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At least 55 records · Page 3
All sourcesNASA NTRSDOE OSTI
NASA NTRSDate not supplied

Global Rescue Response to a Multivehicle Deorbit from the International Space Station

The U.S. Department of Defense (DoD) has been tasked to support rescue efforts in the event of an off-nominal landing of a Commercial Crew Program vehicle transporting NASA crewmembers to or from the International Space Station. The DoD is further tasked to support returning U.S. and International Partner crewmembers on Russian Soyuz spacecraft missions, specifically to ensure aeromedical evacuation capability in the event of a crewmember injury at the time of launch or landing. This DoD mission is primarily considered during planned launch and landing operations, with forces placed in an alert posture to support if needed. However, overall mission concept of operations encompasses a no-notice rescue capability in the event of an on-orbit emergency. Such contingency scenarios are pre-coordinated and simulated to ensure a ready posture of associated DoD assets and to promote coordination of government, commercial, and military stakeholders. To date, planning and simulations have focused on execution of a single rescue mission; the possibility of a multi-vehicle evacuation and rescue scenario has not been adequately explored. This presentation will examine the process of responding to an emergency onboard the International Space Station that results in the early departure and deorbit of multiple docked vehicles to preserve the health and safety of the crew. We will highlight the complexity of this recovery scenario and discuss potential complications that could arise, as well as identify areas in which deliberate planning and simulation can better ensure successful preparation for such a multifaceted recovery operation.

Travis Levon Houser↗
NASA NTRS2024

Search Technology for Optimal Rescue Missions (STORM)

Natural disasters, such as earthquakes, hurricanes, and wildfires are responsible for the deaths of 60,000 to 90,000 people per year. Today, search and rescue (SAR) operations heavily rely on humans to find and deliver life-saving supplies to those affected by these disasters. However, these operations have limits in visibility, navigation, communication systems, and data availability in the area affected, as well as endangering the SAR personnel. Search Technology for Optimal Rescue Missions (STORM) discusses a new system for SAR teams using autonomous drones able to find and deliver supplies to people, without risking more lives in the process. The concept includes the use of two drone types, STORM Search and STORM Rescue, which will survey and locate survivors and be able to drop equipment to the survivors identified, respectively. These two types of drones were optimized in drone design and durability (such as the use of dihedral wings and a toroidal propeller), detection and navigation systems (sturdy thermal and Light Detection and Ranging [LiDAR] cameras), automation and system design (Machine Learning and Computer Vision), server-drone communication (Meshnets), weight, and cost. Once implemented, the STORM concept is expected to improve, ease, and speed up SAR operations, and most important of all, rescue lives that would have never been currently possible to find.

Astha Ingole↗
DOE OSTI2021

Rescuing a black hole in the large- q coupled SYK model

In this paper, we develop a general effective theory for two copies of the Sachdev-Ye-Kitaev (SYK) model with a time-dependent bilinear coupling. For a quantum quench problem with an initial state of the thermofield double state, we show how the evolution of the system is described by a complex reparametrization field with a classical Hamiltonian. We study correlation functions in this system and compare the large-q theory with the bulk low energy effective theory. In particular, we study the special case of a “rescued black hole”, which describes how a time-evolved thermofield double state can evolve to the ground state of a coupled SYK model by a carefully tuned time-dependent coupling. In the low energy region, there is a holographic dual interpretation, which is a geometry that crosses over from an eternal black hole to a global AdS2 vacuum. This family of geometries allow us to access the bulk region that would be the black hole interior without the rescue process. By comparing the large-q and low energy theory, we find that even in the low energy region the deviation from the low energy theory cannot be neglected if the rescue process starts late. This provides evidence that the low energy effective theory of the bulk fails near the inner horizon of the black hole. We note the possibility of a connection to a two-dimensional analog of the higher-dimensional black hole singularity.

2D Gravity↗
DOE OSTI2016

Oxysterol-binding protein ORP3 rescues the Amyotrophic Lateral Sclerosis-linked mutant VAPB phenotype

A mutation in VAPB causes a familial form of Amyotrophic Lateral Sclerosis. The mutant protein (VAPB-P56S) is aggregate prone and blocks retrograde traffic from the endoplasmic reticulum (ER) Golgi intermediate compartment (ERGIC) including trafficking to the nuclear envelope (NE). Here we report a morphological screen where overexpression of oxysterol binding protein-related protein-3 (ORP3) rescued the mutant VAPB phenotype. It resolved the mutant VAPB-induced membrane expansions, restored solubility of the mutant protein in non-ionic detergent, and restored trafficking of Emerin to the NE. Knockdown of ORP3 or VAPB increased the intracellular level of phosphatidylinositol 4-phosphate (PtdIns4P). Decreasing PtdIns4P levels by inhibiting its synthesis reduced the severity of the mutant VAPB-induced membrane expansions and restored Emerin trafficking to the NE. Thus, VAPB and its interacting partners cooperatively regulate protein trafficking through the ERGIC by modulating PtdIns4P levels. - Graphical abstract: Overexpression of ORP3 rescues the mutant VAPB phenotype. It collectively regulates trafficking from the endoplasmic reticulum Golgi intermediate compartment (ERGIC) with VAPB and SAC1 by modulating intracellular levels of phosphatidylinositol 4-phosphate (PtdIns4P). - Highlights: • Co-overexpression of ORP3 rescues the mutant VAPB aggregation phenotype. • It restores mutant VAPB-induced protein trafficking defect. • VAPB and ORP3 collectively regulate intracellular PtdIns4P levels. • PtdIns4P plays a pivotal role in this VAPB-mediated protein trafficking step.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2012

Designing Allosteric Control into Enzymes by Chemical Rescue of Structure

Ligand-dependent activity has been engineered into enzymes for purposes ranging from controlling cell morphology to reprogramming cellular signaling pathways. Where these successes have typically fused a naturally allosteric domain to the enzyme of interest, here we instead demonstrate an approach for designing a de novo allosteric effector site directly into the catalytic domain of an enzyme. This approach is distinct from traditional chemical rescue of enzymes in that it relies on disruption and restoration of structure, rather than active site chemistry, as a means to achieve modulate function. We present two examples, W33G in a {beta}-glycosidase enzyme ({beta}-gly) and W492G in a {beta}-glucuronidase enzyme ({beta}-gluc), in which we engineer indole-dependent activity into enzymes by removing a buried tryptophan side chain that serves as a buttress for the active site architecture. In both cases, we observe a loss of function, and in both cases we find that the subsequent addition of indole can be used to restore activity. Through a detailed analysis of {beta}-gly W33G kinetics, we demonstrate that this rescued enzyme is fully functionally equivalent to the corresponding wild-type enzyme. We then present the apo and indole-bound crystal structures of {beta}-gly W33G, which together establish the structural basis for enzyme inactivation and rescue. Finally, we use this designed switch to modulate {beta}-glycosidase activity in living cells using indole. Disruption and recovery of protein structure may represent a general technique for introducing allosteric control into enzymes, and thus may serve as a starting point for building a variety of bioswitches and sensors.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2018

An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue

Microtubules are heavily regulated dynamic polymers of αβ-tubulin that are required for proper chromosome segregation and organization of the cytoplasm. Polymerases in the XMAP215 family use arrayed TOG domains to promote faster microtubule elongation. Regulatory factors in the cytoplasmic linker associated protein (CLASP) family that reduce catastrophe and/or increase rescue also contain arrayed TOGs, but how CLASP TOGs contribute to activity is poorly understood. Here, using Saccharomyces cerevisiae Stu1 as a model CLASP, we report structural, biochemical, and reconstitution studies that clarify functional properties of CLASP TOGs. The two TOGs in Stu1 have very different tubulin-binding properties: TOG2 binds to both unpolymerized and polymerized tubulin, and TOG1 binds very weakly to either. The structure of Stu1-TOG2 reveals a CLASP-specific residue that likely confers distinctive tubulin-binding properties. The isolated TOG2 domain strongly suppresses microtubule catastrophe and increases microtubule rescue in vitro, contradicting the expectation that regulatory activity requires an array of TOGs. Single point mutations on the tubulin-binding surface of TOG2 ablate its anti-catastrophe and rescue activity in vitro, and Stu1 function in cells. Revealing that an isolated CLASP TOG can regulate polymerization dynamics without being part of an array provides insight into the mechanism of CLASPs and diversifies the understanding of TOG function.

Majumdar, Shreoshi↗
DOE OSTI2022

Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling

Disruption of androgen signaling is known to cause testicular malformation and defective spermatogenesis in zebrafish. However, knockout of cyp17a1 , a key enzyme responsible for the androgen synthesis, in ar -/- male zebrafish paradoxically causes testicular hypertrophy and enhanced spermatogenesis. Because Cyp17a1 plays key roles in hydroxylation of pregnenolone and progesterone (P4), and converts 17α-hydroxypregnenolone to dehydroepiandrosterone and 17α-hydroxyprogesterone to androstenedione, we hypothesize that the unexpected phenotype in cyp17a1 -/-; androgen receptor ( ar )-/- zebrafish may be mediated through an augmentation of progestin/nuclear progestin receptor (nPgr) signaling. In support of this hypothesis, we show that knockout of cyp17a1 leads to accumulation of 17α,20β-dihydroxy-4-pregnen-3-one (DHP) and P4. Further, administration of progestin, a synthetic DHP mimetic, is sufficient to rescue testicular development and spermatogenesis in ar -/- zebrafish, whereas knockout of npgr abolishes the rescue effect of cyp17a1 -/- in the cyp17a1 -/-; ar -/- double mutant. Analyses of the transcriptomes among the mutants with defective testicular organization and spermatogenesis ( ar -/-, ar -/-; npgr -/- and cyp17a -/-; ar -/-; npgr -/-), those with normal phenotype (control and cyp17a1 -/-), and rescued phenotype ( cyp17a1 -/-; ar -/-) reveal a common link between a downregulated expression of insl3 and its related downstream genes in cyp17a -/-; ar -/-; npgr -/- zebrafish. Taken together, our data suggest that genetic or pharmacological augmentation of the progestin/nPgr pathway is sufficient to restore testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling.

Zhai, Gang↗
NASA NTRS1972

An altitude chamber rescue ensemble

Altitude chamber tests accomplished with the astronaut crews in the spacecraft at a simulated altitude of above 200,000 ft requires that a rescue team be provided in the event of an accident in the spacecraft. The rescue crew is stationed in an airlock maintained at an altitude of 18,000 ft. A protective ensemble provides the rescue crew with life support capabilities, communications, and protection in the event of an emergency. In the event of an emergency, repressurization of the chamber is initiated; as the chamber descends, the airlock ascends and the two meet at 25,000 ft. This phase of the emergency repressurization takes less than 30 sec.

Lloyd, R. P.↗
NASA NTRS1972

Safety in earth orbit study. Volume 3: Analysis of tumbling spacecraft, escape and rescue

Detailed and supporting analyses of the hazards of a disabled spacecraft in a tumbling mode and of crew escape, rescue, and survivability are presented for earth orbital operations of the space shuttle program. Tumbling conditions, arresting tumbling by external means, and escape from a tumbling vehicle are discussed. Details on design concepts for the modular space station, integral tank orbiter, drop tank orbiter, and a small space vehicle are included. Results of the crew safety study indicate that the shuttle orbiter should be the primary vehicle for dealing with emergencies and one vehicle should be available for rapid emergency rescue. An Apollo command module should be carried in the orbiter cargo bay in case an orbiter is not available. Approaches for a quicker escape or rescue capability are also recommended.

Source record↗
NASA NTRS1972

The earth orbit shuttle as a space rescue vehicle.

According to present concepts starting with some future date all manned space missions beyond low-earth orbit are to originate in low-earth orbit and to return ultimately to low-earth orbit. The Earth-Orbit-Shuttle (EOS) is visualized as the only vehicle operating between earth and low-earth orbit. The ability of the EOS to provide rescue services in the case of emergency is evaluated. It is found that an employment of the EOS as rescue vehicle is basically feasible, although it has certain limitations. Complementary means of transportation are required for emergencies beyond low-earth orbit. Approaches to enhance the rescue mission utility of the EOS are discussed.

Hinton, M. G., Jr.↗
NASA NTRS1973

The advanced OPLE for search and rescue

Recent technological advances have made it possible to develop an advanced OMEGA position location experiment for a global search and rescue application. This application generated some new problem areas such as the OMEGA lane ambiguity, random access, location accuracy, real time processing, and size and weight of the Search and Rescue Communication (SARCOM). This experiment will demonstrate the feasibility of instantaneous alarm and position location by using a relatively inexpensive, battery operated, three-pound package. This package can transmit the alarm and position through a synchronous satellite to a search and rescue station in less than three minutes.

Morakis, J. C.↗
NASA NTRS1977

Space shuttle search and rescue experiment using synthetic aperture radar

The feasibility of a synthetic aperture radar for search and rescue applications was demonstrated with aircraft experiments. One experiment was conducted using the ERIM four-channel radar and several test sites in the Michigan area. In this test simple corner-reflector targets were successfully imaged. Results from this investigation were positive and indicate that the concept can be used to investigate new approaches focused on the development of a global search and rescue system. An orbital experiment to demonstrate the application of synthetic aperture radar to search and rescue is proposed using the space shuttle.

Sivertson, W. E., Jr.↗
NASA NTRS1980

SARSAT: A rescue system for ships and airplanes

The SARSAT rescue system is described and alternative systems discussed, with SARSAT functioning as either independent satellite within an emergency call system or as an additional search and rescue payload of another satellite system. Geostationary and polar orbits are compared. A low cost SARSAT rescue system utilizing four satellites in a quasi solar, sun synchronized orbit at 1000 kilometers is proposed. Three multiple start satellites in a 57 degree orbit, with a fourth satellite in reserve at a lower orbit are described. Alternative transport systems are discussed and a recommended time table from project approval to launch is given.

Source record↗
NASA NTRS1980

Electronic search and rescue aids

There are two elements to the basic electronic search and rescue problem: a means for immediately alerting potential rescuers and an effective method to guide the rescue forces to the scene of the emergency. An Emergency Locator Transmitter (ELT) used by aircraft or an Emergency Position Indicating Radio Beacon (EPIRB) used by maritime vessels has the capability of providing for both an immediate alert and a homing signal to assist rescue forces in locating the site of the distress. This paper describes the development of ELT/EPIRB systems. Emphasis is placed on the SARSAT project, the COSPAS/SARSAT project, and an experimental 406 MHz ELT/EPIRB system.

Trudell, B. J.↗
NASA NTRS1988

A Space Station crew rescue and equipment retrieval system

This paper studies the possible use of a Space Station crew rescue and equipment retrieval system as a safeguard against the inadvertent separation of crew or equipment from the Space Station. The time to effect rescue and retrieval and the problem of crew separation are discussed. Alternate rescue/retrieval systems are evaluated. It is concluded that telerobotic vehicles provide the lowest cost rescue capability.

Adornato, Rudolph J.↗
NASA NTRS1992

Motion-based carriage simulation of extra-vehicular activity (EVA) rescue

A research program was outlined for a series of Extra-Vehicular Activity (EVA) rescue studies. The general purpose is to get a better appreciation of the characteristics describing an EVA rescue scenario. Several studies have been completed in the Virtual Interactive Environment Workstation (VIEW) at NASA Ames Research Center. Similar studies are planned for a variety of simulators both to get more reliable results for the EVA rescue problem and to baseline the simulators against one another. Work is planned for a motion-based carriage to expand the validity of the previously obtained results.

Brody, Adam R.↗
NASA NTRS1991

TALON and CRADLE: Systems for the rescue of tumbling spacecraft and astronauts

Advanced pressure suit and tool designs are beginning to allow extravehicular astronauts to repair space vehicles and so increase mission life and system reliability. A common spacecraft failure that is a severe challenge to the rescue mission planner is loss of attitude control resulting in tumbling motion. If an extravehicular astronaut flying the Manned Maneuvering Unit (MMU) 'falls' into a tumble, the result could be loss of life. TALON (Tumble Arresting Large Oscillation Nullifier) is a device capable of capturing a target in an uncontrolled three-axis tumble. CRADLE (Concentric Rotating Astronaut Detumble Lifesaving Equipment) is a similar device sized to rescue a suited astronaut. The two rescue vehicles work on the same basic principle. They are structural shells with articulated limbs which can surround a tumbling target and thus align both the chaser and target centers of mass (CM).

Idle, Dunning, V↗
NASA NTRS1992

Group Task Force on Satellite Rescue and Repair

The Group Task Force was chartered by the Administrator of NASA to recommend 'a policy outlining the criteria, the design standards, and the pricing model to guide NASA in assessing the responsibilities for government and nongovernment Satellite Rescue and Repair Missions.' Criteria for accepting such missions, risks, and benefits to all sectors of our economy involved in satellite services, adequacy of planning and training, and the impact on NASA's primary mission were reviewed. The Group began by asking a more fundamental question; is satellite rescue and repair a logical element of NASA's mission? Factors considered were: (1) the probability of rescue or repair opportunities arising; (2) the economic justification for such attempts; (3) the benefits to NASA, both from such ad hoc learning experiences in space operations and the impact on the public perception of NASA; (4) the effect of such unanticipated missions on NASA's scheduled activities; (5) any potential effect on NASA's technical capability to work in space; and (6) any potential effect on U.S. economic competitiveness.

Source record↗