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At least 55 records · Page 3

TMS 2023 - Methodology and Density of PuCl3-NaCl Mixtures

The development of molten salt reactors and their associated components demands reliable and accurate thermophysical property data for design and validation. A candidate fuel salt, PuCl3-NaCl (36 mol% PuCl3) has been synthesized and studied at the Idaho National Laboratory. This study has determined the density of PuCl3-NaCl at multiple compositions and temperatures, providing data for validation of modeling efforts and making improvements on the buoyancy method for density measurements of actinide-bearing molten salts.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Examination of simulated behavior of ND-LAr and TMS detectors using CAFAna for DUNE analysis framework

Simulations are run using the new DUNE CAFAna framework to generate pseudo-data modeling the interactions of neutrinos in the DUNE near detector at truth-level and detector-level. Truth-level analysis of neutrino kinematics reveals strong agreement with expected behavior, validating the kinematic portion of the simulation. Examination of the detector-level reconstructions of coordinates of interaction vertex appear consistent with an interaction density independent of detector position. Track lengths of particles resultant from neutrino interactions are aligned with varied particle identities, but are misaligned with prediction of uniform position density.

Fein, Jarrett [Fermilab]↗

Tuscaloosa Marine Shale Laboratory

The Tuscaloosa Marine Shale (TMS) in Louisiana and Mississippi is an Upper Cretaceous source rock formation sandwiched between the sands of the upper and lower Tuscaloosa sections. The TMS is believed to be the source rock for underlying prolific Tuscaloosa sand formation. The TMS has an unproven estimate of 7,000,000,000 bbls of recoverable oil while its current total average production is about 3,000 bbls of oil per day in 2017. In 2013 and 2014, more than 80 wells were drilled horizontally into the TMS that were fractured using multi-stage fracturing technology. The results from this have been mixed, but recent production for several wells show an appealing initial oil production rate of more than 1000 bbl/day. The preliminary core analysis by industry partners and a few literature studies shows that the TMS is one of the most clay-rich and sensitive shales to water. Due to these and other technical problems, there is high risk for the economic development of TMS compared to other shale plays. The experiences of major industrial players in the TMS show the necessity of open and collaborative efforts to better understand the critical gaps in the development of this challenging and potentially highly economic shale play to enable more cost-efficient and environmentally-sound recovery from this unconventional liquid-rich shale play. The overall objective of this project is to form a consortium of science and industry partners to address the following six major objectives using scientific and technical approaches: 1. To improve wellbore integrity by better understanding the sources of the wellbore instability issues, proposing innovative mud and cement design for the TMS. 2. To improve formation evaluation using laboratory techniques for the evaluation of mineralogical composition, organic content, and produced-water chemistry as well as well log and geophysical analysis. 3. To determine the role of geologic discontinuities on fracture growth and shale creep behavior using digital image correlation technique. 4. To investigate the application of stable CO 2 foam and super-hydrophobic proppants for improved reservoir stimulation. 5. To better understand the nature of water/hydrocarbon/CO 2 flow in clay and organic-rich formation and the role of water/fluid interaction on recovery. 6. To prepare better socio-economic environment for TMS development by community engagement. Subsequently, the TMS virtual laboratory conducted testing and analysis of various properties of rock and formation fluids from the TMS, including but not limited to the following: Analyzing reports and logs to better understand the source of wellbore instability in TMS wells; Experiments to design a customized cement based on TMS requirements; Experiments to obtain the mineralogical and geochemical composition of TMS samples; Seismic analysis of TMS geophysical data to better predict total organic carbon (TOC) content and brittleness in TMS; Well log analysis to better estimate the TOC and geo-mechanical properties of TMS; Experiments on formation water to understand the chemistry of produced water; Experiments to determine the role of lamination and natural fractures on fracture propagation or rock deformation using digital image correlation technique in in-direct tensile tests, semi-circular bend test and creep tests Experiments to determine the stability and rheological properties of nanoparticle-stabilized CO 2 foam in TMS rock samples; Experiments to determine fluid dynamics in un-propped TMS fractures and the role of nano-coating of proppants on fluid dynamics in fractures with proppants; Micro-fluidics experiments to enhance the understanding of fluid dynamics in tight liquidrich pores with high clay content; Socio-economic studies to better engage communities in TMS development.

58 GEOSCIENCES↗

Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action

(Z)-3,5,4′-Trimethoxystilbene (Z-TMS) is a resveratrol analog with increased antiproliferative activity towards a number of cancer cell lines compared to resveratrol, which has been shown to inhibit tubulin polymerization in vitro. The purpose of this study was to investigate if Z-TMS still shows potential for the prevention of metabolic diseases as known for resveratrol. Cell growth inhibition was determined with IC{sub 50} values for Z-TMS between 0.115 μM and 0.473 μM (resveratrol: 110.7 μM to 190.2 μM). Flow cytometric analysis revealed a G{sub 2}/M arrest after Z-TMS treatment, whereas resveratrol caused S phase arrest. Furthermore, Z-TMS was shown to impair microtubule polymerization. Beneficial effects on lipid accumulation were observed for resveratrol, but not for Z-TMS in an in vitro steatosis model. (E)-Resveratrol was confirmed to elevate cAMP levels, and knockdown of AMPK attenuated the antiproliferative activity, while Z-TMS did not show significant effects in these experiments. SIRT1 and AMPK activities were further measured indirectly via induction of the target gene small heterodimer partner (SHP). Thereby, (E)-resveratrol, but not Z-TMS, showed potent induction of SHP mRNA levels in an AMPK- and SIRT1-dependent manner, as confirmed by knockdown experiments. We provide evidence that Z-TMS does not show beneficial metabolic effects, probably due to loss of activity towards resveratrol target genes. Moreover, our data support previous findings that Z-TMS acts as an inhibitor of tubulin polymerization. These findings confirm that the methylation of resveratrol leads to profound changes in the mode of action, which should be taken into consideration when conducting lead structure optimization approaches. - Highlights: • Methylation of resveratrol leads to profound changes in biologic activity. • Z-TMS does not prevent hepatic steatosis, but inhibits tubulin polymerization. • Resveratrol analog Z-TMS does not influence known targets like PDEs, SIRT1, or AMPK. • Resveratrol, but not Z-TMS, potently induces SHP mRNA dependent on AMPK and SIRT1.

60 APPLIED LIFE SCIENCES↗

Kinetics of the functionalization of mesoporous silica nanoparticles: Implications on surface group distributions, adsorption and catalysis

The post-synthesis functionalization (grafting) kinetics of mesoporous silica nanoparticles (MSN) with organotrimethoxysilanes (R-TMS) is studied via solution 1 H NMR spectroscopy. The process involves a rapid adsorption/ desorption pre-equilibrium followed by reaction of R-TMS with surface silanols. Grafting rates are affected by the functional group in R-TMS. For example, the grafting rate of aminopropyl-trimethoxysilane (AP-TMS) is one order of magnitude higher than other R-TMS. High concentrations of AP-TMS result in substrate-inhibition kinetics, likely due to steric and mobility constraints for reactant alignment at high coverage. The higher rates of AP-TMS grafting indicate a catalytic effect of amine groups. This effect depends on the amine’s basicity and can be used to control the grafting rates and degree of condensation of other R-TMS. Adjusting the rate of mercaptopropyl-trimethoxysilane (MP-TMS) grafting using amines gives MP-MSN materials of varying adsorptive and catalytic activities, illustrated by Pd scavenging experiments and use of Pd@MP-MSN as catalysts for a Suzuki-Miyaura cross-coupling reaction.

36 MATERIALS SCIENCE↗

Thermal Management System Design for Electrified Aircraft Propulsion Concepts

This paper describes the development of thermal management systems (TMS) for three electrified aircraft propulsion (EAP) vehicle concepts released by NASA that span the UAM, regional, and single-aisle markets. For each EAP concept, a conventional TMS is designed for two electric component technology levels: state of the art and advanced. The goals for the paper are to compare the TMS designs for the above EAP concepts, to study how changes in requirements affect the TMS subcomponents, and to develop generalized TMS sizing relations. Each conventional TMS concept utilizes a liquid-based cooling methodology and is designed to cool the EAP electrical components only. The design parameters considered in this study include TMS architecture variation due to differing vehicle cooling requirements, electrical component efficiencies, vehicle total fuel burn or energy consumption, and electrical component operating temperatures. Results show that cooling components with low temperature limits increases TMS weight and demonstrate that efficiency gains of the specific technologies can net a lower weight TMS system despite more stringent temperature limits.

Thermal Management System↗

Thermal Management System Design for Electrified Aircraft Propulsion Concepts

This paper describes the development of thermal management systems (TMS) for three electrified aircraft propulsion (EAP) vehicle concepts released by NASA that span the UAM, regional, and single-aisle markets. For each EAP concept, a conventional TMS is designed for two electric component technology levels: state of the art and advanced. The goals for the paper are to compare the TMS designs for the above EAP concepts, to study how changes in requirements affect the TMS subcomponents, and to develop generalized TMS sizing relations. Each conventional TMS concept utilizes a liquid-based cooling methodology and is designed to cool the EAP electrical components only. The design parameters considered in this study include TMS architecture variation due to differing vehicle cooling requirements, electrical component efficiencies, vehicle total fuel burn or energy consumption, and electrical component operating temperatures. Results show that cooling components with low temperature limits increases TMS weight and demonstrate that efficiency gains of the specific technologies can net a lower weight TMS system despite more stringent temperature limits.

Thermal management system↗

Thermal Management System Design for Electrified Aircraft Propulsion Concepts

This paper describes the development of thermal management systems (TMS) for three electrified aircraft propulsion (EAP) vehicle concepts released by NASA that span the UAM, regional, and single-aisle markets. For each EAP concept, a conventional TMS is designed for two electric component technology levels: state of the art and advanced. The goals for the paper are to compare the TMS designs for the above EAP concepts, to study how changes in requirements affect the TMS subcomponents, and to develop generalized TMS sizing relations. Each conventional TMS concept utilizes a liquid-based cooling methodology and is designed to cool the EAP electrical components only. The design parameters considered in this study include TMS architecture variation due to differing vehicle cooling requirements, electrical component efficiencies, vehicle total fuel burn or energy consumption, and electrical component operating temperatures. Results show that cooling components with low temperature limits increases TMS weight and demonstrate that efficiency gains of the specific technologies can net a lower weight TMS system despite more stringent temperature limits.

Thermal management system↗

A beginner's guide to belief revision and truth maintenance systems

This brief note is intended to familiarize the non-TMS audience with some of the basic ideas surrounding classic TMS's (truth maintenance systems), namely the justification-based TMS and the assumption-based TMS. Topics of further interest include the relation between non-monotonic logics and TMS's, efficiency and search issues, complexity concerns, as well as the variety of TMS systems that have surfaced in the past decade or so. These include probabilistic-based TMS systems, fuzzy TMS systems, tri-valued belief systems, and so on.

Mason, Cindy L.↗

Use of a New Analytical Model To Match Production Data and Identify Opportunities To Maximize Well Productivity in the Tuscaloosa Marine Shale Reservoir

The low productivity of the oil wells in the Tuscaloosa Marine Shale (TMS) Trend, located in Louisiana and Mississippi, is a mystery. Production data from 55 wells in the TMS Trend were analyzed to identify possible means of enhancing well productivity. The -1/2 slope in a log–log plot for reservoir linear flow (RLF) was observed for some wells, but not all, and the -1 slope for boundary–dominated flow (BDF) has not been seen in the past 5 years of production. The behavior of the TMS wells is attributed to the ultralow permeability of the TMS matrix and the decline of fracture conductivity, both of which delay the BDF. On the basis of the concept of the distance of investigation, derived from the radius–of–investigation concept, the matrix permeability of the seven TMS wells was estimated to be between 34 and 65 nd, with an average of 51 nd. A new mathematical model for production decline of multifractured horizontal wells was developed taking into consideration the time–dependent fracture conductivity during the BDF period. This model fits TMS–well production data, with an average error of 6.12% and an R2 value of 0.96. Assuming constant matrix permeability, fitting the new model to the production data in the BDF period gives a rate of fracture–conductivity decline of between 0.20 and 0.74% per month. The new mathematical model reveals opportunities to optimize well completion to enhance well productivity in the TMS Trend. For a given amount of fracture proppant allocated to a well, the shortest possible fracture spacing should be used to maximize well productivity. If the number of fractures is fixed as a constraint of well completion design, well productivity is inversely proportional to the square root of fracture spacing (i.e., if the fracture spacing is shortened by fourfold, well productivity is expected to double). If the horizontal wellbore length is fixed as a constraint of well completion, well productivity is inversely proportional to fracture spacing (i.e., if the fracture spacing is shortened by 50%, well productivity is expected to double).

Engineering↗

Role of cAMP in phenotypic changes of osteoblasts

Highlights: • Glucagon receptor and GloSensor expressing osteoblasts were established to induce cAMP elevation by glucagon. • Mineralization of osteoblasts is suppressed by cAMP. • Osteoclast-supporting activity of osteoblasts is induced by cAMP. • Gene expression profile revealed cAMP-induced phenotypic changes in osteoblasts. Bone remodeling is precisely controlled by bone formation and bone resorption, and osteoblasts are responsible for both processes. Osteoblasts exhibit an osteoclastogenic phenotype in response to elevated intracellular cyclic AMP [cAMP]{sub i} levels. However, the role of cAMP in osteoblasts acquiring an osteogenic phenotype is controversial. To elucidate the effect of cAMP on both phenotypes, an osteoblast-like cell line, TMS-12, was established in our laboratory and used in this study. Dibutyryl-cAMP (dBcAMP), a cAMP analogue, inhibited mineralization in TMS-12 cells and MC3T3E1 cells (an osteoblast-like cell line) but promoted osteoclast-supporting activity in TMS-12 cells. Moreover, mineralization was inhibited in glucagon receptor-transduced TMS-12 cells (TMS-12GCGR) after glucagon treatment to increase endogenous [cAMP]{sub i} levels. However, the osteoclast-supporting activity of TMS-12GCGR cells was stimulated by glucagon treatment. These cAMP-induced phenotypic changes of osteoblasts were also supported by their gene expression profile. These results suggest that [cAMP]{sub i} is an important factor mediating phenotypic changes of osteoblasts. Our findings may provide valuable insights into the mechanisms that underlie bone remodeling in both, healthy and diseased states.

60 APPLIED LIFE SCIENCES↗

Comparative analysis of thermal management systems in electric vehicles at extreme weather conditions: Case study on Nissan Leaf 2019 Plus, Chevrolet Bolt 2020 and Tesla Model 3 2020

With the surge in electric vehicle (EV) adoption and the need for extended driving ranges, optimizing energy efficiency, particularly through thermal management, is critical, especially in extreme weather. Managing the substantial energy needed for cabin climate control and battery temperature regulation can increase energy demands by over 50 %, severely limiting range. This study conducts a comparative analysis of thermal management systems (TMS) in three popular EV vehicles, 2020 Chevrolet Bolt, 2019 Nissan Leaf Plus, and 2020 Tesla Model 3, evaluating their distinct TMS configurations and performance under varied weather conditions. Using both numerical simulations and experimental data collected on a controlled test bench at Argonne National Laboratory, we assess how TMS architecture and operational modes influence energy consumption and range. A comprehensive TMS model was developed, integrating cabin and battery thermal sub-models in the Autonomie software platform, to simulate temperature fluctuations and range impacts. Cabin climate was modeled using a mono-zonal approach, while battery cell temperature distribution was estimated through a 2D nodal structure. Each vehicle's distinct TMS setup was evaluated: the Chevrolet Bolt and Tesla Model 3 use a dual evaporator vapor compression cycle with a PTC heater for the cabin and a coolant loop for battery thermal management; the Nissan Leaf Plus employs a heat pump with a PTC heater for the cabin and air-cooling for the battery. Tests conducted at ambient temperatures of 35°C, 22°C, -7°C, and -18°C reveal significant differences in energy use and range reduction across both configurations and conditions. At 35°C, the Tesla Model 3, Chevrolet Bolt, and Nissan Leaf Plus have a range reduction of 8%, 9%, and 13%, respectively, due to air conditioning. In winter, heating technology is paramount; at -7°C, the Nissan Leaf's heat pump configuration achieves a lower range reduction (19.3%) compared to the Tesla and Chevrolet Bolt PTC heaters, which reduce range by 28.3% and 31%, respectively. Further, this study provides valuable insights for automotive engineers, EV technology researchers, and thermal management system designers aiming to enhance electric vehicle performance by understanding how different weather conditions and TMS architectures impact energy consumption and driving range.

33 ADVANCED PROPULSION SYSTEMS↗

SU-E-J-129: A Strategy to Consolidate the Image Database of a VERO Unit Into a Radiotherapy Management System

Purpose: To present a strategy to integrate the imaging database of a VERO unit with a treatment management system (TMS) to improve clinical workflow and consolidate image data to facilitate clinical quality control and documentation. Methods: A VERO unit is equipped with both kV and MV imaging capabilities for IGRT treatments. It has its own imaging database behind a firewall. It has been a challenge to transfer images on this unit to a TMS in a radiation therapy clinic so that registered images can be reviewed remotely with an approval or rejection record. In this study, a software system, iPump-VERO, was developed to connect VERO and a TMS in our clinic. The patient database folder on the VERO unit was mapped to a read-only folder on a file server outside VERO firewall. The application runs on a regular computer with the read access to the patient database folder. It finds the latest registered images and fuses them in one of six predefined patterns before sends them via DICOM connection to the TMS. The residual image registration errors will be overlaid on the fused image to facilitate image review. Results: The fused images of either registered kV planar images or CBCT images are fully DICOM compatible. A sentinel module is built to sense new registered images with negligible computing resources from the VERO ExacTrac imaging computer. It takes a few seconds to fuse registered images and send them to the TMS. The whole process is automated without any human intervention. Conclusion: Transferring images in DICOM connection is the easiest way to consolidate images of various sources in your TMS. Technically the attending does not have to go to the VERO treatment console to review image registration prior delivery. It is a useful tool for a busy clinic with a VERO unit.

60 APPLIED LIFE SCIENCES↗

Growth from Solutions, Structure, and Photoluminescence of Single-Crystal Plates of p-Terphenyl and Its Trimethylsilyl Derivative

Samples of single-crystal plates of p-terphenyl (3Р) and its derivative with terminal substituents–Si(CH{sub 3}){sub 3} (TMS-3P-TMS), up to 25–30 mm in size and 400 μm thick, have been obtained for the first time by the solvent–antisolvent growth method. The crystal structure at temperatures of 293 and 85 K is refined for 3Р and solved (for the first time) for TMS-3P-TMS using X-ray diffraction. The habit of crystals and their surface morphology are investigated by methods of optical and laser confocal microscopy. The influence of substituent terminal groups -Si(CH{sub 3}){sub 3} on the growth and structure of TMS-3P-TMS crystals is analyzed based on experimental data. The optical absorption and photoluminescence spectra of solutions and crystalline samples are investigated.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

EXPERIMENTAL EVALUATION OF ULTRASONIC VELOCITIES AND ANISOTROPY IN THE TUSCALOOSA MARINE SHALE FORMATION

Tuscaloosa Marine Shale (TMS) formation is a clay- and organic-rich emerging shale play with a considerable amount of hydrocarbon resources. Despite the substantial potential, there have been only a few wells drilled and produced in the formation over the recent years. The analyzed TMS samples contain an average of 50 wt% total clay, 27 wt% quartz and 14 wt% calcite and the mineralogy varies considerably over the small intervals. The high amount of clay leads to pronounced anisotropy and the frequent changes in mineralogy result in the heterogeneity of the formation. We studied the compressional (V P ) and shear-wave (V S ) velocities to evaluate the degree of anisotropy and heterogeneity, which impact hydraulic fracture growth, borehole instabilities, and subsurface imaging. The ultrasonic measurements of P- and S-wave velocities from five TMS wells are the best fit to the linear relationship with R 2 = 0.84 in the least-squares criteria. We observed that TMS S-wave velocities are relatively lower when compared to the established velocity relationships. Most of the velocity data in bedding-normal direction lie outside constant V P /V S lines of 1.6–1.8, a region typical of most organic-rich shale plays. For all of the studied TMS samples, the S-wave velocity anisotropy exhibits higher values than P-wave velocity anisotropy. In the samples in which the composition is dominated by either calcite or quartz minerals, mineralogy controls the velocities and V P /V S ratios to a great extent. Additionally, the organic content and maturity account for the velocity behavior in the samples in which the mineralogical composition fails to do so. The results provide further insights into TMS Formation evaluation and contribute to a better understanding of the heterogeneity and anisotropy of the play.

Geochemistry & Geophysics↗

Thermal Management System Modeling in the Heat Transport System Simulation (HeaTSSPy) Package

This paper describes the development of a thermal management system (TMS) concept design and analysis software package called Heat Transport System Simulation (HeaTSSPy). Built within Python using the OpenMDAO framework, HeaTSSPy can be used to size and optimize an active (using liquid/air heat exchangers) or passive (using finned heat sinks) TMS. The package makes use of modular TMS elements that allow for the creation of different system architectures and includes components such as heat sinks, heat exchangers, liquid pumps, fans, ducts, air inlets, air nozzles, and liquid pipes. Modeling methods for these components include a combination of physics-based analytical and empirical equations that relate component sizing criteria to system performance. The HeatSSPy heat sink methods are fully detailed within this paper, while the heat exchanger methods are described and referenced from previous work. This paper also uses high-fidelity simulation to validate two different methods of calculating thermal resistance using CFD results. Once the methods are fully described, the code is exercised to compare an active TMS with that of a passive TMS. Design criteria for this study include rejected heat, system altitude, Mach number, and ambient temperature. These criteria are used to develop a TMS system with estimated performance metrics such as weight, drag, and operational power. Results of this paper show the crossover point when a passive system begins to weigh more than an active system for a given heat rejection.

Thermal management system↗

A Simplified Model of VIPER Thermal Management System. Part II: Integrated Vehicle

NASA’s Volatiles Investigating Polar Exploration Rover (VIPER) thermal management system (TMS) relies on four loop heat pipes (LHPs) to transport electronic waste heat to the vehicle cooling radiative surface and avoid overheating. The TMS has also ten constant conductance heat pipes (CCHPs) dedicated to balance the thermal load within the internal environment where the avionics boxes are mounted, also called warm electronic box (WEB), and to transport the heat from two of the science payload instruments. The TMS also uses two thermal straps to thermally link the batteries to the WEB. These thermal components, in addition to heaters, thermostat, multi-layer insulation (MLIs), and isolators forms the core of the VIPER TMS. The complex heat transport balance managed by the TMS is challenging to characterize and model. The more fidelity and granularity of a model, the more costly the computational resources needed and the longer the simulation and modeling time. When the priority is to provide quick but reliable assessments of the thermal performance or real time thermal feedback for training of console operators, simplified modeling tools are needed. To satisfy that need, this paper describes the effort to develop and correlate a model of VIPER TMS based on control volume approach. The correlation effort in particular focuses on hibernation, cold thermal balance, and hot thermal balance data from the integrated vehicle thermal vacuum (TVAC) test. Thus, the correlated model captures the heat leaks during hibernations and the performance at two extremes, bounding, operating scenarios.

Loop Heat Pipe↗

A Simplified Model of VIPER Thermal Management System. Part II: Integrated Vehicle

NASA’s Volatiles Investigating Polar Exploration Rover (VIPER) thermal management system (TMS) relies on four loop heat pipes (LHPs) to transport electronic waste heat to the vehicle cooling radiative surface and avoid overheating. The TMS has also ten constant conductance heat pipes (CCHPs) dedicated to balance the thermal load within the internal environment where the avionics boxes are mounted, also called warm electronic box (WEB), and to transport the heat from two of the science payload instruments. The TMS also uses two thermal straps to thermally link the batteries to the WEB. These thermal components, in addition to heaters, thermostat, multi-layer insulation (MLIs), and isolators forms the core of the VIPER TMS. The complex heat transport balance managed by the TMS is challenging to characterize and model. The more fidelity and granularity of a model, the more costly the computational resources needed and the longer the simulation and modeling time. When the priority is to provide quick but reliable assessments of the thermal performance or real time thermal feedback for training of console operators, simplified modeling tools are needed. To satisfy that need, this paper describes the effort to develop and correlate a model of VIPER TMS based on control volume approach. The correlation effort in particular focuses on hibernation, cold thermal balance, and hot thermal balance data from the integrated vehicle thermal vacuum (TVAC) test. Thus, the correlated model captures the heat leaks during hibernations and the performance at two extremes, bounding, operating scenarios.

Thermal Modeling↗