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At least 55 records · Page 3

Connectivity, Pathology, and ApoE4 Interactions Predict Longitudinal Tau Spatial Progression and Memory

ABSTRACT Tau pathology spread into neocortex indicates a transition from healthy aging to Alzheimer's disease (AD). Connectivity between tau epicenters and later accumulating regions of cortex has been proposed as a mechanism of tau spread, but how this relationship changes with greater AD pathology burden or genotype is not understood. We investigated tau accumulation in two key regions, precuneus and inferior temporal cortex, using resting state functional connectivity (rsFC) and longitudinal PET imaging from a multicohort sample of cognitively unimpaired older adults. We examined how baseline tau PET, Aβ PET, and ApoE4 genotype status interact with rsFC between hippocampus and these downstream regions to predict rate of tau accumulation in neocortex. We found that the 3‐way interaction between connectivity, baseline tau, and baseline Aβ or ApoE4 status was associated with neocortical tau accumulation in precuneus and inferior temporal cortex. In addition, baseline tau, Aβ, and ApoE4 status also moderated the association between connectivity and rate of memory decline. Together, these results suggest that the extent and distribution of future tau accumulation may be predicted by the interaction of baseline connectivity, AD pathology, and genetic risk.

Neurosciences & Neurology↗

Updates to the Regional Seismic Travel Time (RSTT) Model: 1. Tomography

Abstract A function of global monitoring of nuclear explosions is the development of Earth models for predicting seismic travel times for more accurate calculation of event locations. Most monitoring agencies rely on fast, distance-dependent one-dimensional (1D) Earth models to calculate seismic event locations quickly and in near real-time. RSTT (Regional Seismic Travel Time) is a seismic velocity model and computer software package that captures the major effects of three-dimensional crust and upper mantle structure on regional seismic travel times, while still allowing for fast prediction speed (milliseconds). We describe updates to the RSTT model using a refined data set of regional phases (i.e., Pn, Pg, Sn, Lg) using the Bayesloc relative relocation algorithm. The tomographic inversion shown here acts to refine the previous RSTT public model ( rstt201404um ) and displays significant features related to areas of global tectonic complexity as well as further reduction in arrival residual values. Validation of the updated RSTT model demonstrates significant reduction in median epicenter mislocation (15.3 km) using all regional phases compared to the iasp91 1D model (22.1 km) as well as to the current station correction approach used at the Comprehensive Nuclear-Test-Ban Treaty Organization International Data Centre (18.9 km).

58 GEOSCIENCES↗

Mapping Patterns of Ipsilateral Supraclavicular Nodal Metastases in Breast Cancer: Rethinking the Clinical Target Volume for High-risk Patients

Purpose: To map the location of metastatic supraclavicular (SCV) lymph nodes (LNMs) in breast cancer patients with SCV node involvement and determine whether and where the radiation therapy clinical target volume (CTV) of this region could be modified in high-risk subsets. Methods and Materials: Fifty-five patients with metastatic SCV LNMs were eligible for geographic mapping and atlas coverage analysis. All LNMs and their epicenters were registered proportionally by referencing the surrounding landmarks onto simulation computed tomography images of a standard patient. CTVs based on selected SCV atlases, including the one by the Radiation Therapy Oncology Group (RTOG) were contoured. A modified SCV CTV was tried and shown to have better involved-node coverage and thus theoretically improved prophylaxis in this setting. Results: A total of 50 (91%) and 45 (81.8%) patients had LNMs in the medial and lateral SCV subregions, respectively. Also, 36 patients (65.5%) had LNMs located at the junction of the jugular-subclavian veins. All nodes were covered in only 25.5% to 41.8% of patients by different atlases. The RTOG atlas covered all nodes in 25.5% of patients. Stratified by the nodes in all the patients as a whole, 49.2% to 81.3% were covered, and the RTOG atlas covered 62.6%. The lateral and posterior borders were the most overlooked locations. Modification by extending the borders to natural anatomic barriers allowed the new CTV to cover all the nodes in 81.8% of patients and encompass 96.1% of all the nodes. Conclusions: According to the distribution of SCV LNMs, the extent of existing atlases might not be adequate for potential metastatic sites in certain groups of patients. The extension of the lateral and posterior CTV borders in high-risk or recurrent patients might be a reasonable approach for increasing coverage. However, additional data in more homogeneous populations with localized disease are needed before routine application.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Spatial mapping of the localized corrosion behavior of a magnesium alloy AZ31B tungsten inert gas weld

Sections of a magnesium alloy, AZ31B, joined with tungsten inert gas (TIG) welding, were examined with scanning electrochemical microscopy (SECM) and scanning Kelvin probe force microscopy (SKPFM) to investigate corrosion mechanisms by correlating observed corrosion behavior with weld-affected microstructural variations. Insight into the changing nature of the galvanic couples between weld zones and at localized microgalvanic sites were investigated using SECM and SKPFM to map both electrochemically active regions and Volta potential differences across the weld-affected zones. The formation of an Al-Zn solidification network in the fusion zone (FZ) at and near the TIG weld epicenter differs from the outer heat-affected zone (HAZ), where intermetallic particles (IMPs) are the notable secondary phase from the magnesium matrix. These microstructures were mapped with SKPFM before and after brief exposure to a salt solution, revealing micro-galvanic couples as the main driving force to corrosion initiation and propagation within each zone. The IMPs and Al-Zn solidification network act as strong cathodes and govern the corrosion processes. The galvanic coupling and evolution of the intrinsic corrosion behavior between the weld zones is explained by monitoring the hydrogen evolution reaction (HER) with SECM over time. Anodically induced cathodic activation is confirmed for this welded material, as micro-galvanic couples between microstructural features are found to transition over time to broad electrochemically active areas within the weld-affected zones, resulting in polarity reversal as time of exposure proceeds.

Anodically induced cathodic activation↗

Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain

According to the network model of neurodegeneration, the spread of pathogenic proteins occurs selectively along connected brain regions. We tested in vivo whether the distribution of filamentous tau (measured with [ 18 F]flortaucipir-PET), fibrillar amyloid-β ([ 11 C]PIB-PET) and glucose hypometabolism ([ 18 F]FDG-PET) follows the intrinsic functional organization of the healthy brain. We included 63 patients with Alzheimer's disease (AD; 30 male, 63 ± 8 years) who underwent [ 18 F]flortaucipir, [ 11 C]PIB and [ 18 F]FDG PET, and 1000 young adults (427 male, 21 ± 3 years) who underwent task-free fMRI. We selected six predefined disease epicenters as seeds for whole-brain voxelwise covariance analyses to compare correlated patterns of tracer uptake across AD patients against fMRI intrinsic connectivity patterns in young adults. We found a striking convergence between [18F]flortaucipir covariance patterns and intrinsic connectivity maps (range Spearman rho's: 0.32-0.78, p < .001), which corresponded with expected functional networks (range goodness-of-fit: 3.8-8.2). The topography of amyloid-β covariance patterns was more diffuse and less network-specific, while glucose hypometabolic patterns were more spatially restricted than tau but overlapped with functional networks. These findings suggest that the spatial patterns of tau and glucose hypometabolism observed in AD resemble the functional organization of the healthy brain, supporting the notion that tau pathology spreads through circumscribed brain networks and drives neurodegeneration.

60 APPLIED LIFE SCIENCES↗

Modeling of fault activation and seismicity by injection directly into a fault zone associated with hydraulic fracturing of shale-gas reservoirs

We conducted three-dimensional coupled fluid-flow and geomechanical modeling of fault activation and seismicity associated with hydraulic fracturing stimulation of a shale-gas reservoir. We simulated a case in which a horizontal injection well intersects a steeply dip- ping fault, with hydraulic fracturing channeled within the fault, during a 3-hour hydraulic fracturing stage. Consistent with field observations, the simulation results show that shale-gas hydraulic fracturing along faults does not likely induce seismic events that could be felt on the ground surface, but rather results in numerous small microseismic events, as well as aseismic deformations along with the fracture propagation. The calculated seismic moment magnitudes ranged from about -2.0 to 0.5, except for one case assuming a very brittle fault with low residual shear strength, for which the magnitude was 2.3, an event that would likely go unnoticed or might be barely felt by humans at its epicenter. The calculated moment magnitudes showed a dependency on injection depth and fault dip. We attribute such dependency to variation in shear stress on the fault plane and associated variation in stress drop upon reactivation. Our simulations showed that at the end of the 3-hour injection, the rupture zone associated with tensile and shear failure extended to a maximum radius of about 200 m from the injection well. The results of this modeling study for steeply dipping faults at 1000 to 2500 m depth is in agreement with earlier studies and field observations showing that it is very unlikely that activation of a fault by shale-gas hydraulic fracturing at great depth (thousands of meters) could cause felt seismicity or create a new flow path (through fault rupture) that could reach shallow groundwater resources.

54 ENVIRONMENTAL SCIENCES↗

Long- and short-term triggering and modulation of mud volcano eruptions by earthquakes

Earthquakes can trigger the eruption of mud. In this study, we use eruptions in Azerbaijan, Italy, Romania, Japan, Andaman Islands, Pakistan, Taiwan, Indonesia, and California to probe the nature of stress changes that induce new eruptions and modulate ongoing eruptions. Dynamic stresses produced by earthquakes are usually inferred to be the dominant triggering mechanism; however static stress changes acting on the feeder systems of mud volcanoes may also play a role. In Azerbaijan, eruptions within 2-10 fault lengths from the epicenter are favored in the year following earthquakes where the static stress changes cause compression of the mud source and unclamp feeder dikes. In Romania, Taiwan, and some Italian sites, increased activity is also favored where the static stress changes act to unclamp feeder dikes, but responses occur within days. The eruption in the Andaman Islands, and those of the Niikappu mud volcanoes, Japan are better correlated with amplitude of dynamic stresses produced by seismic waves. Similarly, a new island that emerged off the coast of Pakistan in 2013 was likely triggered by dynamic stresses, enhanced by directivity. At the southern end of the Salton Sea, California earthquakes increase the gas flux at small mud volcanoes. Responses are best correlated with dynamic stresses. The comparison of responses in these nine settings indicates that dynamic stresses are most often correlated with triggering, although permanent stress changes as small as, and possibly smaller than, 0.1 bar may be sufficient to also influence eruptions. Unclamping stresses with magnitude similar to Earth tides (0.01 bar) persist over time and may play a role in triggering delayed responses. Lastly, unclamping stresses may be important contributors to short-term triggering only if they exceed 0.1-1 bar.

58 GEOSCIENCES↗

Infrasound From a Buried Chemical Explosion Recorded on a Balloon in the Lower Stratosphere

Abstract Infrasound waveforms generated by natural and anthropogenic phenomena contain important clues about the size and nature of the event. We show that sensors on balloons in the lower stratosphere can record faithful representations of the near‐source acoustic wave field at unprecedented range. The acoustic signature of a buried chemical explosion recorded at a range of 56 km and an altitude of 21.8 km was nearly identical to that recorded on the ground 0.5 km from the epicenter, but absent on a ground sensor located 46 km away. Our results demonstrate that balloon‐borne infrasound techniques greatly increase the range at which well‐preserved acoustic representations of near‐source physics can be acquired, and that their propagation is simple to model. Our work has implications for monitoring remote regions of the earth for explosions, volcanic eruptions, and other phenomena. It also supports the prospect of balloon‐based infrasound seismology on Venus.

Bowman, Daniel C.↗

A “Floatilla” of Airborne Seismometers for Venus

Abstract Barometers floating on high‐altitude balloons in the relatively clement cloud layer on Venus could detect and characterize acoustic waves generated by seismic activity, avoiding the need for high‐temperature electronics required for surface seismology. Garcia et al. (2022, https://doi.org/10.1029/2022GL098844 ) recently demonstrated the detection of low‐frequency sound (infrasound) caused by earthquakes of magnitudes 7.3 and 7.5 from stratospheric balloons nearly 3,000 km away from the epicenter. They provided a preliminary demonstration of earthquake magnitude and location inversion, and the determination of S‐ and Rayleigh wave velocities using only their acoustic signature. Large earthquakes produce low‐frequency seismic waves that penetrate the interiors of planets; their detection at continental‐scale distances from a high‐vantage point demonstrates the feasibility of balloon‐based investigations of Venus' interior. We contextualize these results within the effort to perform seismology on Venus from balloons, discuss its limitations, and share perspectives on open research questions in this area.

Krishnamoorthy, Siddharth↗

Spatiotemporal Graph Convolutional Networks for Earthquake Source Characterization

Abstract Accurate earthquake location and magnitude estimation play critical roles in seismology. Recent deep learning frameworks have produced encouraging results on various seismological tasks (e.g., earthquake detection, phase picking, seismic classification, and earthquake early warning). Many existing machine learning earthquake location methods utilize waveform information from a single station. However, multiple stations contain more complete information for earthquake source characterization. Inspired by recent successes in applying graph neural networks (GNNs) in graph‐structured data, we develop a Spatiotemporal Graph Neural Network (STGNN) for estimating earthquake locations and magnitudes. Our graph neural network leverages geographical and waveform information from multiple stations to construct graphs automatically and dynamically by adaptive message passing based on graphs' edges. Using a recent graph neural network and a fully convolutional neural network as baselines, we apply STGNN to earthquakes recorded by the Southern California Seismic Network from 2000 to 2019 and earthquakes collected in Oklahoma from 2014 to 2015. STGNN yields more accurate earthquake locations than those obtained by the baseline models and performs comparably in terms of depth and magnitude prediction, though the ability to predict depth and magnitude remains weak for all tested models. Our work demonstrates the potential of using GNNs and multiple stations for better automatic estimation of earthquake epicenters.

58 GEOSCIENCES↗

Nowcasting Earthquakes With Stochastic Simulations: Information Entropy of Earthquake Catalogs

Earthquake nowcasting has been proposed as a means of tracking the change in large earthquake potential in a seismically active area. The method was developed using observable seismic data, in which probabilities of future large earthquakes can be computed using Receiver Operating Characteristic methods. Furthermore, analysis of the Shannon information content of the earthquake catalogs has been used to show that there is information contained in the catalogs, and that it can vary in time. So an important question remains, where does the information originate? In this paper, we examine this question using stochastic simulations of earthquake catalogs. Our catalog simulations are computed using an Earthquake Rescaled Aftershock Seismicity (“ERAS”) stochastic model. This model is similar in many ways to other stochastic seismicity simulations, but has the advantage that the model has only 2 free parameters to be set, one for the aftershock (Omori-Utsu) time decay, and one for the aftershock spatial migration away from the epicenter. Generating a simulation catalog and fitting the two parameters to the observed catalog such as California takes only a few minutes of wall clock time. While clustering can arise from random, Poisson statistics, we show that significant information in the simulation catalogs arises from the “non-Poisson” power-law aftershock clustering, implying that the practice of de-clustering observed catalogs may remove information that would otherwise be useful in forecasting and nowcasting. We also show that the nowcasting method provides similar results with the ERAS model as it does with observed seismicity.

58 GEOSCIENCES↗

Rapid wavefield forecasting for earthquake early warning via deep sequence to sequence learning

We propose a deep learning model, WaveCastNet, to forecast high-dimensional wavefields. WaveCastNet integrates a convolutional long expressive memory architecture into a sequence-to-sequence forecasting framework, enabling it to model long-term dependencies and multiscale patterns in both space and time. By sharing weights across spatial and temporal dimensions, WaveCastNet requires significantly fewer parameters than more resource-intensive models such as transformers, resulting in faster inference times. Crucially, WaveCastNet also generalizes better than transformers to rare and critical seismic scenarios, such as high-magnitude earthquakes. Here, we show the ability of the model to predict the intensity and timing of destructive ground motions in real time, using simulated data from the San Francisco Bay Area. Furthermore, we demonstrate its zero-shot capabilities by evaluating WaveCastNet on real earthquake data. Our approach does not require estimating earthquake magnitudes and epicenters, steps that are prone to error in conventional methods, nor does it rely on empirical ground-motion models, which often fail to capture strongly heterogeneous wave propagation effects.

Geophysics↗

CORONAL SEISMOLOGY USING EIT WAVES: ESTIMATION OF THE CORONAL MAGNETIC FIELD STRENGTH IN THE QUIET SUN

Coronal EIT waves have been observed for many years. The nature of EIT waves is still contentious, however, there is strong evidence that some of them might be fast magnetosonic waves, or at least have a fast magnetosonic wave component. The fast magnetosonic wave speed is formed from two components; the Alfven speed (magnetic) and the sound speed (thermal). By making measurements of the wave speed, coronal density and temperature it is possible to calculate the quiet-Sun coronal magnetic field strength through coronal seismology. In this paper, we investigate an EIT wave observed on 2009 February 13 by the SECCHI/EUVI instruments on board the STEREO satellites. The wave epicenter was observed at disk center in the STEREO B (Behind) satellite. At this time, the STEREO satellites were separated by approximately 90 deg., and as a consequence the STEREO A (Ahead) satellite observed the wave on the solar limb. These observations allowed us to make accurate speed measurements of the wave. The background coronal density was derived through Hinode/Extreme-ultraviolet Imaging Spectrometer observations of the quiet Sun and the temperature was estimated through the narrow temperature response in the EUVI bandpasses. The density, temperature, and speed measurements allowed us to estimate the quiet-Sun coronal magnetic field strength to be approximately 0.7 {+-} 0.7 G.

79 ASTRONOMY AND ASTROPHYSICS↗

Novel neutron sources at the Radiological Research Accelerator Facility

Since the 1960s, the Radiological Research Accelerator Facility (RARAF) has been providing researchers in biology, chemistry and physics with advanced irradiation techniques, using charged particles, photons and neutrons. We are currently developing a unique facility at RARAF, to simulate neutron spectra from an improvised nuclear device (IND), based on calculations of the neutron spectrum at 1.5 km from the epicenter of the Hiroshima atom bomb. This is significantly different from a standard fission spectrum, because the spectrum changes as the neutrons are transported through air, and is dominated by neutron energies between 0.05 and 8 MeV. This facility will be based on a mixed proton/deuteron beam impinging on a thick beryllium target. A second, novel facility under development is our new neutron microbeam. The neutron microbeam will, for the first time, provide a kinematically collimated neutron beam, 10-20 micron in diameter. This facility is based on a proton microbeam, impinging on a thin lithium target near the threshold of the Li-7(p,n)Be-7 reaction. Lastly, this novel neutron microbeam will enable studies of neutron damage to small targets, such as single cells, individual organs within small animals or microelectronic components.

61 RADIATION PROTECTION AND DOSIMETRY↗

Ground motion response to an ML 4.3 earthquake using co-located distributed acoustic sensing and seismometer arrays

The PoroTomo research team deployed two arrays of seismic sensors in a natural laboratory at Brady Hot Springs, Nevada in March 2016. The 1500 m (length) by 500 m (width) by 400 m (depth) volume of the laboratory overlies a geothermal reservoir. The surface Distributed Acoustic Sensing (DAS) array consisted of 8700 m of fiber-optic cable in a shallow trench, including 340 m in a well. The conventional seismometer array consisted of 238 three- component geophones. The DAS cable was laid out in three parallel zig-zag lines with line segments approximately 100 meters in length and geophones were spaced at approximately 60- meter intervals. Both DAS and conventional geophones recorded continuously over 15 days during which a moderate-sized earthquake with a local magnitude of 4.3 was recorded on March 21, 2016. Its epicenter was approximately 150-km south-southeast of the laboratory. Several DAS line segments with co-located geophone stations were used to compare signal-to-noise (SNR) ratios in both time and frequency domains and to test relationships between DAS and geophone data. The ratios were typically within a factor of five of each other with DAS SNR often greater for P-wave but smaller for S-wave relative to geophone SNR. The SNRs measured for an earthquake can be better than for active sources, because the earthquake signal contains more low frequency energy and the noise level is also lower at those lower frequencies. Amplitudes of the sum of several DAS strain-rate waveforms matched the finite difference of two geophone waveforms reasonably well, as did the amplitudes of DAS strain waveforms with particle-velocity waveforms recorded by geophones. Similar agreement was found between DAS and geophone observations and synthetic strain seismograms. In conclusion, the combination of good SNR in the seismic frequency band, high-spatial density, large N, and highly accurate time control among individual sensors suggests that DAS arrays have potential to assume a role in earthquake seismology.

60 signal-to-noise ratio↗

Continental-scale water-level response to a large earthquake

© 2014 John Wiley & Sons Ltd. Co-seismic groundwater-level changes induced by earthquakes have been reported for thousands of years. The M8.0 Wenchuan earthquake caused co-seismic groundwater-level responses across the Chinese mainland. Three types of changes were recorded in 197 monitoring wells: co-seismic oscillations ranging in amplitude from 0.004 to 1.1 m, immediate co-seismic step changes ranging from 0.0039 to 9.188 m, and more gradual postseismic changes ranging from 0.014 to 1.087 m. We find that the co-seismic groundwater-level response is complex. There is neither a clear relationship between the response amplitude and the distance from the epicenter, nor a clear relationship between the groundwater response and lithology at the continental scale. Both the sign and amplitude of water-level changes are random at the continental scale, and a poroelastic response to the co-seismic static strain cannot explain most of the co-seismic changes. However, wells located near the edges of tectonically active blocks have larger response amplitudes than those in the middle of these 'stable' blocks. Considered together, these observations indicate that permeability enhancement caused by the earthquake is a significant or dominant mechanism causing water-level changes. These data indicate that large earthquakes can cause the widespread permeability changes in the shallow crust although the magnitude of permeability change is uncertain.

Shi, Z↗

SU-F-J-223: Patterns of Failure for Laryngeal Cancer Patients Treated with Definitive IMRT: Comparing Two Different Methods for Determining the Origin of Recurrence From Follow-Up PET/CT Scans

Purpose: To determine patterns of failure in laryngeal cancer treated with definitive IMRT by comparing two different methods for identifying the recurrence epicenter on follow-up PET/CT. Methods: We identified 20 patients treated for laryngeal squamous cell carcinoma with definitive IMRT who had loco-regional recurrence diagnosed on PET/CT. Recurrence PET/CT scans were co-registered with the original treatment planning CT using deformable image registration with the VoxAlign deformation engine in MIM Software. Recurrence volumes were delineated on co-registered follow-up scans using a semi-automatic PETedge tool and two separate methods were used to identify the recurrence point of origin: a) Finding the point within the recurrence volume for which the maximum distance to the surface of the surrounding recurrence volume is smaller than for any other point. b) Finding the point within the recurrence volume with the maximum standardized uptake value (SUVmax), without geometric restrictions.For each method the failure pattern was determined as whether the recurrence origin fell within the original high-dose target volumes GTV70, CTV70, PTV70 (receiving 70Gy), intermediate-risk PTV59 (receiving 59.4Gy) or low-risk PTV54 (receiving 54.1Gy), in the original treatment planning CT. Results: 23 primary/nodal recurrences from the 20 patients were analyzed. The three-dimensional distance between the two different origins was on average 10.5mm (std.dev. 10mm). Most recurrences originated in the high-dose target volumes for both methods with 13 (57%) and 11 (48%) in the GTV70 and 20 (87%) and 20 (87%) in the PTV70 for method a) and b), respectively. There was good agreement between the two methods in classifying the origin target volumes with 69% concordance for GTV70, 89% for CTV70 and 100% for PTV70. Conclusion: With strong agreement in patterns of failure between two separate methods for determining recurrence origin, we conclude that most recurrences occurred within the high-dose treatment region, which influences potential risk-adaptive treatment strategies.

60 APPLIED LIFE SCIENCES↗

T-wave propagation from the Pacific to the Atlantic: The 2020 Mw 7.4 Kermadec Trench earthquake case

An Mw7.4 submarine earthquake occurred in the Kermadec Trench, northeast of New Zealand, on 18 June, 2020. This powerful earthquake triggered energetic tertiary waves (T-waves) that propagated through the South Pacific Ocean into the South Atlantic Ocean, where the T-waves were recorded by a hydrophone station near Ascension Island, 15 127 km away from the epicenter. Different T-wave arrivals were identified during the earthquake period with arrival angles deviating from the geodesic path. A three-dimensional sound propagation model has been utilized to investigate the cause of the deviation and confirm the horizontal diffraction of the T-waves at the Drake Passage.

Oliveira, Tiago C. A.↗