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Strength training reduces arterial blood pressure but not sympathetic neural activity in young normotensive subjects

The effects of resistance training on arterial blood pressure and muscle sympathetic nerve activity (MSNA) at rest have not been established. Although endurance training is commonly recommended to lower arterial blood pressure, it is not known whether similar adaptations occur with resistance training. Therefore, we tested the hypothesis that whole body resistance training reduces arterial blood pressure at rest, with concomitant reductions in MSNA. Twelve young [21 +/- 0.3 (SE) yr] subjects underwent a program of whole body resistance training 3 days/wk for 8 wk. Resting arterial blood pressure (n = 12; automated sphygmomanometer) and MSNA (n = 8; peroneal nerve microneurography) were measured during a 5-min period of supine rest before and after exercise training. Thirteen additional young (21 +/- 0.8 yr) subjects served as controls. Resistance training significantly increased one-repetition maximum values in all trained muscle groups (P < 0.001), and it significantly decreased systolic (130 +/- 3 to 121 +/- 2 mmHg; P = 0.01), diastolic (69 +/- 3 to 61 +/- 2 mmHg; P = 0.04), and mean (89 +/- 2 to 81 +/- 2 mmHg; P = 0.01) arterial blood pressures at rest. Resistance training did not affect MSNA or heart rate. Arterial blood pressures and MSNA were unchanged, but heart rate increased after 8 wk of relative inactivity for subjects in the control group (61 +/- 2 to 67 +/- 3 beats/min; P = 0.01). These results indicate that whole body resistance exercise training might decrease the risk for development of cardiovascular disease by lowering arterial blood pressure but that reductions of pressure are not coupled to resistance exercise-induced decreases of sympathetic tone.

NASA Discipline Neuroscience↗

Polymer-Oxygen Compatibility Testing: Effect of Oxygen Aging on Ignition and Combustion Properties

The oxygen compatibility of six polymers used in oxygen service was evaluated after exposure for 48 hours to oxygen pressures ranging from 350 to 6200 kPa (50 to 900 psia), and temperatures ranging from 50 to 250 C (122 to 302 F). Three elastomers were tested: CR rubber (C873-70), FKM fluorocarbon rubber (Viton A), and MPQ silicone rubber (MIL-ZZ-765, Class 2); and three thermoplastics were tested: polyhexamethylene adipamide (Zytel 42), polytetrafluoroethylene (Teflon TFE), and polychlorotrifluoroethylene (Neoflon CTFE M400H). Post-aging changes in mass, dimensions, tensile strength, elongation at break, and durometer hardness were determined. Also, the compression set was determined for the three elastomers. Results show that the properties under investigation were more sensitive to oxygen pressure at low to moderate temperatures, and more sensitive to temperature at low to moderate oxygen pressures. Inspection of the results also suggested that both chain scissioning and cross-linking processes were operative, consistent with heterogeneous oxidation. Attempts are underway to verify conclusively the occurrence of heterogeneous oxidation using a simple modulus profiling technique. Finally, the effect of aging at 620 kpa (90 psia) and 121 C (250 F) on ignition and combustion resistance was determined. As expected, aged polymers were less ignitable and combustible (had higher AlTs and lower heats of combustion). Special attention was given to Neoflon CTFE. More specifically, the effect of process history (compression versus extrusion molding) and percent crystallinity (quick- versus slow-quenched) on the AIT, heat of combustion, and impact sensitivity of Neoflon CTFE was investigated. Results show the AIT, heat of combustion, and impact sensitivity to be essentially independent of Neoflon CTFE process history and structure.

Waller, Jess M.↗

A new thermal vacuum facility at the Martin Marietta Waterton plant

A new thermal-vacuum facility has been recently completed at the Martin Marietta Waterton plant near Denver, Colorado. The facility was designed, fabricated, installed, and tested as a turn-key project by Pitt-Des Moines Inc. and CVI Inc. The chamber has a 5.49 M by 6.10 M (18 ft by 20 ft) flat floor and a half-cylindrical roof with a diameter of 5.49 M (18 ft). Both ends of the chamber have full cross section doors, with one equipped with translating motors for horizontal motion. The chamber is provided with four 0.91 M (36 inches) cryopumps to obtain an ultimate pressure of 9 x 10(exp -8) Torr (Clean-Dry-Empty). The thermal shroud is designed to operate at a maximum of -179 C (-290 F) with an internal heat input of 316 MJ/Hr (300,000 BTU/Hr) using liquid nitrogen. The shroud is also designed to operate at any temperature between -156 C (-250 F) and 121 C (+250 F) using gaseous nitrogen, and heat or cool at a rate of 1.1 C (2 F) per minute.

Watson, Robert N.↗

A method for determining landing runway length for a STOL aircraft

Based on data obtained from flight tests of the augmentor wing jet STOL research aircraft, a method is proposed for determining the length of the landing runway for powered-lift STOL aircraft. The suggested method determines runway landing length by summing three segments: the touchdown-dispersion distance, the transition distance from touchdown to application of brakes, and the stopping distance after brakes are applied. It is shown how the landing field length can be reduced either through improved autoland system design or by providing the pilot with appropriate information to allow him to identify a "low probability" long or short landing and to execute a go-around. The proposed method appears to determine a safe runway landing length for the STOL application and offers the potential for reducing runway length if great emphasis is placed on a short-runway capability. FAR Parts 25 and 121 appear conservative and suitable for the situation where no great emphasis is placed on reducing the runway length requirement.

Watson, D. M.↗

Impairment of Human Ocular Tracking with Low-Dose Alcohol

Previous studies have documented adverse effects of alcohol on oculomotor performance. For example, moderate-dose alcohol (yielding a Blood Alcohol Concentration or BAC of 0.04-0.1%) has been shown to decrease steady-state pursuit gain (Fransson et al., 2010, Clin Neurophysiol, 121(12): 2134; Moser et al., 1998, J Neurol, 245(8): 542; Roche & King, 2010, Psychopharmacology, 212(1): 33), to increase saccade latency (Moser et al., 1998, J Neurol, 245(8): 542; Roche & King, 2010, Psychopharmacology, 212(1): 33), to decrease peak saccadic velocity (Fransson et al., 2010, Clin Neurophysiol, 121(12): 2134; Roche & King, 2010, Psychopharmacology, 212(1): 33), and to increase the frequency of catch-up saccades (Moser et al., 1998, J Neurol, 245(8): 542). Here, we administered two doses of ethanol on different days, yielding moderate (0.06%) and low (0.02%) levels of initial BAC, to examine the effects on human ocular tracking over BACs ranging from 0.00 to 0.07%. Twelve subjects (8 females) participated in a 5-day study. Three days of at-home measurements of daily activity and sleep were monitored, followed by two laboratory days where, ~5 hours after awakening, we administered one of the two possible single doses of alcohol. Using a previously published paradigm (Liston & Stone, 2014, J Vis, 14(14): 12), we measured oculomotor performance multiple times throughout the day with three pre-dosing baseline runs and bi-hourly post-dosing test runs until the subject recorded a BAC of 0.00% for two hours. BAC was measured before each run using an Alco-Sensor IV breathalyzer (Intoximeters, Inc., St. Louis, MO). For each of the oculometric measures, for each subject, we computed the within-subject % deviation for each test run from their baseline averaged across their three pre-dosing runs. We then averaged the data across subjects in 0.01% BAC bins. Finally, we used linear regression to compute the slope and x-intercept (threshold) of the mean binned % deviation as a function of BAC. We found that pursuit initiation was impaired at very low BAC levels, with significant (p < 0.002) linear trends in latency (+1.3%/0.01%BAC) and initial acceleration (-4.6%/0.01%BAC) with extrapolated absolute thresholds at or below 0.01% BAC. We also found that steady-state tracking was impaired showing significant (p < 0.002) linear trends in gain (- 3.8%/0.01%BAC) and catch-up saccade amplitude (+9.1%/0.01%BAC), again with extrapolated absolute thresholds around 0.01% BAC. We also found a significant (p < 0.02) increase in pursuit direction noise (+9.8%/0.01%BAC) with an extrapolated absolute threshold below 0.01% BAC. Many aspects of ocular tracking are impaired in a dose-dependent manner beginning at a BAC level around 0.01%, with significant effects at levels lower than previously reported and up to 8-times lower than the legal limit for driving in most states.

human performance↗

Prevention of hypercalciuria and stone-forming propensity during prolonged bedrest by alendronate

The bone loss and hypercalciuria induced by immobilization or the decreased gravitational forces of space are well described. Using a model of bedrest immobilization, the ability of a potent aminobisphosphonate, alendronate, to avert hypercalciuria and stone-forming propensity was tested. Sixteen male subjects participated in a randomized, placebo-controlled trial in which they received either 20 mg of alendronate or placebo 2 weeks prior to and during 3 weeks of strict bedrest. Parameters of bone and calcium metabolism and urinary crystallization of stone-forming salts were measured before and at the end of bedrest. In the placebo group, bedrest increased urinary calcium (209 +/- 47 to 267 +/- 60 mg/day, p < 0.01) and the saturation of calcium phosphate. Before bedrest, the alendronate group had a significantly lower serum calcium (8.8 +/- 0.4 vs. 9.6 +/- 0.5 mg/dl, p < 0.01) and higher serum PTH (62.4 +/- 33.1 vs. 23.1 +/- 7.5 pg/ml, p < 0.01) compared with the placebo group. Moreover, the alendronate group had a lower urinary calcium (75 +/- 41 mg/day) and saturation of calcium oxalate and calcium phosphate. These effects of alendronate were sustained during bedrest. Following bedrest in the alendronate group, urinary calcium rose to 121 +/- 50 mg/day, a value less than that in the placebo group before or during bedrest. Similarly, urinary saturation of calcium oxalate and calcium phosphate rose with bedrest in the alendronate-treated patients but remained lower than values obtained in placebo-treated patients before or during bedrest. Alendronate inhibits bone mineral loss and averts the hypercalciuria and increased propensity for the crystallization of stone-forming calcium salts which occurs during 3 weeks of strict bedrest.

Non-NASA Center↗

Interim Measures Pilot Study Completion Report, South Repeater Building, Solid Waste Management Unit 121, Hydraulic Containment and Groundwater Treatment System for Per- and Polyfluoroalkyl Substances

This Per- and Polyfluoroalkyl Substances (PFAS) Interim Measures Pilot Study Completion Report was prepared for the National Aeronautics and Space Administration by AECOM Technical Services, Inc. under Contract 80KSC019D0010, Task Order 80KSC021F0096. The purpose of this report is to document the pilot study activities at the South Repeater Building, Solid Waste Management Unit (SWMU) 121. This report details the additional assessment activities completed from June 2023 through November 2023 and the subsequent pilot study completed at the South Repeater Building conducted in December 2023 through February 2024. Initial activities were conducted in accordance with the Pilot Study Work Plan (NASA 2023), submitted to the KSC Remediation Team and accepted by the team on October 26, 2023. The objectives of the pilot study were to: • Provide information on aquifer characteristics and to aid in future modeling and remedial design activities to mitigate off-KSC migration of PFAS compounds. • Develop information on characteristics of the surficial aquifer system, specifically transmissivity, storage coefficient, hydraulic conductivity, and vertical hydraulic conductivity. • Obtain data to support construction and calibration of a groundwater flow model. • Acquire design parameters necessary for future remedial design activities, specifically radius of influence, drawdown, flow rates, and pump settings. The following activities were completed to meet the pilot study objectives: • Groundwater and surface water sampling • Geophysical investigation via Hydraulic Profiling Tool (HPT) and soil sampling • Installation of observation and extraction wells via rotosonic techniques • Slug, step, and pump testing activities • Initial modeling efforts for a groundwater hydraulic containment system. Results of the pilot study and modeling activities are being used in the development of a groundwater containment and treatment system for the site.

PFAS↗

Hydrogen Isotopic Composition of Hydrous Minerals in Particles From Bennu

On September 24, 2023, NASA’s OSIRIS-REx mission delivered to Earth ~121 g of pristine carbonaceous regolith from asteroid Bennu. A first series of mineralogical observations and chemical/isotopic analyses of Bennu aggregate samples (fine to coarse particles up to a few mm) revealed that this material resembles the most chemically primitive chondrites and the samples returned by the JAXA’s Hayabusa2 mission from the carbonaceous asteroid Ryugu. Laboratory studies have confirmed the story gleaned from the spacecraft encounter that Bennu’s rock fragments underwent extensive aqueous alteration and are predominantly composed of hydrated minerals (serpentine, smectite) and other secondary minerals (e.g., magnetite, carbonates). The secondary phases were likely formed under the presence of liquid water on Bennu’s parent asteroid. The isotopic compositions of hydrous minerals and secondary phases can increase our understanding of the source and distribution of water and volatile elements in the protoplanetary disk [e.g., 5-8]. However, direct estimates of the hydrogen isotopic ratios (D/H) in hydrous minerals cannot be obtained easily in primitive rocks due to the difficulty in estimating the organic matter (OM) contribution to the whole H budget. In order to obtain hints on the initial constituents of Bennu’s parent asteroid and to test if Bennu's parent asteroid have formed beyond the snow line (hypothesis 4 of [9]), we measured the D/H and C/H ratios in chondritic matrices by secondary ion mass spectrometry (SIMS) and obtain information on the D/H ratio of water retained in the hydrated minerals. The method also gives clues on the hydrogen isotope variability among different Bennu rock fragments made available for measurement.

L Piani↗

South Repeater Building (Swmu 121) Pilot Study Work Plan, Kennedy Space Center, Florida

This document is a Pilot Study Work Plan for a groundwater remediation system at the South Repeater Building (N6-1118) located at the John F. Kennedy Space Center (KSC), Florida. Aqueous fire-fighting foam was applied near the building in the late 1990s during a wildfire. Per- and polyfluoroalkyl substances (PFAS) are components of the foam. Sampling completed at and near the South Repeater Building identified PFAS in groundwater, surface water and soil. KSC is planning to design and install a groundwater remediation system to address the potential for off-Center migration of PFAS compounds in groundwater. This Pilot Study Work Plan outlines subsurface hydrogeologic data that will be collected to use in the construction of a groundwater flow model that will guide the design of a full-scale remediation system. This document was prepared by AECOM Technical Services, Inc., for NASA under Indefinite Delivery Indefinite Quantity Contract 80KSC019D0010, Task Order 80KSC019F0096.

PFAS↗