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Genomes to Structure and Function Workshop Report 2022

The goal of the U.S. Department of Energy (DOE) Biological and Environmental Research (BER) Program is to achieve a predictive understanding of complex biological, earth, and environmental systems with the aim of advancing the nation’s energy and infrastructure security. (https://www.energy.gov/science/ ber/biological-and-environmental-research). To pursue this goal, collaborations among experts in diverse research areas that lead to multidisciplinary projects are indispensable. The roles of DOE’s User Facilities, which offer unique and powerful resources for such research projects, are evolving, and expectations for the facilities are increasing. To respond to Users’ needs, the Joint Genome Institute (JGI) and Environmental Molecular Sciences Laboratory (EMSL) initiated the Facilities Integrating Collaborations for User Science (FICUS) program in 2014. This collaboration has grown into a popular and successful program, advancing more than 100 multidisciplinary projects to date. Similarly, the new interFacility collaborations among the JGI, EMSL, and User resources for BER structural biology and imaging at the Basic Energy Science (BES) Program’s synchrotron and neutron facilities are becoming essential for cutting-edge transdisciplinary science. To further explore the need for the BER research community to combine genomic, functional, and structural approaches to advance their research, an organizing committee was formed to develop and jointly host a 3-part workshop. The committee’s members represented seven DOE National Laboratory User Facilities (Appendix 1 lists the members). The “Genomes to Structure and Function” virtual workshop (see Appendices 2–5) was composed of three sessions. The first session, titled “Molecular Structures” (October 27– 28, 2021), highlighted diverse integrative experimental and computational approaches correlating structural data with sequencing and functional information, as well as predicting protein structures to model complex biological systems. The second session, “Intracellular Organization, and Material Synthesis and Decomposition” (December 15–16, 2021), covered imaging methods for observing, quantifying, and manipulating biosystems. The third session, “Imaging the Rhizosphere and Cellular Organization” (January 26–27, 2022) emphasized advanced and non-invasive imaging techniques applied to plant root-microbe-soil interactions.

59 BASIC BIOLOGICAL SCIENCES↗

IX Cell Wall Research Conference 2022 (IXCWRC): Cell wall research for new fundamental discoveries and applications in plant biology

This application is for securing funds to offset the registration fees and lodging costs for US-based early career investigators (ERCs) to participate to the IX Cell Wall Research Conference 2022 (IXCWRC 2022): Cell wall research for new fundamental discoveries and applications in plant biology. The conference will be held in East Lansing, Michigan on June 13-17, 2022. The conference will focus on the plant cell wall. Plant cells are encapsulated by the cell wall, a dynamic structure that protects them, enables them to interface with the external environment and supports the growth of the entire organism. There is a growing interest in understanding the complex processes necessary to build and deconstruct the plant cell wall. A better understanding of how the cell wall is synthesized during plant growth and in response to the environment, and how it is deconstructed for a broad variety of applications can inform and improve biotechnological processes for increasing biomass yield and improving industrial processes for the recovery of valuable, sustainable polymers. Acquiring such knowledge requires the exchange of new ideas and results as well as the development and application of new technologies. The IXCWRC 2022 aims to reach this goal by providing an opportunity for an open forum to discuss new ideas and theories and develop collaborations for scientists across the globe in a diverse and supportive environment. A distinction of the IXCWRC 2022 from all the preceding plant cell wall conferences will be its focus on the training and inclusion of the next generation of scientists, the ERCs. The overall goal of this application is to broaden the participation of ERCs with a focus on underrepresented communities. The specific goal of this application is to secure support for registration and lodging for US-based ERCs to attend the conference. Priority will be given to ERCs from underrepresented communities in science. We expect that support from DOE will allow the development of an exciting and innovative program to discuss the latest scientific advances in cell wall biology research, advance the next generation of plant cell wall researchers and foster the foundations of an inclusive community in science.

59 BASIC BIOLOGICAL SCIENCES↗

FuncQEE CT Scans - Set 11

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

B Division Overview: Welcome and Overview

The Laboratory is a complex, dynamic system of people, facilities, materials, and services. LANL contributions to biological science span decades.

59 BASIC BIOLOGICAL SCIENCES↗

X-ray CT Scans - Bats (Set 5)

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

FuncQEE CT Scans - Set 6

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

X-ray CT Scans - Bats (Set 1)

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

X-ray CT Scans - Bats (Set 2)

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

FuncQEE CT Scans (Set 2)

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

FuncQEE CT Scans (Set 4)

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

FuncQEE CT Scans (Set 5)

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

X-ray CT Scans - Rodents - Set 4

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Ocean physical‐biogeochemical interactions in the CMIP6 and E3SM Earth System Models

The primary objectives of this project are to quantify the spatio‐temporal linkages between physical climate and ocean biogeochemical variables in the U.S. Department of Energy (DOE) Energy Exascale Earth System Model (E3SM), in CMIP6 Earth System Models (ESMs), and in historical observations, to evaluate the E3SM’s ability to reproduce the observations, and to develop a solid diagnostic package to do so. It will revolve around four hypotheses and will focus on key physical and biogeochemical processes that regulate the upper ocean carbon and oxygen cycling: water mass distribution, ventilation, and biological production.

54 ENVIRONMENTAL SCIENCES↗

X-ray CT Scans - Bats - Set 3

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

X-ray CT Scans - Set 1

A collection of x-ray computed tomography scans of specimens from the Museum of Southwestern Biology.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗