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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Mass-Constrained hybrid Gaussian radial basis neural networks: Development, training, and applications to modeling nonlinear dynamic noisy chemical processes
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Corrosion of rebar in concrete. Part IV. On the theoretical basis of the chloride threshold
A theory is developed for calculating the chloride threshold (CT) from the Point Defect Model (PDM). CT is defined as the ratio [Cl - ]/[OH - ] at which the passivity breakdown voltage (E b ) equals the corrosion potential, ECP. CT is sensitive to the T, ECP, pH, and E b , because all four appear in the exponent X in CT = 10 X . Small uncertainties in these parameters translate into a large uncertainty in CT, emphasizing the need for accurate T, ECP, pH, and E b data. We demonstrate the theory by successfully calculating CT using data for selected systems.
Multi-modal analysis of oxidation on Fe-Cr-Ni austenitic stainless steel 304 exposed to beyond-design basis temperatures
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Large-scale first-principles quantum transport simulations using plane wave basis set on high performance computing platforms
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Dissecting van der Waals interactions with density functional theory – Wannier-basis approach
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Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurpos
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Chemical kinetic basis of synergistic blending for research octane number
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Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD
Neutralizing antibodies (NAbs) hold great promise for clinical interventions against SARS-CoV-2 variants of concern (VOCs). Understanding NAb epitopedependent antiviral mechanisms is crucial for developing vaccines and therapeutics against VOCs. Here we characterized two potent NAbs, EH3 and EH8, isolated from an unvaccinated pediatric patient with exceptional plasma neutralization activity. EH3 and EH8 cross-neutralize the early VOCsandmediatestrong Fc-dependent effector activity in vitro. Structural analyses of EH3 and EH8 in complex with the receptor-binding domain (RBD) revealed the molecular determinantsoftheepitope-drivenprotectionandVOCevasion.WhileEH3represents the prevalent IGHV3-53 NAb whose epitope substantially overlaps with the ACE2 binding site, EH8 recognizes a narrow epitope exposed in both RBD-up and RBD-down conformations. When tested in vivo, a single-dose prophylactic administration of EH3 fully protected stringent K18-hACE2 micefrom lethal challenge with Delta VOC. Our study demonstrates that protective NAbs responses converge in pediatric and adult SARS-CoV-2 patients.
Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N[superscript 2]-et
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Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 reveals the basis of m
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Structural basis of KdpD histidine kinase binding to the second messenger c-di-AMP
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Structural basis for template switching by a group II intron–encoded non-LTR-retroelement reverse transcriptase
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Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants
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