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At least 55 records · Page 3
All sourcesNASA NTRSDOE OSTI
NASA NTRS2002

Regulation of root hair initiation and expansin gene expression in Arabidopsis

The expression of two Arabidopsis expansin genes (AtEXP7 and AtEXP18) is tightly linked to root hair initiation; thus, the regulation of these genes was studied to elucidate how developmental, hormonal, and environmental factors orchestrate root hair formation. Exogenous ethylene and auxin, as well as separation of the root from the medium, stimulated root hair formation and the expression of these expansin genes. The effects of exogenous auxin and root separation on root hair formation required the ethylene signaling pathway. By contrast, blocking the endogenous ethylene pathway, either by genetic mutations or by a chemical inhibitor, did not affect normal root hair formation and expansin gene expression. These results indicate that the normal developmental pathway for root hair formation (i.e., not induced by external stimuli) is independent of the ethylene pathway. Promoter analyses of the expansin genes show that the same promoter elements that determine cell specificity also determine inducibility by ethylene, auxin, and root separation. Our study suggests that two distinctive signaling pathways, one developmental and the other environmental/hormonal, converge to modulate the initiation of the root hair and the expression of its specific expansin gene set.

NASA Discipline Plant Biology↗
NASA NTRS2008

Radiation Measured during ISS-Expedition 13 with Different Dosimeters

Radiation in low Earth orbit (LEO) is mainly composed of Galactic Cosmic Rays (GCR), solar energetic particles and particles in SAA (South Atlantic Anomaly). The biological impact of space radiation to astronauts depends strongly on the particles linear energy transfer (LET) and is dominated by high LET radiation. It is important to measure the LET spectrum for the space radiation field and to investigate the influence of radiation on astronauts. At present, the preferred active dosimeters sensitive to all LET are the tissue equivalent proportional counter (TEPC) and silicon detectors in various configurations; the preferred passive dosimeters are thermoluminescence dosimeters (TLDs) and optically stimulated luminescence dosimeters (OSLDs) sensitive to low LET as well as CR-39 plastic nuclear track detectors (PNTDs) sensitive to high LET. The TEPC, CR-39 PNTDs, TLDs and OSLDs were used to investigate the radiation exposure for the ISS mission Expedition 13 (ISS-12S) in LEO. LET spectra and radiation quantities (fluence, absorbed dose, dose equivalent and quality factor) were measured for the space mission with different dosimeters. This paper introduces the operational principles for the dosimeters, describes the method to combine the results measured by TLDs/OSLDs and CR-39 PNTDs, and presents the LET spectra and the radiation quantities measured. Keywords: space radiation; cosmic rays; active and passive dosimeters; LET spectra

Zhou, D.↗
NASA NTRS2010

Radiation Measured with Different Dosimeters for ISS-Expedition 18-19/ULF2 on Board International Space Station during Solar Minimum

Radiation field of particles in low Earth orbit (LEO) is mainly composed of galactic cosmic rays (GCR), solar energetic particles and particles in SAA (South Atlantic Anomaly). GCR are modulated by solar activity, at the period of solar minimum activity, GCR intensity is at maximum and the main contributor for space radiation is GCR. At present for space radiation measurements conducted by JSC (Johnson Space Center) SRAG (Space Radiation Analysis Group), the preferred active dosimeter sensitive to all LET (Linear Energy Transfer) is the tissue equivalent proportional counter (TEPC); the preferred passive dosimeters are thermoluminescence dosimeters (TLDs) and optically stimulated luminescence dosimeters (OSLDs) sensitive to low LET as well as CR-39 plastic nuclear track detectors (PNTDs) sensitive to high LET. For the method using passive dosimeters, radiation quantities for all LET can be obtained by combining radiation results measured with TLDs/OSLDs and CR-39 PNTDs. TEPC, TLDs/OSLDs and CR-39 detectors were used to measure the radiation field for the ISS (International Space Station) - Expedition 18-19/ULF2 space mission which was conducted from 15 November 2008 to 31 July 2009 - near the period of the recent solar minimum activity. LET spectra (differential and integral fluence, absorbed dose and dose equivalent) and radiation quantities were measured for positions TEPC, TESS (Temporary Sleeping Station, inside the polyethylene lined sleep station), SM-P 327 and 442 (Service Module - Panel 327 and 442). This paper presents radiation LET spectra measured with TEPC and CR-39 PNTDs and radiation dose measured with TLDs/OSLDs as well as the radiation quantities combined from results measured with passive dosimeters.

Zhou, Dazhuang↗
NASA NTRS2019

Characterization of Sensory and Shelter Enrichment in the Rodent Research Habitat

The ISS provides a platform for conducting Rodent Research (RR) in microgravity and 9 missions have been successfully conducted. The results from these experiments have begun to provide new insights into the effects of spaceflight on mammalian physiological systems. After RR-1-4, the Flight IACUC required inclusion of additional cage enrichment into the Rodent Habitats (RH) to "enhance animal well-being by providing animals with sensory and motor stimulation, through structures and resources that facilitate the expression of species typical behaviors". A Hut, in the form of a rigid, mesh igloo-like shelter was implemented beginning with RR-5. The potential influence of the Hut in the novel cage environment of RH on various spaceflight-sensitive physiological systems has not been fully explored. To understand the effects of the Hut, mice (female C57Bl/6J, 15wks) were housed in Vivarium cage (n=5), RH with Hut (n=5), No Hut (n=5), Nestlet (n=10), and Cocoon (n=10) for 7 weeks. There were no differences in weekly body mass or food consumption. Tail blood draw indicated no differences in plasma corticosterone levels, immune cell types, or IgA levels. 24hrs prior to euthanasia, Open Field (OF) and Novel Object (NO) tests were performed. There were no differences across groups, all mice engaged in thigmotaxis (arena wall proximity) in the OF over 50% of the recorded time, and thigmotaxis declined when a NO was introduced. Additional behavioral analysis from daily videos are in progress to quantify activity levels. Post-euthanasia, there were no differences in soleus muscle or adrenal gland mass. Analysis of distal femur cancellous revealed some differences in microarchitecture. These results show that introduction of the Hut may diminish differences observed between spaceflight and ground controls, warranting improved validation of Hut effects in space, and also underscore the value of thorough preflight, ground based testing.

Shirazi-Fard, Yasaman↗
NASA NTRS1993

The effect of hypogravity and hypergravity on cells of the immune system

This article reviews the gravity effects discovered in T lymphocytes and other cells of the immune system. The strong depression of mitogenic activation first observed in an experiment conducted in Spacelab 1 in 1983 triggered several other investigations in space and on the ground in the clinostat and in the centrifuge in the past 10 years. During this period, great progress was made in our knowledge of the complex mechanism of T cell activation as well as the technology to analyze the lymphokines produced during stimulation. Nevertheless, several aspects of the steps leading to activation are not yet clear. Studies in hypogravity and hypergravity may contribute to answering some of the questions. A recent investigation in the U.S. Spacelab SLS-1, based on a new technology in which leukocytes are attached to microcarrier beads, showed that the strong inhibition of activation in microgravity is due to a malfunction of monocytes acting as accessory cells. In fact, interleukin-1 production is nearly nil in resuspended monocytes, whereas T cell activation is doubled in attached cells. In hypergravity, but not at 1g, concanavalin A bound to erythrocytes activates B lymphocytes in addition to T cells. The activation of Jurkat cells is also severely impaired in space. These recent results have raised new questions that have to be answered in experiments to be conducted in space and on Earth in this decade. The experimental system, based on the mitogenic activation of T lymphocytes and accessory cells attached to microcarriers, offers an optimum model for studying basic biological mechanisms of the cell to assess the immunological fitness of humans in space and to test the feasibility of bioprocesses in space as well as on Earth.

NASA Discipline Regulatory Physiology↗
NASA NTRS2026

Effects of Multisensory Virtual Reality Nature on Affect, Presence, and Restorativeness

Virtual reality (VR) can provide access to restorative environments and sensory stimulation for individuals in isolated, confined, and extreme environments. We developed a nature-based VR intervention featuring three scenes (Garden, Forest, Beach) and examined the effects of multisensory augmentation with location-based olfactory, wind, and thermal stimuli (VR+OWT). Over a two-week period, fifty-one participants were assigned to a no-intervention control, standard audiovisual VR, or augmented VR (VR+OWT) condition. Data collection included weekly assessments of affect, stress, and cognitive performance; post-VR measures of affect, presence, and perceived restorativeness; and open-ended feedback. Both VR and VR+OWT groups produced immediate and sustained reductions in negative affect with no sustained systematic benefits on cognitive performance. The addition of olfactory, wind, and thermal stimuli enhanced presence for some scenes; however, feedback indicated that sensory mismatches and stimulus intensity occasionally detracted from the experience and may have contributed to lower coherence ratings in the VR+OWT group. In contrast, the perceived restorativeness of the VR environment was driven primarily by scene content (Garden vs Forest vs Beach) rather than the level of sensory stimulation. These findings support the potential of virtual nature to promote well-being and underscore the importance of coherence across sensory modalities for multisensory augmentation.

Virtual Reality Intervention↗
NASA NTRS2000

Vestibular stimulation leads to distinct hemodynamic patterning

Previous studies demonstrated that responses of a particular sympathetic nerve to vestibular stimulation depend on the type of tissue the nerve innervates as well as its anatomic location. In the present study, we sought to determine whether such precise patterning of vestibulosympathetic reflexes could lead to specific hemodynamic alterations in response to vestibular afferent activation. We simultaneously measured changes in systemic blood pressure and blood flow (with the use of Doppler flowmetry) to the hindlimb (femoral artery), forelimb (brachial artery), and kidney (renal artery) in chloralose-urethane-anesthetized, baroreceptor-denervated cats. Electrical vestibular stimulation led to depressor responses, 8 +/- 2 mmHg (mean +/- SE) in magnitude, that were accompanied by decreases in femoral vasoconstriction (23 +/- 4% decrease in vascular resistance or 36 +/- 7% increase in vascular conductance) and increases in brachial vascular tone (resistance increase of 10 +/- 6% and conductance decrease of 11 +/- 4%). Relatively small changes (<5%) in renal vascular tone were observed. In contrast, electrical stimulation of muscle and cutaneous afferents produced pressor responses (20 +/- 6 mmHg) that were accompanied by vasoconstriction in all three beds. These data suggest that vestibular inputs lead to a complex pattern of cardiovascular changes that is distinct from that which occurs in response to activation of other types of somatic afferents.

NASA Discipline Neuroscience↗
NASA NTRS1979

Laser-stimulated migration of adsorbed atoms on solid surfaces

This paper presents a unified theory of the coherent, multiple-photon excitation and laser-stimulated migration of atoms adsorbed on solid surfaces. We show that under steady-state excitation the migration of the adsorbed atom on the surface is diffusional, with diffusion constant dependent upon field intensity, surface temperature, relaxation constants, dipole moment strength, laser frequency, and the vibrational frequency of the adsorbed atom. In particular, it is shown that the rate of diffusion is proportional to the field intensity. Finally, we discuss the utility of laser-stimulated migration in the enhancement of surface chemical reactions, as well as in the analysis of surface relaxational processes.

Slutsky, M. S.↗
NASA NTRS1984

Field-aligned electron density irregularities near 500 km. Equator to polar cap topside sounder Z mode observations

In addition to spread F, evidence for field-aligned electron density irregularities is commonly observed on Alouette 2 topside sounder ionograms recorded near perigee (500 km). This evidence is provided by distinctive signal returns from sounder-generated Z mode waves. At low latitudes these waves become guided in wave ducts caused by field-aligned electron density irregularities and give rise to strong long-duration echoes. At high latitudes, extending well into the polar cap, these Z mode waves (and stimulated electrostatic waves at the plasma frequency) produce a series of vertical bars on the ionogram display as the satellite traverses discrete field-aligned density structures. The radio frequency (RF) noise environment to be expected in the 400 to 500 km altitude region from low to high latitudes was examined by analyzing perigee Alouette 2 topside sounder data. All observed noise bands were scaled on nearly 200 topside sounder ionograms recorded near perigee at low, mid, and high latitude telemetry stations. The minimum and maximum frequencies of each noise band were entered into a data base or compuer analysis. The signals of primary interest in the perigee study were found to be sounder-generated.

Benson, R. F.↗
NASA NTRS1985

Field-aligned electron density irregularities near 500 km Equator to polar cap topside sounder observations

In addition to spread F, evidence for field-aligned electron density irregularities is commonly observed on Alouette 2 topside sounder ionograms recorded near perigee (500 km). This evidence is provided by distinctive signal returns from sounder-generated Z mode waves. At low latitudes these waves become guided in wave ducts caused by field-aligned electron density irregularities and give rise to strong long-duration echoes. At high latitudes, extending well into the polar cap, these Z mode waves (and stimulated electrostatic waves at the plasma frequency) produce a series of vertical bars on the ionogram display as the satellite traverses discrete field-aligned density structures. The radio frequency (RF) noise environment to be expected in the 400 to 500 km altitude region from low to high latitudes was examined by analyzing perigee Alouette 2 topside sounder data. All observed noise bands were scaled on nearly 200 topside sounder ionograms recorded near perigee at low, mid, and high latitude telemetry stations. The minimum and maximum frequencies of each noise band were entered into a data base or computer analysis. The signals of primary interest in the perigee study were found to be sounder-generated.

Benson, R. F.↗
NASA NTRS1996

NASA Specialized Center of Research and Training (NSCORT) in Gravitational Biology

The mission of our NSCORT is to investigate the effects of gravity and other environmental factors on biological function at the cellular and molecular level. The research efforts, training opportunities, and scientific exchange will promote the expansion of a scientific peer group well-educated in space-related biological issues. This will stimulate the interest of the larger scientific community and insure the continuing development of rigorous flight investigations in Gravitational Biology.

Mclntire, Larry V.↗
NASA NTRS2001

Generic Divide and Conquer Internet-Based Computing

The rapid growth of internet-based applications and the proliferation of networking technologies have been transforming traditional commercial application areas as well as computer and computational sciences and engineering. This growth stimulates the exploration of new, internet-oriented software technologies that can open new research and application opportunities not only for the commercial world, but also for the scientific and high -performance computing applications community. The general goal of this research project is to contribute to better understanding of the transition to internet-based high -performance computing and to develop solutions for some of the difficulties of this transition. More specifically, our goal is to design an architecture for generic divide and conquer internet-based computing, to develop a portable implementation of this architecture, to create an example library of high-performance divide-and-conquer computing agents that run on top of this architecture, and to evaluate the performance of these agents. We have been designing an architecture that incorporates a master task-pool server and utilizes satellite computational servers that operate on the Internet in a dynamically changing large configuration of lower-end nodes provided by volunteer contributors. Our designed architecture is intended to be complementary to and accessible from computational grids such as Globus, Legion, and Condor. Grids provide remote access to existing high-end computing resources; in contrast, our goal is to utilize idle processor time of lower-end internet nodes. Our project is focused on a generic divide-and-conquer paradigm and its applications that operate on a loose and ever changing pool of lower-end internet nodes.

Radenski, Atanas↗
NASA NTRS2003

Generic Divide and Conquer Internet-Based Computing

The growth of Internet-based applications and the proliferation of networking technologies have been transforming traditional commercial application areas as well as computer and computational sciences and engineering. This growth stimulates the exploration of Peer to Peer (P2P) software technologies that can open new research and application opportunities not only for the commercial world, but also for the scientific and high-performance computing applications community. The general goal of this project is to achieve better understanding of the transition to Internet-based high-performance computing and to develop solutions for some of the technical challenges of this transition. In particular, we are interested in creating long-term motivation for end users to provide their idle processor time to support computationally intensive tasks. We believe that a practical P2P architecture should provide useful service to both clients with high-performance computing needs and contributors of lower-end computing resources. To achieve this, we are designing dual -service architecture for P2P high-performance divide-and conquer computing; we are also experimenting with a prototype implementation. Our proposed architecture incorporates a master server, utilizes dual satellite servers, and operates on the Internet in a dynamically changing large configuration of lower-end nodes provided by volunteer contributors. A dual satellite server comprises a high-performance computing engine and a lower-end contributor service engine. The computing engine provides generic support for divide and conquer computations. The service engine is intended to provide free useful HTTP-based services to contributors of lower-end computing resources. Our proposed architecture is complementary to and accessible from computational grids, such as Globus, Legion, and Condor. Grids provide remote access to existing higher-end computing resources; in contrast, our goal is to utilize idle processor time of lower-end Internet nodes. Our project is focused on a generic divide and conquer paradigm and on mobile applications of this paradigm that can operate on a loose and ever changing pool of lower-end Internet nodes.

Follen, Gregory J.↗
NASA NTRS1995

A Review of Nonlinear Low Frequency (LF) Wave Observations in Space Plasmas: On the Development of Plasma Turbulence

As the lead-off presentation for the topic of nonlinear waves and their evolution, we will illustrate some prominent examples of waves in space plasmas. We will describe recent observations detected within planetary foreshocks, near comets and in interplanetary space. It is believed that the nonlinear LF plasma wave features discussed here are part of and may be basic to the development of plasma turbulence. In this sense, this is one area of space plasma physics that is fundamental, with applications to fusion physics and astrophysics as well. It is hoped that the reader(s) will be stimulated to study nonlinear wave development themselves, if he/she is not already involved.

Space Plasmas↗
NASA NTRSDate not supplied

Plasma and Brain Cytokine Responses to Single and Combinatorial Spaceflight Stressors in Male and Female Mice

Spaceflight involves exposure to multiple environmental stressors, including Ionizing Radiation (IR), microgravity, and social isolation. We hypothesize that spaceflight stressors combine synergistically to trigger an oxidative stress response that, in turn, alters immune homeostasis, brain structure/function, and neurobehavioral/cognitive performance. Here, we report plasma and brain cytokine findings from two studies of crew age-matched (24-week-old) male and female mice exposed to simulated 5-Ion GCRsim at the NASA Space Radiation Laboratory (NSRL). In Study 1, mice were exposed to 0, 5, 15, or 50cGy 5-ion GCRsim. Immune and brain measures were acquired either at ‘Acute’ (within 3 days post-irradiation; IR), ‘Intermediate’ (IR+14 days) or ‘Delayed’ (IR+125 days) timepoints. In Study 2, mice were exposed singly and in combination to 15cGy 5-ion GCRsim, simulated microgravity via continuous head-down tilt/hindlimb unloading (HU), and social isolation. Plasma and brain cytokine cytokine profiling revealed sex-specific as well as sex-common responses. Notably, plasma granulocyte colony stimulating factor (GCSF) levels showed significant regulation compared to a single stressor alone, suggesting a potential biomarker responder. Increased GCSF was correlated with corresponding increased blood neutrophil populations. Futhermore, our study provides evidence for robust effects of HU relative to IR alone. This project addresses NASA’s efforts to characterize risks in both women and men in anticipation of future space missions beyond low earth orbit (BLEO). Ensuring crew health and performance during extended transits to the moon and beyond necessitates that sensorimotor and cognitive abilities remain strong to avoid potentially catastrophic health and safety outcomes.

mouse radiation hindlimb unloading spaceflight↗
NASA NTRS1994

The Influence of Gravito-Inertial Force on Sensorimotor Integration and Reflexive Responses

Sensorimotor responses (e.g.. eye movements, spinal reflexes, etc depend upon the interpretation of the neural signals from the sensory systems. Since neural signals from the otoliths may represent either tilt (gravity) or translation (linear inertial force), sensory signals from the otolith organs are necessarily somewhat ambiguous. Therefore. the neural responses to changing otolith signals depend upon the context of the stimulation (e.g- active vs. passive, relative orientation of gravity, etc.) as well as upon other sensory signals (e.g., vision. canals, etc.). This session will focus upon the -role -played by the sensory signals from the otolith organs in producing efficient sensorimotor and behavioral responses. Curthoys will show the influence of the peripheral anatomy and physiology. Tomko will discuss the influence of tilt and translational otolith signals on eye movements. Merfeld will demonstrate the rate otolith organs play during the interaction of sensory signals from the canals and otoliths. Watt will show the influence of the otoliths on spinal/postural responses. Guedry will discuss the contribution of vestibular information to "path of movement"' perception and to the development of a stable vertical reference. Sensorimotor responses to the ambiguous inertial force stimulation provide an important tool to investigate how the nervous system processes patterns of sensory information and yields functional sensorimotor responses.

Curthoys, Ian S.↗
NASA NTRS1986

Theoretical studies of Resonance Enhance Stimulated Raman Scattering (RESRS) of frequency doubled Alexandrite laser wavelengths in cesium vapor

It is well known that the presence of a real atomic level which is nearly resonant with the pump field can greatly enhance the Raman emission cross section. In order to accurately calculate the Raman gain in systems where resonance enhancement plays a dominant role, expressions for the pump and signal susceptibilities must be derived. These expressions should be valid for arbitrary field strengths in order to allow for pump and signal saturation. In addition, the theory should allow for arbitrary longitudinal and transverse relaxation rates. This latter point is extremely vital for three level atomic systems such as the alkali earth metals since they do not have population reservoirs and can have widely varying spontaneous lifetimes on the three pertinent transitions. Moreover, the dephasing rates are strong functions of electron states and are therefore also different for the three coupled pairs of levels. These considerations are not as important when molecular systems are concerned since the large reservoir of rotational states serve to produce essentially equal longitudinal recovery rates for the population of the three levels. The three level system with three arbitrary longitudinal and transverse relaxation rates was solved. There is no need for setting either pair of rates equal and the expressions are valid for arbitrarily strong fields.

Lawandy, N. M.↗
NASA NTRS1972

Heating rate controller for thermally stimulated conductivity and thermoluminescence measurements.

A temperature controller is described which enables the temperature of a sample mounted on a cold finger to be varied linearly with time. Heating rates between 0.5 and 10 K/min can be achieved for temperatures between 90 and 300 K. Provision for terminating the sample heating at any temperature between these extremes is available. The temperature can be held at the terminating temperature or be reduced to the starting temperature in a matter of minutes. The controller has been used for thermally stimulated conductivity measurements and should be useful for thermoluminescence measurements as well.

Manning, E. G.↗