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At least 541 records · Page 30

Red blood cell metabolism (M114), part D

Statistically significant differences were found between Skylab simulation crews and controls for glycolytic enzymes. The absence of simultaneous controls for the pre- and postchamber analyses leaves the significance of the findings in the crew during these periods indeterminate.

Mengel, C. E.↗

Study of blood forming organ dose as a function of proton environment

It is demonstrated that a dosimeter which consists of four ion chambers, each with different wall thickness, is able to reproduce the BFO dose with reasonable accuracy. This generalized dosimetric system is only slightly more complex than dosimeters in current use. This preliminary development had two built-in assumptions; the isotropicity of the radiation and the neglect of nuclear reaction effects. Only the nuclear reaction effects have been calculated.

Khandelwal, G. S.↗

Blood volume changes

Analysis of radionuclide volume determinations made for the crewmembers of selected Gemini and Apollo missions showed that orbital spaceflight has an effect on red cell mass. Because the methods and the protocol developed for earlier flights were used for the crews of the three Skylab missions, direct comparisons are possible. After each Skylab mission, decreases were found in crewmembers' red cell masses. The mean red cell mass decrease of 11 percent or 232 milliliters was approximately equal to the 10 percent mean red cell mass decrease of the Apollo 14 to 17 crewmembers. The red cell mass drop was greatest and the postrecovery reticulocyte response least for crewmembers of the 28-day Skylab 2 mission. Analyses of data from the red cell mass determinations indicate that the red cell mass drops occurred in the first 30 days of flight and that a gradual recovery of the red cell mass deficits began approximately 60 days after launch. The beginning of red cell mass regeneration during the Skylab 4 flight may explain the higher postmission reticulocyte counts.

Johnson, P. C.↗

Engineering studies of vectorcardiographs in blood pressure measuring systems, appendix 3

The following subjects were covered: (1) ASM80 manual, (2) signal preprocessing as an aid to on-line EKG analysis, and (3) high speed evaluation of magnetic tape recordings of electrocardiograms. A description of the ASM80 symbolic assembly program for the INTEL 8080 microprocessor and a user's manual were presented. The capability of three redundancy reduction algorithms to produce adequate representations of electrocardiographic data was examined. A hardware device was constructed which carried out zero order interpolation on a signal. Examination of the zero order interpolators reconstructed signal indicated that this representation was adequate for analysis of rhythm. A system to analyze magnetic tapes of electrocardiograms recorded over 24 hour intervals was designed. The recordings are sampled 200 times per second using a Nova computer and a special interface system. This system was tested on several recordings of clinical data, containing over 75 premature ventricular contractions, each one of which was flagged.

Mark, R. G.↗

Engineering studies of vectorcardiographs in blood pressure measuring systems, appendix 1

A small, portable, relatively inexpensive computer system was developed for on-line use in clinical or laboratory situations. The system features an integrated hardware-software package that permits use of all peripherals, such as analog-to-digital converter, oscilloscope, plotter, digital bus, with an interpreter constructed around the BASIC programming language. The system is conceptually similar to the LINC system developed in 1962, but is more compact and powerful due to intervening advances in integrated circuit technology. A description of the hardware of the system was given. A reference manual, user manual, and programming guides were also presented. Finally, a stereo display system for vectorcardiograms was described.

Mark, R. G.↗

Motions of a liquid in a pulsating bulb with application to problems of blood flow

Potential flows may be utilized to represent motions produced in pulsating bulbs. While the initial bulb shape may be arbitrary, sequential shapes are related by affine transformations. Two components appear in the distribution of pressure, one dependent on the instantaneous velocity and the other on the acceleration. For flows with stationary streamlines the inertial impedance is that of a simple mass, and is proportional to the first moment of the actual mass of fluid contained within the bulb. Examples treated are: (1) Expanding and collapsing circular cylinders, and (2) elliptical cylinders in which the perimeter is held constant. The thickness of the pulsatile laminar boundary layer is found to be approximately on millimeter for conditions in the vicinity of the heart. Conditions for separation and turbulence differ from those in steady flow.

Jones, R. T.↗

Elementary theory of synchronous arterio-arterial blood pumps

In the technique of arterio-arterial pumping, a volume of fluid is withdrawn from the aorta during systole and reinjected during diastole, thereby reducing the systolic pressure of the heart and adding energy to the systemic circulation. It is found that an upper bound for the effectiveness of such devices is given by a formula that considers stroke output of the unaided heart and the increment caused by the pump with a stroke. The division of effort of the pump between the reduction of pressure and the increase of flow depends on the physiological mechanical impedance of the heart. The total effect is, however, independent of the impedance.

Jones, R. T.↗