IMP D&E /AIMP/ PFM encoding system interface document
Digital data processor, circuit design and fabrication, digital word readout, and interfaces for IMP D and IMP E pulse frequency modulation encoding system
IMP↗
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Role of the Mobile Active Site Flap in IMP Dehydrogenase Inhibitor Binding
Inosine 5′-monophosphate dehydrogenase (IMPDH) is a promising antibiotic target. This enzyme catalyzes the NAD-dependent oxidation of inosine 5′-monophosphate (IMP) to xanthosine 5′-monophosphate (XMP), which is the rate-limiting step in guanine nucleotide biosynthesis. Bacterial IMPDH-specific inhibitors have been developed that bind to the NAD + site. These inhibitors display varied affinities to different bacterial IMPDHs that are not easily rationalized by X-ray crystal structures of enzyme–inhibitor complexes. Inspection of X-ray crystal structures of 25 enzyme–inhibitor complexes, including 10 newly described, suggested that a mobile active site flap may be a structural determinant of inhibitor potency. Saturation transfer difference NMR experiments also suggested that the flap may contact the inhibitors to varying extents in different IMPDHs. Flap residue Leu413 contacted some inhibitors but was not structured in the crystal structures of other inhibitor complexes. The substitution of Leu413 with Phe or Ala in Bacillus anthracis IMPDH had inhibitor-selective effects, suggesting residue 413 could be a structural determinant of affinity. Curiously, the Ala substitution increased the potency of most inhibitors, even those that contacted Leu413 in the crystal structures. Presteady-state and steady-state kinetics experiments showed that the Leu413Ala substitution had comparable effects on inhibitor binding to the noncovalent E·IMP complex and the covalent intermediate E-XMP*, suggesting that the flap had similar interactions in both complexes. These results demonstrate that contacts do not necessarily indicate favorable interactions, and poorly structured mobile regions should not be discounted when assessing binding determinants.
Conformation↗
A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity
The steadily rising frequency of emerging diseases and antibiotic resistance creates an urgent need for new drugs and targets. Inosine 5'-monophosphate dehydrogenase (IMP dehydrogenase or IMPDH) is a promising target for the development of new antimicrobial agents. IMPDH catalyzes the oxidation of IMP to XMP with the concomitant reduction of NAD + , which is the pivotal step in the biosynthesis of guanine nucleotides. Potent inhibitors of bacterial IMPDHs have been identified that bind in a structurally distinct pocket that is absent in eukaryotic IMPDHs. The physiological role of this pocket was not understood. Here, we report the structures of complexes with different classes of inhibitors of Bacillus anthracis , Campylobacter jejuni , and Clostridium perfringens IMPDHs. These structures in combination with inhibition studies provide important insights into the interactions that modulate selectivity and potency. We also present two structures of the Vibrio cholerae IMPDH in complex with IMP/NAD + and XMP/NAD + . In both structures, the cofactor assumes a dramatically different conformation than reported previously for eukaryotic IMPDHs and other dehydrogenases, with the major change observed for the position of the NAD+ adenosine moiety. More importantly, this new NAD + -binding site involves the same pocket that is utilized by the inhibitors. Thus, the bacterial IMPDH-specific NAD + -binding mode helps to rationalize the conformation adopted by several classes of prokaryotic IMPDH inhibitors. As a result, these findings offer a potential strategy for further ligand optimization.
60 APPLIED LIFE SCIENCES↗
Magnetospheric electron density measurements from upper hybrid resonance noise observed by IMP-6
A band of natural radio noise between the local electron plasma frequency and the upper hybrid resonance frequency is observed by the IMP-6 satellite. The band exists over a large range of geocentric radial distances extending from inside the plasmapause boundary to greater than 10 earth radii in the outer magnetosphere. The center frequency of the noise band decreases with increasing radial distance, and changes abruptly at the plasmapause boundary. The broadband electric field strength of this noise is very small, seldom exceeding 10 microvolts/meter, and probably could not be detected without using long electric antennas of IMP-6. It is believed that this noise is produced by incoherent Cerenkov emission from super-thermal electrons. In some cases a second very narrow noise band was observed at a frequency slightly above the second harmonic of the electron gyrofrequency.
Shaw, R. R.↗
TRW plasma wave experiment for the IMP-H mission
The IMP-H plasma wave experiment is designed to extend knowledge of wave-particle interactions in the disturbed cislunar region, the distant geomagnetic tail, the upstream solar wind, and the flanks of the magnetosheath-shock interface. It is expected to identify plasma instabilities, study particle acceleration and heating at collisionless shocks and other discontinuities, analyze turbulent conductivity and field line merging, and provide new information on dissipation processes for suprathermal particles. Instrumentation for the plasma wave experiment is designed to measure local electric and magnetic field oscillations over the frequency range 10 Hz to 100 kHz. A 24 inch electric dipole, a 7 inch diameter air core search coil, and the associated preamplifiers are mounted on a spacecraft counterweight boom. The frequency range of 10 Hz to 100 kHz for both E and B is processed using an eight-channel spectrum analyzer located in the instrument main-body package (a standard IMP trapezoidal module, 3 inches high). Electric fields as small as 10-100 microvolts/meter and magnetic signals as small as 1-3 milligamma will be detected.
Virobik, P. F.↗
IMP J summary technical report
The IMP J Summary Technical Report provides technical and administrative guidance for design, fabrication, integration, testing, and prelaunch activity on future spacecraft programs. General problems encountered on the IMP J program are described, and a recommendation is offered for these problems on future programs.
Source record↗
IMS/Satellite Situation Center report: Predicted orbit plots for IMP-J-1976
Predicted orbit plots for the IMP-J satellite were given for the time period January-December 1976. These plots are shown in three projections. The time period covered by each set of projections is 12 days and 6 hours, corresponding approximately to the period of IMP-J. The three coordinate systems used are the Geocentric Solar Ecliptic system (GSE), the Geocentric Solar Magnetospheric system (GSM), and the Solar Magnetic system (SM). For each of the three projections, time ticks and codes are given on the satellite trajectories. The codes are interpreted in the table at the base of each plot. Time is given in the table as year/day/decimal hour, and the total time covered by each plot is shown at the bottom of each table.
Source record↗
Magnetosheath bursts of predominantly medium nuclei observed with Imp 8 on February 16, 1974
This paper presents observations made with detectors aboard Imp 8 of a unique series of charged particle bursts that occurred on February 16, 1974, while the spacecraft was traversing the dawn magnetosheath region. This event was unlike any other observation of Imp 7 and 8 in 5.5 years of operation in orbit. The measurements are most directly interpreted as an intense (6000/(sq cm s sr MeV/nucleon)), highly collimated beam flowing in the antisolar direction composed of medium (carbon, nitrogen, or oxygen) nuclei. Both the degree of collimation in arrival direction and the composition are unique to this event. The event is possibly an important signature of terrestrial O(+) ions escaping from the magnetosphere.
Armstrong, T. P.↗
IMP-8. Volume 2: Scientific section
Results of the analysis of the IMP-8 data, which was collected during the first six and one-half years after launch of the IMP-8 spacecraft are presented. The plasma wave experiment data were processed and are available in an easily accessible summary form. These data continue to provide a valuable source for comparative studies with plasma wave experiments on other spacecraft operating in the solar wind and within the Earth's magnetosphere.
Source record↗
Radial gradient of cosmic ray intensity from a comparative study of data from Voyager 1 and 2 and IMP 8
The IMP 8 satellite and Voyager 1 and 2 space probes obtained cosmic ray measurements during the late 1977 to mid-1982 period. Comparisons of 27-day averages of the data show that a positive radial intensity gradient existed on the average during this period, and that the cosmic ray intensity decrease toward solar maximum in 1980-1981 proceeds in a stepwise fashion. The cosmic ray minimum reached in late 1980/early 1981 appears almost simultaneously at 1 AU and at 10 AU, with and without propagation time delay effects, between IMP 8 and the Voyager spacecraft. These data are generally consistent with a heliolatitudinal gradient of 0 + or - 1 percent/deg. Attention is given to the implications of these results in the overall context of cosmic ray modulation theory.
Venkatesan, D.↗
Energetic neutral atoms (E approximately 50 keV) from the ring current - IMP 7/8 and ISEE 1
Energetic neutral atoms (ENA), emitted from the magnetosphere with energies of about 50 keV, have been measured with solid state detectors on the IMP 7/8 and ISEE 1 spacecraft; they are produced when singly charged trapped ions collide with the exosphere neutral hydrogen geocorona and the energetic ions are neutralized by charge exchange. ENA observations during the recovery phase of two moderate geomagnetic storms are analyzed: November 22-23, 1973, from IMP 8 at 33 earth radii and December 17, 1977, from ISEE 1 at 20 earth radii.
Roelof, E. C.↗
IMP-8 observations of traveling compression regions - New evidence for near-earth plasmoids and neutral lines
An examination of IMP-8 tail lobe magnetic field measurements has been conducted to determine whether the traveling compression region (TCR) phenomena detected by ISEE-3 in the distant geotail, and believed to be caused by tailward moving plasmoids, are present closer to the earth. The study produced 16 examples of TCRs at distances of X = -31 to -37 R(E). For two events considered in detail, TCRs were observed in close association with substorm growth phase signatures in the lobes. The lengths of these TCRs are estimated to be 8-12 R(E). The conclusion is that the IMP-8 TCR observations provide new evidence that small plasmoids and, hence, multiple reconnection neutral lines can sometimes exist earthward of X = -35 R(E).
Slavin, J. A.↗
Magnetotail views at 33R(sub E): IMP 8 magnetometer observations
This paper presents magnetic field vector (B) maps, electric current vector (curl B) maps, magnetic force (JxB) contour maps, and total field contour maps covering the full tail cross section in the yz plane. The maps are based on 16 years of 5-min averages of Interplanetary Monitoring Platform (IMP) 8 magnetic field data. During this time, IMP 8 traversed the tail between -25R(sub E) and -40R(sub E) in the x direction. Its average x distance was -33R(sub E). For this average distance we show separate maps for low and high dipole tilts, corresponding to equinox and northern hemisphere summer seasons. The low-tilt (equinox) maps show symmetrical field and current patterns; the high-tilt (solstice) maps show the cross-tail current sheet arcing above the equatorial diagonal in the center and dipping below it on the flanks. The shape of warped current sheet fits Fairfield's (1980) displaced ellipse model fairly well. The distance at which the current sheet is hinged to the magnetic equator is found to be 9.88R(sub E) and is independent of Kp. The z profile of current density shows a central peak, 3R(sub E) full width at half maximum, and smaller, flanking shoulders. A Harris sheet profile with a 7R(sub E) thickness fits the B(sub x) profile. Though these are magnetic field data, the JxB maps clearly outline the plasma sheet. This approach also gives 7R(sub E) thickness. Many of the average field and current features inferred and demonstrated in earlier studies are confirmed here; some of them are seen for the first time in full cross-section view. Among new features revealed are a large current vortex in the winter hemisphere lobe, a dawn-dusk asymmetry in the JxB force in the plasma sheet (it is stronger on the duskside), and a separation of the cross-tail current sheet into core and wing parts.
Kaymaz, Zerefsan↗
Radial evolution of the solar wind from IMP 8 to Voyager 2
Voyager 2 and Interplanetary Monitoring Platform (IMP) 8 data from 1977 through 1994 are presented and compared. Radial velocity and temperature structures remain intact over the distance from 1 to 43 AU, but density structures do not. Temperature and velocity changes are correlated and nearly in phase at 1 AU, but in the outer heliosphere temperature changes lead velocity changes by tens of days. Solar cycle variations are detected by both spacecraft, with minima in flux density and dynamic pressure near solar maxima. Differences between Voyager 2 and IMP 8 observations near the solar minimum in 1986-1987 are attributed to latitudinal gradients in solar wind properties. Solar rotation variations are often present even at 40 AU. The Voyager 2 temperature profile is best fit with a R(exp -0.49 +/- 0.01) decrease, much less steep than an adiabatic profile.
Richardson, John D.↗
Integrated Micro-Power System (IMPS) Development at NASA Glenn Research Center
Glenn Research Center (GRC) has a long history of energy related technology developments for large space related power systems, including photovoltaics, thermo-mechanical energy conversion, electrochemical energy storage. mechanical energy storage, power management and distribution and power system design. Recently, many of these technologies have begun to be adapted for small, distributed power system applications or Integrated Micro-Power Systems (IMPS). This paper will describe the IMPS component and system demonstration efforts to date.
Wilt, David↗
[Development Of 25-Year Imp 8 Bow Shock Crossing "List, Ingestion Of This List To Cdaweb, & Enhancement"]
The MIT portion of this project was to use the plasma data from IMP 8 to identify bow shock crossings for construction of a bow shock data base. In collaboration with Goddard, we determined which shock parameters would be included in the catalog and developed a set of flags for characterizing the data. IMP 8 data from 1973-2001 were surveyed for bow shock crossings; the crossings apparent in the plasma data were compared to a list of crossing chosen in the magnetometer data by Goddard. Differences were reconciled to produce a single list. The data were then provided to the NSSDC for archiving. All the work ascribed to MIT in the proposal was completed.
Merka, J.↗
Preliminary results from the ames research center plasma probe observations of the solar- wind-geomagnetic field interaction region on imp-ii and ogo-i.
IMP-II and OGO-I measurements on plasma characteristics in transition region between solar wind and geomagnetic field
PLASMA PROBE↗
IMP D TE-M-458 retromotor and igniter safety and handling plan
Safety procedures for handling IMP retrorocket and igniter
IGNITER↗