Site A2 PNNL Surface Met Station / Raw Data
This dataset contains low-speed weather information and high-speed sonic anemometer data from AWAKEN Site A2.
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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Site A2 PNNL Surface Met Station / Reviewed Data
This dataset contains low-speed weather information and high-speed sonic anemometer data at the AWAKEN Site A2.
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Site A4 PNNL Surface Met Station / Raw Data
Low-speed weather information and high-speed sonic anemometer data at AWAKEN Site A4
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Site A4 PNNL Surface Met Station / Reviewed Data
Low-speed weather information and high-speed sonic anemometer data at AWAKEN Site A4
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Site A5 PNNL Surface Met Station / Raw Data
Low-speed weather information and high-speed sonic anemometer data at AWAKEN Site A5
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Site A5 PNNL Surface Met Station / Reviewed Data
This dataset contains low-speed weather information and high-speed sonic anemometer data from AWAKEN Site A5.
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Site A7 PNNL Surface Met Station / Raw Data
Low-speed weather information and high-speed sonic anemometer data at AWAKEN Site A7.
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Site A7 PNNL Surface Met Station / Reviewed Data
This dataset contains low-speed weather information and high-speed sonic anemometer data from AWAKEN Site A7.
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Site B PNNL Surface Met Station / Raw Data
Low-speed weather information and high-speed sonic anemometer data at AWAKEN Site B
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Site B PNNL Surface Met Station / Reviewed Data
This dataset contains low-speed weather information and high-speed sonic anemometer data from AWAKEN Site B.
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Site C1 PNNL Surface Met Station / Raw Data
Low-speed weather information and high-speed sonic anemometer data at American WAKE experimeNt (AWAKEN) Site C1
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Site C1 PNNL Surface Met Station / Reviewed Data
Low-speed weather information and high-speed sonic anemometer data at American WAKE experimeNt (AWAKEN) Site C1.
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AWAKEN Site G PNNL Surface Met Station / Raw Data
This dataset contains low-speed weather information and high-speed sonic anemometer data from AWAKEN Site G.
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Site G PNNL Surface Met Station / Reviewed Data
This dataset contains low-speed weather information and high-speed sonic anemometer data from AWAKEN Site G.
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AWAKEN Site A1 - PNNL Surface Met Station / Raw Data
This dataset contains low-speed weather information and anemometer data from AWAKEN Site A1.
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AWAKEN Site H - PNNL Surface Met Station / Raw Data
This dataset contains low-speed weather information and anemometer data from AWAKEN Site H.
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MVCO site - UTD Surface Met / Raw Data
This dataset contains raw data from the WFIP3 MVCO site UTD sonic anemometer.
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Impaired cardiac glycolysis and glycogen depletion are linked to poor myocardial outcomes in juvenile male swine with metabolic syndrome and ischemia
Abstract Obesity continues to rise in the juveniles and obese children are more likely to develop metabolic syndrome (MetS) and related cardiovascular disease. Unfortunately, effective prevention and long‐term treatment options remain limited. We determined the juvenile cardiac response to MetS in a swine model. Juvenile male swine were fed either an obesogenic diet, to induce MetS, or a lean diet, as a control (LD). Myocardial ischemia was induced with surgically placed ameroid constrictor on the left circumflex artery. Physiological data were recorded and at 22 weeks of age the animals underwent a terminal harvest procedure and myocardial tissue was extracted for total metabolic and proteomic LC/MS–MS, RNA‐seq analysis, and data underwent nonnegative matrix factorization for metabolic signatures. Significantly altered in MetS versus. LD were the glycolysis‐related metabolites and enzymes. In MetS compared with LD Glycogen synthase 1 (GYS1)‐glycogen phosphorylases (PYGM/PYGL) expression disbalance resulted in a loss of myocardial glycogen. Our findings are consistent with the concept that transcriptionally driven myocardial changes in glycogen and glucose metabolism‐related enzymes lead to a deficiency of their metabolite products in MetS. This abnormal energy metabolism provides insight into the pathogenesis of the juvenile heart in MetS. This study reveals that MetS and ischemia diminishes ATP availability in the myocardium via altering the glucose‐G6P‐pyruvate axis at the level of metabolites and gene expression of related enzymes. The observed severe glycogen depletion in MetS coincides with disbalance in expression of GYS1 and both PYGM and PYGL. This altered energy substrate metabolism is a potential target of pharmacological agents for improving juvenile myocardial function in MetS and ischemia.
Broadwin, Mark↗