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All sourcesNASA NTRSDOE OSTI
NASA NTRS2019

Maturation of Dynamic Power Convertors for Radioisotope Power Systems

Dynamic Radioisotope Power Systems (DRPS) are being developed by NASA’s Radioisotope Power Systems (RPS) Program in collaboration with the U.S. Department of Energy (DOE) for space science and exploration missions. A development effort is currently underway to mature dynamic power convertors for infusion into a potential future flight generator. This convertor maturation effort was formulated by the RPS Program at NASA Headquarters based on successful maturation models and utilizes expertise from agency’s technology and mission centers to support requirements development and technology assessments. The effort is being executed by Glenn Research Center’s (GRC) DRPS Project and the Thermal Energy Conversion Branch. The Dynamic Power Convertor (DPC) contracts consist of three phases to enable design, fabrication, and independent assessment of prototypes after delivery to the government. The contracts are intended to gather data on candidate dynamic conversion technologies to fill knowledge gaps, support assessments of dynamic conversion technologies, and elicit generator requirements. The 110-watt Stirling Radioisotope Generator (SRG-110) and Advanced Stirling Radioisotope Generator (ASRG) flight development projects provided Stirling convertor demonstration units and engineering models to verify and validate convertors against performance specifications and mission requirements. These units utilize temperature resistant materials and non-contacting bearings to demonstrate wear-free, long-life operation. This maturation effort builds on past lessons-learned and new requirements focused on demonstrating convertor robustness to critical environments meant to stress key aspects of each convertor within the margins of the design. This effort seeks to realize the full potential of dynamic power conversion technologies for NASA’s space science and exploration missions.

Wilson, Scott↗
NASA NTRS2019

Maturation of Dynamic Power Convertors for Radioisotope Power Systems

Dynamic Radioisotope Power Systems (DRPS) are being developed by NASA's RPS Program in collaboration with the U.S. Department of Energy (DOE) for space science and exploration missions. A development effort is currently underway to mature dynamic power convertors for infusion into a potential future flight generator. This convertor maturation effort was formulated by the RPS Program at NASA Headquarters based on successful maturation models and utilizes expertise from agency technology and mission centers to support requirements development and technology assessments. The effort is being executed by Glenn Research Center's Dynamic Radioisotope Power Systems (DRPS) project and the Thermal Energy Conversion Branch. The Dynamic Power Convertor (DPC) contracts consist of three phases to enable design, fabrication, and independent assessment after delivery to the government. The contracts are intended to gather data on candidate dynamic conversion technologies to fill knowledge gaps, support assessments of dynamic conversion technologies, and elicit generator requirements. The SRG-110 (Stirling Radioisotope Generator) and ASRG (Advanced Stirling Radioisotope Generator) flight development projects provided Stirling convertor demonstration units and engineering models to verify and validate convertors against performance specifications and mission requirements. These units utilize temperature resistance materials and non-contacting bearings to demonstrate wear-free, long-life operation. This maturation effort builds on past lessons learned and new requirements focused on demonstrating convertor robustness to critical environments meant to stress key aspects of each convertor within the margins of the design. This effort seeks to realize the full potential of dynamic power conversion technologies for NASA's space science and exploration missions.

Wilson, Scott↗
DOE OSTI2022

[FeFe]-Hydrogenase In Vitro Maturation

The [FeFe]-hydrogenase H-cluster is a complex organometallic cofactor whose assembly and installation requires three dedicated accessory proteins referred to as HydE, HydF, and HydG. The roles of these maturases and the precise mechanisms by which they synthesize and insert the H-cluster are not fully understood. This Minireview will focus on new insights into the [FeFe]-hydrogenase maturation process that have been provided by in vitro approaches in which the biosynthetic pathway has been partially or fully reconstructed using semisynthetic and enzyme-based approaches. Specifically, the application of these in vitro, semisynthetic, and fully defined approaches has shed light on the roles of individual maturation enzymes, the nature of H-cluster assembly intermediates, the molecular precursors of H-cluster ligands, and the sequence of steps involved in [FeFe]-hydrogenase maturation.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2024

Characterization of two affinity matured Anti-Yersinia pestis F1 human antibodies with medical countermeasure potential

Yersinia pestis , the causative agent of plague and a biological threat agent, presents an urgent need for novel medical countermeasures due to documented cases of naturally acquired antibiotic resistance and potential person-to-person spread during a pneumonic infection. Immunotherapy has been proposed as a way to circumvent current and future antibiotic resistance. Here, we describe the development and characterization of two affinity matured human antibodies (αF1Ig AM2 and αF1Ig AM8) that promote survival of mice after exposure to aerosolized Y . pestis . We share details of the error prone PCR and yeast display technology-based affinity maturation process that we used. The resultant matured antibodies have nanomolar affinity for Y . pestis F1 antigen, are produced in high yield, and are resilient to 37°C stress for up to 6 months. Importantly, in vitro assays using a murine macrophage cell line demonstrated that αF1Ig AM2 and αF1Ig AM8 are opsonic. Even more importantly, in vivo studies using pneumonic plague mouse models showed that 100% of the mice receiving 500 μg of IgGs αF1Ig AM2 and αF1Ig AM8 survived lethal challenge with aerosolized Y . pestis CO92. Combined, these results provide evidence of the quality and robustness of αF1Ig AM2 and αF1Ig AM8 and support their development as potential medical countermeasures against plague.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

Chlorophyll fluorescence is a potential indicator to measure photochemical efficiency in early to late soybean maturity groups under changing day lengths and temperatures

In this study, we employed chlorophyll a fluorescence technique, to indicate plant health and status in response to changing day lengths (photoperiods) and temperatures in soybean early and late maturity groups. Chlorophyll a fluorescence study indicates changes in light reactions in photosystem II. Experiments were performed for 3-day lengths (12.5, 13.5, and 14.5 h) and five temperatures (22/14°C, 26/18°C, 30/22°C, 34/26°C, and 40/32°C), respectively. The I-P phase declined for changing day lengths. Active reaction centers decreased at long day length for maturity group III. We observed that low temperatures impacted the acceptor side of photosystem II and partially impacted electron transport toward the photosystem I end electron acceptor. Results emphasized that higher temperatures (40/32°C) triggered damage at the oxygen-evolving complex and decreased electron transport and photosynthesis. We studied specific leaf areas and aboveground mass. Aboveground parameters were consistent with the fluorescence study. Chlorophyll a fluorescence can be used as a potential technique for high-throughput phenotyping methods. The traits selected in the study proved to be possible indicators to provide information on the health status of various maturity groups under changing temperatures and day lengths. These traits can also be deciding criteria for breeding programs to develop inbreed soybean lines for stress tolerance and sensitivity based on latitudinal variations.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

Synchrotron Microanalytical Characterization and K/Ar Dating of the GL-O-1 Glauconite Reference Material at the Single Pellet Scale and Reassessment of the Age of Visually Mature Pellets

The K/Ar chronology of glauconite pellets is a long-used method for directly dating marine sedimentary deposits. Many papers have explored the processes that form glauconite and the factors that lead to greater reliability in the ages. Although K/Ar ages of glauconite are generally in agreement with other measures of stratigraphic age, there are examples of occurrences with ages too old and examples with ages too young. This paper seeks to build on the accumulated knowledge of glauconite, using synchrotron radiation to non-destructively characterize individual pellets and then consecutively measure the argon and potassium to obtain a K/Ar age. This strategy provides the advantage of measurements on a single aliquot while avoiding recoil loss of 40 Ar in the nuclear reactor during irradiation for 40 Ar/ 39 Ar dating. We have used the glauconite reference material GL-O-1 to showcase several non-destructive methods for evaluating the maturity of individual pellets. In our argon measurements, we have found that the radiogenic argon concentration of large bulk samples underestimates the values for individual visually mature pellets, and we determined a K/Ar age of 101.0 ± 0.3 Ma (1σ SEM), M.S.W.D. 0.54 from 15 of 16 visually mature individual pellets. This age is 6% older than the reference value of 95.03 ± 1.11 Ma (1σ), and it is in good agreement with constraints from the U-Pb dating of volcanic minerals near the Albian–Cenomanian boundary.

36 MATERIALS SCIENCE↗
NASA NTRSDate not supplied

Tailoring Early Concept Maturity Levels for Small Satellite Missions

The Concept Maturity Level (CML) framework has gained widespread acceptance as a process to assess mission concept maturity, particularly for early mission concepts in the formulation phase. Popularized by the Jet Propulsion Laboratory almost 15 years ago to evaluate large NASA science mission concepts, the CML method offers wide-ranging programmatic and technical evaluation criteria to assess and measure the progress of mission concepts at all stages of maturity. It also provides a useful tool to facilitate stakeholder relationships through effective engagement, interaction, and communication. The CML approach is modeled largely after the widespread Technology Readiness Level (TRL) scale, a measure of how new technology progresses from early concept through to being operational at the mission flight system level. Tailoring the CML framework for small satellites allows for more relevant technical and programmatic evaluations for these missions. Given the diversity of small satellite mission objectives, cost constraints, complexity, and risk tolerance, this modified CML framework enables study teams and stakeholders to determine the appropriate CML fidelity to implement based upon the opportunity and strategic investment approach. A decision process flow method is proposed to guide teams through the logic of determining what CML fidelity to implement in evaluating small satellite mission concepts. The goal is to provide enhanced stakeholder engagement such that CML assessments are clearly articulated and understood early in the design study. This would allow for more appropriate application of CML methodology by study teams developing University led missions, technology demonstrations, commercial constellations, and more complex planetary science missions.

Concept Maturity Level↗
NASA NTRSDate not supplied

NASA Technology Maturation Plan for In-space Manufacturing of Metals

As the International Space Station’s (ISS) life approaches its end, NASA intends to travel back to the Moon and establish a sustainable presence, paving a pathway towards Mars. A fundamental shift in the current logistics strategy is required to support extended missions. On-demand manufacturing enables reduced operational cost and increased long term sustainability providing a pathway towards reducing NASA’s logistics burden. The In-Space Manufacturing (ISM) portfolio at Marshall Space Flight Center is developing additive polymers, metals, and electronics manufacturing technologies to enable a sustainable presence on the Moon and enable long-duration transit missions. Manufacturing systems for in-space applications must meet a unique set of constraints requiring a maturation path independent from processes targeted for terrestrial use. In May 2023, the On Demand Manufacturing of Metals (ODMM) project, part of the ISM portfolio funded through the Game Changing Development (GCD) program office, was canceled; however, prior to cancelation, the engineering team developed a technology maturation plan for in-space manufacturing of metallic components. The status of ODMM at closeout and an overview of the technology maturation plan for ODMM are discussed.

In Space Manufacturing↗
NASA NTRS2026

Integrated Computational Materials Engineering (ICME) Capability Maturity Levels for Ecosystems Enabling Digital Transformation

Digital engineering (DE) and integrated computational materials engineering (ICME) are widely recognized as critical enablers of faster, more affordable, and more reliable aerospace systems. However, many organizations have struggled to realize the promised return on investment (ROI) from digital initiatives. A primary reason is the absence of a shared, decision-focused framework that distinguishes simple digitization of existing workflows from true digital transformation that fundamentally changes how engineering decisions are made. This paper introduces an ICME capability maturity framework that fills this gap. The framework defines six cumulative ICME capability maturity levels (CMLs), explicitly tied to decision authority, engineering integration, optimization, and uncertainty management across material, process, structure, and performance scales. It is designed to complement established readiness metrics such as technology readiness levels (TRLs), manufacturing readiness levels (MRLs), and integration readiness levels (IRLs), by addressing a missing dimension: the conditions required for model-informed decision authority across scales. A unifying figure and capability table illustrate the six-level ICME Capability Maturity Framework, showing how organizations progress from digitization—with limited or negative ROI—to true digital transformation, where ICME-enabled workflows deliver measurable improvements in decision quality, cycle time, risk reduction, and reuse. The framework is intended for both technical practitioners and executive leadership, providing a common language to assess current state, guide roadmaps, align software ecosystem investments, and set realistic expectations for digital transformation outcomes. A regulatory-relevant statement clarifying the relationship between ICME capability and existing certification frameworks is provided.

ICME↗
DOE OSTI2022

[FeFe]‐Hydrogenase In Vitro Maturation

Abstract The [FeFe]‐hydrogenase H‐cluster is a complex organometallic cofactor whose assembly and installation requires three dedicated accessory proteins referred to as HydE, HydF, and HydG. The roles of these maturases and the precise mechanisms by which they synthesize and insert the H‐cluster are not fully understood. This Minireview will focus on new insights into the [FeFe]‐hydrogenase maturation process that have been provided by in vitro approaches in which the biosynthetic pathway has been partially or fully reconstructed using semisynthetic and enzyme‐based approaches. Specifically, the application of these in vitro, semisynthetic, and fully defined approaches has shed light on the roles of individual maturation enzymes, the nature of H‐cluster assembly intermediates, the molecular precursors of H‐cluster ligands, and the sequence of steps involved in [FeFe]‐hydrogenase maturation.

Pagnier, Adrien↗
DOE OSTI2025

Timing based clustering of childhood BMI trajectories reveals differential maturational patterns; Study in the Northern Finland Birth Cohorts 1966 and 1986

Children’s biological age does not always correspond to their chronological age. In the case of BMI trajectories, this can appear as phase variation, which can be seen as shift, stretch, or shrinking between trajectories. With maturation thought of as a process moving towards the final state - adult BMI, we assessed whether children can be divided into latent groups reflecting similar maturational age of BMI. The groups were characterised by early factors and time-related features of the trajectories. We used data from two general population birth cohort studies, Northern Finland Birth Cohorts 1966 and 1986 (NFBC1966 and NFBC1986). Height (n = 6329) and weight (n = 6568) measurements were interpolated in 34 shared time points using B-splines, and BMI values were calculated between 3 months to 16 years. Pairwise phase distances of 2999 females and 3163 males were used as a similarity measure in k-medoids clustering. We identified three clusters of trajectories in females and males (Type 1: females, n = 1566, males, n = 1669; Type 2: females, n = 1028, males, n = 973; Type 3: females, n = 405, males, n = 521). Similar distinct timing patterns were identified in males and females. The clusters did not differ by sex, or early growth determinants studied. Trajectory cluster Type 1 reflected to the shape of what is typically illustrated as the childhood BMI trajectory in literature. However, the other two have not been identified previously. Type 2 pattern was more common in the NFBC1966 suggesting a generational shift in BMI maturational patterns.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2023

The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells

The intracellular cholesterol transporter NPC1 functions in late endosomes and lysosomes to efflux unesterified cholesterol, and its deficiency causes Niemann–Pick disease Type C, an autosomal recessive lysosomal disorder characterized by progressive neurodegeneration and early death. Here, we use single-nucleus RNA-seq on the forebrain of Npc1 –/– mice at P16 to identify cell types and pathways affected early in pathogenesis. Our analysis uncovers significant transcriptional changes in the oligodendrocyte lineage during developmental myelination, accompanied by diminished maturation of myelinating oligodendrocytes. We identify upregulation of genes associated with neurogenesis and synapse formation in Npc1 –/– oligodendrocyte lineage cells, reflecting diminished gene silencing by H3K27me3. Npc1 –/ – oligodendrocyte progenitor cells reproduce impaired maturation in vitro, and this phenotype is rescued by treatment with GSK-J4, a small molecule inhibitor of H3K27 demethylases. Moreover, mobilizing stored cholesterol in Npc1 –/– mice by a single administration of 2-hydroxypropyl-β-cyclodextrin at P7 rescues myelination, epigenetic marks, and oligodendrocyte gene expression. Our findings highlight an important role for NPC1 in oligodendrocyte lineage maturation and epigenetic regulation, and identify potential targets for therapeutic intervention.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

AmeriFlux FLUXNET-1F US-HB2 Hobcaw Barony Mature Longleaf Pine

This is the AmeriFlux Management Project (AMP) created FLUXNET-1F version of the carbon flux data for the site US-HB2 Hobcaw Barony Mature Longleaf Pine. This is the FLUXNET version of the carbon flux data for the site US-HB2 Hobcaw Barony Mature Longleaf Pine produced by applying the standard ONEFlux (1F) software. Site Description - A mature longleaf pine forest that is periodically managed with fire

Forsythe, Jeremy D.↗
DOE OSTI2023

AmeriFlux FLUXNET-1F US-Wi4 Mature red pine (MRP)

This is the AmeriFlux Management Project (AMP) created FLUXNET-1F version of the carbon flux data for the site US-Wi4 Mature red pine (MRP). This is the FLUXNET version of the carbon flux data for the site US-Wi4 Mature red pine (MRP) produced by applying the standard ONEFlux (1F) software. Site Description - The Wisconsin Mature Red Pine site is located in the Washburn Ranger District of the northeastern section of Chequamegon National Forest. A member of the northern coniferous-deciduous biome, surveys from the mid-19th century indicate the region consisted of a mixed stand of red, white, and jack pines. After extensive timber harvesting, wildfires, and farming activity, the region turned into a fragmented mosaic of stands of various ages and composition. As an assemblage, the ten Wisconsin sites are indicative of the successional stages of development in the predominant stand types of a physically homogeneous landscape. Thinned every 7 years until they reach 100 to 150 years of age, the red pine plantations of all ages occupy approximately 25% of the region.

Chen, Jiquan↗
DOE OSTI2025

Maturing Rational Design Methodologies and Industry Consensus Engineering Standards: Critical Fastened Joints - Solar PV Industry

Critical structural joints can be seen throughout a solar array and are called upon to secure modules and keep racking assembled and able to resist large demands from winds and snow loads. In the relatively new and fast-growing solar PV industry, the important role these hardware assemblies (e.g. clips, clamps, bolts, nuts, washers) play is not well understood by product designers. Failures with critical structural joints are surprisingly common and point to the need for maturing the engineering and assembly of these joints. The wide variety of design concepts (Figure 2&2) demonstrate interesting and innovative ideas but are lacking the basics of fastener engineering seen in matured industries (e.g. transportation, buildings). Complicating the maturing process for critical structural joints is that they are one component in rack supporting structures that exhibits a systems behavior; each component will affect the other and play a key role in maintaining structural integrity. When wind loads the surface of a module, the underlying racking members deflect and twist which in turn imparts forces back into the joints and into the mounted modules. Often, these supporting rack structures exhibit high deflections and low natural frequencies which amplify the demands placed into the joints even in moderate winds. Current engineering practices and associated structural conventions view solar racking support structures as they would a high mass building that exhibit more static behaviors in wind events. Solar structures are unique from high mass buildings and require the development of solar specific industry engineering consensus standards.

14 SOLAR ENERGY↗
DOE OSTI2023

User Guide to the Facility Cybersecurity Capability Maturity Model (F-C2M2) Assessment

The Facility Cybersecurity Capability Maturity Model (F-C2M2) assessment was designed to help facilities address their unique cybersecurity challenges. Building upon the foundational principles of the U.S. Department of Energy (DOE) Cybersecurity Capability Maturity Model (C2M2), the F-C2M2 was explicitly tailored for federal facilities to help evaluate, benchmark, and enhance the cybersecurity capabilities of both their information technology (IT) and operational technology (OT) environments. This user guide was developed to facilitate a thorough understanding of the tool. Whether users are familiar with the original C2M2 or are new to the maturity model concept, this guide was designed to offer clarity, direction, and support.

97 MATHEMATICS AND COMPUTING↗
NASA NTRS1975

Specific surface area as a maturity index of lunar fines

Mature surface fines have an equilibrium specific surface area of about 0.6 sq m/g the equivalent mean particle size being about 3 microns. The adsorption behavior of inert gases (reversible isotherms) indicates that the particles are also nonporous in the size range of pores from 10 to 3000 A. Apparently, in mature soils there is a balance in the forces which cause fining, attrition, pore filling, and growth of lunar dust grains. Immature, lightly irradiated soils usually have coarser grains which reduce in size as aging proceeds. The specific surface area, determined by nitrogen or krypton sorption at 77 K, is a valuable index of soil maturity.

Gammage, R. B.↗
NASA NTRS1977

Effects of soil maturation on grain size-dependence of trapped solar gases

A description is presented of a simple two-part model which relates the retention of solar-wind-implanted noble gases and N in different grain sizes of lunar soils to the maturation level of that soil. It is assumed that concentrations of solar-wind gases are implanted into surfaces of soil grains in inverse proportion to grain diameter and that differences in irradiation probability and surface saturation as a function of grain diameter generally are not a major factor. The model demonstrates that incorporation of a major fraction of this surface-correlated gas into constructional particles such as agglutinates causes much of the gas to become volume-correlated in mature soils. This volume-correlated gas produces a relative enrichment in gas concentrations in coarser grains and a selective enrichment of more retentive gases (e.g., N) over less retentive gases (e.g., He). It is shown that the maturity model plays a major role in determining the complexities of the distribution of solar-wind gases in soils.

Bogard, D. D.↗