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Reflex limb dilatation following norepinephrine and angiotensin II in conscious dogs

The extent to which norepinephrine (NE) and angiotensin II (AN) constrict the mesenteric, renal, and iliac beds in conscious dogs is evaluated with a view to elicit opposing reflex actions tempering the vasoconstriction in the limb of the animals tested. The afferent and efferent mechanisms mediating this reflex are analyzed. It is shown that intravenous NE and AN cause striking reflex iliac dilatation in the limb of the conscious dog. The afferent arc of this reflex involves both arterial baroreceptor and vagal path-ways, whereas the efferent mechanism involves an interaction of alpha-adrenergic and histaminergic receptors.

Vatner, S. F.

The effect of dilatancy on velocity anisotropy in Westerly granite

Jacketed samples of Westerly granite were fractured at confining pressures up to 1 kbar, and compressional and horizontally as well as vertically polarized shear velocities were measured in orthogonal directions perpendicular to the compression axis. Changes occurring with increased strain are described, and the velocity data were analyzed by application of the Anderson et al (1974) approach. Observed and calculated velocities are found to be in good agreement, and the degree of dilatancy was determined from the differences between the strains measured perpendicularly to the compression axis and the estimated elastic strains in those directions.

Soga, N.

Periodically correlated processes and their stationary dilations

An explicit form for a stationary dilation for periodically correlated random processes is obtained. This is then used to give spectral conditions for a periodically correlated process to be non-deterministic, purely deterministic, minimal, and to have a positive angle between its past and future.

Miamee, A. G.

Distortion of homogeneous turbulence by axisymmetric strain and dilatation

Rapid distortion theory is applied to study distortion of homogeneous turbulence subject to two different axisymmetric strain modes: the axisymmetric contraction (AC, nozzle-type flow), and the axisymmetric expansion (AE, diffuser-type flow). The paper explores the differences in effects of the two axisymmetric strain modes on the anisotropy of correlations and structures of turbulence; examines the effect of dilatation on the distortion of turbulence; and provides a theoretical background for turbulence model development. It is found that velocity and vorticity fluctuations are enhanced more efficiently by contraction than by expansion; contraction produces much higher anisotropy in velocity and vorticity than expansion; root-mean-square pressure is slightly reduced during contraction, whereas it increases rapidly during expansion; and vortical structures of rodlike shape develop in a contraction flow, while disklike structures develop in an expansion flow. A simple model that reflects the dependence of turbulence evolution on structural parameters such as the Reynolds-stress anisotropy and total strain is proposed, and is shown to outperform all other models for all cases examined, regardless of the mean strain rate.

Lee, Moon Joo

Efficient algorithms for dilated mappings of binary trees

The problem is addressed to find a 1-1 mapping of the vertices of a binary tree onto those of a target binary tree such that the son of a node on the first binary tree is mapped onto a descendent of the image of that node in the second binary tree. There are two natural measures of the cost of this mapping, namely the dilation cost, i.e., the maximum distance in the target binary tree between the images of vertices that are adjacent in the original tree. The other measure, expansion cost, is defined as the number of extra nodes/edges to be added to the target binary tree in order to ensure a 1-1 mapping. An efficient algorithm to find a mapping of one binary tree onto another is described. It is shown that it is possible to minimize one cost of mapping at the expense of the other. This problem arises when designing pipelined arithmetic logic units (ALU) for special purpose computers. The pipeline is composed of ALU chips connected in the form of a binary tree. The operands to the pipeline can be supplied to the leaf nodes of the binary tree which then process and pass the results up to their parents. The final result is available at the root. As each new application may require a distinct nesting of operations, it is useful to be able to find a good mapping of a new binary tree over existing ALU tree. Another problem arises if every distinct required binary tree is known beforehand. Here it is useful to hardwire the pipeline in the form of a minimal supertree that contains all required binary trees.

Iqbal, M. Ashraf

Periodically correlated processes and their stationary dilations

An explicit form for a stationary dilation for periodically correlated random processes is obtained. This is then used to give spectral conditions for a periodically correlated process to be non-deterministic, purely deterministic, minimal, and to have a positive angle between its past and future.

Miamee, A. G.

Is there cosmological time dilation in gamma-ray bursts?

Norris et al. report that the temporal structure of faint gamma-ray bursts is longer than that of bright bursts, as expected for time dilation in the cosmological models of burst origin. I show that the observed trends can easily be produced by a burst luminosity function and thus may not result from cosmological effects. A cosmological signature may be present, but the tests Norris et al. present are not powerful enough to detect these signatures.

Band, David L.

On the nature of gamma-ray burst time dilations

The recent discovery that faint gamma-ray bursts are stretched in time relative to bright ones has been interpreted as support for cosmological distances: faint bursts have their durations redshifted relative to bright ones. It was pointed out, however, that the relative time stretching can also be produced by an intrinsic correlation bewteen duration and luminosity of gamma-ray bursts in a nearby, bounded distribution. While both models can explain the average amount of time stretching, we find a difference between them in the way the duration distribution of faint bursts deviates from that of bright ones, assuming the luminosity function of gamma-ray bursts is independent of distance. This allows us to distinguish between these two broad classes of model on the basis of the duration distributions of gamma-ray bursts, leading perhaps to an unambiguous determination of the distance scale of gamma-ray bursts. We apply our proposed test to the second Burst and Transient Source Experiment (BATSE) catalog and conclude, with some caution, that the data favor a cosmological interpretation of the time dilation.

Wijers, Ralph A. M. J.

An Assessment of the Axial and Radial Dilation of a DPIMS Tantalum Cartridge for Space Shuttle Flight Experiments

Ground-based heat treatment tests are planned on an argon gas-filled tantalum cartridge developed as pan of a Diffusion Processes in Molten Semiconductors (DPIMS) experiment conducted on NASA's Space Shuttle. The possibility that the cartridge may creep during testing and touch the furnace walls is of real concern in this program. The present paper discusses the results of calculations performed to evaluate this possibility. Deformation mechanism maps were constructed using literature data in order to identify the creep mechanism dominant under the appropriate stresses and temperatures corresponding to the test conditions. These results showed that power-law creep was dominant when the grain size of the material exceeded 55 gm but Coble creep was the important mechanism below this value of grain size. Finite element analysis was used to analyze the heat treatment tWs assuming a furnace run away condition (which is a worst case scenario) using the appropriate creep parameters corresponding to grain sizes of 1 and 100 gm. Calculations were also conducted to simulate the effect of an initial 3 tilt of the cartridge assembly, the maximum possible tilt angle. The von Mises stress and su-ain distributions were calculated assuming that the cartridge was fixed at one end as it was heated from ambient temperature to 1823 K in 1.42 h, maintained at 1823 K for 9.5 h and then further heated to an over temperature condition of 2028 K in 0.3 h. The inelastic axial and radial displacements of the cartridge walls were evaluated by resolving the von Mises strain along the corresponding directions. These calculations reveal that the maximum axial and radial displacements are expected to be about 2.9 and 0.25 mm, respectively, for both fine and coarse-grained materials at 2028 K. It was determined that these displacements occur during heat-up to temperature and creep of the cartridge is likely to be relatively insignificant irrespective of grain size. Furthermore, with a 3' tilt of the cartridge, the deflection is increased by only 0.39 gm which is negligible. Since the gap between the furnace heating elements and the cartridge is about 7.5 mm and less than the maximum radial dilation of 0.25 mm at 2028 K, it is concluded that the cartridge is unlikely to touch the furnace walls during the experiments.

Raj, S.V.

Usefulness of microvolt T-wave alternans for prediction of ventricular tachyarrhythmic events in patients with dilated cardiomyopathy: results from a prospective observational study

OBJECTIVES: This study was designed to evaluate the ability of microvolt-level T-wave alternans (MTWA) to identify prospectively patients with idiopathic dilated cardiomyopathy (DCM) at risk of ventricular tachyarrhythmic events and to compare its predictive accuracy with that of conventional risk stratifiers. BACKGROUND: Patients with DCM are at increased risk of sudden death from ventricular tachyarrhythmias. At present, there are no established methods of assessing this risk. METHODS: A total of 137 patients with DCM underwent risk stratification through assessment of MTWA, left ventricular ejection fraction, baroreflex sensitivity (BRS), heart rate variability, presence of nonsustained ventricular tachycardia (VT), signal-averaged electrocardiogram, and presence of intraventricular conduction defect. The study end point was either sudden death, resuscitated ventricular fibrillation, or documented hemodynamically unstable VT. RESULTS: During an average follow-up of 14 +/- 6 months, MTWA and BRS were significant univariate predictors of ventricular tachyarrhythmic events (p < 0.035 and p < 0.015, respectively). Multivariate Cox regression analysis revealed that only MTWA was a significant predictor. CONCLUSIONS: Microvolt-level T-wave alternans is a powerful independent predictor of ventricular tachyarrhythmic events in patients with DCM.

Evaluation Studies

Geometric differences of the mitral apparatus between ischemic and dilated cardiomyopathy with significant mitral regurgitation: real-time three-dimensional echocardiography study

BACKGROUND: This study was conducted to elucidate the geometric differences of the mitral apparatus in patients with significant mitral regurgitation caused by ischemic cardiomyopathy (ICM-MR) and by idiopathic dilated cardiomyopathy (DCM-MR) by use of real-time 3D echocardiography (RT3DE). METHODS AND RESULTS: Twenty-six patients with ICM-MR caused by posterior infarction, 18 patients with DCM-MR, and 8 control subjects were studied. With the 3D software, commissure-commissure plane and 3 perpendicular anteroposterior (AP) planes were generated for imaging the medial, central, and lateral sides of the mitral valve (MV) during mid systole. In 3 AP planes, the angles between the annular plane and each leaflet (anterior, Aalpha; posterior, Palpha) were measured. In ICM-MR, Aalpha measured in the medial and central planes was significantly larger than that in the lateral plane (39+/-5 degrees, 34+/-6 degrees, and 27+/-5 degrees, respectively; P<0.01), whereas Palpha showed no significant difference in any of the 3 AP planes (61+/-7 degrees, 57+/-7 degrees, and 56+/-7 degrees, P>0.05). In DCM-MR, both Aalpha (38+/-8 degrees, 37+/-9 degrees, and 36+/-7 degrees, P>0.05) and Palpha (59+/-6 degrees, 58+/-5 degrees, and 57+/-6 degrees, P>0.05) revealed no significant differences in the 3 planes. CONCLUSIONS: The pattern of MV deformation from the medial to the lateral side was asymmetrical in ICM-MR, whereas it was symmetrical in DCM-MR. RT3DE is a helpful tool for differentiating the geometry of the mitral apparatus between these 2 different types of functional mitral regurgitation.

Evaluation Studies

Initial clinical experience of real-time three-dimensional echocardiography in patients with ischemic and idiopathic dilated cardiomyopathy

The geometry of the left ventricle in patients with cardiomyopathy is often sub-optimal for 2-dimensional ultrasound when assessing left ventricular (LV) function and localized abnormalities such as a ventricular aneurysm. The aim of this study was to report the initial experience of real-time 3-D echocardiography for evaluating patients with cardiomyopathy. A total of 34 patients were evaluated with the real-time 3D method in the operating room (n = 15) and in the echocardiographic laboratory (n = 19). Thirteen of 28 patients with cardiomyopathy and 6 other subjects with normal LV function were evaluated by both real-time 3-D echocardiography and magnetic resonance imaging (MRI) for obtaining LV volumes and ejection fractions for comparison. There were close relations and agreements for LV volumes (r = 0.98, p <0.0001, mean difference = -15 +/- 81 ml) and ejection fractions (r = 0.97, p <0.0001, mean difference = 0.001 +/- 0.04) between the real-time 3D method and MRI when 3 cardiomyopathy cases with marked LV dilatation (LV end-diastolic volume >450 ml by MRI) were excluded. In these 3 patients, 3D echocardiography significantly underestimated the LV volumes due to difficulties with imaging the entire LV in a 60 degrees x 60 degrees pyramidal volume. The new real-time 3D echocardiography is feasible in patients with cardiomyopathy and may provide a faster and lower cost alternative to MRI for evaluating cardiac function in patients.

NASA Discipline Cardiopulmonary

Investigation of the aerodynamic noise generating region of a jet engine by means of the simple source fluid dilatation model

An experiment was conducted on a full-scale jet engine to investigate the aerodynamic noise generating regions in the free jet. Cross-correlation measurements were made between the static pressure fluctuations and the farfield radiated sound. These measurements were made for two different static pressure probe positions and a large number of farfield positions (at various angles). In addition, each test geometry was run for four different jet exit velocities. The measured, normalized cross-correlation functions varied between 0.004 and 0.155. A new Q-function, based on the above normalized cross correlation is defined and plotted. This function represents the source strength per unit volume within the jet region. This Q-function shows dependence on the probe position, the angular position of the farfield microphone, and the jet exit Mach number. Third-octave analyses of both the probe signal and the farfield radiated sound were made. The results show that cross-correlation techniques are a valuable tool in the investigation of the aerodynamic noise generating regions of an actual jet engine.

Hurdle, P. M.

Dilation of force-free magnetic flux tubes

A general study is presented of the mapping functions which relate the magnetic-field profiles across a force-free rope in segments subjected to various external pressures. The results reveal that if the external pressure falls below a certain critical level (dependent on the flux-current relation which defines the tube), the magnetic profile consists of an invariant core sheathed in a layer permeated by an azimuthal magnetic field.

Frankenthal, S.