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PERCEPTIVE: an R shiny $\underline{p}$ipelin$\underline{e}$ for the p$\underline{r}$edi$\underline{c}$tion of $\underline{ep}$igenetic modula$\underline{t}$ors $\underline{i}$n no$\underline{v}$el sp$\underline{e}$cies

Epigenetic processes are central to regulating gene expression, genome stability, and metabolic function across the tree of life; yet, their roles remain underexplored in microalgae, especially as new species continue to be identified and characterized. This is likely due to the cumbersome nature and species-dependent attributes of epigenetic wet-lab methodologies, which preclude the rapid identification of epigenetic modifications and modulators. However, there is high conservation of epigenetic processes from budding yeast to humans; in many cases, one may infer how behavior and function are epigenetically regulated in novel species by identifying epigenetic modulators, or the proteins responsible for conferring epigenetic modifications. Here, to this end, we have developed a graphical software package, titled PERCEPTIVE (pipeline for the prediction of epigenetic modulators in novel species). This platform solely uses the genomic sequence of an algal species, and preexisting information from other model organisms, to predict the epigenetic modulators and associated modifications in algae. Predictions are presented to the user in a graphical interface, which provides literature-based interpretation of results, enabling users to quickly understand potential epigenetic processes in their algal species of interest and plan follow-up experiments. To test PERCEPTIVE, we predicted epigenetic modulators in several feedstock candidate algae species. To validate these predictions, wet-lab studies were performed, including mass spectrometry; these results underscore the high accuracy of PERCEPTIVE predictions. Overall, PERCEPTIVE represents a powerful in silico tool for the research and manipulation of algal species, which does not require a priori knowledge of epigenetics and is accessible to a broad set of investigators.

59 BASIC BIOLOGICAL SCIENCES

A Behavior Tree Approach for Battery-Aware Inspection of Large Structures Using Drones

Electric multi-rotor drones have been used to inspect several structures, including large buildings and dams. In these inspections, energy consumption is a concern. To prevent the drone from running out of battery, commercial drones usually come back to their home position when the battery level reaches a minimum threshold. The pilots then need to replace the battery and use their own experience to restart the inspection mission approximately from where it ended before the drone returned home. Instead of relying on the human operator, in this paper, we automate this process using behavior trees, which is an effective way to perform autonomous mission control and supervision. By integrating battery management strategies into a behavior tree framework, this paper demonstrates the drone’s adaptive and resilient decision-making when confronted with limited power constraints. We implemented our methodology using a commercial drone and tested the proposed ideas in a photogrammetry-based inspection task.

42 ENGINEERING

HumoNet: A Framework for Realistic Modeling and Simulation of Human Mobility Network

Understanding, analyzing, and predicting human mobility and dynamics are valuable to solving pressing problems, developing effective plans, and prescribing timely remedies. As a computational approach, realistic human mobility simulations allow us to understand, analyze, and predict complex systems, including human societies. Accurate simulations rely on (1) the model that captures interactions and behaviors of myriad entities in our society and (2) the mapping of model instances to real-world entities. Taking this into account, this paper introduces the Human Mobility Network simulation framework (HumoNet), an integrated patterns of life (POL) simulation framework that leverages real-world data layers including transportation networks, points of interest, populations, popularity, and human trajectories. HumoNet is a data informed model in which agents are equipped with activities, locomotion, and planning capabilities. To simulate realistic kinematic maneuvers of individuals in transportation networks, HumoNet harnesses a microscopic traffic simulator that provides interaction among vehicles and traffic objects. In this paper, we describe the framework, outline our methodologies, and discuss the data processing and challenges of each data layer. Through experiments, we demonstrate that our simulations capture key features of human mobility by comparing them to the literature and real data using standard measures of human mobility (i.e., the radius of gyration, number of locations visited, level of exploration) and metrics scoring (i.e., Jensen-Shannon divergence). We envision that the synthetic data produced by HumoNet will serve as a benchmark for analyzing epidemics, deploying EV charging networks, and validating AI/ML tasks such as location prediction.

Kim, Joon-Seok

2022 Bull E-Bike Pilot Program Study

In 2022, the City of Durham conducted an e-bike pilot program study to learn more about how electric bikes (e-bikes) could improve the transportation experience in the "Bull City" (a.k.a., Durham, North Carolina). The study used pedal-assist e-bikes, which feature an electric motor and battery to help power the bike. The motor amplifies the power behind each pedal stroke, augmenting the energy you put into the bike. #### Data Collection Agency The City of Durham's Transportation Department conducted the study. #### Survey Methodology Program participants used electric-assist e-bikes for at least 4 weeks between August and November 2022 in exchange for sharing information about their experiences, including tracking their travel via a smartphone app. In addition to the e-bike, participants received maintenance support along with a helmet, bike lock, and other accessories. Data collection was enabled by the [NLR OpenPATH platform](https://www.nlr.gov/transportation/openpath.html). #### Survey Records and Data Survey records include a total of 76 participants. The dataset contains 3 months of partially automated travel diaries, combining sensed and surveyed travel behavior data—patterns of multimodal, end-to-end, individual human mobility—as well as demographic and socioeconomic information from participants. The number of total trips was 6,488, the number of e-bike trips was 2,183, and the number of e-bike miles traveled was 5,450.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI

2021–2022 Can Do Colorado E-Bike Full-Scale Pilot Program Study

In 2021–2022, the Colorado Energy Office conducted a full-scale pilot program study on e-bike usage as part of the Can Do Colorado initiative, providing e-bikes to low-income participants across the state. A [2020 mini pilot program study](https://www.nlr.gov/transportation/secure-transportation-data/tsdc-2020-can-do-colorado-e-bike-pilot-program.html) informed the full-scale study. Both studies used pedal-assist e-bikes, which feature an electric motor and battery to help power the bike. The motor amplifies the power behind each pedal stroke, augmenting the energy you put into the bike. #### Data Collection Agency The Colorado Energy Office conducted the study in partnership with local organizations in Adams and Broomfield counties (Smart Commute Metro North), Boulder (Community Cycles), Durango (Four Corners Office for Resource Efficiency), Fort Collins (City of Fort Collins), Pueblo (Pueblo County), and Vail (Town of Vail). #### Survey Methodology Program participants received an e-bike and accessories at no cost and manually submitted travel data and feedback via the CanBikeCO smartphone app. Developed in partnership with NLR, the app used a customized version of the open-source [NLR OpenPATH platform](https://www.nlr.gov/transportation/openpath.html). #### Survey Records and Data Survey records include 170 participants. The six datasets contain up to 18 months of partially automated travel diaries, combining sensed and surveyed travel behavior data—patterns of multimodal, end-to-end, individual human mobility—as well as demographic information from participants. The number of e-bike trips and e-bike miles traveled per location are 1,560 and 4,179 for Adams and Broomfield counties; 8,481 and 27,000 for Boulder; 2,815 and 6,307 for Durango; 3,483 and 7,080 for Fort Collins; 4,022 and 14,887 for Pueblo, and 1,206 and 3,3361 for Vail.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI

Adoption of AI in the Utility T&D Sector: Use Cases, Consequence, Assessment and Benefits

Digital transformation and utilization of artificial intelligence (AI) in the electric grid are fundamentally changing the industry’s approach to common problems and enabling a broader paradigm shift in grid planning and operations. The change in approach is circularly both enabling and driving modernization, with load growth and reliable management of data center and AI infrastructure shifting away from planning approaches with relatively predictable behaviors and toward a mix of consumer and industrial choices that surpass human cognitive abilities to process. This movement has potential to condition humans to not understand the system on which the AI depends, while requiring it for development of the necessary infrastructure. Approaches which would address most likely grid conditions and events, such as faults, aging of equipment, and weather, now must also account for large loads which shift not based upon weather or time of day, but the computational load. Quantifying computational load is independent of the traditional grid forecasting variables, where a data center’s aggregate load is determined by user and AI system behavior and decoupled from normal grid planning and operations. AI is both the cause and solution for these challenges, with new grid planning tools integrating massive amounts of decisions into frameworks.

24 POWER TRANSMISSION AND DISTRIBUTION

Machine Learning Classification Strategy to Improve Streamflow Estimates in Diverse River Basins in the Colorado River Basin

Streamflow in the Colorado River Basin (CRB) is significantly altered by human activities including land use/cover alterations, reservoir operation, irrigation, and water exports. Climate is also highly varied across the CRB which contains snowpack-dominated watersheds and arid, precipitation-dominated basins. Recently, machine learning methods have improved the generalizability and accuracy of streamflow models. Previous successes with LSTM modeling have primarily focused on unimpacted basins, and few studies have included human impacted systems in either regional or single-basin modeling. We demonstrate that the diverse hydrological behavior of river basins in the CRB are too difficult to model with a single, regional model. We propose a method to delineate catchments into categories based on the level of predictability, hydrological characteristics, and the level of human influence. Lastly, we model streamflow in each category with climate and anthropogenic proxy data sets and use feature importance methods to assess whether model performance improves with additional relevant data. Overall, land use cover data at a low temporal resolution was not sufficient to capture the irregular patterns of reservoir releases, demonstrating the importance of having high-resolution reservoir release data sets at a global scale. On the other hand, the classification approach reduced the complexity of the data and has the potential to improve streamflow forecasts in human-altered regions.

54 ENVIRONMENTAL SCIENCES

Autonomous Operations for Advanced Reactors Utilizing Supervisory Control

Automation is a critical tenet of reactor plant operations as reliance on nuclear energy increases. Nuclear power plants require a large workforce which does not scale with output; that is, the cost per megawatt increases as reactor output becomes smaller. The economic viability of advanced reactors, particularly small modular reactors (SMRs) and microreactors, requires a significantly reduced onsite workforce. The logical solution is establishing a systematic process of elimination of reliance on human operators, and to the extent possible, replacing these actions with automated functions. In this paper, we propose a method for such transformation to establish a robust technical basis to enable transition to autonomy. Our method is based on finite state automata (FSA)—also known as finite state machines (FSMs). Relying on this method allows us to exploit the rich set of mathematical proofs available in the field of regular languages. FSA are one of the mathematical tools to model discrete event systems (DES). These properties are applied to produce an automated startup controller for the Massachusetts Institute of Technology Research Reactor (MITR). The startup procedure is captured in terms of discrete changes from one state to another while an independent supervisory control system directs the sequence of states and alerts a human in the event of an abnormal operation. First, the design and behavior of the MITR rod control system were modeled in Simulink. Then, the startup procedure was applied to the rod control system and the DES performed a startup by procedurally withdrawing rods to the subcritical position. The simulation also stops rod motion in response to an uncontrollable event and restarts rod motion once the event has been cleared.

46 - INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AN

Deer Vigilance and Movement Behavior Are Affected by Edge Density and Connectivity

ABSTRACT Animal behavior is an important component of individual, population, and community responses to anthropogenic habitat alteration. For example, antipredator behavior (e.g., vigilance) and animal movement behavior may both be important behavioral responses to the increased density of habitat edges and changes in patch connectivity that characterize highly modified habitats. Importantly, edge density and connectivity might interact, and this interaction is likely to mediate animal behavior: linear, edge‐rich landscape features often provide structural connectivity between patches, but the functional connectedness of patches for animal use could depend upon how edge density modifies animal vigilance and movement. Using remote cameras in large‐scale experimental landscapes that manipulate edge density (high‐ vs. low‐density edges) and patch connectivity (isolated or connected patches), we examined the effects of edge density and connectivity on the antipredator behavior and movement behavior of white‐tailed deer ( Odocoileus virginianus ). Deer vigilance was 1.38 times greater near high‐density edges compared to low‐density edges, regardless of whether patches were connected or isolated. Deer were also more likely to move parallel to connected high‐density edges than all other edge types, suggesting that connectivity promotes movement along high‐density edges. These results suggest that increases in edge density that accompany human fragmentation of existing habitats may give rise to large‐scale changes in the antipredator behavior of deer. These results also suggest that conservation strategies that simultaneously manipulate edge density and connectivity (i.e., habitat corridors) may have multiple effects on different aspects of deer behavior: linear habitat corridors were areas of high vigilance, but also areas where deer movement behavior implied increased movement along the habitat edge.

Bartel, Savannah L. [University of Wisconsin‐Madis

Human in vitro metabolism of an environmental mixture of polycyclic aromatic hydrocarbons (PAH) found at the Portland Harbor Superfund Site

Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that pose health risks to humans. Toxicity testing approaches of PAHs have evolved from traditional rodent models to New Approach Methodologies (NAMs), such as high-throughput screening in zebrafish, enabling rapid evaluation of chemical hazards. However, translating toxicity findings from laboratory systems to humans remains difficult due to complexity and species-specific differences. Chemical dosimetry modeling offers a quantitative framework to bridge this gap, but its accuracy depends on robust knowledge of PAH metabolism. The objective of this study was to measure human metabolism rates of Supermix-10, the ten most abundant PAHs found at the Portland Harbor Superfund Site, to support development of human pharmacokinetic models. We incubated individual PAHs from Supermix-10 in pooled human liver microsomes and quantified parent PAH disappearance using high-performance liquid chromatography (HPLC) with UV and florescent detection. To assess the potential of mixture interactions, we also measured metabolism of all 10 compounds in an equimolar mixture and compared rates of parent disappearance to those observed for individual PAHs. All Supermix-10 PAHs demonstrated rapid parent compound disappearance in human hepatic microsomes. PAHs grouped into three metabolism patterns: high metabolism rates and capacity (2-methylnaphthalene, acenaphthylene, fluorene, naphthalene), high affinity metabolism that rapidly achieves low-level saturation (benzo[a]anthracene, chrysene), and moderate metabolism rates and capacity (fluoranthene, pyrene, retene, phenanthrene). Smaller PAHs exhibited faster metabolism, and higher metabolism rates correlated inversely with molecular weight. When incubated in an equimolar mixture, Supermix-10 demonstrated significantly slower metabolism (47–89 %) compared to metabolism of individual PAHs at the same concentration. These findings enhance our understanding of PAH metabolism in humans and demonstrate significant mixture interactions under the conditions tested. Furthermore, our findings offer insights into the metabolic behavior of Supermix-10 and provide critical metabolism rate data to support the development of physiological based pharmacokinetic (PBPK) models. Dosimetry models can translate PAH chemical dosimetry from high-throughput testing platforms, like zebrafish and cellular system assays, to human exposures enhancing the accuracy and reliability of PAH risk assessments.

2-methylnaphthalene

The Kinematics of Proal Chewing in Rats

Chewing kinematics are well-documented in several mammal species with fused mandibular symphyses, but relatively understudied in mammals with an unfused symphysis, despite the fact that more than half of extant Mammalia have an unfused mandibular symphysis. The Wistar brown rat (Rattus norvegicus) is widely used in human health research, including studies of mastication or neurological studies where mastication is the output behavior. These animals are known to have unfused mandibular symphyses and proal jaw (rostrocaudal) motion during occlusion, but the lack of high resolution, 3-dimensional analysis of rat chewing leaves the functional significance of symphyseal mobility unknown. We used biplanar fluoroscopy and the X-ray reconstruction of moving morphology workflow to quantify chewing kinematics in 3 brown rats, quantifying overall jaw kinematics, including motions about the temporomandibular joint and unfused mandibular symphysis. During occlusion, the teeth and the mandibular condyle translate almost exclusively anteriorly (proal) during occlusion, with little motion in any other degrees of freedom. At the symphysis, we observed minimal flexion throughout the chew cycle. Overall, there are fundamental differences in jaw kinematics between rats and other mammals and therefore rats are not an appropriate proxy for ancestral mammal jaw mechanics. Additionally, differences between humans and rat chewing kinematics must be considered when using rats as a clinical model for pathological feeding research.

59 BASIC BIOLOGICAL SCIENCES

Psychosocial experiences are associated with human brain mitochondrial biology

Psychosocial experiences affect brain health and aging trajectories, but the molecular pathways underlying these associations remain unclear. Normal brain function relies on energy transformation by mitochondria oxidative phosphorylation (OxPhos). Two main lines of evidence position mitochondria both as targets and drivers of psychosocial experiences. On the one hand, chronic stress exposure and mood states may alter multiple aspects of mitochondrial biology; on the other hand, functional variations in mitochondrial OxPhos capacity may alter social behavior, stress reactivity, and mood. But are psychosocial exposures and subjective experiences linked to mitochondrial biology in the human brain? By combining longitudinal antemortem assessments of psychosocial factors with postmortem brain (dorsolateral prefrontal cortex) proteomics in older adults, we find that higher well-being is linked to greater abundance of the mitochondrial OxPhos machinery, whereas higher negative mood is linked to lower OxPhos protein content. Combined, positive and negative psychosocial factors explained 18 to 25% of the variance in the abundance of OxPhos complex I, the primary biochemical entry point that energizes brain mitochondria. Moreover, interrogating mitochondrial psychobiological associations in specific neuronal and nonneuronal brain cells with single-nucleus RNA sequencing (RNA-seq) revealed strong cell-type-specific associations for positive psychosocial experiences and mitochondria in glia but opposite associations in neurons. As a result, these “mind-mitochondria” associations were masked in bulk RNA-seq, highlighting the likely underestimation of true psychobiological effect sizes in bulk brain tissues. Thus, self-reported psychosocial experiences are linked to human brain mitochondrial phenotypes.

59 BASIC BIOLOGICAL SCIENCES

Machine-Learning-Driven Discovery of Water Splitting BaFe 2 O 4 and Human-in-the-Loop Improvement via Al-Substitution for Increased Thermal Stability

Thermochemical hydrogen (TCH) production offers a promising method for converting thermal energy into hydrogen fuel through heat-driven redox cycles of metal oxides. Here, in this work a defect graph neural network (dGNN) was used to predict oxygen vacancy formation energies ΔH V O combined with Materials Project predictions of oxygen chemical potential stability to screen candidate oxides via high-throughput database analysis. BaFe 2 O 4 was identified as a promising material for experimental validation based on its predicted ΔH V O , oxygen chemical potential stability range, and potential for tunable substitutions to improve thermal properties. Experimental validation using thermogravimetric analysis (TGA), stagnation flow reactor (SFR), X-ray diffraction (XRD), and electron microscopy confirmed positive water-splitting behavior but also revealed limitations in thermal stability under aggressive reduction conditions. To address this, a human-in-the-loop modification strategy was employed introducing Al substitution in BaFe 2–x Al x O 4 ; this modification improves thermal stability, alters the crystal structure and enhances overall performance. These results demonstrate a combined computational and experimental workflow in which machine learning accelerates identification of promising candidates, while targeted experimental design enables optimization of functional performance. This approach advances the development of robust, cost-effective TCH materials and highlights the importance of integrating data-driven discovery with human-guided materials design in paving the way for scalable hydrogen production technologies.

organic

Speeding-up fuzzing through directional seeds

Abstract Fuzzing is an automated process for discovering inputs in a program that may trigger unexpected behavior. Today, fuzzing has become a standard practice for the discovery of bugs and security vulnerabilities. However, the main issue with such practices is that the exploration of the input space of programs can often be prohibitively expensive. Therefore, several alternative fuzzing strategies have been introduced during the last few years. Some fuzzing techniques rely on human expertise to provide a plausible set of initial input examples, namely, seeds. However, the process of handcrafting seeds for fuzzing purposes often becomes strenuous for humans as it requires a deeper understanding of the Program-Under-Test (PUT). Also, the use of known inputs to programs often does not trigger vulnerable program behavior or may not reach potentially vulnerable code locations. To address those issues, we propose a seed generation framework that enables Human-In-The-Loop (HITL) directed fuzzing where the human assumes a more active role in the creation of seeds that can penetrate and assess desired locations of the PUT. Our proposed framework uses Symbolic Execution (SE) to generate seeds that exercise paths to target program locations. Moreover, our framework enables the visualization of the explored execution paths in the binary of the PUT for the generated seeds. We evaluated our approach on a set of 12 carefully designed C programs with diverse characteristics that mimic real-world programs. The experimental results show the effectiveness of the proposed approach in improving the performance of standard fuzzing tools such as the American Fuzzy Lop ("Image missing" <#comment/> ). Specifically, our solution can generate seeds that substantially enhance the performance of the fuzzer, achieving speedups ranging from $$1.46\times $$ 1.46 × to $$68.53\times $$ 68.53 × for branch conditions, $$1.39\times $$ 1.39 × to $$254.62\times $$ 254.62 × for branch depths, $$14,879.59\times $$ 14 , 879.59 × to $$30,295.88\times $$ 30 , 295.88 × for branch widths over traditional seeds. Additionally, the speedup increases with the number of target function ranging from $$12,260\times $$ 12 , 260 × to $$22,856.07\times $$ 22 , 856.07 × over traditional seeds while only requiring less than 15 seconds on average for the seed generation step.

97 MATHEMATICS AND COMPUTING

Avian Activity Classification Using Recurrent Networks to Fuse Videos with Metadata on Imbalanced Datasets

Activity classification plays a crucial role in various real-life scenarios involving both humans and animals. There is an increasing need for precise activity classification focused on avian-solar interactions, as the usage of solar energy facilities, such as photovoltaic array power stations, has been observed to impact bird species richness, behavior, and activity. However, there has been no work to develop an automated system to monitor and classify these avian-solar interactions. All current methods rely on human observers, which is time and human resources costly and subject to errors related to searcher efficiency. With the recent success of Deep Learning models in activity classification problems, this paper develops a recurrent neural network-based model to automatically classify six avian activities around solar energy facilities. Our proposed model integrates critical feature engineering metadata with video frame data, enabling improved learning and more accurate activity classification. Furthermore, we address the challenge of data imbalance during training and demonstrate the efficacy of our model in detecting and classifying different activities within video tracks. Additionally, we analyze the saliency/backpropagation map of the trained proposed model and validate its decision-making rationale.

Avian activity classification; bidirectional LSTM;

Bacterial vampirism mediated through taxis to serum

Bacteria of the family Enterobacteriaceae are associated with gastrointestinal (GI) bleeding and bacteremia and are a leading cause of death, from sepsis, for individuals with inflammatory bowel diseases. The bacterial behaviors and mechanisms underlying why these bacteria are prone to bloodstream entry remain poorly understood. Herein, we report that clinical isolates of non-typhoidal Salmonella enterica serovars, Escherichia coli , and Citrobacter koseri are rapidly attracted toward sources of human serum. To simulate GI bleeding, we utilized an injection-based microfluidics device and found that femtoliter volumes of human serum are sufficient to induce bacterial attraction to the serum source. This response is orchestrated through chemotaxis and the chemoattractant L-serine, an amino acid abundant in serum that is recognized through direct binding by the chemoreceptor Tsr. We report the first crystal structures of Salmonella Typhimurium Tsr in complex with L-serine and identify a conserved amino acid recognition motif for L-serine shared among Tsr orthologues. We find Tsr to be widely conserved among Enterobacteriaceae and numerous World Health Organization priority pathogens associated with bloodstream infections. Lastly, we find that Enterobacteriaceae use human serum as a source of nutrients for growth and that chemotaxis and the chemoreceptor Tsr provide a competitive advantage for migration into enterohemorrhagic lesions. We define this bacterial behavior of taxis toward serum, colonization of hemorrhagic lesions, and the consumption of serum nutrients as ‘bacterial vampirism’, which may relate to the proclivity of Enterobacteriaceae for bloodstream infections.

59 BASIC BIOLOGICAL SCIENCES

Interactions Between Climate Policy and Technology-influenced Travel Behavior: Mitigating Induced Demand from CACC

Advances in vehicle technology have influenced the development of automated vehicle systems, where vehicles that do not require human intervention are already deployed in the roadway networks. While these advances are proved to increase roadway safety and highway capacity, more research is needed to understand the long-term and regional-level impacts on mobility, land use, energy consumption, and emissions. This study proposes a multi-model approach to analyze the effect of vehicle automation and deep decarbonization policies over a period from 2020 to 2040 in Austin, Texas. We use the Global Change Analysis Model (GCAM) to develop internally the scenarios that are then passed to the SMART Mobility modeling workflow, a large-scale simulation framework combining the POLARIS activity-based travel demand model and mesoscopic traffic simulator with the Autonomie vehicle energy consumption model and the UrbanSim land use simulator. Results suggest that the introduction of vehicles with advanced automation could increase fuel consumption when no decarbonization policies are implemented. Also, advances in vehicle technology research and development could lead to a decline in energy use in the long-term. Energy pricing and vehicle electrification incentives could help reduce the impact of vehicle automation. Finally, our analysis indicates the relevance of introducing land use processes in longterm vehicle automation studies.

land use

ML-based calibration and control of the GlueX Central Drift Chamber

The GlueX Central Drift Chamber (CDC) in Hall D at Jefferson Lab, used for detecting and tracking charged particles, is calibrated and controlled during data taking using a Gaussian process. The system dynamically adjusts the high voltage applied to the anode wires inside the chamber in response to changing environmental and experimental conditions such that the gain is stabilized. Control policies have been established to manage the CDC's behavior. These policies are activated when the model's uncertainty exceeds a configurable threshold or during human-initiated tests during normal production running. Finally, we demonstrate the system reduces the time detector experts dedicate to calibration of the data offline, leading to a marked decrease in computing resource usage without compromising detector performance.

47 OTHER INSTRUMENTATION