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NASA NTRS2016

Colonoscopy Screening in the US Astronaut Corps

BACKGROUND: Historically, colonoscopy screenings for astronauts have been conducted to ensure that astronauts are in good health for space missions. Recently this historical data has been identified as being useful for developing an occupational surveillance requirement. It can be used to assess overall colon health and to have a point of reference for future tests in current and former astronauts, as well as to follow-up and track rates of colorectal cancer and polyps. These rates can be compared to military and other terrestrial populations. In 2003, the active astronaut colonoscopy requirements changed to require less frequent colonoscopies. Since polyp removal during a colonoscopy is an intervention that prevents the polyp from potentially developing into cancer, the procedure decreases the individual's risk for colon cancer. The objective of this study is to evaluate the possible effect of increased follow-up times between colonoscopies on the number and severity of polyps identified during the procedures among both current and former NASA astronauts. Initial results and forward work regarding astronaut colonoscopy screenings will be presented. METHODS: A retrospective study of all colonoscopy procedures performed on NASA astronauts between 1962 and 2015 (both during active career and retirement) was conducted by review of the JSC Clinic Electronic Medical Record and Lifetime Surveillance of Astronaut Health (LSAH) database for colonoscopy screening procedures and pathology reports. The timeframe of interest was from the time of selection into the Astronaut Corps through May 2015 or death. For each colonoscopy report, the following data were captured: date of procedure, age at time of procedure, reason for procedure, quality of bowel prep, completion of procedure and/or reason for termination of procedure, findings of procedure, subsequent treatment (if any), recommended follow-up interval, actual follow up interval, family history of polyps or colon cancer, and other significant items or discrepancies. The population consisted of 338 astronauts: 52 females, 286 males. Of these, 56 were deceased, and 11 astronauts had no record of any colonoscopies. Because of a screening requirement change in 2003, analyses were conducted to determine if there were differences between the two time periods. One-sided Wilcoxon rank sum tests were used to identify statistically significant differences between the two time periods. RESULTS: There was a combined total of 1,964 colonoscopy screenings identified. The average follow-up intervals between colonoscopies were indeed longer after the screening requirement change than before the change. The mean follow-up interval pre -2003 was 3.59 years, while post-2003 it increased to 4.35 years. The statistical significance of this difference was confirmed using a one sided Wilcoxon rank sum test which yielded p<.001. Colonoscopies performed after the requirement change tended to have a higher incidence and greater severity of polyps. From pre-2003 to post-2003 the percentage of colonoscopy procedures yielding no polyps decreased from 83.77% to 74.70%. Not only did post-2003 procedures yield more polyp findings, but the polyps recorded were more often of severe pathology. Before 2003 3.62% of colonoscopy findings were polyps of the hyperplastic type (the least severe polyp type) and only 3.35% were of greater severity. Post-2003, 4.21% of findings were hyperplastic polyps while 11.44% were of greater severity. Upon the investigation of other possible contributing factors to these results, we also found that mean age post-2003 was 54.55 years which was significantly higher than during the pre-2003 timeframe (47.32 years). This was observed with a one-sided Wilcoxon rank sum test, resulting in a p<0.001. The increased average age of astronauts could also be a contributing factor to the greater number of polyps found since the risk of developing polyps increases with age. Further work is needed to better understand the increased incidence and greater severity of polyps found in astronaut colonoscopy outcomes.

Masterova, K.↗

NASA NTRS2017

Conjunction Assessment Screening Volume Sizing and Event Filtering in Light of Natural Conjunction Event Development Behaviors

Conjunction Assessment screening volumes used in the protection of NASA satellites are constructed as geometric volumes about these satellites, of a size expected to capture a certain percentage of the serious conjunction events by a certain time before closest approach. However, the analyses that established these sizes were grounded on covariance-based projections rather than empirical screening results, did not tailor the volume sizes to ensure operational actionability of those results, and did not consider the adjunct ability to produce data that could provide prevenient assistance for maneuver planning. The present study effort seeks to reconsider these questions based on a six-month dataset of empirical screening results using an extremely large screening volume. The results, pursued here for a highly-populated orbit regime near 700 km altitude, identify theoretical limits of screening volume performance, explore volume configuration to facilitate both maneuver remediation planning as well as basic asset protection, and recommend sizing principles that maximize volume performance while minimizing the capture of "chaff" conjunctions that are unlikely ever to become serious events.

screening volume↗

NASA NTRS1974

Wicking of liquids in screens

An investigation was conducted to determine the magnitude of the wicking rates of liquids in various screens. Evaluation of the parameters characterizing the wicking process resulted in the development of an expression which defined the wicking velocity in terms of screen and system geometry, liquid properties, and gravitational effects. Experiment data obtained both in normal gravity and in weightlessness demonstrated that the model successfully predicted the functional relation of the liquid properties and the distance from the liquid source to the wicking velocity. Because the pore geometry in the screens was complex, several screen geometric parameters were lumped into a single constant which was determined experimentally for each screen.

Symons, E. P.↗

NASA NTRS1976

Study of liquid jet impingement on screens

A model is presented for an unconfined flow, such as a free jet, impinging on a screen which incorporates the influence of liquid deflection by the screen. The boundary layer blockage coefficient is introduced. This coefficient depends on the screen weave geometry and the jet impingement angle, and essentially accounts for the increase in fluid particle trajectory length through the screen resulting from the flow deflection. Comparisons were made with previous experimental studies to determine empirical values of the blockage coefficient. It is concluded that the new model reliably predicts the bulk flow and penetration characteristics of an impinging liquid jet interacting with a screen.

Dodge, F. T.↗

NASA NTRS1978

Effect of vibration on retention characteristics of screen acquisition systems

The design of surface tension propellant acquisition systems using fine-mesh screen must take into account all factors that influence the liquid pressure differentials within the system. One of those factors is spacecraft vibration. Analytical models to predict the effects of vibration have been developed. A test program to verify the analytical models and to allow a comparative evaluation of the parameters influencing the response to vibration was performed. Screen specimens were tested under conditions simulating the operation of an acquisition system, considering the effects of such parameters as screen orientation and configuration, screen support method, screen mesh, liquid flow and liquid properties. An analytical model, based on empirical coefficients, was most successful in predicting the effects of vibration.

Tegart, J. R.↗

NASA NTRS1985

Flow through very porous inclined screens

The steady, inviscid flow through and around a screen inclined at a uniform angle to the incoming flow was investigated. For a screen placed in an infinite flow field, an asymptotic analysis for small resistance coefficients was performed, and the effects of inclination were determined. The velocity at first order in the asymptotic expansion was nonuniform along the screen. This nonuniformity caused the wake behind the screen to contain distributed vorticity at second order. These effects therefore occurred at one order lower than for normal screens.

Muramoto, K. K.↗

NASA NTRS1985

Electrostatic shielding of a charged conducting sphere by a fine-mesh grounded screen

A simple model of an electrostatic-shielding arrangement that will reduce the electric field from the Near Infrared Mapper Spectrometer aboard the Galileo spacecraft is presented. The system considered consists of a charged conducting sphere held at a fixed absolute potential via a power source. This system is screened by a larger, concentric sphere made of fine mesh which is grounded. A derivation based on elementary principles of electrostatics is used to show that the shielding effectiveness of the screen can be expressed in terms of the separation between the two spheres and another quantity B that is an intrinsic property of the screen. For a given screen, B can be determined by measuring the capacitance per unit area and separation between a flat piece of the screen and a parallel metal plate.

Edmonds, L.↗

NASA NTRS1985

Flow through very porous inclined screens

Muramoto, K. K.↗

NASA NTRS1989

Large screen display for the Mission Control Center

The Mission Control Center (MCC), located at the Johnson Space Center near Houston, Texas, is the primary point of control and monitoring for National Space Transportation System (NSTS) flight activities. NSTS flight managers monitor and command spacecraft from one of two Flight Control Rooms (FCR). Each FCR is equipped with five large screen displays for group dissemination of spacecraft system status and vehicle position relative to Earth geography. The primary or center screen display is ten feet in height and twenty feet in width. The secondary or side screens are seven and one-hald feet high and ten feet wide. The center screen projection system is exhibiting high maintenance costs and is considered to be in wear-out phase. The replacement of the large center screen displays at the MCC is complicated by the unique requirements of the Flight Controller user. These requirements demand a very high performance, multiple color projection system capable of the display of high resolution text, graphics and images produced in near real time. The current system to be replaced, the replacement system requirements, the efforts necessary to procure the major element of this system (the projector) for the government, and how the new capabilities are to be integrated into the existing MCC operational configuration are discussed.

Skudlarek, Martin J.↗

NASA NTRS1991

Vapor-Screen-Density Controller

Density of vapor screen in wind tunnel maintained for vapor-screen photography. Vapor-screen density controller developed to control reflectivity by closed-loop means. Eliminates large step-response corrections and possesses more than enough frequency response to maintain nearly constant density in vapor screen in undisturbed flow ahead of model. Device enables user to control density of vapor screen via set-point indicator. User given indication of percentage transmittance across test section.

Byrd, James E.↗

NASA NTRS1993

SLR data screening; location of peak of data distribution

At the 5th Laser Ranging Instrumentation Workshop held at Herstmonceux in 1984, consideration was given to the formation of on-site normal points by laser stations, and an algorithm was formulated. The algorithm included a recommendation that an iterated 3.0 x rms rejection criterion should be used to screen the data, and that arithmetic means should be formed within the normal point bins of the retained data. From Sept. 1990 onwards, this algorithm and screening criterion have been brought into effect by various laser stations for forming on-site normal points, and small variants of the algorithm are used by most analysis centers for forming normal points from full-rate data, although the data screening criterion they use ranges from about 2.5 to 3.0 x rms. At the CSTG Satellite Laser Ranging (SLR) Subcommission, a working group was set up in Mar. 1991 to review the recommended screening procedure. This paper has been influenced by the discussions of this working group, although the views expressed are primarily those of this author. The main thrust of this paper is that, particularly for single photon systems, a more important issue than data screening is the determination of the peak of a data distribution and hence, the determination of the bias of the peak from the mean. Several methods of determining the peak are discussed.

Sinclair, Andrew T.↗

NASA NTRS1995

Automated Propulsion Data Screening demonstration system

A fully-instrumented firing of a propulsion system typically generates a very large quantity of data. In the case of the Space Shuttle Main Engine (SSME), data analysis from ground tests and flights is currently a labor-intensive process. Human experts spend a great deal of time examining the large volume of sensor data generated by each engine firing. These experts look for any anomalies in the data which might indicate engine conditions warranting further investigation. The contract effort was to develop a 'first-cut' screening system for application to SSME engine firings that would identify the relatively small volume of data which is unusual or anomalous in some way. With such a system, limited and expensive human resources could focus on this small volume of unusual data for thorough analysis. The overall project objective was to develop a fully operational Automated Propulsion Data Screening (APDS) system with the capability of detecting significant trends and anomalies in transient and steady-state data. However, the effort limited screening of transient data to ground test data for throttle-down cases typical of the 3-g acceleration, and for engine throttling required to reach the maximum dynamic pressure limits imposed on the Space Shuttle. This APDS is based on neural networks designed to detect anomalies in propulsion system data that are not part of the data used for neural network training. The delivered system allows engineers to build their own screening sets for application to completed or planned firings of the SSME. ERC developers also built some generic screening sets that NASA engineers could apply immediately to their data analysis efforts.

Hoyt, W. Andes↗

NASA NTRS1959

Experimental Investigation of Expanded Duct Sections and Screens for Reducing FLow Distortions at Subsonic Flows

An investigation of expanded duct sections and the effect of their design parameters on flow distortion over a duct Mach number range of 0.19 to 0.67 was conducted in the small tunnel facility of the Lewis Research Center. The parameters investigated were: (1) entrance angle of expanded section, (2) length of expanded section, (3) area ratio of expanded section, (4) location of expanded section relative to the engine face, and (5) the use of screens of varying solidities and mesh. Expansion half-angles of deg, 15 deg, and 30 deg reduced the total-pressure distortions induced in the duct. The larger expansion angles reduced circumferential distortion more effectively than radial distortion. However, the half-angle of 15 deg appeared to be optimum for reducing both radial and circumferential distortions while still maintaining a high total-pressure recovery. Increasing the expanded-section area ratio and increasing the expanded-section lengths with-the 150 expansion half-angle led to less total-pressure distortion with no appreciable loss in pressure recovery. Screens incorporated in the expanded section indicated that 22.2-percent- solidity screens decreased distortion still further.while 37.3-percent- solidity screens generally increased distortion above that of a constant- area duct incorporating the same solidity screen.

Chiccine, Bruce G.↗

NASA NTRS2005

Screen Channel Liquid Acquisition Devices for Cryogenic Propellants

This paper describes an on-going project to study the application screen channel liquid acquisition devices to cryogenic propellant systems. The literature of screen liquid acquisition devices is reviewed for prior cryogenic experience. Test programs and apparatus are presented to study these devices. Preliminary results are shown demonstrating bubble points for 200 x 1400 wires per inch and 325 x 2300 wires per inch Dutch twill screens. The 200 x 1400 screen has a bubble point of 15.8 inches of water in isopropyl alcohol and 6.6 inches of water in liquid nitrogen. The 325 x 2300 screen has a bubble point of 24.5 inches of water in isopropyl alcohol, 10.7 inches of water in liquid nitrogen, and 1.83 inches of water in liquid hydrogen. These values are found to be in good agreement with the results reported in the literature.

Chato, David J.↗

NASA NTRS1980

Low conducting metal screen support flange

In a very high or very low temperature duct system in which duct insulation is terminated at selected locations so as to be not coextensive with the duct, an annular metal perforated or mesh screen support flange is used, as a low conductor of heat or cold, between the duct and an outer insulation cover to retain the end of the insulation and to support its usually very thin cover. The screen may be Z-shaped in cross section having a small diameter annular portion to surround and be secured to the duct adjacent the end of the insulation. A generally radially extending portion of the screen extends outwardly from the small diameter portion and adjacent the end of the insulation. The periphery of the radially extending portion is in alignment with the outer peripheral surface of the insulation and the outer peripheral surface of the insulation cover. A large diameter annular portion of the screen extends longitudinally from the periphery in the direction opposite the small diameter portion, and is adapted to surround the insulation and its cover and be secured thereto. The screen may also be U or channel-shaped with one longitudinally directed leg secured to the insulation cover and the other leg secured to the duct under the insulation.

Lestak, Robert G.↗

NASA NTRS2011

Cryogenic Quenching Process for Electronic Part Screening

The use of electronic parts at cryogenic temperatures (less than 100 C) for extreme environments is not well controlled or developed from a product quality and reliability point of view. This is in contrast to the very rigorous and well-documented procedures to qualify electronic parts for mission use in the 55 to 125 C temperature range. A similarly rigorous methodology for screening and evaluating electronic parts needs to be developed so that mission planners can expect the same level of high reliability performance for parts operated at cryogenic temperatures. A formal methodology for screening and qualifying electronic parts at cryogenic temperatures has been proposed. The methodology focuses on the base physics of failure of the devices at cryogenic temperatures. All electronic part reliability is based on the bathtub curve, high amounts of initial failures (infant mortals), a long period of normal use (random failures), and then an increasing number of failures (end of life). Unique to this is the development of custom screening procedures to eliminate early failures at cold temperatures. The ability to screen out defects will specifically impact reliability at cold temperatures. Cryogenic reliability is limited by electron trap creation in the oxide and defect sites at conductor interfaces. Non-uniform conduction processes due to process marginalities will be magnified at cryogenic temperatures. Carrier mobilities change by orders of magnitude at cryogenic temperatures, significantly enhancing the effects of electric field. Marginal contacts, impurities in oxides, and defects in conductor/conductor interfaces can all be magnified at low temperatures. The novelty is the use of an ultra-low temperature, short-duration quenching process for defect screening. The quenching process is designed to identify those defects that will precisely (and negatively) affect long-term, cryogenic part operation. This quenching process occurs at a temperature that is at least 25 C colder than the coldest expected operating temperature. This quenching process is the opposite of the standard burn-in procedure. Normal burn-in raises the temperature (and voltage) to activate quickly any possible manufacturing defects remaining in the device that were not already rejected at a functional test step. The proposed inverse burn-in or quenching process is custom-tailored to the electronic device being used. The doping profiles, materials, minimum dimensions, interfaces, and thermal expansion coefficients are all taken into account in determining the ramp rate, dwell time, and temperature.

Sheldon, Douglas J.↗

NASA NTRS2017

Screening and Management of Asymptomatic Renal Stones in Astronauts

Management guidelines were created to screen and manage asymptomatic renal stones in U.S. astronauts. The true risk for renal stone formation in astronauts due to the space flight environment is unknown. Proper management of this condition is crucial to mitigate health and mission risks. The NASA Flight Medicine Clinic electronic medical record and the Lifetime Surveillance of Astronaut Health databases were reviewed. An extensive review of the literature and current aeromedical standards for the monitoring and management of renal stones was also done. This work was used to develop a screening and management protocol for renal stones in astronauts that is relevant to the spaceflight operational environment. In the proposed guidelines all astronauts receive a yearly screening and post-flight renal ultrasound using a novel ultrasound protocol. The ultrasound protocol uses a combination of factors, including: size, position, shadow, twinkle and dispersion properties to confirm the presence of a renal calcification. For mission-assigned astronauts, any positive ultrasound study is followed by a low-dose renal computed tomography scan and urologic consult. Other specific guidelines were also created. A small asymptomatic renal stone within the renal collecting system may become symptomatic at any time, and therefore affect launch and flight schedules, or cause incapacitation during a mission. Astronauts in need of definitive care can be evacuated from the International Space Station, but for deep space missions evacuation is impossible. The new screening and management algorithm has been implemented and the initial round of screening ultrasounds is under way. Data from these exams will better define the incidence of renal stones in U.S. astronauts, and will be used to inform risk mitigation for both short and long duration spaceflights.

Reyes, David↗

NASA NTRS2017

Screening and Management of Asymptomatic Renal Stones in Astronauts

Reyes, David↗