycle. This conclusion was supported by NMR, UV–Vis, IR, and Raman spectroscopies, as well as single-crystal X-ray crystallography. Attempts to form the in-macrocycle complex of BAM, however, were unsuccessful. Here, the reaction of BAM with [UO 2 (OTf) 2 (THF) 3 ] in THF/CH 2 Cl 2 unexpectedly afforded crystals of [H 2 BAM][OTf] 2 , where the protons are derived from solvate water in the BAM crystal lattice.

Actinide↗

Modeling stratified flames with and without shear using multiple mapping conditioning

A stochastic sparse particle approach is coupled with an artificial thickening flame (ATF) model for large eddy simulations (LES) to predict a series of turbulent premixed-stratified flames with and without shear and stratification. The thickened reaction progress variable serves as reference variable for the multiple mapping conditioning (MMC) mixing model which emulates turbulent mixing of the stochastic particles. The key feature of MMC is to enforce localness in this reference space when particle pairs are mixed and prevents unphysical mixing of burnt and unburnt fluid across the flame front. We apply MMC-ATF to three flames of a series of turbulent stratified flames and validate the method by comparison with experimental data. The new measurements feature increased accuracy in comparison to previously published data of the same flames due to a better signal-to-noise ratio and a setup which is less prone to beam steering. All flame locations are well predicted by the LES-ATF approach and an analysis of the MMC particle statistics demonstrates that MMC preserves the flamelet-like behaviour in regions where the experiments show low scatter around the flamelet solution. Predicted (local) deviations from the flamelet-solution are comparable to deviations observed in the measurements and variations in the flame structure due to differences in stratification and shear are reasonably well captured by the method.

47 OTHER INSTRUMENTATION↗

Finite domain solution of a KGD hydraulic fracture in the viscosity-dominated regime

This paper describes a numerical algorithm for solving the classic problem of a plane strain (KGD) fracture propagating in an impermeable elastic medium with zero toughness. The method, which takes advantage of the self-similar nature of the solution, combines a domain-based scheme to solve the elasticity equations and a finite volume method to solve the nonlinear lubrication equation. This work represents a first step towards developing a model able to account for pore pressure diffusion in the medium and corresponding poroelastic effects, noting that these processes are more efficiently solved using a domain-based rather than a boundary integral method. To enhance the efficiency and accuracy of the numerical scheme, the far-field crack asymptotics is embedded in the discretized elastic relationship between the fluid pressure and the crack opening, while the coupled fluid-solid tip asymptote is enforced in a weak form when solving the nonlinear lubrication equation. The proposed technique yields results that closely match the analytical solution, even with a coarse mesh. This approach offers potential for addressing more complex hydraulic fracturing problems in the future.

Domain-based method↗

How do the research and public communities view biofuel development?

Understanding how public and research view biofuel development, especially the unsynchronized views, can explain the gaps between the actual biofuel production and consumption and the government mandates in the US. Applying a comparative text mining technique, these views are explored using 9924 news articles and 57,849 research abstracts. It is found both the public and research communities respond actively to major policy and incentive programs and market conditions and the public has been closely following important research advances. However, research and practice should be coordinated to achieve economies of scale for regular and alternative biofuels. Priority is particularly needed for policy research to support legislation and enforcement and remove technical barriers to commercialization; meanwhile, greater attention is needed to prompt the commercialization of mature technologies. In addition, sentiment analysis shows positive public perceptions in general and negative perceptions primarily stemming from fraud in biofuel tax-credit programs with minor concerns on unintended negative impacts of biofuel development and policy implementation issues. This study contributes to methodology by using cutting-edge text-mining techniques to the largest and most up-to-date datasets of public news articles and research publication abstracts so as to compare public and academic views on biofuel development. As a result, this study also contributes to knowledge discovery by providing new perspectives on biofuel development, which will support policy design and identify future research directions.

09 BIOMASS FUELS↗

Current and future federal and state sampling guidance for per- and polyfluoroalkyl substances in environmental matrices

Per- and polyfluoroalkyl substances (PFAS) are a class of emerging contaminants composed of an estimated 5000 to 10,000 human-made, fluorinated, organic chemicals. Due to the complexity of PFAS, the need for multiple environmental matrix considerations and the absence of a promulgated federal standard for environmental sampling and analysis, U.S. states have begun developing health-based regulatory and/or guidance values for a limited number of PFAS in environmental matrices. As there is a growing body of science to inform PFAS sampling guidance standard development, it is important to understand which U.S. states are implementing sampling guidelines and how they plan to handle emerging PFAS. This critical review discusses the current and impending federal and state sampling guidelines for PFAS in environmental matrices, the data gaps surrounding PFAS sampling guidance in U.S. states, and the future impacts of impending guidance documents and regulations. Ten federal guidance documents are available for PFAS sampling guidance and analysis. The maximum number of PFAS covered in these guidance documents is 25 analytes spanning across 8 unique media. While the EPA has developed several different sampling and analytical guidelines for PFAS, there is no formal regulation of PFAS or requirements of states to enforce these guidelines. Consequently, only 31 states have informally adopted sampling guidelines, while the other 19 states have no guidance documentation in place for PFAS. The introduction of new PFAS sampling guidelines by the EPA, as well as updated analytical guidelines that target more PFAS or total organofluoride, is expected to continuously shift the landscape of federal and state guidance for PFAS sampling moving forward.

54 ENVIRONMENTAL SCIENCES↗

Virtual storage capability of residential buildings for sustainable smart city via model-based predictive control

This paper evaluates the virtual storage capability of a residential air-conditioning (AC) system by utilizing the building mass as a thermal storage to enable sustainable cities through model-based predictive control (MPC). The control-oriented building model was developed with a grey-box model structure based on the experimental data to predict the indoor air temperature. Based on the model, the operation cost-saving potential of the MPC was investigated in a single house with different comfort levels, electricity prices, and prediction horizons. The cost-saving of the MPC was approximately 10.6 % compared to the conventional control. The MPC was expanded to a residential building cluster considering the peak demand charge. In an hourly shedding and load-up scenario, the performances of the MPC and the heuristic prior-based control (PBC) are promising. When shedding was enforced all day, the peak demand saving of the MPC was 36~38 %, whereas that of the PBC was 25.7 % compared to the baseline. In addition, the monthly electricity bill, including the operation and peak demand cost, was investigated with different demand charge rates and weather conditions. The total saving decreased with a low demand charge rate and hot conditions, and the operation cost saving was compromised with more aggressive demand shedding.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent inhibition of GSK-3β

Oxidative stress can contribute to the development and progression of liver diseases, such as drug-induced or alcoholic liver injury, nonalcoholic fatty liver disease, and nonalcoholic steatohepatitis. Nectandrin B is a bioactive lignan isolated from nutmeg extract. To date, little information is available about its pharmacological activities in the liver. This study investigated the hepatocyte-protective effect of nectandrin B against tert-butylhydroperoxide-induced oxidative injury and the underlying molecular mechanism. The cell viability assay revealed that nectandrin B prevents apoptosis stimulated by tert-butylhydroperoxide in both HepG2 cells and primary mouse hepatocytes. Nectandrin B also attenuated ROS production and restored the depleted glutathione level. Real-time PCR and immunoblot analyses showed that the expression of glutamate-cysteine ligase, an enzyme responsible for the glutathione biosynthesis, was induced by nectandrin B, indicating its indirect antioxidative effect. The NF-E2-related factor-2 (Nrf2) regulates gene expression of an array of antioxidant enzymes in hepatocytes. Nectandrin B stimulated Nrf2 activation as evidenced by its enhanced nuclear accumulation and increased antioxidant response element (ARE)-luciferase activity. Intriguingly, the hepatocyte-protective effect of nectandrin B against oxidative damage was completely abrogated by Nrf2 knockdown using Nrf2 specific siRNA. Nectandrin B promoted ERK activation, but inactivated GSK-3β through the AMPK-mediated inhibitory phosphorylation. The enforced overexpression of dominant-negative mutant of MEK1 or AMPKα, or wild-type GSK-3β inhibited the increase in the NQO1-ARE-luciferase activity stimulated by nectandrin B, suggesting that both ERK and AMPK-GSK-3β signalings are involved in the activation of Nrf2/ARE pathway by nectandrin B. Consistent with this, cytoprotection and restoration of glutathione level by nectandrin B was also blocked by the overexpression of dominant-negative MEK1 or wild-type GSK-3β. Finally, our data demonstrate that nectandrin B has the ability to protect hepatocytes against oxidative injury through the activation of Nrf2/ARE pathway mediated by ERK phosphorylation and AMPK-dependent inactivation of GSK-3β. - Highlight: • Nectandrin B, a nutmeg lignan protects hepatocytes against oxidative damage. • Nectandrin B exerts an indirect antioxidative effect via the activation of Nrf2. • Both ERK and GSK-3β pathways contribute to the activation of Nrf2 and hepatocyte-protection by nectandrin B. • Nectandrin B can inactivate GSK-3β through the activation of AMPK in HepG2 cells.

60 APPLIED LIFE SCIENCES↗

Samarium isotope compositions of uranium ore concentrates: A novel nuclear forensic signature

Uranium ore is mined and milled to produce uranium ore concentrate (UOC), a regulated product of the nuclear fuel cycle. Additionally, diversion of UOC from the fuel cycle into possible weapons production is a key concern in global nonproliferation efforts. As such, the ability to trace the origin of seized nuclear materials is imperative to law enforcement efforts. Although isotopic signatures of UOCs have proven fruitful to pinpoint sample provenance, new isotopic signatures are needed because most existing isotopic signatures are not indicative of the original ore body from which the U is derived. In this work, we developed a new method to separate samarium (Sm) from a U-rich sample matrix and report the first Sm isotope compositions of 32 UOCs derived from a variety of worldwide uranium mines. Relative to terrestrial standards, approximately half the UOCs have resolved and anticorrelated 149 Sm- 150 Sm isotope compositions, consistent with the capture of thermal neutrons by 149 Sm in the ore body. The UOCs with anomalous Sm isotope compositions tend to derive from older (~>1.5Ga) and higher-grade ore bodies, although other factors, such as the presence of neutron moderators like water, also play a role. Nonetheless, the Sm isotope compositions of UOCs directly reflects the neutron fluence over the history of the original ore body and can be used to discern different geologic conditions associated with that ore body. Overall, this work demonstrates the potential use of Sm isotopes as a novel nuclear forensics signature for origin assessment of UOCs.

58 GEOSCIENCES↗

Regulating TNCs: Should Uber and Lyft set their own rules?

We evaluate the impact of three proposed regulations of transportation network companies (TNCs) like Uber, Lyft and Didi: (1) A minimum wage for drivers, (2) a cap on the number of drivers or vehicles, and (3) a per-trip congestion tax. The impact is assessed using a queuing theoretic equilibrium model which incorporates the stochastic dynamics of the app-based ride-hailing matching platform, the ride prices and driver wages established by the platform, and the incentives of passengers and drivers. We show that a floor placed under driver earnings can push the ride-hailing platform to hire more drivers and offer more rides, at the same time that passengers enjoy faster rides and lower total cost, while platform rents are reduced. Contrary to standard competitive labor market theory, enforcing a minimum wage for drivers benefits both drivers and passengers, and promotes the efficiency of the entire system. This surprising outcome holds for almost all model parameters, and it occurs because the wage floor curbs TNC labor market power. In contrast to a wage floor, imposing a cap on the number of vehicles hurts drivers, because the platform reaps all the benefits of limiting supply. The congestion tax has the expected impact: fares increase, wages and platform revenue decrease. Here, we also construct variants of the model to briefly discuss platform subsidy, platform competition, and autonomous vehicles.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗