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NASA NTRS1983

Vortical flow management for improved configuration aerodynamics: Recent experiences

Recent progress in vortex-control applications for alleviating the adverse consequences of three dimensional separation and vortical interactions on slender body/swept wing configurations is reported. Examples include helical separation trip to alleviate the side force due to forebody vortex asymmetry; hinged strakes to avoid vortex breakdown effects; compartmentation of swept leading edge separation to delay the pitch-up instability; under wing vortex trip and vortex trip and vortex flaps for drag reduction at high lift; and an apex-flap trimmer to fully utilize the lift capability of trailing-edge flaps for take off and landing of delta wings. Experimental results on generic wind-tunnel models are presented to illustrate the vortex-management concepts involved and to indicate their potential for enhancing the subsonic aerodynamics of supersonic-cruise type vehicles.

Rao, D. M.↗

NASA NTRS1984

Air intakes for a probative missile of rocket ramjet

The methods employed to test air intakes for a supersonic guided ramjet powered missile being tested by ONERA are described. Both flight tests and wind tunnel tests were performed on instrumented rockets to verify the designs. Consideration as given to the number of intakes, with the goal of delivering the maximum pressure to the engine. The S2, S4, and S5 wind tunnels were operated at Mach nos. 1.5-3 for the tests, which were compartmentalized into fuselage-intake interaction, optimization of the intake shapes, and the intake performance. Tests were performed on the length and form of the ogive, the presence of grooves, the height of traps in the boundary layer, the types and number of intakes and the lengths and forms of diffusers. Attention was also given to the effects of sideslip, effects of the longitudinal and circumferential positions of the intakes were also examined. Near optimum performance was realized during Mach 2.2 test flights of the prototype rockets.

Laruelle, G.↗

NASA NTRS1983

Response of amphibian egg cytoplasm to novel gravity orientation and centrifugation

The effects of inversion and centrifugation on the compartmentalization of cytoplasm in Xenopus laevis eggs are investigated experimentally. The rearrangement of yolk-platelet compartments (YPC) characterized by morphology, density, and viscosity differences is studied in fertilized, unfertilized, and unfertilized electrically activated eggs in normal, and inverted positions and with and without centrifugation at 10-183 x g for 5 min. The eggs are fixed and embedded in plastic or paraffin prior to sagittal sectioning (0.5, 4, or 8 microns) and microscopic examination; the results are presented in a diagram and discussed. A density-compartment model combining both animal/vegetal and dorsal/ventral polarities is proposed: YPC determined without gravity orientation during oogenesis respond to both sperm entrance point and gravity after fertilization, and the response involves breaking of the radial symmetry of the egg. It is predicted that Xenopus eggs in a microgravity environment will encounter difficulties in establishing a primary embryonic axis.

Neff, A. W.↗

NASA NTRS1984

Influence of clinostat rotation on fertilized amphibian egg pattern specification

Pattern specification in fertile Xenopus eggs rotated on horizontal clinostats was monitored with respect to primary embryonic axis formation, subsequent morphogenesis, and compartmentalization of the cytoplasm. At the speeds of 1 to 24 rpm (which are believed to simulate microgravity) a large percentage of eggs developed normal axial structures. Eggs clinostated at 12 rpm showed a randomization of dorsal/ventral polarity. The cytoplasmic compartments showed some clinostat effects but no abnormal mixing, disruption or dislocation of compartments. It is predicted that Xenopus eggs fertilized and allowed to develop in space will retain normal cytoplasmic density compartments, establish primary axes and undergo normal morphogenesis in space. Their dorsal/ventral polarity may not, however, be determined by the sperm entrance site (as is the case for 1 g eggs).

Neff, A. W.↗

NASA NTRS1986

Electrocrystallization in microgravity

Electrocrystallization under microgravity conditions is proposed as a potential method of crystallization that would be almost completely free of fluid convection. Such crystallization may result in purer, more perfect, and larger crystals than is possible under normal gravity conditions. Observations made and data collected during the crystallization process under convection-free conditions should add to our knowledge of the crystallization process. The proposed method would allow easy comparison of crystals growth in space with those grown under normal gravity conditions. Nine types of electrocrystallization are presented: an example of each is discussed. Electrocrystallization is compared with the compartmental crystallization method used by 3M Corporation in recent shuttle experiments.

May, C. E.↗

NASA NTRS1986

Models of glycolysis: Glyceraldehyde as a source of energy and monomers for prebiotic condensation reactions

All organisms require energy in a chemical form for maintenance and growth. In contemporary life this chemical energy is obtained by the synthesis of the phosphoanhydride bonds of ATP. Among the biological processes that yield ATP, fermentation is generally considered primitive, because it operates under anaerobic conditions by substrate-level phosphorylation which does not require compartmentation by membranes. Fermentation by the glycolytic pathway, which is found in almost every living cell, is an especially attractive energy source for primitive life. Glycolysis not only produces useful chemical energy (ATP), but intermediates of this pathway are also involved in amino acid synthesis and photosynthetic carbon-fixation. It is believed that energy and substrates needed for the origin of life were provided by nonenzymatic chemical reactions that resemble the enzyme-mediated reactions of glycolysis. These nonenzymatic reactions would have provided a starting point for the evolutionary development of glycolysis.

Weber, A. L.↗

NASA NTRS1985

Microgravity changes in heart structure and cyclic-AMP metabolism

The effects of microgravity on cardiac ultrastructure and cyclic AMP metabolism in tissues of rats flown on Spacelab 3 are reported. Light and electron microscope studies of cell structure, measurements of low and high Km phosphodiesterase activity, cyclic AMP-dependent protein kinase activity, and regulatory subunit compartmentation show significant deviations in flight animals when compared to ground controls. The results indicate that some changes have occurred in cellular responses associated with catecholamine receptor interactions and intracellular signal processing.

Philpott, D. E.↗

NASA NTRS1987

Vortical flow management techniques

The aerodynamic performance and controllability of advanced, highly maneuverable supersonic aircraft can be enhanced by means of 'vortex management', which refers to the purposeful manipulation and reordering of stable and concentrated vortical structures due to flow separations from highly swept leading edges and slender forebodies at moderate-to-high angles-of-attack. Attention is presently given to a variety of results obtained in the course of experiments on generic research models at NASA Langley, clarifying their underlying aerodynamics and evaluating their performance-improvement potential. The vortex-management concepts discussed encompass aerodynamic compartmentation of highly swept leading edges, vortex lift augmentation and modulation, and forebody vortex manipulation.

Rao, Dhanvada M.↗

NASA NTRS1986

Amphibian egg cytoplasm response to altered g-forces and gravity orientation

Elucidation of dorsal/ventral polarity and primary embryonic axis development in amphibian embryos requires an understanding of cytoplasmic rearrangements in fertile eggs at the biophysical, physiological, and biochemical levels. Evidence is presented that amphibian egg cytoplasmic components are compartmentalized. The effects of altered orientation to the gravitational vector (i.e., egg inversion) and alterations in gravity force ranging from hypergravity (centrifugation) to simulated microgravity (i.e., horizontal clinostat rotation) on cytoplasmic compartment rearrangements are reviewed. The behavior of yolk compartments as well as a newly defined (with monoclonal antibody) nonyolk cytoplasmic compartment, in inverted eggs and in eggs rotated on horizontal clinostats at their buoyant density, is discussed.

Neff, A. W.↗

NASA NTRS1988

An investigation of transitional management problems for the NSTS at NASA, executive summary

A summary is given of the work of the University of Houston research team for the third quarter of effort in a yearly grant for the National Space Transportation System (NSTS). As such it serves as a resting place for the ideas and concepts developed this quarter with the collaboration of the Management Integration Offices of NASA. Another objective is the hope that the report will help to stimulate the healthy problem solving process already present at NASA. The main goal of the contractual work is to help NASA to find ways and means of moving into a truly operational era with the shuttle program. This work is a continuation of early work and the reader is encouraged to read the final reports of earlier years. Chapter One of the report is an introduction. Chapter Two deals with industrial adaptation and is in two parts: theory and application. In the theory section, impressions of the management system immediately after reflight are discussed. A key issue, in the author's opinion is the seeming lack of purpose of the program. The application section has six appendices: 1988 Demographic Survey, Field Notes of Interview with HL/P South Texas Nuclear Project, a comparison of the Agendas of the current manager with that of a previous manager, a note on compartmentalization to assist in manifesting, a study on launch prediction for STS-26, and a discussion of a statistical decision-making course for upper level managers. Chapter Three deals with theoretical results returned on flow shop scheduling which will be of use downstream. Chapter Four deals with a statistical model developed to predict the flight rate in future years and indicates the program will have trouble making its schedule. Chapter Five covers the constructural effort and shows the work to be on schedule.

Hunsucker, John↗

NASA NTRS1989

UNIX security in a supercomputing environment

The author critiques some security mechanisms in most versions of the Unix operating system and suggests more effective tools that either have working prototypes or have been implemented, for example in secure Unix systems. Although no computer (not even a secure one) is impenetrable, breaking into systems with these alternate mechanisms will cost more, require more skill, and be more easily detected than penetrations of systems without these mechanisms. The mechanisms described fall into four classes (with considerable overlap). User authentication at the local host affirms the identity of the person using the computer. The principle of least privilege dictates that properly authenticated users should have rights precisely sufficient to perform their tasks, and system administration functions should be compartmentalized; to this end, access control lists or capabilities should either replace or augment the default Unix protection system, and mandatory access controls implementing multilevel security models and integrity mechanisms should be available. Since most users access supercomputing environments using networks, the third class of mechanisms augments authentication (where feasible). As no security is perfect, the fourth class of mechanism logs events that may indicate possible security violations; this will allow the reconstruction of a successful penetration (if discovered), or possibly the detection of an attempted penetration.

Bishop, Matt↗

NASA NTRS1991

Cyclic AMP-receptor proteins in heart muscle of rats flown on Cosmos 1887

The cellular compartmentalization of the cyclic AMP-receptor proteins in heart ventricular tissue obtained from rats flown on the Cosmos 1887 is determined. Photoaffinity labeling of soluble and particular cell fractions with a (32P)-8-azido analog of cyclic AMP is followed by electrophoretic separation of the proteins and by autoradiographic identification of the labeled isoforms of cAPK R subunits. It is shown that RII in the particulate subcellular fraction was significantly decreased in heart cells from rats in the flight group when compared to controls. Protein banding patterns in both the cytoplasmic fraction and in a fraction enriched in chromatin-bound proteins exhibited some variability in tissues of individual animals, but showed no changes that could be directly attributed to flight conditions. No significant change was apparent in the distribution of RI or RII cyclic AMP binding in the soluble fractions. It is inferred that the cardiac cell integrity or its protein content is not compromised under flight conditions.

Mednieks, Maija I.↗

NASA NTRS1991

System monitoring and diagnosis with qualitative models

A substantial foundation of tools for model-based reasoning with incomplete knowledge was developed: QSIM (a qualitative simulation program) and its extensions for qualitative simulation; Q2, Q3 and their successors for quantitative reasoning on a qualitative framework; and the CC (component-connection) and QPC (Qualitative Process Theory) model compilers for building QSIM QDE (qualitative differential equation) models starting from different ontological assumptions. Other model-compilers for QDE's, e.g., using bond graphs or compartmental models, have been developed elsewhere. These model-building tools will support automatic construction of qualitative models from physical specifications, and further research into selection of appropriate modeling viewpoints. For monitoring and diagnosis, plausible hypotheses are unified against observations to strengthen or refute the predicted behaviors. In MIMIC (Model Integration via Mesh Interpolation Coefficients), multiple hypothesized models of the system are tracked in parallel in order to reduce the 'missing model' problem. Each model begins as a qualitative model, and is unified with a priori quantitative knowledge and with the stream of incoming observational data. When the model/data unification yields a contradiction, the model is refuted. When there is no contradiction, the predictions of the model are progressively strengthened, for use in procedure planning and differential diagnosis. Only under a qualitative level of description can a finite set of models guarantee the complete coverage necessary for this performance. The results of this research are presented in several publications. Abstracts of these published papers are presented along with abtracts of papers representing work that was synergistic with the NASA grant but funded otherwise. These 28 papers include but are not limited to: 'Combined qualitative and numerical simulation with Q3'; 'Comparative analysis and qualitative integral representations'; 'Model-based monitoring of dynamic systems'; 'Numerical behavior envelopes for qualitative models'; 'Higher-order derivative constraints in qualitative simulation'; and 'Non-intersection of trajectories in qualitative phase space: a global constraint for qualitative simulation.'

Kuipers, Benjamin↗

NASA NTRS1993

[Volume Homeostasis and Renal Function in Rats Exposed to Simulated and Actual Microgravity]

This project has investigated mechanisms that influence alterations in compartmental fluid and electrolyte balance in microgravity and evaluates countermeasures to control renal fluid and electrolyte losses. Determining the alterations due to space flight in fluid compartments and renal function is an important component in understanding long term adaptation to spaceflight and the contribution to post-flight orthostatic intolerance. Four definition phase studies and two studies examining neuro-humoral and vascular mechanisms have been completed.

Tucker, Bryan J.↗

NASA NTRS1999

Launch Vehicle Design Process Description and Training Formulation

A primary NASA priority is to reduce the cost and improve the effectiveness of launching payloads into space. As a consequence, significant improvements are being sought in the effectiveness, cost, and schedule of the launch vehicle design process. In order to provide a basis for understanding and improving the current design process, a model has been developed for this complex, interactive process, as reported in the references. This model requires further expansion in some specific design functions. Also, a training course for less-experienced engineers is needed to provide understanding of the process, to provide guidance for its effective implementation, and to provide a basis for major improvements in launch vehicle design process technology. The objective of this activity is to expand the description of the design process to include all pertinent design functions, and to develop a detailed outline of a training course on the design process for launch vehicles for use in educating engineers whose experience with the process has been minimal. Building on a previously-developed partial design process description, parallel sections have been written for the Avionics Design Function, the Materials Design Function, and the Manufacturing Design Function. Upon inclusion of these results, the total process description will be released as a NASA TP. The design function sections herein include descriptions of the design function responsibilities, interfaces, interactive processes, decisions (gates), and tasks. Associated figures include design function planes, gates, and tasks, along with other pertinent graphics. Also included is an expanded discussion of how the design process is divided, or compartmentalized, into manageable parts to achieve efficient and effective design. A detailed outline for an intensive two-day course on the launch vehicle design process has been developed herein, and is available for further expansion. The course is in an interactive lecture/workshop format to engage the participants in active learning. The course addresses the breadth and depth of the process, requirements, phases, participants, multidisciplinary aspects, tasks, critical elements,as well as providing guidance from previous lessons learned. The participants are led to develop their own understanding of the current process and how it can be improved. Included are course objectives and a session-by-session outline of course content. Also included is an initial identification of visual aid requirements.

Atherton, James↗

NASA NTRS1999

Computer Modeling of Sand Transport on Mars Using a Compart-Mentalized Fluids Algorithm (CFA)

It has been postulated that aeolian transport on Mars may be significantly different from that on Earth. From laboratory experiments simulating martian grain transport [2], it has been observed that (saltating) grains striking the bed can cause hundreds of secondary reptation trajectories when impact occurs at speeds postulated for Mars. Some of the ballistically induced trajectories "die ouf' and effectively join the ranks on the creep population that is merely nudged along by impact. Many of the induced reptation trajectories, however, are sufficiently high for the grains to become part of the saltation load (it is irrelevant to the boundary layer how a grain attained its initial lift force). When these grains, in turn, strike the surface, they too are capable of inducing more reptating grains. This cascading effect has been discussed in connection with terrestrial aeolian transport in an attempt to dispel the notion that sand motion is divisible only into creep and saltation loads. On Earth, only a few grains are splashed by impact. On Mars, it may be hundreds. We developed a computer model to address this phenomenon because there are some important ramifications: First, this ratio may mean that martian aeolian transport is dominated by reptation flux rather than saltation. On Earth, the flux would be a roughly balanced mixture between reptation/creep and saltation. On Venus, there would be no transport other than by saltation. In other words, an understanding of planetary aeolian processes may not be necessarily understood by extrapolating from the "Earth case", with only gravity and atmospheric density/viscosity being considered as variables. Second, the reptation flux on Mars may be self sustaining, so that little input is required by the wind once transport has been initiated. The number of grains saturating the boundary layer near the bed may mean that average grain speed on Mars might conceivably be less than that on Earth. This would say much for models of sand comminution on Mars. A multiple-grain transport model using just the equations of grain motion describing lift and drag is impossible to develop owing to stochastic effects --the very effects we wish to model. Also, unless we were to employ supercomputing techniques and extremely complex computer codes that could deal with millions of grains simultaneously, it would also be difficult to model grain transport if we attempted to consider every grain in motion. No existing computer models were found that satisfactorily used the equations of motion to arrive at transport flux numbers for the different populations of saltation and reptation. Modeling all the grains in a transport system was an intractable problem within our resources, and thus we developed what we believe to be a new modeling approach to simulating grain transport. The CFA deals with grain populations, but considers them to belong to various compartmentalized fluid units in the boundary layer. In this way, the model circumvents the multigrain problem by dealing primarily with the consequences of grain transport --momentum transfer between air and grains, which is the physical essence of a dynamic grain-fluid mixture. We thus chose to model the aeolian transport process as a superposition of fluids. These fluids include the air as well as particle populations of various properties. The prime property distinguishing these fluids is upward and downward grain motion. In a normal saltation trajectory, a grain's downwind velocity increases with time, so a rising grain will have a smaller downwind velocity than a failing grain. Because of this disparity in rising and falling grain proper-ties, it seemed appropriate to track these as two separate grain populations within the same physical space. The air itself can be considered a separate fluid superimposed within and interacting with the various grain-cloud "fluids". Additional informaiton is contained in the original.

Marshall, J.↗

NASA NTRS2000

A Review of Electrical Impedance Spectrometry Methods for Parametric Estimation of Physiologic Fluid Volumes

Electrical impedance spectrometry involves measurement of the complex resistance of a load at multiple frequencies. With this information in the form of impedance magnitude and phase, or resistance and reactance, basic structure or function of the load can be estimated. The "load" targeted for measurement and estimation in this study consisted of the water-bearing tissues of the human calf. It was proposed and verified that by measuring the electrical impedance of the human calf and fitting this data to a model of fluid compartments, the lumped-model volume of intracellular and extracellular spaces could be estimated, By performing this estimation over time, the volume dynamics during application of stimuli which affect the direction of gravity can be viewed. The resulting data can form a basis for further modeling and verification of cardiovascular and compartmental modeling of fluid reactions to microgravity as well as countermeasures to the headward shift of fluid during head-down tilt or spaceflight.

Dewberry, B.↗

NASA NTRS1999

Modeling Calcium Loss from Bones During Space Flight

Calcium loss from bones during space flight creates a risk for astronauts who travel into space, and may prohibit space flights to other planets. The problem of calcium loss during space flight has been studied using animal models, bed rest (as a ground-based model), and humans in-flight. In-flight studies have typically documented bone loss by comparing bone mass before and after flight. To identify changes in metabolism leading to bone loss, we have performed kinetic studies using stable isotopes of calcium. Oral (Ca-43) and intravenous (Ca-46) tracers were administered to subjects (n=3), three-times before flight, once in-flight (after 110 days), and three times post-flight (on landing day, and 9 days and 3 months after flight). Samples of blood, saliva, urine, and feces were collected for up to 5 days after isotope administration, and were analyzed for tracer enrichment. Tracer data in tissues were analyzed using a compartmental model for calcium metabolism and the WinSAAM software. The model was used to: account for carryover of tracer between studies, fit data for all studies using the minimal number of changes between studies, and calculate calcium absorption, excretion, bone calcium deposition and bone calcium resorption. Results showed that fractional absorption decreased by 50% during flight and that bone resorption and urinary excretion increased by 50%. Results were supported by changes in biochemical markers of bone metabolism. Inflight bone loss of approximately 250 mg Ca/d resulted from decreased calcium absorption combined with increased bone resorption and excretion. Further studies will assess the time course of these changes during flight, and the effectiveness of countermeasures to mitigate flight-induced bone loss. The overall goal is to enable human travel beyond low-Earth orbit, and to allow for better understanding and treatment of bone diseases on Earth.

Wastney, Meryl E.↗