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At least 55 records · Page 3
All sourcesNASA NTRSDOE OSTI
DOE OSTI2018

Profiling neuron-autonomous lncRNA changes upon ischemia/reperfusion injury

Highlights: • Tnxa-ps1 is up regulated after OGD/R. • Tnxa-ps1 knockdown promoted neuronal survival after OGD/R. • Tnxa-ps1 up-regulation is associated with the four mRNA changes after OGD/R. Extensive changes of neuronal transcriptome occur post ischemic stroke and during the following reperfusion. Although numerous studies focused on transcriptome changes of mRNAs associated with ischemic stroke, little is known about whether and how long non-coding RNAs (lncRNAs), which play critical roles in cellular homeostasis, are involved in this process. In this study, we performed high throughput screening to analyze expression changes of lncRNAs in primarily cultured hippocampal neurons under an oxygen-glucose deprivation/reperfusion (OGD/R) condition at 0 h, 6 h, 12 h, and 18 h, respectively. Knock down of one validated lncRNAs (Tnxa-ps1) promoted neuronal survival by inhibiting apoptosis. Coding non-coding co-expression network analysis revealed that the expression of Tnxa-ps1 was highly correlated with changes of a particular group of genes, many of which are associated with neural protection. Finally, we showed that down-regulation of Tnxa-ps1 reversed the expression changes of four mRNAs post OGD/R, revealing a regulatory effect between Tnxa-ps1 and selected genes. Together, our data revealed possible participation of lncRNAs in the pathophysiology of OGD/R and thereby provided new insights into the studies of potential therapeutic targets for ischemic stroke.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1931

Superchargers

It seems hardly necessary to use a supercharger near sea level simply to mix the gases. The importance of the supercharger will increase with the use of heavy fuels. Before long we shall probably be using two-stroke-cycle and four-stroke-cycle scavenging engines on airplanes. In accord with the present tendency, we shall present here the French solutions of the problem in a practical rather than in a purely theoretical manner.

Leglise, Pierre↗
NASA NTRS2014

Modelflow Estimates of Stroke Volume Do Not Correlate With Doppler Ultrasound Estimates During Upright Posture

Orthostatic intolerance affects 60‐80% of astronauts returning from long‐duration missions, representing a significant risk to completing mission‐critical tasks. While likely multifactorial, a reduction in stroke volume (SV) represents one factor contributing to orthostatic intolerance during stand and head up tilt (HUT) tests. Current measures of SV during stand or HUT tests use Doppler ultrasound and require a trained operator and specialized equipment, restricting its use in the field. BeatScope (Finapres Medical Systems BV, The Netherlands) uses a modelflow algorithm to estimate SV from continuous blood pressure waveforms in supine subjects; however, evidence supporting the use of Modelflow to estimate SV in subjects completing stand or HUT tests remain scarce. Furthermore, because the blood pressure device is held extended at heart level during HUT tests, but allowed to rest at the side during stand tests, changes in the finger arterial pressure waveform resulting from arm positioning could alter modelflow estimated SV. The purpose of this project was to compare Doppler ultrasound and BeatScope estimations of SV to determine if BeatScope can be used during stand or HUT tests. Finger photoplethysmography was used to acquire arterial pressure waveforms corrected for hydrostatic finger‐to‐heart height using the Finometer (FM) and Portapres (PP) arterial pressure devices in 10 subjects (5 men and 5 women) during a stand test while simultaneous estimates of SV were collected using Doppler ultrasound. Measures were made after 5 minutes of supine rest and while subjects stood for 5 minutes. Next, SV estimates were reacquired while each arm was independently raised to heart level, a position similar to tilt testing. Supine SV estimates were not significantly different between all three devices (FM: 68+/-20, PP: 71+/-21, US: 73+/-21 ml/beat). Upon standing, the change in SV estimated by FM (‐18+/-8 ml) was not different from PP (‐21+/-12), but both were significantly less than US (‐37+/-16 ml, p<.05). Raising finger BP devices to heart level caused no significant change in SV measured with any of the devices (FM: 1.5+/-19, PP: 1.7+/-26, US: 0.5+/-6), although variability was 3‐6x greater as assessed by both blood pressure devices compared to US. Retrospective analysis of blood pressure data to assess SV in 11 supine subjects revealed significantly different estimates between methods (FM: 95+/-17, US: 75+/-32, p<.05), but the change in SV resulting from HUT was similar between methods (FM: ‐37+/-9, US: ‐40+/-18 ml). However, the correlation coefficient determined from pairs of SV estimated by US and FM was weak (r2=0.03). These data suggest Modelflow cannot be used in lieu of Doppler ultrasound to estimate SV during stand or HUT tests. Further investigation should focus on identifying factors contributing to differences between these measurement techniques in order to make use of a simple method for assessing beat‐by‐beat changes in SV during postural changes, especially during field testing.

Ferguson, Connor R.↗
NASA NTRS2002

Comparison of echocardiographic changes after short- and long-duration spaceflight

BACKGROUND: Previous echocardiographic studies of astronauts before and after short-duration (4-17 d) missions have demonstrated a decrease in resting left ventricular stroke volume, but maintained ejection fraction (EF) and cardiac output. Similar studies before and after long-duration (129-144 d) spaceflight have been rare and their overall results equivocal. METHODS: Echocardiographic measurements (M-mode, 2-D, and Doppler) were obtained from short-duration (n = 13) and long-duration (n = 4) crewmembers to evaluate cardiac chamber sizes and function. RESULTS: Compared with short-duration astronauts, long-duration crewmembers had decreases in EF (+6+/-0.02 vs. -10.5+/-0.03%, p = 0.005) and percent fractional shortening (+7+/-0.03 vs. -11+/-0.07%, p = 0.015), and an increase in left ventricular end systolic volume (-12+/-0.06 vs. +39+/-0.24%, p = 0.011). CONCLUSIONS: These data suggest a reduction in cardiac function that relates to mission duration. As the changes in BP and circulating blood volume are reported to be similar after short- and long-duration flights, the smaller EF after longer spaceflights may be due to a decrease in cardiac function rather than altered blood volume.

short duration↗
NASA NTRS2000

Comparison of Echocardiographic Measurements Before and After Short and Long Duration Spaceflight

Previous echocardiography studies in astronauts before and after short duration (4 - 17 days) missions have demonstrated a decrease in resting left ventricular (LV) stroke volume (SV), but maintained ejection fraction (EF) and cardiac output. Similar studies before and after long duration (129 - 144 days) spaceflight have been rare and their overall results equivocal. The purpose of this work was to compare the echocardiographic measurements (M-mode, 2-D and Doppler) from short duration (n = 13) and long duration (n = 4) crewmembers. Compared to short duration astronauts, long duration crewmembers had a significantly greater percent decrease in EF (+6+/-0.02 vs.-10.5+/-0.03, p = 0.005) and percent fractional shortening (+7+/-0.03 vs. -11+/-0.07, p = 0.0 15), and an increase in LV end systolic volume (-12+/-0.06 vs. +39+/-0.24, p = 0.011). These data suggest a reduction in cardiac function that relates to mission duration. As the changes in blood pressure and circulating blood volume (9% - 12%) are reported to be similar after short and long duration flights, the drop in EF after longer spaceflights is likely due to a decrease in cardiac function rather than altered blood volume.

Fritsch-Yelle, Janice M.↗
DOE OSTI2013

United Kingdom Carotid Artery Stent Registry: Short- and Long-Term Outcomes

Background: Carotid artery stenting (CAS) has evolved to treat carotid artery disease with the intention of prevent stroke. The British Society of Interventional Radiologists developed a voluntary registry to monitor the practice of this novel procedure. We present the data from the United Kingdom (UK) CAS registry for short and long-term outcomes for symptomatic and asymptomatic carotid disease. Methods: The UK CAS registry collected data from 1998 to 2010 from 31 hospitals across the UK for 1,154 patients. All interventions were enrolled in the registry for both asymptomatic and symptomatic patients. Initial entry forms were completed for each patient entered with data including indications, demographic data, CAS data (including stents and protection device details) and 30-day outcomes. Complications were documented. Follow-up data were collected at yearly intervals. Results: Nine hundred fifty-three (83 %) symptomatic and 201 (17 %) asymptomatic patients were enrolled into the registry. The 30-day all stroke and death rates for symptomatic patients were 5.5 and 2.2 % for those with asymptomatic disease. The 30-day mortality rate was 1.7 % for symptomatic and 0.6 % for asymptomatic patients. For symptomatic patients undergoing CAS, the 7-year all-cause mortality rate was 22.2 % and for asymptomatic patients 18.1 %. The 7-year all-cause mortality and disabling stroke rates were 25.3 and 19.4 %, respectively. Conclusion: These data indicate that outside of the tight constraints of a randomised trial, CAS provides effective prophylaxis against stroke and death.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2015

Solving the Issue of Restenosis After Stenting of Intracranial Stenoses: Experience with Two Thin-Strut Drug-Eluting Stents (DES)—Taxus Element™ and Resolute Integrity™

PurposeThin-strut, flexible DES are suitable for intracranial stenting and may improve long-term vessel patency. The purpose of this study was to report our experience with two new-generation DES for the treatment of intracranial atherosclerotic disease.Patients and MethodsWe retrospectively reviewed all patients treated with Taxus Element™ or Resolute Integrity™ stent for an intracranial atherosclerotic stenosis between March 2011 and August 2013. Technical success was defined as the ability to deploy the device at the desired location and reduce the degree of stenosis below 50 %. All procedure-related strokes were recorded. Control angiography was scheduled after 6 weeks, 3, 6, and 12 months and yearly thereafter. A luminal narrowing ≥50 % was regarded as a restenosis. Stroke recurrence in the territory of the treated artery was reported.ResultsIn the defined period we treated 101 patients harboring 117 intracranial stenoses. The procedure was successful in 100 (85.5 %) lesions. Procedure-related strokes occurred in 10 (9.9 %) patients with a permanent morbidity in 3 (3.0 %). Follow-up angiography was available for 83 of 100 (83.0 %) successfully treated lesions with an average of 355 days (IQR 153–482 days). Three (3.6 %) asymptomatic restenoses were detected. All occurred after treatment with Resolute Integrity™, none after Taxus Element™ (p = 0.059). New strokes in the territory of the treated artery were encountered in 2 (2.6 %) occasions.ConclusionThin-strut DES improve long-term patency and reduce the risk of subsequent stroke. Differences between devices may exist. Feasibility is comparable to bare-metal balloon-mounted stents and procedure-related strokes occurred within the expected range.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2015

TU-EF-204-02: Hiigh Quality and Sub-MSv Cerebral CT Perfusion Imaging

Purpose: CT Perfusion (CTP) imaging is of great importance in acute ischemic stroke management due to its potential to detect hypoperfused yet salvageable tissue and distinguish it from definitely unsalvageable tissue. However, current CTP imaging suffers from poor image quality and high radiation dose (up to 5 mSv). The purpose of this work was to demonstrate that technical innovations such as Prior Image Constrained Compressed Sensing (PICCS) have the potential to address these challenges and achieve high quality and sub-mSv CTP imaging. Methods: (1) A spatial-temporal 4D cascaded system model was developed to indentify the bottlenecks in the current CTP technology; (2) A task-based framework was developed to optimize the CTP system parameters; (3) Guided by (1) and (2), PICCS was customized for the reconstruction of CTP source images. Digital anthropomorphic perfusion phantoms, animal studies, and preliminary human subject studies were used to validate and evaluate the potentials of using these innovations to advance the CTP technology. Results: The 4D cascaded model was validated in both phantom and canine stroke models. Based upon this cascaded model, it has been discovered that, as long as the spatial resolution and noise properties of the 4D source CT images are given, the 3D MTF and NPS of the final CTP maps can be analytically derived for a given set of processing methods and parameters. The cascaded model analysis also identified that the most critical technical factor in CTP is how to acquire and reconstruct high quality source images; it has very little to do with the denoising techniques often used after parametric perfusion calculations. This explained why PICCS resulted in a five-fold dose reduction or substantial improvement in image quality. Conclusion: Technical innovations generated promising results towards achieving high quality and sub-mSv CTP imaging for reliable and safe assessment of acute ischemic strokes. K. Li, K. Niu, Y. Wu: Nothing to disclose. G.-H. Chen: Research funded, GE Healthcare; Research funded, Siemens AX.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1985

Design and testing of a coaxial linear magnetic spring with integral linear motor

The design of a coaxial linear magnetic spring which incorporates a linear motor to control axial motion and overcome system damping is presented, and the results of static and dynamic tests are reported. The system has nominal stiffness 25,000 N/m and is designed to oscillate a 900-g component over a 4.6-mm stroke in a Stirling-cycle cryogenic refrigerator being developed for long-service (5-10-yr) space applications (Stolfi et al., 1983). Mosaics of 10 radially magnetized high-coercivity SmCO5 segments enclosed in Ti cans are employed, and the device is found to have quality factor 70-100, corresponding to energy-storage efficiency 91-94 percent. Drawings, diagrams, and graphs are provided.

Patt, P. J.↗
DOE OSTI2018

Rnf112 deletion protects brain against intracerebral hemorrhage (ICH) in mice by inhibiting TLR-4/NF-κB pathway

Highlights: • Rnf112{sup −/−} mice exhibits accelerated brain injury and neuroinflammation. • Rnf112{sup −/−} promotes inflammation by enhancing TLR-4/NF-κB pathway. • Over-expressing Rnf112 attenuates brain injury after intracerebral hemorrhage. Intracerebral hemorrhage (ICH) is reported as a common and often fatal type of stroke accompanied with high morbidity and mortality, and it frequently results in long-lasting neurological dysfunctions. However, the pathogenesis that contributes to ICH has not been fully understood. Rnf112, also known as Znf179, is a member of the RING finger protein family. The expression of Rnf112 is abundant in the brain and is modulated during brain progression and development. The study aimed to explore the role of Rnf112 in brain injury after ICH, as well as the underlying molecular mechanisms. The results indicated that ICH led to a significant decrease in Rnf112, which was confirmed in oxyhemoglobin (oxyHb)-incubated astrocytes and microglial cells. Moreover, the Rnf112 knockout (Rnf112{sup −/−}) mice and wild type (WT) mice induced by ICH were further employed. Compared to the WT/ICH group, Rnf112{sup −/−} mice exhibited accelerated brain injury, as evidenced by the increased brain water contents and neurological deficit scores (NDS). In comparison to WT/ICH group, a remarkable up-regulation in the release of pro-inflammatory cytokines, including tumor necrotic factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β, was observed in perihematoma tissues of Rnf112{sup −/−} mice on day 3 post-ICH. The process was along with promoted glial fibrillary acidic protein (GFAP) and Iba1 expression and reduced NeuN levels. Furthermore, ICH-induced increases in toll-like receptor (TLR)-4 and myeloid differentiation primary response protein (MyD88) expression were exacerbated by the loss of Rnf112. The phosphorylated expression of IKKα, inhibitor of NF-κB (IκBα) and nuclear factor-kappa B (NF-κB) induced by ICH in perihematoma tissues of mice was markedly enhanced in Rnf112{sup −/−} mice. Rnf112 repression-induced inflammatory response was verified in lipopolysaccharide (LPS)-incubated glial cells. In contrast, over-expressing Rnf112 markedly attenuated ICH-induced brain injury by restraining inflammation via inactivating TLR-4/NF-κB pathway. In summary, our findings suggested that Rnf112 expression was highly involved in the progression of ICH, and targeting Rnf112 signaling might be a promising therapeutic strategy against ICH development.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1991

Echocardiographic evaluation of the cardiovascular effects of short-duration spaceflight

Results are presented of echocardiographic investigations and hemodynamic measurements performed on 24 astronauts before and after short-duration (4-5 days) spaceflight, including data on the heart rate, blood pressure, and cardiac volumes. Cardiovascular changes which were found to occur after 4-5 day long spaceflight included decreased the left ventricular end-diastolic volume and the stroke volume indices, with a compensatory increased heart rate and the cardiac output being maintained; in addition, altered total peripheral vascular resistance was found to occur, with an apparent reduction in the ability to augment the peripheral vascular tone upon assuming the standing position. These cardiovascular characteristics normalized within 48 hrs of landing.

Mulvagh, Sharon L.↗
NASA NTRS2002

Improved Electrohydraulic Linear Actuators

A product line of improved electrohydraulic linear actuators has been developed. These actuators are designed especially for use in actuating valves in rocket-engine test facilities. They are also adaptable to similar industrial uses. The advantageous features of the improved electrohydraulic linear actuators are best described with respect to shortcomings of prior electrohydraulic linear actuators that the improved ones are intended to supplant. The shortcomings are the following: They perform unreliably and inconsistently as positioning devices. Their capabilities for end-of-stroke buffering (that is, deceleration to gentle stops at designated stopping positions) range from unsatisfactory to nonexistent, with consequent potential for inducing catastrophic failures. It takes long times to modify standard actuators to meet specifications, and the costs of such modifications are high. In the cases of actuators equipped with fail-safe shutdown systems, the stroking times of these systems cannot be adjusted in the field.

Hamtil, James↗
DOE OSTI2023

Characteristics of upward-connecting-leader current leading to attachment in downward negative cloud-to-ground lightning strokes

For this work, we analyzed currents associated with upward connecting leaders (UCLs) initiated from the Kennedy Space Center Industrial Area Tower in two negative cloud-to-ground strokes that struck the tower. One stroke was also recorded using a high-speed video camera located 760 m from the KSC IAT. The NLDN-reported peak currents for the two strokes were – 31.7 and – 98.5 kA. During the UCL development phase the current waveforms exhibited a monotonically (quasi-exponentially) increasing “background” current overlaid with 10-μs scale pulses with a median amplitude of 51.1 A. The UCL current durations for the two strokes were 1039 and 449 μs, respectively. During the pre-attachment processes (UCL and slow front) the total negative charge effectively transferred to ground were 70.2 and 55 mC, respectively. For the stroke captured on high-speed video, the average line-charge-density for the 109-m long UCL was found to be 0.5 mC/m. The average UCL 2-D speed was 2.4 × 10 5 m/s, and it was observed to accelerate toward the downward leader prior to attachment. We observed that UCL-pulse amplitudes are larger, background currents are higher, and interpulse intervals are shorter at later times during UCLs, which can be attributed to the intensification of the local electric field due to the approaching downward negative leader. The median positive charge injected into the UCL by a pulse was 297 μC. The UCL associated with the higher peak-current stroke produced the highest injected pulse-charge values about three times sooner during its development, likely due to the 2–2.7 times faster average downward leader vertical speeds.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1983

Free-piston stirling engine endurance test program

The Free-Piston Stirling Engine (FPSE) has the potential to be a long-lived, highly reliable, power conversion device attractive for many product applications such as space, residential, or remote-site power. The purpose of endurance testing the FPSE is to demonstrate its potential for long life. The endurance program was directed at obtaining 1000 operational hours under various test conditions: low power, full stroke, duty cycle, and stop/start. Critical performance parameters were measured to note any change and/or trend. Inspections were conducted to measure and compare critical seal/bearing clearance. The engine performed well throughout the program, completing the 1000 hours. Hardware inspection, including the critical clearances, showed no significant change in hardware or clearance dimensions. The performance parameters did not exhibit any increasing or decreasing trends. The test program confirms the potential for long-life FPSE applications. Additional testing is planned to increase the test hours to 10,000.

Dochat, G.↗
NASA NTRS1985

Free-piston Stirling engine/linear alternator 1000-hour endurance test

The Free Piston Stirling Engine (FPSE) has the potential to be a long lived, highly reliable, power conversion device attractive for many product applications such as space, residential or remote site power. The purpose of endurance testing the FPSE was to demonstrate its potential for long life. The endurance program was directed at obtaining 1000 operational hours under various test conditions: low power, full stroke, duty cycle and stop/start. Critical performance parameters were measured to note any change and/or trend. Inspections were conducted to measure and compare critical seal/bearing clearances. The engine performed well throughout the program, completing more than 1100 hours. Hardware inspection, including the critical clearances, showed no significant change in hardware or clearance dimensions. The performance parameters did not exhibit any increasing or decreasing trends. The test program confirms the potential for long life FPSE applications.

Rauch, J.↗
NASA NTRS2000

Tropical Cyclone Lightning Distribution and Its Relationship to Convection and Intensity Change

The long distance National Lightning Detection Network (NLDN) was used to monitor the distribution of lightning strokes in various 1998 and 1999 western North Atlantic tropical cyclones. These ground-based lightning observations together with the Defense Meteorological Satellite Program (DMSP) Special Sensor Microwave/Imager (SSM/I) and the Tropical Rain Mapping Mission (TRMM) Microwave Instrument (TMI) derived convective rain rates were used to monitor the propagation of electrically charged convective rain bands aid to qualitatively estimate intensification. An example of the lightning analyses was performed on hurricane George between 25-28 September, 1998 when the system left Key West and moved towards the Louisiana coast. During this period of time, George's maximum winds increased from 38 to 45 meters per second on 25 September and then remained steady state until it made landfall. Time-radius displays of the lightning strokes indicated that the greatest number of lightning strokes occurred within the outer core region (greater than 165 km) with little or no lightning strokes at radii less than 165 km. The trend in these lightning strokes decreased as George move into the Gulf of Mexico and showed no inward propagation. The lack inward propagating lightning strokes with time indicated that there was no evidence that an eye wall replacement was occurring that could alter George's intensity. Since George was steady state at this time, this result is not surprising. Time-azimuth displays of lightning strokes in an annulus whose outer and inner radii were respectively, 222 and 333 km from George's center were also constructed. A result from this analysis indicated that the maximum number of strokes occurred in the forward and rear right quadrant when George was over the Gulf of Mexico. This result is, consistent with the aircraft and satellite observations of maximum rainfall.

Rodgers, Edward↗
NASA NTRSDate not supplied

A Field Campaign to Study Lightning that Ignites the Bush

The impact of recent wildland fires in the United States and Australia have received much attention in the past several years. As a result, NASA has developed a new Earth Science program to better understand, predict, and manage this phenomenon, as well as a future suborbital mission to studying pyro-cumulonimbus clouds and their effects on the Earth system. In Australia, government and philanthropic stakeholders are supporting a series of field campaigns over the next few years to inform science requirements and advance technology for a future satellite mission to monitor Bushfires. Lightning flashes are a major source of wildland fires, but uncertainties remain about the physical characteristics of lightning and their parent thunderstorms responsible for igniting wildfires. It was long believed that most lightning-ignited wildfires are largely caused by positive flashes to the ground (CGs) and multi-stroke CGs, but a recent study looking at 26-years of NLDN data indicate otherwise. Perhaps this finding is due to statistical chance—there are more negative CGs that occur globally—or perhaps there is some unknown electrical property of the thundercloud from which the igniting flashes emanate. Regardless, new observing strategies are needed. Additionally, long continuing current CGs, which are more likely to ignite a fire, can elude detection by operational ground-based lightning location systems, making it difficult to efficiently identify potential wildland fires and manage them before they have adverse impacts. To address these science and operational gaps, NASA’s Lightning Mapping Array along with electric and magnetic field change meters will be deployed for the Australian Bushfire campaign to document the electrical structure and properties of thunderstorms and lightning that occur in a wildland fire susceptible region. Another aspect of the campaign will be the use of NASA’s airborne lightning observatory, which includes a spectrometer and high-speed imager, to document the radiometric attributes of these flashes coincident with the ground-based RF observations. These observations will be used to better understand the properties of lightning that ignite wildland fires as well as inform design of a lightning detection system for the future Bushfire Monitoring satellite mission.

lightning↗